期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s10549-023-07188-4
关键词
Cancer; Obesity; Diabetes; FTO; Genetic
类别
This study identifies the FTO gene as a major shared gene between breast cancer, type 2 diabetes mellitus, and obesity based on two DNA repair and inflammatory mechanisms. These findings provide a new perspective on the important role of the FTO gene and repair mechanism in the relationship between these diseases.
PurposeBreast cancer (BC), obesity, and type 2 diabetes mellitus (T2DM) are three complex diseases and health problems that are prevalent worldwide. The aim of this study was to investigate the common genetic associations between these diseases by referring back to the previous genome-wide association studies (GWAS).MethodsTo this end, significant GWAS variants and common variants associated with BC, obesity, or diabetes were identified from the GWAS catalog. To perform candidate variants, the 1000-Genomes Project was used to find variants with linkage disequilibrium. Common variants between each category were identified (common candidate haplotypic variants). Finally, these variants and their associated genes were examined for SNP function analysis, gene expression, gene-gene correlation, and pathway analysis.ResultsThe results identified 7 variants associated with both T2DM and BC, 8 variants associated with both obesity and BC, and 167 variants associating obesity with T2DM. 91 variants and 4 haplotypic blocks such as CTC were identified on the FTO gene associated with obesity, BC, and T2DM. The results of TCGA data showed that FTO in gene expression was correlated with 6 other genes in the DNA repair pathway in BC subjects.ConclusionsThis study suggests that the FTO gene is one of the major genes shared by BC, T2DM, and obesity based on two DNA repair and inflammatory mechanisms. These results may provide a new perspective on the important role of the FTO gene and repair mechanism in the relationship between BC, obesity, and T2DM for future studies.
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