4.7 Review

Trabecular Bone Score (TBS) in Individuals with Type 2 Diabetes Mellitus: An Updated Review

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Journal of Bone Metabolism (2021)

Article Endocrinology & Metabolism

Glucose variability and low bone turnover in people with type 2 diabetes

Jakob Starup-Linde et al.

Summary: In this study, individuals with T2D showed lower levels of bone turnover markers compared to controls, with s-CTX and s-P1NP being negatively associated with glycemic variability. Specifically, s-CTX was negatively associated with both MAGE and dawn glucose levels, while s-P1NP was only negatively associated with dawn glucose levels. Further research is needed to explore the impact of reducing glycemic variability on bone turnover markers.
Article Endocrinology & Metabolism

Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes

Praveer Sihota et al.

Summary: This study investigated alterations in bone tissue properties in individuals with type 2 diabetes following fragility hip fracture. The findings provide evidence of hyperglycemia's detrimental effects on trabecular bone quality at multiple scales, leading to reduced energy absorption and toughness, indicative of increased propensity to bone fragility.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Review Endocrinology & Metabolism

Type 2 Diabetes Mellitus and Vertebral Fracture Risk

Fjorda Koromani et al.

Summary: Recent studies have shown that vertebral fracture risk is increased in individuals with type 2 diabetes mellitus, and is associated with higher risk of non-vertebral fractures and mortality. An increased amount of bone marrow fat may contribute to bone fragility in T2DM. Both teriparatide and denosumab have been found effective in reducing vertebral fracture risk in individuals with T2DM.

CURRENT OSTEOPOROSIS REPORTS (2021)

Article Endocrinology & Metabolism

Plasma periostin as a biomarker of osteoporosis in postmenopausal women with type 2 diabetes

Junyan Li et al.

Summary: This study found a significant correlation between plasma periostin levels and bone mineral density in postmenopausal women with type 2 diabetes, suggesting that periostin may serve as a novel biochemical marker for osteoporosis in this population.

JOURNAL OF BONE AND MINERAL METABOLISM (2021)

Article Endocrinology & Metabolism

In Men With Obesity, T2DM Is Associated With Poor Trabecular Microarchitecture and Bone Strength and Low Bone Turnover

Francesca Vigevano et al.

Summary: In men, the combination of obesity and T2D is associated with reduced bone turnover and poorer trabecular bone microarchitecture and bone strength compared to those who are obese but without T2D, suggesting worse bone disease.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Cell Biology

A promising biomarker of elevated galanin level in hypothalamus for osteoporosis risk in type 2 diabetes mellitus

Penghua Fang et al.

Summary: Type 2 diabetes mellitus is considered a risk factor for osteoporosis, but the bone abnormalities associated with these two conditions may differ. Neuropeptide galanin plays a significant role in the pathogenesis of both T2DM and osteoporosis.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Review Endocrinology & Metabolism

Gut Microbiota in Bone Health and Diabetes

Julie Kristine Knudsen et al.

Summary: The review highlights the increased risk of osteopathogenesis and skeletal fragility in patients with diabetes mellitus, and suggests that the gut microbiota may play a role in the pathology of both diseases. Future studies should focus on the involvement of gut microbiota in both diabetes and osteopathy.

CURRENT OSTEOPOROSIS REPORTS (2021)

Review Medicine, General & Internal

The Impact of Antiosteoporotic Drugs on Glucose Metabolism and Fracture Risk in Diabetes: Good or Bad News?

Athanasios D. Anastasilakis et al.

Summary: The study found that there is currently insufficient data to prove the significant impact of bone therapies on glucose metabolism in diabetic patients. It is uncertain whether antiosteoporotic drugs have different effects on fracture incidence between diabetic and nondiabetic patients. More research is needed to address these issues and provide stronger recommendations.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Endocrinology & Metabolism

Risk Factors for Incident Fracture in Older Adults With Type 2 Diabetes: The Framingham Heart Study

Alyssa B. Dufour et al.

Summary: Age, sex, HbA1c, history of falls, history of fractures, and weak grip strength are associated with fractures in older adults with type 2 diabetes. Other factors like bone mineral density, BMI, smoking, physical function, chronic diseases, medications were not found to be associated with fracture incidence in this study.

DIABETES CARE (2021)

Review Orthopedics

Fracture Risk Assessment An Update

Andrew J. Cozadd et al.

Summary: Advancements in clinical data and tools have improved our ability to identify individuals at high fracture risk. DXA and TBS are important screening tools, and fracture risk assessment tools can further aid in identifying high-risk patients.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2021)

Article Endocrinology & Metabolism

Circulating Carboxylated Osteocalcin Correlates With Skeletal Muscle Mass and Risk of Fall in Postmenopausal Osteoporotic Women

Jacopo Antonino Vitale et al.

