4.6 Review

Unraveling the Intricacies of CD73/Adenosine Signaling: The Pulmonary Immune and Stromal Microenvironment in Lung Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Low B-cell content is associated with a CD73-low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma

Johanna Grund et al.

Summary: In this study, it was found that the B-cell content in the tumour microenvironment (TME) is associated with prognosis in patients with classic Hodgkin lymphoma (HL) after treatment with ABVD. Whole slide image analysis of routine slides can be used to predict treatment outcomes, with a high B-cell content being associated with a favorable prognosis. B cells in the TME were not correlated with B cells in peripheral blood.

BRITISH JOURNAL OF HAEMATOLOGY (2023)

Article Oncology

First-in-human study of oleclumab, a potent, selective anti-CD73 monoclonal antibody, alone or in combination with durvalumab in patients with advanced solid tumors

Johanna Bendell et al.

Summary: This study evaluated the use of oleclumab in patients with advanced colorectal cancer, pancreatic ductal adenocarcinoma, and epidermal growth factor receptor-mutant non-small-cell lung cancer. The results showed that oleclumab had a manageable safety profile and demonstrated antitumor activity.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

Article Oncology

Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation

Yun-Shan Lin et al.

Summary: The CD39-CD73-adenosinergic pathway plays a critical role in inhibiting anti-tumor immune responses. This study investigates the prognostic significance of CD39 and CD73 in colon adenocarcinoma (COAD) and suggests that targeting CD73 could improve anti-tumor immunity and benefit COAD patients. The study found that CD73 expression in tumor cells was associated with tumor stage and metastasis risk, while CD39 expression in stromal cells was related to favorable survival outcome. Evaluating the therapeutic response to chemotherapy, it was observed that high CD73 expression was linked to poor response and increased risk of metastasis.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

Article Cell Biology

Estrogen downregulates CD73/adenosine axis hyperactivity via adaptive modulation PI3K/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress

Marie Louise Ndzie Noah et al.

Summary: Estrogen and CD73 interact via the PI3K/Akt signaling pathway to normalize the CD73/Adenosine axis and protect the heart from injury during chronic stress.

CELL COMMUNICATION AND SIGNALING (2023)

Article Neurosciences

Aberrant adenosine signaling in patients with focal cortical dysplasia

Mengyi Guo et al.

Summary: In this study, the adenosine signaling in FCD type I and type II patients was analyzed, revealing upregulation of adenosine-metabolizing enzymes ADK and ADA, as well as adenosine-producing enzyme CD73 in BCs. Moreover, an increase in A(2A)R density, a decrease in GLT-1 levels, and an increase in mTOR levels were observed in FCD specimens. These findings suggest that dysregulation of the adenosine system is a common pathological feature of both FCD type I and type II, and may serve as a therapeutic target for epilepsy associated with FCD.

MOLECULAR NEUROBIOLOGY (2023)

Article Pathology

Prognostic impact of CD73/adenosine 2A receptor (A2AR) in renal cell carcinoma and immune microenvironmental status with sarcomatoid changes and rhabdoid features

Dai Takamatsu et al.

Summary: This study analyzed the expression of CD73/A2AR in renal cell carcinoma (RCC) and its relationship with immune microenvironments and prognosis. The results showed that high expression of CD73/A2AR was associated with unfavorable prognosis and increased numbers of regulatory T cells and M2 macrophages.

PATHOLOGY RESEARCH AND PRACTICE (2023)

Article Respiratory System

Abnormal adenosine metabolism of neutrophils inhibits airway inflammation and remodeling in asthma model induced by Aspergillus fumigatus

Ting-ting Liu et al.

Summary: This study aims to investigate the role of abnormal adenosine metabolism of neutrophils in the asthmatic airway inflammation microenvironment. An asthma model was established in CD73 gene-knockout and wild-type mice by intratracheal instillation of Aspergillus fumigatus extract. CD73 knockout inhibited pulmonary epithelial cell proliferation and bronchial fibrosis induced by Aspergillus extract, and reduced the production of various cytokines and chemokines. Finally, the CD73 inhibitor APCP was administered to alleviate inflammation and subcutaneous fibrosis.

BMC PULMONARY MEDICINE (2023)

Article Oncology

Transcriptomic Determinants of Response to Pembrolizumab Monotherapy across Solid Tumor Types

Razvan Cristescu et al.

