Low circulating levels of miR-17 and miR-126-3p are associated with increased mortality risk in geriatric hospitalized patients affected by cardiovascular multimorbidity

Review Endocrinology & Metabolism

Micro-RNA: A Future Approach to Personalized Diagnosis of Bone Diseases

Giovanni Lombardi et al.

Summary: Osteoporosis is a prevalent bone disease and circulating microRNAs have shown potential as diagnostic and prognostic markers. However, the lack of standardization and harmonization of methods limits their application.

CALCIFIED TISSUE INTERNATIONAL (2023)

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Review Cell Biology

A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity

Geovanny Genaro Reivan Ortiz et al.

Summary: Aging is a biological process that leads to a decrease in the organism's standard of living due to time-related cellular and functional impairments. Recent advances in aging investigation have revealed that the rate of senescence can be regulated through genetic pathways and biological processes. Hematopoietic stem cells (HSCs) maintain blood generation throughout an organism's lifetime but are also affected by the senescence process, resulting in a decline in their capabilities. MicroRNAs (miRNAs) play a crucial role in controlling HSCs and can modulate senescence and age-associated diseases.

CELL COMMUNICATION AND SIGNALING (2023)

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Article Endocrinology & Metabolism

MicroRNA biomarkers of type 2 diabetes: evidence synthesis from meta-analyses and pathway modelling

Hongmei Zhu et al.

Summary: This study synthesized the evidence from microRNA-type 2 diabetes association studies and microRNA-regulated type 2 diabetes pathway delineation studies to identify and validate statistically and biologically significant microRNAs as type 2 diabetes biomarkers. Sixteen microRNAs were found to meet the criteria for biomarker selection.

DIABETOLOGIA (2023)

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Letter Clinical Neurology

Association of admission serum levels of neurofilament light chain and in-hospital mortality in geriatric patients with COVID-19

Francesca Marchegiani et al.

JOURNAL OF NEUROLOGY (2023)

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Article Biochemistry & Molecular Biology

DIANA-miRPath v4.0: expanding target-based miRNA functional analysis in cell-type and tissue contexts

Spyros Tastsoglou et al.

Summary: DIANA-miRPath is an online miRNA analysis platform that allows exploration of combined miRNA effects through predicted or experimentally supported miRNA interactions. Its latest version introduces a customizable target-based miRNA functional analysis engine, enriched with interaction, annotation, and parameterization options. The platform integrates various datasets and enables enrichment analysis on GO terms, pathways, and expression data for a wide range of states. Additionally, it provides a module for utilizing CRISPR knock-out screen datasets to identify miRNAs with potentially crucial roles.

NUCLEIC ACIDS RESEARCH (2023)

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Article Multidisciplinary Sciences

m6A reader IGF2BP1 accelerates apoptosis of high glucose-induced vascular endothelial cells in a m6A-HMGB1 dependent manner

Anru Liang et al.

Summary: Emerging evidence suggests that m6A plays a critical role in vascular biology. However, the underlying mechanism of m6A regulation on vascular endothelial cells in high glucose conditions is unclear.

PEERJ (2023)

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Article Geriatrics & Gerontology

Clinical impacts of frailty on 123,172 people with diabetes mellitus considering the age of onset and drugs of choice: a nationwide population-based 10-year trajectory analysis

Shih-Tsung Huang et al.

Summary: This study aimed to investigate the interrelationships between the age of onset, frailty, anti-diabetic medications and clinical outcomes in people with diabetes mellitus (DM). The proportion of frailty increased with age at diagnosis amongst people with incident DM and the mFI scores increased significantly during the 10-year follow-up. Frailty assessment and management should be implemented into routine diabetes care.

AGE AND AGEING (2023)

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Article Public, Environmental & Occupational Health

PRMT5 up-regulation improves myocardial hypertrophy by mediating E2F-1/NF-KB/NLRP3 pathway

Limin Zhang et al.