Summary: The study investigated the relationship between osteocalcin (OC) and body composition, risk of fall, and bone-muscle crosstalk in osteoporotic postmenopausal women. Results showed that serum cOC levels correlated with skeletal muscle mass and function, acting as a mediator in the bone-muscle crosstalk. Circulating levels of cOC and uOC may be differentially regulated in fractured and unfractured osteoporotic women, indicating potential differences in bone metabolism.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Postmenopausal Osteoporosis: Latest Guidelines

Rod Marianne Arceo-Mendoza et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2021)

Article Endocrinology & Metabolism

Diabetes and Osteoporosis Part I, Epidemiology and Pathophysiology

G. Isanne Schacter et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2021)

Review Endocrinology & Metabolism

Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus

Sundeep Khosla et al.

Summary: Increased fracture risk in patients with type 2 diabetes mellitus may be due to impairments in bone material properties and increases in cortical porosity, highlighting potential areas for therapeutic intervention.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Article Medicine, Research & Experimental

Attitude of the surgical approach in hyperparathyroidism: A retrospective study

Claudiu Eduard Nistor et al.

Summary: The study demonstrated the effectiveness of the surgical treatment for hyperparathyroidism patients at the Department of Thoracic Surgery of the Central Military Emergency University Hospital 'Dr. Carol Davila' in Romania. Immediate and 30-day postoperative evaluations showed positive results in terms of normalization of blood tests and improvement in clinical and imaging anomalies.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Review Endocrinology & Metabolism

Differences in the roles of types 1 and 2 diabetes in the susceptibility to the risk of fracture: a systematic review and meta-analysis

Jiaqing Dou et al.

Summary: This study found that T1DM causes a higher risk of all fractures, including fractures at the hip, upper arm, and ankle, compared to T2DM. Further studies are needed to directly compare the differences between T1DM and T2DM in the risk of fractures at various sites.

DIABETOLOGY & METABOLIC SYNDROME (2021)

Article Endocrinology & Metabolism

Evidence of impaired bone quality in men with type 1 diabetes: a cross-sectional study

Unni Syversen et al.

Summary: This study found compromised bone material strength and microarchitecture in men with T1D. Additionally, the data confirmed a modest decrease in BMD and low bone turnover in T1D patients, indicating that bone should be recognized as a target of diabetic complications.

ENDOCRINE CONNECTIONS (2021)

Review Endocrinology & Metabolism

DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis

Enisa Shevroja et al.

Summary: This review focuses on the role of trabecular bone score (TBS) in assessing bone health in endocrine disorders, emphasizing its ability to predict fractures independently of bone mineral density (BMD).

ENDOCRINE (2021)

Article Endocrinology & Metabolism

The diabetes-fracture association in women with type 1 and type 2 diabetes is partially mediated by falls: a 15-year longitudinal study

E. P. Thong et al.

Summary: This study evaluated mediators of fracture risk in postmenopausal women with type 1 (T1D) and type 2 diabetes (T2D) over a 15-year follow-up period. The increased fracture risk in women with T1D or T2D is partially explained by falls, and a shorter reproductive lifespan in women with T1D contributes modestly to fracture risk in this cohort.

OSTEOPOROSIS INTERNATIONAL (2021)

Review Endocrinology & Metabolism

Diabetes and Bone Fragility

Camila Romero-Diaz et al.

Summary: Diabetes has a significant impact on bone health, with both T1D and T2D associated with a higher risk of fractures through different mechanisms. Chronic hyperglycemia induces non-enzymatic glycation of collagen, increasing the risk of fractures. Timely monitoring of fracture risk and appropriate treatment can greatly reduce the risk of fractures in diabetic patients.

DIABETES THERAPY (2021)

Article Endocrinology & Metabolism

Vertebral Fractures in Individuals With Type 2 Diabetes: More Than Skeletal Complications Alone

Fjorda Koromani et al.

DIABETES CARE (2020)

Article Endocrinology & Metabolism

Bone Mineral Density across the Lifespan in Patients with Type 1 Diabetes

Eitan Halper-Stromberg et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Endocrinology & Metabolism

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update

Dolores Shoback et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Medicine, General & Internal

A Screening Test for Early Diagnosis of Microcellular Bronchopulmonary Cancer-Pilot Study

Claudiu-Eduard Nistor et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Endocrinology & Metabolism

TSH suppressive therapy and bone

Alessro Brancatella et al.

ENDOCRINE CONNECTIONS (2020)

Article Endocrinology & Metabolism

Bone Turnover Markers Do Not Predict Fracture Risk in Type 2 Diabetes

Nicola Napoli et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Article Public, Environmental & Occupational Health

Epidemiology of Type 2 Diabetes - Global Burden of Disease and Forecasted Trends

Moien Abdul Basith Khan et al.

JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH (2020)

Article Endocrinology & Metabolism

Contribution of Android and Gynoid Adiposity to Bone Mineral Density in Healthy Postmenopausal Thai Women

Sirianong Namwongprom et al.

JOURNAL OF CLINICAL DENSITOMETRY (2019)

Review Rheumatology

Bone disorders associated with diabetes mellitus and its treatments

Bernard Cortet et al.

JOINT BONE SPINE (2019)

Article Obstetrics & Gynecology

Status of bone strength and factors associated with vertebral fracture in postmenopausal women with type 2 diabetes

Fang-Ping Chen et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2019)

Article Endocrinology & Metabolism

Altered Tissue Composition, Microarchitecture, and Mechanical Performance in Cancellous Bone From Men With Type 2 Diabetes Mellitus

Heather B. Hunt et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2019)

Article Endocrinology & Metabolism

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline

Richard Eastell et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Article Endocrinology & Metabolism

Association between trabecular bone score and type 2 diabetes: a quantitative update of evidence

L. T. Ho-Pham et al.

OSTEOPOROSIS INTERNATIONAL (2019)

Review Endocrinology & Metabolism

Effects of Diabetes on Bone Material Properties

Sashank Lekkala et al.

CURRENT OSTEOPOROSIS REPORTS (2019)

Article Endocrinology & Metabolism

Fat Mass Does Not Increase the Precision Error of Trabecular Bone Score Measurements

Carmelo Messina et al.

JOURNAL OF CLINICAL DENSITOMETRY (2019)

Article Endocrinology & Metabolism

Effect of diabetes on BMD and TBS values as determinants of bone health in the elderly: Bushehr Elderly Health program

Mahbube Ebrahimpur et al.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2019)

Review Endocrinology & Metabolism

Advanced Glycation End Products (AGEs), Receptor for AGEs, Diabetes, and Bone: Review of the Literature

Kamyar Asadipooya et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2019)

Article Endocrinology & Metabolism

Fracture risk assessment in postmenopausal women with diabetes: comparison between DeFRA and FRAX tools

Gloria Bonaccorsi et al.

GYNECOLOGICAL ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030

Christian Bommer et al.

DIABETES CARE (2018)

Review Endocrinology & Metabolism

Assessment of bone quality in patients with diabetes mellitus

N. Jiang et al.

OSTEOPOROSIS INTERNATIONAL (2018)

Article Medicine, General & Internal

Usefulness of the Trabecular Bone Score for assessing the risk of osteoporotic fracture

L. Redondo et al.

REVISTA CLINICA ESPANOLA (2018)

Review Endocrinology & Metabolism

Diagnosis and management of bone fragility in diabetes: an emerging challenge

S. L. Ferrari et al.

OSTEOPOROSIS INTERNATIONAL (2018)

Review Multidisciplinary Sciences

Skeletal fragility in diabetes

Mishaela R. Rubin

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

Article Endocrinology & Metabolism

A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX

Eugene V. McCloskey et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2016)

Article Endocrinology & Metabolism

Trabecular bone score in type 1 diabetes-a cross-sectional study

T. Neumann et al.

OSTEOPOROSIS INTERNATIONAL (2016)

Article Endocrinology & Metabolism

Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes

Jie Zhang et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2016)

Article Biochemistry & Molecular Biology

Interactions Between Muscle Tissues and Bone Metabolism

Naoyuki Kawao et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2015)

Article Endocrinology & Metabolism

Fracture Risk Prediction by Non-BMD DXA Measures: the 2015 ISCD Official Positions Part 2: Trabecular Bone Score

Barbara C. Silva et al.

JOURNAL OF CLINICAL DENSITOMETRY (2015)

Article Endocrinology & Metabolism

Bone Cells and Bone Turnover in Diabetes Mellitus

Mishaela R. Rubin

CURRENT OSTEOPOROSIS REPORTS (2015)

Article Endocrinology & Metabolism

Bone quality assessment in type 2 diabetes mellitus

R. Dhaliwal et al.

OSTEOPOROSIS INTERNATIONAL (2014)

Article Endocrinology & Metabolism

Trabecular bone score improves fracture risk prediction in non-osteoporotic women: the OFELY study

S. Boutroy et al.

OSTEOPOROSIS INTERNATIONAL (2013)

Article Endocrinology & Metabolism

Type 2 Diabetes and Bone

William D. Leslie et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2012)

Article Endocrinology & Metabolism

Bone Microarchitecture Assessed by TBS Predicts Osteoporotic Fractures Independent of Bone Density: The Manitoba Study

Didier Hans et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2011)