Summary: By exploring the relationships between gene expression signatures and Pembrolizumab response, this study found that besides T-cell inflammation, features such as angiogenesis, mMDSC, and stroma/EMT/TGFb were negatively associated with response to Pembrolizumab monotherapy, suggesting the involvement of other tumor biology axes in Pembrolizumab combinations.

CLINICAL CANCER RESEARCH (2022)

Article Biochemistry & Molecular Biology

Tumor Infiltration with CD20+CD73+ B Cells Correlates with Better Outcome in Colorectal Cancer

Frederik J. Hansen et al.

Summary: CD73, an important enzyme, has been found to be associated with the survival and metastasis of colorectal cancer (CRC) patients. The highest expression of CD73 was seen on tumor-infiltrating B-cells, and higher infiltration of CD73(+) B-cells in CRC tumors was correlated with better overall survival. The role of CD73(+) B-cells and their subsets in CRC development should be further investigated.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Oncology

Anti-CD73 antibody activates human B cells, enhances humoral responses and induces redistribution of B cells in patients with cancer

Richard A. Miller et al.

Summary: This study evaluated the effects of Mupadolimab on immune cells and found that it activates B cells and stimulates the production of antigen specific antibodies. These results support further investigation of Mupadolimab as an immunotherapy for cancer and its potential use as a vaccine adjuvant.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Article Oncology

Identification of CD73 as a Novel Biomarker Encompassing the Tumor Microenvironment, Prognosis, and Therapeutic Responses in Various Cancers

Kun Tang et al.

Summary: CD73 plays an important role in tumor immunity, with high expression associated with poor prognosis. It can regulate the behavior of immune cells in the tumor microenvironment and may serve as a new immune checkpoint in future tumor immunotherapy.

CANCERS (2022)

Article Oncology

Isolation and characterization of head and neck cancer-derived peritumoral and cancer-associated fibroblasts

Jiefu Zhou et al.

Summary: The study found that matched CAFs and PtFs in HNSCC patients are heterogeneous in their proliferation, migration, and angiogenesis-promoting capacity. Despite this heterogeneity, CAFs overall induced stronger carcinoma cell proliferation and HUVEC tube formation, while PtFs promoted migration of tumor cells more strongly.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer

Ryohei Yoshida et al.

Summary: This study reveals that MET amplification upregulates CD73 to suppress tumor cell STING induction and T-cell responsiveness in TKI-resistant, EGFR-mutated lung cancer, identifying a strategy to enhance immunogenicity and improve treatment.

CANCER RESEARCH (2022)

Article Immunology

Intratumoral CD73: An immune checkpoint shaping an inhibitory tumor microenvironment and implicating poor prognosis in Chinese melanoma cohorts

Zixu Gao et al.

Summary: High CD73 expression is associated with an inhibitory tumor microenvironment and adverse clinical outcomes in melanoma. Compared to PD-L1, CD73 is more prevalent and has more definite prognostic significance in Chinese melanomas. Therefore, it may serve as a prognostic indicator and immunotherapeutic target alongside PD-L1 in melanoma for the Chinese population.

FRONTIERS IN IMMUNOLOGY (2022)

Article Pharmacology & Pharmacy

Pan-cancer analysis identifies NT5E as a novel prognostic biomarker on cancer-associated fibroblasts associated with unique tumor microenvironment

Xin-miao Xue et al.

Summary: NT5E is aberrantly expressed in various cancers and is associated with worse prognosis in several cancer types. It is positively correlated with the infiltration level of cancer-associated fibroblasts (CAFs) and endothelial cells. Single-cell analysis reveals that NT5E may affect cancer progression by promoting the epithelial-mesenchymal transition (EMT) function of CAFs.

FRONTIERS IN PHARMACOLOGY (2022)

Article Gastroenterology & Hepatology

Skewed CD39/CD73/adenosine pathway contributes to B-cell hyperactivation and disease progression in patients with chronic hepatitis B

Shuang-Nan Zhou et al.

Summary: The study revealed that skewed CD39 and CD73 expression on B-cells in chronic hepatitis B patients was associated with high viral burden, liver inflammation, and antiviral efficacy, and the skewed CD39/CD73/adenosine pathway contributed to B-cell hyperactivation.