Summary: This study investigated the role of PRMT5 in myocardial hypertrophy and found that overexpression of PRMT5 could reduce myocardial hypertrophy, fibrosis, inflammation, and oxidative stress. Knockdown of PRMT5 had the opposite effect. PRMT5 regulated the activation of NLRP3 inflammasome by modulating the E2F-1/NF-KB pathway, thereby attenuating myocardial hypertrophy.

PREVENTIVE MEDICINE (2023)

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Article Geriatrics & Gerontology

Multimorbidity patterns in older persons and their association with self-reported quality of life and limitations in activities of daily living

Jennifer E. Lutomski et al.

Summary: As populations age, multimorbidity becomes increasingly common. This study identified five common patterns of chronic diseases in older persons and examined their effect on quality of life over a one-year period. The results showed that these patterns did not have a significant impact on quality of life.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2023)

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Article Geriatrics & Gerontology

Goals of older hospitalized patients with multimorbidity

Sanne Tent et al.

Summary: This study aimed to explore the treatment goals of older hospitalized patients with multimorbidity and compare them to those of older hospitalized patients without multimorbidity. It was found that there were no significant differences in treatment goals between patients with and without multimorbidity, but approximately 41% of patients mentioned goals that were unrelated to their diseases. This emphasizes the importance of healthcare professionals eliciting treatment goals from patients within hospital care to provide integrated care.

EUROPEAN GERIATRIC MEDICINE (2023)

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Article Biochemistry & Molecular Biology

Silencing of IGF2BP1 restrains ox-LDL-induced lipid accumulation and inflammation by reducing RUNX1 expression and promoting autophagy in macrophages

Mingxin Liu et al.

Summary: IGF2BP1 plays a role in promoting foam cell formation in atherosclerosis, and its silencing can attenuate lipid accumulation and inflammation, as well as enhance autophagy. RUNX1, which is known to inhibit autophagy, interacts with IGF2BP1. Therefore, the IGF2BP1/RUNX1 axis may be a potential therapeutic target.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022)

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Article Cell Biology

miR-126-3p and miR-21-5p as Hallmarks of Bio-Positive Ageing; Correlation Analysis and Machine Learning Prediction in Young to Ultra-Centenarian Sicilian Population

Giulia Accardi et al.

Summary: This study found that the levels of four circulating miRNAs gradually increase with age, except for the ultra-centenarians who show levels comparable to young individuals. These miRNAs may serve as biomarkers of ageing and have diagnostic/prognostic relevance for age-related diseases.

CELLS (2022)

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Article Medicine, General & Internal

The association between multimorbidity and mobility disability-free life expectancy in adults aged 85 years and over: A modelling study in the Newcastle 85+cohort

Laurie E. Davies et al.

Summary: This study found that multimorbidity is a significant determinant of mobility disability and the number of years spent living with it in individuals aged 85 and older. Increasing long-term conditions were associated with a higher risk of incident mobility disability, reduced chances of recovery from this state, and an increased risk of death with mobility disability. The findings highlight the importance of preventing multimorbidity and maintaining independence in older populations.

PLOS MEDICINE (2022)

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Article Geriatrics & Gerontology

Do neutrophil to lymphocyte ratio and platelet to lymphocyte ratio associate with frailty in elderly inpatient with comorbidity?

Lijuan Guan et al.

Summary: This study explored the relationship between NLR, PLR and frailty in elderly inpatients with comorbidity, revealing positive associations between neutrophils, NLR, and frailty but NLR not being an independent risk factor for frailty.

EXPERIMENTAL GERONTOLOGY (2022)

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Review Medicine, Research & Experimental

Relationship of miRNA-126 and miRNA-122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta-analysis

Yaling He et al.

