Current Trends in Surgical Management of Hepatocellular Carcinoma

Article Oncology

Pembrolizumab Versus Placebo as Second-Line Therapy in Patients From Asia With Advanced Hepatocellular Carcinoma: A Randomized, Double-Blind, Phase III Trial

Shukui Qin et al.

Summary: Pembrolizumab significantly prolonged overall survival and progression-free survival in previously treated advanced hepatocellular carcinoma patients from Asia, with a higher objective response rate compared to placebo.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Surgery

Low vs Standard-Dose Indocyanine Green in the Identification of Biliary Anatomy Using Near-Infrared Fluorescence Imaging: A Multicenter Randomized Controlled Trial

Alexandra D. Ladd et al.

Summary: This study investigates the use of a lower dose of intravenous indocyanine green (ICG) to improve the visualization of biliary anatomy, and finds that low-dose ICG leads to quantitative improvement in biliary visualization by minimizing liver fluorescence.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2023)

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Article Surgery

Perioperative and Disease-Free Survival Outcomes after Hepatectomy for Centrally Located Hepatocellular Carcinoma Guided by Augmented Reality and Indocyanine Green Fluorescence Imaging: A Single-Center Experience

Wen Zhu et al.

Summary: This study evaluated the efficacy of an augmented reality navigation (ARN) system combined with fluorescence imaging (ARN-FI) in laparoscopic hepatectomy for centrally located hepatocellular carcinoma. The results showed that compared to the non-ARN-FI group, the ARN-FI group had significantly less intraoperative blood loss, lower transfusion rate, shorter postoperative hospital stay, and lower postoperative complication rate. These findings suggest that the ARN system and fluorescence imaging can improve the success rate of surgery, reduce postoperative complications, accelerate postoperative recovery, and shorten hospital stay.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2023)

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Article Gastroenterology & Hepatology

Intermittent Pringle maneuver combined with controlled low Central venous pressure prolongs hepatic hilum occlusion time in patients with hepatocellular carcinoma complicated by post hepatitis B cirrhosis: a randomized controlled trial

Jinghe Li et al.

Summary: The study found that prolonging the hepatic hilum occlusion time from 15 to 20 minutes in hepatocellular carcinoma patients can reduce operation time and postoperative infection risk without increasing the risk of postoperative bleeding and bile leakage.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2023)

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Article Gastroenterology & Hepatology

Complete tumor necrosis confirmed by conversion hepatectomy after atezolizumab-bevacizumab treatment for advanced-stage hepatocellular carcinoma with lung metastasis

Atsushi Fukunaga et al.

Summary: A combined therapy of atezolizumab and bevacizumab showed efficacy in treating an unresectable advanced-stage hepatocellular carcinoma (HCC) patient with lung metastases. Despite the side effects during treatment, the patient's tumor shrank significantly after multiple cycles, leading to a successful curative hepatic resection and no cancer recurrence.

CLINICAL JOURNAL OF GASTROENTEROLOGY (2023)

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Article Surgery

Evolution of minimally invasive techniques and surgical outcomes of ALPPS in Italy: a comprehensive trend analysis over 10 years from a national prospective registry

Matteo Serenari et al.

Summary: This study analyzed the trend and influencing factors of ALPPS in Italy. It was found that the use of ALPPS has slightly declined, but the use of minimally invasive techniques has increased, leading to a reduced 90-day mortality rate. Post-hepatectomy liver failure (PHLF) still remains an unresolved issue.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2023)

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Article Dermatology

Surgical site wound infection and pain after laparoscopic repeat hepatectomy for recurrent hepatocellular carcinoma

Xiao-Bo Wang et al.

Summary: This study compared the effects of laparoscopic repeat liver resection (LRLR) and open repeat liver resection (ORLR) on surgical site wound infection and pain in recurrent hepatocellular carcinoma. The results showed that LRLR significantly reduced the rates of surgical site wound infection, superficial wound infection, bile leakage, organ/space wound infection, and surgical site wound pain. Therefore, LRLR for recurrent hepatocellular carcinoma can effectively reduce wound infection rates and improve postoperative wound pain.

INTERNATIONAL WOUND JOURNAL (2023)

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Review Oncology

Minimally Invasive ALPPS Procedure: A Review of Feasibility and Short-Term Outcomes

Luigi Cioffi et al.