GASTROENTEROLOGY REPORT (2021)

Article Oncology

CD73 expression defines immune, molecular, and clinicopathological subgroups of lung adenocarcinoma

Pedro Rocha et al.

Summary: The study revealed an association between CD73 expression levels in LUAD with immune infiltration and PD-L1 protein expression, with tumors showing higher CD73 expression exhibiting augmented immune response. Further exploration of the role of CD73 in immunotherapeutic response of LUAD is warranted based on our findings.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Oncology

Loss of CD73 shifts transforming growth factor-β1 (TGF-β1) from tumor suppressor to promoter in endometrial cancer

Katherine C. Kurnit et al.

Summary: The loss of CD73 in endometrial carcinomas shifts the activity of TGF-beta from tumor suppressor to promoter, affecting cell functions and invasiveness.

CANCER LETTERS (2021)

Article Biology

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Lorna B. Jarvis et al.

Summary: This study shows that expanded human Tregs switch their metabolism to aerobic glycolysis and enhance suppressive function through HIF1A-driven acquisition of CD73 expression, allowing them to convert ATP to immunosuppressive adenosine in conjunction with CD39. Therefore, the data suggests that Treg expansion protocols should be optimized for CD39/CD73 co-expression to maximize therapeutic benefits.

COMMUNICATIONS BIOLOGY (2021)

Article Multidisciplinary Sciences

CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer

Nataliia Petruk et al.

Summary: Inhibition of CD73 significantly decreases cellular viability and migration in vitro, suppresses hypoxia-induced increase in viability, and prevents cell protrusion elongation in both normoxia and hypoxia. CD73 suppression also leads to decreased tumor growth and metastasis in vivo by maintaining a more epithelial phenotype.

SCIENTIFIC REPORTS (2021)

Review Oncology

The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis

Paris Jabeen Asif et al.

Summary: Metastasis in cancer is closely associated with cancer-associated fibroblasts (CAFs), which play a key role in cancer progression by contributing to extracellular matrix deposition and remodeling, extensive crosstalk with cancer cells, epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and therapy resistance. Understanding the role of CAFs in the process of metastasis, particularly in colorectal cancer (CRC) with high stromal infiltration, is crucial for developing targeted therapeutics and advancing research in this field.

CANCERS (2021)

Article Medicine, Research & Experimental

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

Shi Yong Neo et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

A novel proangiogenic B cell subset is increased in cancer and chronic inflammation

Willem van de Veen et al.

SCIENCE ADVANCES (2020)

Article Pharmacology & Pharmacy

Targeting CD73 to augment cancer immunotherapy

Meejeon Roh et al.

CURRENT OPINION IN PHARMACOLOGY (2020)

Review Oncology

The adenosine pathway in immuno-oncology

Bertrand Allard et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Multidisciplinary Sciences

Memory CD73+IgM+B cells protect againstPlasmodium yoelii infection and express Granzyme B

Marcela Parra et al.

PLOS ONE (2020)

Article Oncology

Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma

Abhishek Tripathi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Oncology

Downregulation of CD73 associates with T cell exhaustion in AML patients

Yaxian Kong et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Cell Biology

Cell type- and tissue-specific functions of ecto-5′-nucleotidase (CD73)

Marquet Minor et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

Review Immunology

CD73: an emerging checkpoint for cancer immunotherapy

Siqi Chen et al.

IMMUNOTHERAPY (2019)

Review Oncology

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

Detlev Boison et al.

CANCER CELL (2019)

Article Medicine, Research & Experimental

Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC

Julia Kargl et al.

JCI INSIGHT (2019)

Article Oncology

CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8(+) T Cells

Fernando P. Canale et al.

CANCER RESEARCH (2018)

Review Immunology

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

Bertrand Allard et al.

IMMUNOLOGICAL REVIEWS (2017)

Article Medicine, Research & Experimental

IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade

Mark Ayers et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Pharmacology & Pharmacy

Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure

Eunyoung Tak et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)

Article Oncology

CD73 Expression Is an Independent Prognostic Factor in Prostate Cancer

Bruno G. Leclerc et al.

CLINICAL CANCER RESEARCH (2016)

Article Medicine, Research & Experimental

Loss of CD73-mediated actin polymerization promotes endometrial tumor progression

Jessica L. Bowser et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Oncology

Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis

Deepak Mittal et al.