Summary: This study conducted a meta-analysis on the relationship between miR-126 and miR-122 expression and the risk of T2DM as well as related glucose metabolism parameters. The results showed that higher miR-126 expression was associated with lower T2DM risk, fasting blood glucose levels, and insulin resistance index (HOMA-IR), while higher miR-122 expression was correlated with higher fasting blood glucose levels and HOMA-IR. These findings have significant clinical and public health implications for screening and controlling glucose metabolic disorders, insulin resistance, and T2DM development.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Review Medicine, General & Internal

Role of noncoding RNAs and untranslated regions in cancer: A review

Yiping Zhang et al.

Summary: This review discusses the role and importance of ncRNAs in cancer, including miRNAs, lncRNAs, circRNAs, and UTRs. ncRNAs function as tumor suppressors or oncogenes, interfering with different axes and pathways involved in cancer progression, with their characteristic expression allowing them to be used as biomarkers for early diagnosis and therapeutic candidates. Furthermore, there is a complex network of interactions between ncRNAs, which is crucial for cancer diagnosis and treatment.

MEDICINE (2022)

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Article Multidisciplinary Sciences

Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study

Hiroya Yamada et al.

Summary: This study found that high levels of circulating miR-21 and miR-29a were significantly associated with an increased risk of total death, cancer death, and CVD death, while individuals with low levels of circulating miR-126 were more likely to experience total death. This suggests that circulating miRNAs may serve as potential biomarkers for early detection of high-risk individuals.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases

Fabiola Olivieri et al.

Summary: Inflammaging is a key concept in understanding how aging contributes to the development of age-related diseases, with a focus on the role of miRNAs in regulating inflammatory pathways. The assessment of individual genetic make-up alone is insufficient to depict the trajectories of age-related inflammation, and studies have shown that circulating inflammamiRs could be used to measure the degree of inflammaging.

AGEING RESEARCH REVIEWS (2021)

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Article Cardiac & Cardiovascular Systems

MicroRNA-17-5p Promotes Cardiac Hypertrophy by Targeting Mfn2 to Inhibit Autophagy

Xuan Xu et al.

Summary: This study demonstrated that miR-17-5p inhibits Mfn2 expression, activates the PI3K/AKT/mTOR pathway, and suppresses autophagy to promote pathological cardiac hypertrophy.

CARDIOVASCULAR TOXICOLOGY (2021)

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Article Geriatrics & Gerontology

Moving geroscience from the bench to clinical care and health policy

Felipe Sierra et al.

Summary: Geriatricians and others need to embrace the emerging field of geroscience, which focuses on the modifiability of biological aging and its potential impact on delaying or preventing diseases and disorders. The importance of involving experts from various disciplines to translate geroscience discoveries into clinical care and health policy is emphasized, especially in the context of the current COVID-19 pandemic where biological aging has been identified as one of the key factors.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

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Article Cardiac & Cardiovascular Systems

Impact of high neutrophil-to-lymphocyte ratio on the cardiovascular benefit of PCSK9 inhibitors in familial hypercholesterolemia subjects with atherosclerotic cardiovascular disease: Real-world data from two lipid units

Roberto Scicali et al.

Summary: NLR is a novel inflammatory biomarker strongly associated with ASCVD. This study found that FH subjects with low-NLR experienced a significant reduction of PWV after PCSK9-i therapy, suggesting a role of NLR in predicting PCSK9-i effects in this population.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Article Mathematical & Computational Biology

Establishment and analysis of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA identifies functional genes in heart failure

Xudan Ma et al.

Summary: The study established an HF-related ceRNA network based on lncRNA, miRNA, and mRNA, revealing the importance of certain lncRNA as hub nodes. Five subnetworks were formed around miR-17-5p, miR-20b-5p, miR107, miR-125a-5p, and miR-140-5p, with enrichment in cell cycle pathways observed in the ceRNA network. The research sheds new light on the essential functions of the ceRNA network in HF development and suggests potential diagnostic and therapeutic applications of hub nodes.

MATHEMATICAL BIOSCIENCES AND ENGINEERING (2021)

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Article Cardiac & Cardiovascular Systems

Value of Neutrophil to Lymphocyte Ratio and Its Trajectory in Patients Hospitalized With Acute Heart Failure and Preserved Ejection Fraction

Kalyani Anil Boralkar et al.

