4.6 Article

The antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors

Amanda J. Sales et al.

Summary: SAMe exerts antidepressant effects by regulating serotonin synthesis and 5-HT1A receptor activation, reducing immobility time in the forced swimming test in mice.

NEUROCHEMISTRY INTERNATIONAL (2023)

Article Neurosciences

nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity

Caroline Biojone et al.

Summary: A recent study has identified the nitration of TRKB receptors as a new molecular brake on plasticity, demonstrating the inhibitory effect of nitric oxide on neural plasticity.

PROGRESS IN NEUROBIOLOGY (2023)

Article Immunology

Uncovering associations between mental illness diagnosis, nitric oxide synthase gene variation, and peripheral nitric oxide concentration

Rhiannon McNeill et al.

Summary: Nitric oxide (NO) signaling has been studied in relation to mental illnesses, but its specific contribution remains unclear. This study investigated the association between peripheral NO concentration, specific diagnoses, and genetic variation in NO synthase (NOS) genes. The results showed that patients with schizophrenia had significantly higher peripheral NO metabolite concentrations compared to other groups. Additionally, carriers of the NOS1 VNTR1 short allele had increased NO concentrations, which remained significant even at discharge. The data also suggested that patients with unresolved depressive symptoms had higher NO concentrations, with a positive correlation between symptom severity and NO concentration.

BRAIN BEHAVIOR AND IMMUNITY (2022)

Review Neurosciences

Targeting neuronal nitric oxide synthase and the nitrergic system in post-traumatic stress disorder

Mohammad Amin Sadeghi et al.

Summary: Current pharmacological approaches for PTSD lack effectiveness, so new molecular targets are needed. Fear learning and memory in PTSD occur in different stages, involving different cellular pathways and brain regions. Targeting the NMDAR receptor has side effects, so targeting downstream signaling proteins like nNOS may be a solution. Modulating nNOS shows therapeutic potential for PTSD.

PSYCHOPHARMACOLOGY (2022)

Article Clinical Neurology

Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?

Adriano Jose Maia Chaves Filho et al.

Summary: The study demonstrates that doxycycline (DOXY) alone or in combination with lithium can reverse cognitive impairment and neuroinflammation induced by the d-amphetamine model in mice, showing promising therapeutic effects for treating bipolar disorder.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2021)

Review Behavioral Sciences

Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry

Adriano Jose Maia Chaves Filho et al.

Summary: Major mental disorders such as schizophrenia, bipolar disorder, and major depressive disorder are the leading cause of disability worldwide. Conventional pharmacotherapy has limitations, leading to interest in repurposing anti-inflammatory agents like tetracyclines such as minocycline and doxycycline for these disorders due to their neuroprotective and anti-inflammatory properties. Tetracyclines have shown promising results in clinical trials for schizophrenia by inhibiting microglial reactivity and toxic inflammation, although the molecular mechanisms underlying their effects are not fully understood.

BEHAVIOURAL PHARMACOLOGY (2021)

Article Clinical Neurology

Doxycycline at subantimicrobial dose combined with escitalopram reverses depressive-like behavior and neuroinflammatory hippocampal alterations in the lipopolysaccharide model of depression

Bruna Stefania Ferreira Mello et al.

Summary: The combination of doxycycline (DOXY) and the antidepressant escitalopram (ESC) appears to be an effective strategy in reversing inflammatory changes and providing protection against depression in mice.

JOURNAL OF AFFECTIVE DISORDERS (2021)

Article Behavioral Sciences

CBD modulates DNA methylation in the prefrontal cortex and hippocampus of mice exposed to forced swim

Amanda J. Sales et al.

BEHAVIOURAL BRAIN RESEARCH (2020)

Review Cell Biology

Nitric oxide signalling and antidepressant action revisited

Samia R. L. Joca et al.

CELL AND TISSUE RESEARCH (2019)

Article Biochemistry & Molecular Biology

Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse

Jie Tang et al.

NEUROCHEMICAL RESEARCH (2018)

Review Psychiatry

CHALLENGES OF TREATMENT-RESISTANT DEPRESSION

James Paul Pandarakalam

PSYCHIATRIA DANUBINA (2018)

Review Neurosciences

Neuronal nitric oxide synthase and affective disorders

Qi-Gang Zhou et al.