Summary: Recent advancements in laparoscopic surgery and technical modifications have shown potential for improving clinical outcomes, feasibility, and patient safety in extensive liver tumor surgeries, leading to reduced complications and mortality rates.

CANCERS (2023)

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Review Oncology

Adoptive Cell Therapy in Hepatocellular Carcinoma: A Review of Clinical Trials

Muhammet Ozer et al.

Summary: Immunotherapy is the standard treatment for advanced hepatocellular carcinoma (HCC), but drug resistance is a limitation. This review discusses adoptive cell therapy (ACT) as an emerging cancer therapy for HCC and provides a summary of ongoing clinical trials.

CANCERS (2023)

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Review Oncology

Recent advances in oncolytic virus therapy for hepatocellular carcinoma

Licheng Zhu et al.

Summary: Hepatocellular carcinoma (HCC) is a highly refractory cancer and the fourth leading cause of cancer-related mortality worldwide. Oncolytic viruses have been extensively researched as a new cancer therapeutic agent in the treatment of HCC. These viruses can increase targeting to HCC, kill tumor cells, inhibit HCC growth, and have shown promising results in clinical trials.

FRONTIERS IN ONCOLOGY (2023)

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Article Medicine, General & Internal

Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study

Shukui Qin et al.

Summary: This study compared the efficacy and safety of the anti-PD-1 antibody camrelizumab plus the VEGFR2-targeted TKI rivoceranib with sorafenib as a first-line treatment for unresectable hepatocellular carcinoma. The results showed that camrelizumab-rivoceranib significantly improved progression-free survival and overall survival compared with sorafenib. This provides a new and effective treatment option for patients with unresectable hepatocellular carcinoma.

LANCET (2023)

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Article Oncology

Protocol of the RACB study: a multicenter, single-arm, prospective study to evaluate the efficacy of resection of initially unresectable hepatocellular carcinoma with atezolizumab combined with bevacizumab

Masayuki Okuno et al.

Summary: This study aims to evaluate the efficacy of atezo + bev in achieving conversion surgery and prolonged progression-free survival (PFS) for initially unresectable HCC.

BMC CANCER (2023)

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Article Oncology

Stereotactic Body Radiotherapy for Hepatocellular Carcinoma: A Brief Overview

Yukinori Matsuo

Summary: Stereotactic body radiotherapy (SBRT) is an effective alternative therapy for hepatocellular carcinoma (HCC) when standard treatments are not suitable. It has the potential to improve prognosis of HCC by achieving high local control rates. However, further research is needed to determine optimal use of SBRT in combination with other treatments and the evaluation of post-SBRT imaging.

CURRENT ONCOLOGY (2023)

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Article Surgery

Asia-Pacific multicentre randomized trial of laparoscopic versus open major hepatectomy for hepatocellular carcinoma (AP-LAPO trial)

Kelvin K. C. Ng et al.

Summary: This study aims to compare the effectiveness of laparoscopic major hepatectomy and open major hepatectomy for hepatocellular carcinoma. The study will assess the impact of both surgical approaches on tumor recurrence and survival, with the primary outcome being 2-year recurrence-free survival. Secondary outcomes include hospital mortality, postoperative complications, time to functional recovery, quality of life, long-term survival, and postoperative serum surgical stress-related cytokines.

BJS OPEN (2023)

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Article Oncology

Global, regional and national burden of primary liver cancer by subtype

Harriet Rumgay et al.

Summary: This study provides worldwide, regional, and national estimates of the incidence of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). The results show that HCC contributes the largest burden of liver cancer globally, with the highest rates in Eastern Asia, Northern Africa, and Southeastern Asia. iCCA rates are highest in Southeastern Asia, Eastern Asia, Northern Europe, the Caribbean and Central America, and Oceania.

EUROPEAN JOURNAL OF CANCER (2022)

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Article Oncology

Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial

Thomas Yau et al.

Summary: First-line nivolumab treatment did not significantly improve overall survival compared with sorafenib in patients with advanced hepatocellular carcinoma, but clinical activity and a favorable safety profile were observed in some patients.

LANCET ONCOLOGY (2022)

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Article Surgery

Safety of intermittent Pringle maneuver during minimally invasive liver resection in patients with hepatocellular carcinoma with and without cirrhosis

Santiago A. Ortiz Galindo et al.

