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Article
Sport Sciences
Kaname Tagawa et al.
Summary: This study investigated the effects of eccentric exercise on myocardial perfusion index. The results showed that eccentric exercise significantly improved myocardial perfusion and decelerated decay. This suggests that eccentric exercise has beneficial effects on heart function.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Xiaoyan Wang et al.
Summary: This study developed a pseudo-targeted metabolomics approach to discover ginsenoside markers for the precise authentication of ginseng and its use in compound formulation products (CFPs). By conducting mass spectrometry experiments, the researchers successfully characterized 567 components and established key identification points for 12 ginseng species using multiple reaction monitoring (MRM) of 262 ion pairs. The simultaneous detection of 14 markers enabled the identification of ginseng from 15 ginseng-containing CFPs, and the pseudo-targeted metabolomics strategy outperformed the full-scan high-resolution mass spectrometry approach in differentiating among multiple ginseng.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Neurosciences
Christiana J. J. Raymond-Pope et al.
Summary: This study investigated the impact of restricting activity on metabolism and skeletal muscle function following injury, and aimed to enhance the metabolic and contractile function of the remaining muscle through treatment with formoterol. The results showed that restricting activity had a significant effect on metabolism and skeletal muscle function, while formoterol treatment alleviated these effects and promoted muscle recovery.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Nutrition & Dietetics
Bruno Costa Teixeira et al.
Summary: Different types of muscle contraction have different effects on the musculature and inflammatory responses. Acute increases in inflammation markers can increase the risk of thrombus formation and cardiovascular events. This study investigates the effects of concentric and eccentric exercise on hemostasis markers and CRP levels.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
MacRae F. Linton et al.
Summary: Epidemiologic studies have shown that HDL-C levels are inversely related to ASCVD, suggesting that HDL-C is a major risk factor for ASCVD. However, clinical trials have questioned the role of HDL-C in mediating ASCVD risk. Progress in understanding the composition of HDL particles has revealed that HDL-C levels do not necessarily reflect HDL function. HDL has been found to have antiatherogenic functions, such as reverse cholesterol transport and suppression of inflammation, but its oxidative modifications can lead to dysfunction and inflammation.
CIRCULATION RESEARCH
(2023)
Article
Immunology
William C. McCarthy et al.
Summary: Hepatic innate immune function plays an important role in the pathogenesis of various diseases. This study found that endotoxemia induces a zone-specific acute phase response (APR) in mouse hepatocytes, with certain genes, including C-reactive protein (CRP), being more highly expressed in the pericentral/centrilobular hepatocytes. It was also discovered that the transcription factor NF-KB subunit p50 binds to the CRP promoter and its nuclear translocation is associated with the zone-specific APR. Overall, these results suggest that the murine hepatocyte innate immune response to endotoxemia involves zone-specific activation of transcription factors and target gene expression.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Jialin Huang et al.
Summary: This study investigated the virulence of T. pallidum in a rabbit model of continuous infection and found that its virulence gradually weakened during interaction with host cells or testicular passage, which was also related to generation. Furthermore, the adhesive ability of T. pallidum decreased with increasing generation.
ACS INFECTIOUS DISEASES
(2023)
Review
Food Science & Technology
Zarina Mushtaq et al.
Summary: Apigenin, a phenolic compound abundantly found in plants, has been extensively studied for its low toxicity and anti-inflammatory effects. It can be obtained from various fruits, vegetables, nuts, herbs, honey, and plant-based drinks. Research has shown that apigenin has potential in managing inflammatory-related diseases and offers promising benefits in slowing down the development of chronic diseases.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Materials Science, Biomaterials
Weiqiang Lin et al.
Summary: We designed and synthesized a new fluorescent probe, PerqdOH, which can monitor intracellular O-2(center dot-) during T. pallidum infection in real time. In vitro infection experiments showed decreased green fluorescence and enhanced red fluorescence simultaneously. The probe also exhibited a remarkable signal in treponemal lesions in a rabbit model. PerqdOH has great potential for application in clarifying the infectious process caused by T. pallidum in real time.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Neurosciences
Yunfei Xu et al.