AMERICAN JOURNAL OF CARDIOLOGY (2020)

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Review Biochemistry & Molecular Biology

microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics

Marta Gomarasca et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Editorial Material Biology

AGING AND GEROSCIENCE Putting epigenetic biomarkers to the test for clinical trials

Jamie N. Justice et al.

ELIFE (2020)

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Article Multidisciplinary Sciences

Twelve-year clinical trajectories of multimorbidity in a population of older adults

Davide L. Vetrano et al.

NATURE COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Dicing the Disease with Dicer: The Implications of Dicer Ribonuclease in Human Pathologies

Eleni I. Theotoki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Geriatrics & Gerontology

Measuring multimorbidity in older adults: comparing different data sources

Samantha Gontijo Guerra et al.

BMC GERIATRICS (2019)

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Review Genetics & Heredity

Perspectives on miRNAs as Epigenetic Markers in Osteoporosis and Bone Fracture Risk: A Step Forward in Personalized Diagnosis

Michela Bottani et al.

FRONTIERS IN GENETICS (2019)

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Review Medicine, General & Internal

Circulating miRNAs as Diagnostic and Prognostic Biomarkers in Common Solid Tumors: Focus on Lung, Breast, Prostate Cancers, and Osteosarcoma

Michela Bottani et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Multidisciplinary Sciences

Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients

Ophelie Fourdinier et al.

SCIENTIFIC REPORTS (2019)

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Review Economics

A Systematic Review of Cost-of-Illness Studies of Multimorbidity

Lili Wang et al.

APPLIED HEALTH ECONOMICS AND HEALTH POLICY (2018)

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Article Cardiac & Cardiovascular Systems

Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure

Ravi Shah et al.

JAMA CARDIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Impact of Frailty on Mortality and Hospitalization in Chronic Heart Failure: A Systematic Review and Meta-Analysis

Xiaobo Yang et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

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Article Medicine, General & Internal

Elevated neutrophil to lymphocyte ratio predicts mortality in medical inpatients with multiple chronic conditions

Vivian Isaac et al.

MEDICINE (2016)

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Article Medicine, General & Internal

The impact of multimorbidity on adult physical and mental health in low- and middle-income countries: what does the study on global ageing and adult health (SAGE) reveal?

Perianayagam Arokiasamy et al.

BMC MEDICINE (2015)

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Article Multidisciplinary Sciences

A multifaceted program causes lasting progress for the very poor: Evidence from six countries

Abhijit Banerjee et al.

SCIENCE (2015)

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Review Immunology

The role of Crk adaptor proteins in T-cell adhesion and migration

Alex Braiman et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Geriatrics & Gerontology

The Report-AGE project: a permanent epidemiological observatory to identify clinical and biological markers of health outcomes in elderly hospitalized patients in Italy

Silvia Bustacchini et al.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2015)

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Article Cell Biology

Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells

Fabiola Olivieri et al.

AGING-US (2014)

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Article Endocrinology & Metabolism

Profiling of Circulating MicroRNAs Reveals Common MicroRNAs Linked to Type 2 Diabetes That Change With Insulin Sensitization

Francisco J. Ortega et al.

DIABETES CARE (2014)

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Article Genetics & Heredity

Circulating inflamma-miRs in aging and age-related diseases

Fabiola Olivieri et al.

Frontiers in Genetics (2013)

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Article Medicine, General & Internal

Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study

Karen Barnett et al.

LANCET (2012)

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Article Medicine, General & Internal

A New Equation to Estimate Glomerular Filtration Rate

Andrew S. Levey et al.

ANNALS OF INTERNAL MEDICINE (2009)

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Article Multidisciplinary Sciences

Distinctions in the specificity of E2F function revealed by gene expression signatures

EP Black et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Low circulating levels of miR-17 and miR-126-3p are associated with increased mortality risk in geriatric hospitalized patients affected by cardiovascular multimorbidity

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