IBRO REPORTS (2018)

Article Multidisciplinary Sciences

Behavioral stress alters corticolimbic microglia in a sex- and brain region-specific manner

Justin L. Bollinger et al.

PLOS ONE (2017)

Review Cell Biology

Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse

Sophie A. Bradley et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Pharmacology & Pharmacy

Psychosocial stress inhibits additional stress-induced hyperexpression of NO synthases and IL-1β in brain structures

Anna Gadek-Michalska et al.

PHARMACOLOGICAL REPORTS (2016)

Article Neurosciences

Interplay Between Nitric Oxide and Brain-Derived Neurotrophic Factor in Neuronal Plasticity

Caroline Biojone et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2015)

Article Neurosciences

Atypical Neurotransmitters and the Neurobiology of Depression

Samia Regiane Joca et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2015)

Article Clinical Neurology

Role of the nitric oxide donor sodium nitroprusside in the antidepressant effect of ketamine in mice

Miriam A. Vogt et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2015)

Article Chemistry, Multidisciplinary

Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis

Alina Elena Parvu et al.

ACTA PHARMACOLOGICA SINICA (2013)

Review Public, Environmental & Occupational Health

The Epidemiology of Depression Across Cultures

Ronald C. Kessler et al.

ANNUAL REVIEW OF PUBLIC HEALTH, VOL 34 (2013)

Article Psychiatry

Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration

Bruna Stefania Ferreira Mello et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2013)

Article Clinical Neurology

Possible role of adrenomedullin and nitric oxide in major depression

Abdullah Akpinar et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2013)

Article Biochemistry & Molecular Biology

Working memory deficits in neuronal nitric oxide synthase knockout mice: Potential impairments in prefrontal cortex mediated cognitive function

Sandra P. Zoubovsky et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Review Pharmacology & Pharmacy

Role of Nitric Oxide in Motor Control: Implications for Parkinson's Disease Pathophysiology and Treatment

Elaine Del-Bel et al.

CURRENT PHARMACEUTICAL DESIGN (2011)

Review Biochemistry & Molecular Biology

Nitric oxide and major depression

Ashish Dhir et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2011)

Article Biochemical Research Methods

Proteomic analysis of the anti-inflammatory action of minocycline

Christopher R. Dunston et al.

PROTEOMICS (2011)

Article Neurosciences

Nitric oxide is involved in the regulation of marble-burying behavior

Maarja Krass et al.

NEUROSCIENCE LETTERS (2010)

Review Clinical Neurology

Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice

Neeraj Gilhotra et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2009)

Review Clinical Neurology

Increased plasma nitric oxide level associated with suicide attempt in depressive patients

Yong-Ku Kim et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2006)

Article Neurosciences

Increased plasma nitric oxide metabolites in suicide attempters

Bun-Hee Lee et al.

NEUROPSYCHOBIOLOGY (2006)

Review Neurosciences

Dual role of nitric oxide in adult neurogenesis

A Cárdenas et al.

BRAIN RESEARCH REVIEWS (2005)

Article Clinical Neurology

Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-β in an animal model of repeated trauma

BH Harvey et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2005)

Review Neurosciences

The physiology and pathophysiology of nitric oxide in the brain

FX Guix et al.

PROGRESS IN NEUROBIOLOGY (2005)

Review Cell Biology

Role of nitric oxide on motor behavior

EA Del Bel et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2005)

Article Pharmacology & Pharmacy

NO signaling in the CNS: from the physiological to the pathological

A Bishop et al.

TOXICOLOGY (2005)

Article Pharmacology & Pharmacy

Neuroprotection by tetracyclines

M Domercq et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2004)

Review Pharmacology & Pharmacy

Assessing antidepressant activity in rodents: recent developments and future needs

JF Cryan et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2002)

Article Neurosciences

Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice

EA Del Bel et al.

PSYCHOPHARMACOLOGY (2002)

Article Neurosciences

Chemical neuromodulation of frontal-executive functions in humans and other animals

TW Robbins

EXPERIMENTAL BRAIN RESEARCH (2000)