Summary: This study found that cerebral ischemia reperfusion can induce ferroptosis, while PGE2 inhibits ferroptosis by reducing Fe2+, glutathione oxidation, and lipid peroxidation. In contrast, the COX-2 inhibitor pranoprofen plays an opposite role in regulating ferroptosis.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Caixia Yuan et al.
Summary: Depression is a common mental illness, and inflammation is considered a significant factor in its development. This review systematically sorts the literature on the anti-inflammatory mechanisms that have an antidepressant effect and summarizes the natural compounds related to inflammation in the past 20 years.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yi Yang et al.
Summary: This study investigates the mechanism of action of Ginsenoside Rg1 in Alzheimer's disease. The results show that Rg1 can improve cognitive function and protect neurons by regulating oxidative stress, apoptosis, and neuroinflammation through the Wnt signaling pathway. This provides a theoretical basis for the clinical application of Rg1 in Alzheimer's disease.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Chemistry, Medicinal
Hui Ye et al.
Summary: S-nitrosation (SNO) is a posttranslational modification of cysteine residues induced by nitric oxide (NO), which regulates various protein functions and is closely related to pathophysiological processes. Site-specific identification of SNO proteins is crucial for understanding the molecular mechanisms of protein function regulation. SNO modification data could be a potential research direction for drug target identification and discovery, with importance in NO donor drugs and classic target-based drug design.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Nazanin Sabet et al.
Summary: Exercise has a renoprotective effect on kidney injury patients by increasing the expression and activity of SIRT1. However, further research is needed to determine the role of SIRT1 in different types and severities of kidney injury following exercise.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Chemistry, Medicinal
Rodrigo de Souza Miranda et al.
Summary: This review provides an overview of the anti-inflammatory effects of various triterpenes and their presumed mechanisms of action, based on articles published in the last 15 years. The findings suggest that triterpenes could be valuable natural products with potential pharmaceutical applications.
PHYTOTHERAPY RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Taylor Schultz et al.
Summary: Duchenne muscular dystrophy (DMD) is a rare and devastating disease, affecting approximately 1 in every 3,500 male births worldwide. Cardiomyopathy has become the most common cause of death in DMD patients. Current research aims to identify therapeutic targets for treating DMD cardiomyopathy.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Cell Biology
Jun Guo et al.
Summary: Ginsenoside Rg1 exerts a positive effect on sepsis-induced acute kidney injury by regulating the process of ferroptosis in renal tubular epithelial cells.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Cell Biology
Keita Kanzaki et al.
Summary: Eccentric contractions can lead to muscle damage and force deficits, but training that includes eccentric phases can activate muscle remodeling genes more effectively. Strategies to reduce muscle damage from eccentric contractions are important. This review discusses the effects of eccentric contractions on muscles and the role of nutritional supplementations.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2022)
Review
Physiology
Joanna Kruk et al.
Summary: Research has shown that polyphenols, as antioxidant supplements, can have a positive impact on oxidative stress and inflammation control during acute exercise. However, there is still debate regarding their effects on physical performance. Further studies should investigate optimal dosage, timing of supplementation, and the response and adaptations of different sports disciplines to polyphenols.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2022)
Review
Rheumatology
Noriko Komatsu et al.
Summary: This review provides an overview of the mechanisms contributing to joint damage in rheumatoid arthritis (RA) and discusses the interactions among immune cells, fibroblasts, and bone. The authors highlight the importance of understanding these mechanisms for the development of novel therapies in RA.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Immunology
Mahmood Ahmad Khan et al.
Summary: The objective of this study was to investigate the anti-inflammatory and anti-arthritic effects of ellagic acid (EA) in collagen-induced arthritis (CIA). The findings demonstrated that EA significantly reduced inflammation and oxidative stress, and inhibited the development of arthritis in rats. These results suggest that EA could serve as a potential new drug for the treatment of arthritis.
INFLAMMOPHARMACOLOGY
(2022)
Article
Physiology
Brandon N. VanderVeen et al.
Summary: Research has shown that 5-fluorouracil (5FU) monotherapy leads to weight loss and muscle mass reduction, along with negative impact on skeletal muscle immune cells. Additionally, 5FU decreases immune cells in skeletal muscle and impairs infiltration following damage, contributing to disrupted muscle repair processes. These findings provide insights into the impact of 5FU on skeletal muscle and offer a potential explanation for impaired tissue repair in some patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Plant Sciences
Xiaoxu Han et al.