CANCER RESEARCH (2016)

Article Cell Biology

TGF-beta in tolerance, development and regulation of immunity

Chris J. C. Johnston et al.

CELLULAR IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF

Tsuguhide Takeshima et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Immunology

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

Vinit Kumar et al.

TRENDS IN IMMUNOLOGY (2016)

Review Immunology

Purinergic Signaling to Terminate TLR Responses in Macrophages

Kajal Hamidzadeh et al.

FRONTIERS IN IMMUNOLOGY (2016)

Review Oncology

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

Suzanne L. Topalian et al.

NATURE REVIEWS CANCER (2016)

Review Oncology

Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities

Luca Antonioli et al.

TRENDS IN CANCER (2016)

Article Physiology

A hypoxic episode during cardiogenesis downregulates the adenosinergic system and alters the myocardial anoxic tolerance

Elodie Robin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2015)

Editorial Material Medicine, General & Internal

Releasing the Brakes on Cancer Immunotherapy

Antoni Ribas

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Oncology

Anti-CD73 therapy impairs tumor angiogenesis

Bertrand Allard et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Article Genetics & Heredity

Adenosine-a physiological or pathophysiological agent?

Bertil B. Fredholm

JOURNAL OF MOLECULAR MEDICINE-JMM (2014)

Article Oncology

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

Inbal Mishalian et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)

Article Cell Biology

Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages

Balazs Koscso et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

Review Biochemistry & Molecular Biology

CD39 and CD73 in immunity and inflammation

Luca Antonioli et al.

TRENDS IN MOLECULAR MEDICINE (2013)

Article Hematology

Regulation of Neutrophil Function by Adenosine

Kathryn E. Barletta et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Article Oncology

CD73-Deficient Mice Are Resistant to Carcinogenesis

John Stagg et al.

CANCER RESEARCH (2012)

Article Immunology

A germinal center-independent pathway generates unswitched memory B cells early in the primary response

Justin J. Taylor et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Article Multidisciplinary Sciences

Differential Macrophage Activation Alters the Expression Profile of NTPDase and Ecto-5′-Nucleotidase

Rafael Fernandes Zanin et al.

PLOS ONE (2012)

Review Oncology

CD73 promotes tumor growth and metastasis

Bin Zhang

ONCOIMMUNOLOGY (2012)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Immunology

Immune cell regulation by autocrine purinergic signalling

Wolfgang G. Junger

NATURE REVIEWS IMMUNOLOGY (2011)

Article Biochemistry & Molecular Biology

Cancer associated fibroblasts (CAFs) in tumor microenvironment

Fei Xing et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2010)

Article Immunology

CD73 represses pro-inflammatory responses in human endothelial cells

Jana K. G. Gruenewald et al.

JOURNAL OF INFLAMMATION-LONDON (2010)

Review Biochemistry & Molecular Biology

Extracellular adenosine triphosphate and adenosine in cancer

J. Stagg et al.

ONCOGENE (2010)

Article Biochemistry & Molecular Biology

Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs

Joerg Reutershan et al.

FASEB JOURNAL (2009)

Article Hematology

VAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation

Sirpa Jalkanen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

Article Immunology

CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes

Masahide Takedachi et al.

JOURNAL OF IMMUNOLOGY (2008)

Review Immunology

Interferons, immunity and cancer immunoediting

Gavin P. Dunn et al.

NATURE REVIEWS IMMUNOLOGY (2006)

Article Multidisciplinary Sciences

A2A adenosine receptor protects tumors from antitumor T cells

Akio Ohta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Medicine, General & Internal

Coffee, cirrhosis, and transaminase enzymes

Arthur L. Klatsky et al.

ARCHIVES OF INTERNAL MEDICINE (2006)

Article Immunology

Crucial role for ecto-5-′nucleotidase (CD73) in vascular leakage during hypoxia

LF Thompson et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

Article Oncology

Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8

H Schaider et al.

INTERNATIONAL JOURNAL OF CANCER (2003)

Review Biochemistry & Molecular Biology

The roles of IFNγ in protection against tumor development and cancer immunoediting

H Ikeda et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2002)

Article Cell Biology

Regulation of ecto-5 '-nucleotidase by TNF-alpha in human endothelial cells

K Kalsi et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2002)