期刊
PHARMACOECONOMICS-OPEN
卷 -, 期 -, 页码 -出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s41669-023-00448-5
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This study aims to develop a value set that reflects the preferences of the US general population for health states described by the FACT-8D, a multi-attribute utility instrument derived from the FACT-General questionnaire. A discrete choice experiment was conducted to value these health states using a representative sample of the US general population.
ObjectivesTo develop a value set reflecting the United States (US) general population's preferences for health states described by the Functional Assessment of Cancer Therapy (FACT) eight-dimensions preference-based multi-attribute utility instrument (FACT-8D), derived from the FACT-General cancer-specific health-related quality-of-life (HRQL) questionnaire.MethodsA US online panel was quota-sampled to achieve a general population sample representative by sex, age (>= 18 years), race and ethnicity. A discrete choice experiment (DCE) was used to value health states. The valuation task involved choosing between pairs of health states (choice-sets) described by varying levels of the FACT-8D HRQL dimensions and survival (life-years). The DCE included 100 choice-sets; each respondent was randomly allocated 16 choice-sets. Data were analysed using conditional logit regression parameterized to fit the quality-adjusted life-year framework, weighted for sociodemographic variables that were non-representative of the US general population. Preference weights were calculated as the ratio of HRQL-level coefficients to the survival coefficient.Results2562 panel members opted in, 2462 (96%) completed at least one choice-set and 2357 (92%) completed 16 choice-sets. Pain and nausea were associated with the largest utility weights, work and sleep had more moderate utility weights, and sadness, worry and support had the smallest utility weights. Within dimensions, more severe HRQL levels were generally associated with larger weights. A preference-weighting algorithm to estimate US utilities from responses to the FACT-General questionnaire was generated. The worst health state's value was -0.33.ConclusionsThis value set provides US population utilities for health states defined by the FACT-8D for use in evaluating oncology treatments.
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