Summary: This study generated the first chromosome-scale genome of Angelica sinensis, a renowned herb known for its medicinal values. It identified the molecular basis of simple coumarin biosynthesis and the evolutionary history of genes involved in furanocoumarin biosynthesis. The study also revealed the role of whole-genome duplication and tandem duplication in phenylpropanoid biosynthesis. Additionally, key genes and transcription factors regulating simple coumarin biosynthesis were identified through transcriptomic and metabolomic analysis. Phylogenomic synteny network analysis provided evidence for the evolution of prenyltransferase genes involved in furanocoumarin biosynthesis. This study sheds light on coumarin biosynthesis and provides a benchmark for further research and breeding in A. sinensis.
Article
Cell & Tissue Engineering
H. Choe et al.
Summary: By investigating the impact of quorum sensing in Acinetobacter spp. on osseointegration, it was found that quorum sensing played a significant role in inducing interleukin 1 and inhibiting osseointegration in mice. Targeting Gram-negative acyl-homoserine lactone quorum sensing may be particularly effective for patients with Acinetobacter spp. infections.
EUROPEAN CELLS & MATERIALS
(2022)
Article
Veterinary Sciences
S. A. Hussein et al.
Summary: This study evaluated the protective effect of Spirulina and alpha-lipoic acid against aspartame-induced oxidative stress and brain damage in rabbits. The results showed that the co-administration of Spirulina and alpha-lipoic acid can significantly improve oxidative stress and attenuate DNA damage in the brain tissue.
JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY
(2022)
Article
Rehabilitation
Rachel E. Ellis et al.
Summary: The study aimed to determine the effectiveness of eccentric exercise in improving function and quality of life in heart failure patients. The results showed no significant superiority of eccentric exercise over concentric exercise or a waitlist control group.
DISABILITY AND REHABILITATION
(2022)
Article
Rehabilitation
Aqsa Mujaddadi et al.
Summary: The study found that sub-maximal eccentric exercise causes significantly greater muscle damage in elderly COPD patients compared to healthy controls, which suggests that initial exercise should be progressed with lower intensities to prevent undue muscle damage in these patients.
PHYSIOTHERAPY THEORY AND PRACTICE
(2021)
Review
Cardiac & Cardiovascular Systems
Gabriele G. Schiattarella et al.
Summary: HFpEF is a common chronic cardiovascular disease, where metabolic disturbance and inflammatory burden play important roles in its pathogenesis. The interplay between these two processes is complex, with metabolic inflammation having a central role in shaping the pathophysiology of HFpEF.
CARDIOVASCULAR RESEARCH
(2021)
Article
Sport Sciences
Susan Y. Kwiecien et al.
Summary: The study tested the efficacy of prolonging the duration of cooling using phase change material (PCM) on various recovery markers following a marathon run. Results showed that prolonging the cooling duration with PCM did not accelerate the resolution of any dependent variables related to muscle damage. Despite differences in soreness and countermovement jump height between groups, there was no significant advantage seen with PCM treatment.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Chemistry, Multidisciplinary
Qingxia Huang et al.
Summary: The study confirms that ginsenoside Rc promotes the activity of SIRT1, leading to improved mitochondrial function and energy metabolism, thus enhancing cardio- and neuroprotective functions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Engineering, Environmental
Lloyd J. Winchell et al.
Summary: Per- and polyfluoroalkyl substances (PFAS) are difficult to degrade and can be partially destroyed through incineration processes. While other thermal technologies show promise, incineration remains the only commercial approach available for destroying PFAS.
WATER ENVIRONMENT RESEARCH
(2021)
Article
Pathology
Rubens P. Homme et al.
Summary: Long-term inhibition of NF-KB can mitigate retinal vasculopathy in a type 1 diabetic mouse model, protecting retinal structure and function by reducing inflammatory mediators, maintaining key junction molecules, and improving vision-guided behavior.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Endocrinology & Metabolism
Tom S. O. Jameson et al.
Summary: The study found that ingesting protein-polyphenol drinks can accelerate the recovery of muscle function by attenuating inflammatory NF-.B transcriptional signaling, rather than increasing myofibrillar protein synthesis rates.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Plant Sciences
Yan Wan et al.