Summary: The study aimed to analyze the impact of minimally invasive intermittent Pringle maneuver (IPM) on postoperative outcomes in patients with hepatocellular carcinoma (HCC) and liver cirrhosis. The findings suggest that the use of IPM in minimally invasive liver resection is safe and feasible for patients with HCC, including those with compensated liver cirrhosis, without increasing the risk of intraoperative blood transfusion or postoperative complications, and without affecting postoperative liver function tests for cirrhotic patients.

LANGENBECKS ARCHIVES OF SURGERY (2022)

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Article Oncology

Surgery versus Radiofrequency Ablation for Small Hepatocellular Carcinoma: A Randomized Controlled Trial (SURF Trail)

Tadatoshi Takayama et al.

Summary: This study compared the survival rates of surgery and RFA for small HCC and found no significant difference between the two treatments.

LIVER CANCER (2022)

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Review Oncology

Recent advances in systemic therapy for hepatocellular carcinoma

Huajun Zhang et al.

Summary: Hepatocellular carcinoma (HCC) is a common and lethal malignancy worldwide. While therapeutic options for advanced HCC are limited, sorafenib has been the only proven effective systemic drug for more than a decade. However, the rapid progress of molecular targeted therapies in the past three years has significantly changed the treatment landscape for advanced HCC. The incorporation of immune checkpoint therapies and their combination with molecular targeted therapy are emerging tools to enhance the immune response.

BIOMARKER RESEARCH (2022)

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Article Immunology

Evaluating the Benefits and Risks of Ex Vivo Liver Resection and Autotransplantation in Treating Hepatic End-stage Alveolar Echinococcosis

Yiwen Qiu et al.

Summary: This study analyzed the benefits and risks of ex vivo liver resection and autotransplantation (ELRA) in end-stage hepatic alveolar echinococcosis (AE). The long-term overall survival of the ELRA group was superior to that of the nonsurgical group, and patients with a predicted 12-month mortality risk >75% would significantly benefit from ELRA.

CLINICAL INFECTIOUS DISEASES (2022)

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Review Gastroenterology & Hepatology

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

Maria Reig et al.

Summary: There have been significant advances in the treatment strategies for hepatocellular carcinoma since the last update in 2018. However, some interventions still lack sufficient data for clinical incorporation, and personalized clinical management requires consideration of multiple parameters.

JOURNAL OF HEPATOLOGY (2022)

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Article Surgery

Safety and feasibility of robotic liver resection after previous abdominal surgeries

Linda Feldbruegge et al.

Summary: The study found that robotic liver surgery is safe and feasible for patients with prior abdominal surgeries, despite limited experience in the field. Baseline characteristics and perioperative outcomes in robotic liver resection showed no significant differences between patients with and without prior surgeries.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2022)

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Article Surgery

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for advanced hepatocellular carcinoma with macrovascular invasion

Giammauro Berardi et al.

Summary: The ALPPS procedure is an extreme rescue approach for advanced hepatocellular carcinoma patients with macrovascular invasion, which can improve the prognosis of patients. However, the procedure carries high risks and patient selection is crucial.

UPDATES IN SURGERY (2022)

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Article Gastroenterology & Hepatology

A case of conversion hepatectomy for huge hepatocellular carcinoma with adrenal metastasis and vascular invasion after atezolizumab-bevacizumab treatment

Takashi Hoshino et al.

Summary: We report a case of huge hepatocellular carcinoma (HCC) with adrenal metastasis and vascular invasion successfully treated by conversion hepatectomy after atezolizumab-bevacizumab treatment. The tumor decreased in size and tumor marker levels returned to normal range after treatment. Pathological analysis showed a complete response to atezolizumab-bevacizumab treatment.

CLINICAL JOURNAL OF GASTROENTEROLOGY (2022)

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Article Surgery

Application of associating liver partition and portal vein ligation for staged hepatectomy for initially unresectable hepatocellular carcinoma

Haoqi Chen et al.

Summary: The safety and efficacy of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in the treatment of initially unresectable hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) were evaluated. ALPPS proved to be a safe and effective treatment for HBV-associated HCC, but had a high incidence of postoperative complications.

BMC SURGERY (2022)

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Article Oncology

Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma (COSMIC-312) : a multicentre, open-label, randomised, phase 3 trial

Robin Kate Kelley et al.

Summary: This study evaluated the combination of cabozantinib and atezolizumab versus sorafenib as first-line systemic treatment for advanced hepatocellular carcinoma. The combination treatment group showed better progression-free survival compared to the sorafenib group, but overall survival did not reach statistical significance. Common adverse events in the combination group included liver enzyme elevation, hypertension, and skin reactions. The study suggests that cabozantinib plus atezolizumab may be a treatment option, but further research is needed.

