4.4 Article

Use of Novel Open-Source Deep Learning Platform for Quantification of Ki-67 in Neuroendocrine Tumors - Analytical Validation

期刊

INTERNATIONAL JOURNAL OF GENERAL MEDICINE
卷 16, 期 -, 页码 5665-5673

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DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJGM.S443952

关键词

digital image analysis; histopathology; Ki-67 proliferation index; neuroendocrine tumors; machine learning

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This study evaluates the performance of the open-source deep learning platform DeepLIIF in quantifying Ki-67 expression in neuroendocrine tumors and compares it with manual assessments. The results show that DeepLIIF achieves high accuracy and reduces analysis time, making it valuable for clinical practice. This study highlights the potential of open-source deep learning platforms in enhancing diagnostic accuracy and patient care in the field of neuroendocrine oncology.
Background: Neuroendocrine tumors (NETs) represent a diverse group of neoplasms that arise from neuroendocrine cells, with Ki-67 immunostaining serving as a crucial biomarker for assessing tumor proliferation and prognosis. Accurate and reliable quantification of Ki-67 labeling index is essential for effective clinical management. Methods: We aimed to evaluate the performance of open-source/open-access deep learning cloud-native platform, DeepLIIF (https://deepliif.org), for the quantification of Ki-67 expression in gastrointestinal neuroendocrine tumors and compare it with the Results: Our results demonstrate that the DeepLIIF quantification of Ki-67 in NETs achieves a high degree of accuracy with an intraclass correlation coefficient (ICC) = 0.885 with 95% CI (0.848-0.916) which indicates good reliability when compared to manual assessments by experienced pathologists. DeepLIIF exhibits excellent intra- and inter-observer agreement and ensures consistency in Ki-67 scoring. Additionally, DeepLIIF significantly reduces analysis time, making it a valuable tool for high-throughput clinical settings. Conclusion: This study showcases the potential of open-source/open-access user-friendly deep learning platforms, such as DeepLIIF, for the quantification of Ki-67 in neuroendocrine tumors. The analytical validation presented here establishes the reliability and robustness of this innovative method, paving the way for its integration into routine clinical practice. Accurate and efficient Ki-67 assessment is paramount for risk stratification and treatment decisions in NETs and AI offers a promising solution for enhancing diagnostic accuracy and patient care in the field of neuroendocrine oncology.

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