Summary: Panax ginseng and its ginsenosides are effective options for treating chemotherapy-induced side effects, with mechanisms including antioxidation, anti-inflammation, anti-apoptosis, and modulation of various signaling pathways.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Plant Sciences
Wen-Chung Huang et al.
Summary: The study showed that ginsenoside Rg3 significantly reduced airway inflammation, oxidative stress, and airway hyperresponsiveness in asthmatic mice, as well as decreased eosinophil infiltration. In tracheal epithelial cells, ginsenoside Rg3 also reduced inflammatory responses and oxidative stress.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Oncology
Benjamin Schoeps et al.
Summary: The study found that TIMP1 is associated with neutrophil activation in PDAC patients and directly triggers the formation of NETs, impacting the progression of PDAC. By combining plasma levels of TIMP1 and NETs, different prognostic subgroups of PDAC patients can be better identified.
Article
Veterinary Sciences
Lynn M. Pezzanite et al.
Summary: This study evaluated the effects of Toll-like and nucleotide-binding oligomerization domain (NOD)-like receptor ligand stimulation on antibacterial and immunomodulatory properties in equine mesenchymal stromal cells. The TLR-3 pIC activation was found to be most effective in enhancing antibacterial and cytokine responses in MSCs, with serum reduction affecting these responses. These findings suggest that TLR-3 activation of equine MSCs could be a potential strategy to improve antibacterial properties for treating antibiotic-resistant infections.
VETERINARY SURGERY
(2021)
Article
Medicine, Research & Experimental
Yaodong Zhang et al.
Summary: The study showed that LPS exposure induced significant neuronal damage in HT22 cells, while treatment with ginsenoside Rg1 (Rg1) significantly reduced LPS-induced neuronal damage. Rg1 may protect neurons by inhibiting NOX2-NLRP1 inflammasome activation and ROS production.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ozgur Ozturk et al.
Summary: This study investigated the frequency of MCP-1 CCR2 gene polymorphisms in patients with OLP and control participants, finding differences in certain genotypes but no statistically significant results.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Immunology
M. A. Sunil et al.
Summary: The study demonstrated that catechin inhibited several inflammatory mediators in LPS-stimulated RAW 264.7 cells while also up-regulating IL-10 production. Furthermore, catechin down-regulated the mRNA expression of COX-2, iNOS, TNF-α, NF-κB, and p38 MAPK.
INFLAMMOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Tao Zhang et al.
Summary: Extraordinary efforts have been made over 35 years to understand the function and regulating mechanism of NF-kappa B, leading to significant progress. NF-kappa B has been suggested to play an important role in human diseases and become an attractive target for disease treatment. Further investigations on the precise functions and underlying mechanisms of NF-kappa B are urgently needed for the development of drugs targeting inflammatory diseases and cancer treatment with minimal side effects.
Review
Biochemistry & Molecular Biology
Dehai Xian et al.
Summary: Oxidative stress is a redox imbalance caused by an excess of oxidants over antioxidants, leading to various skin diseases. Flavonoids, as plant secondary metabolites, have potent antioxidant capacity and can effectively suppress oxidative stress, playing a role in preventing and managing oxidative stress-related skin disorders.
Article
Medicine, General & Internal
Jinqiu Zhao et al.
Summary: The study showed that G-Rg1 protected against acute liver injury by promoting autophagy, reducing inflammation and apoptosis. The regulation of NF-κB/NLRP3 pathway was involved in the protective effect of G-Rg1 in acute liver injury.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Genetics & Heredity
Nakisa Soltani et al.
PUBLIC HEALTH GENOMICS
(2020)
Review
Biochemistry & Molecular Biology
George I. Lambrou et al.
MOLECULAR BIOLOGY REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Muneeb U. Rehman et al.
CURRENT DRUG METABOLISM
(2020)
Review
Food Science & Technology
Fatemeh Babaei et al.
FOOD SCIENCE & NUTRITION
(2020)
Review
Biochemistry & Molecular Biology
Guanghong Jia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Review
Cell Biology
Leen Catrysse et al.
TRENDS IN CELL BIOLOGY
(2017)