LANCET ONCOLOGY (2022)

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Article Oncology

Atezolizumab Plus Bevacizumab in Patients with Advanced and Progressing Hepatocellular Carcinoma: Retrospective Multicenter Experience

Friedrich Sinner et al.

Summary: Hepatocellular cancer is the most common type of primary liver cancer, and its treatment depends on the patient's overall health and the spread of the tumor. The combination of atezolizumab plus bevacizumab has shown to prolong the survival of patients with advanced hepatocellular cancer and has a good safety profile.

CANCERS (2022)

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Review Oncology

Lenvatinib as First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Shijie Wang et al.

Summary: This study reviewed the efficacy and safety of lenvatinib as a first-line treatment for unresectable hepatocellular carcinoma (HCC) and compared it with sorafenib. The analysis of 24 studies showed that lenvatinib can provide better tumor responses and survival benefits for unresectable HCC patients compared to sorafenib, with a comparable incidence of adverse events.

CANCERS (2022)

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Article Gastroenterology & Hepatology

Global burden of primary liver cancer in 2020 and predictions to 2040

Harriet Rumgay et al.

Summary: The burden of liver cancer varies across the world, and it is a major cause of death in many countries. The number of liver cancer cases and deaths is predicted to increase, with a significant rise expected by 2040.

JOURNAL OF HEPATOLOGY (2022)

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Article Surgery

Hemihepatic versus total hepatic inflow occlusion for laparoscopic hepatectomy: A randomized controlled trial

Yufu Peng et al.

Summary: Both the TIO and HIO approaches could be safely performed for LLR in selected patients when performed by experienced surgeons. The TIO technique for LLR had the advantage of being easier to master than the HIO approach. Additionally, when the transection plane was located on the liver Cantlie's plane, TIO seems to have some superior perioperative outcomes.

INTERNATIONAL JOURNAL OF SURGERY (2022)

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Review Oncology

Dendritic-Cell-Vaccine-Based Immunotherapy for Hepatocellular Carcinoma: Clinical Trials and Recent Preclinical Studies

Long-Bin Jeng et al.

Summary: This review summarizes the evidence from clinical trials and recent preclinical studies on dendritic cell (DC)-based vaccines as mono- or combination immunotherapy for treating hepatocellular carcinoma (HCC). DCs, as the most potent antigen-presenting cells in the human immune system, play an important role in activating immune responses against tumor cells. DC-based vaccines have been developed as a promising personalized cancer immunotherapy. This review provides a comprehensive summary of the evidence from clinical trials and preclinical studies on the safety, feasibility, and efficacy of DC-based vaccines in treating HCC patients and highlights the development of strategies for optimizing the efficacy of DC-vaccine-based immunotherapy for HCC.

CANCERS (2022)

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Article Oncology

Novel irreversible electroporation ablation (Nano-knife) versus radiofrequency ablation for the treatment of solid liver tumors: a comparative, randomized, multicenter clinical study

Xiaobo Zhang et al.

Summary: This study demonstrated that the safety and efficacy of IRE in the treatment of solid liver tumors is non-inferior to a regular radiofrequency device.

FRONTIERS IN ONCOLOGY (2022)

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Review Health Care Sciences & Services

Liver Function-How to Screen and to Diagnose: Insights from Personal Experiences, Controlled Clinical Studies and Future Perspectives

Matthias Buechter et al.

Summary: This review discusses and evaluates various tools for screening and diagnosis of liver diseases, including insights from personal experiences, controlled clinical studies, and future perspectives. It also provides a novel diagnostic algorithm for screening patients with presumptive acute or chronic liver disease in daily clinical practice.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article Surgery

ALPPS Versus Portal Vein Embolization for Hepatitis-related Hepatocellular Carcinoma A Changing Paradigm in Modulation of Future Liver Remnant Before Major Hepatectomy

Albert Chan et al.

Summary: The study aimed to evaluate the short- and long-term outcomes of ALPPS for hepatitis-related HCC and found that ALPPS had a higher resection rate with comparable oncological outcomes to PVE in these patients.

ANNALS OF SURGERY (2021)

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Article Gastroenterology & Hepatology

Identification of liver lesions using fluorescence imaging: comparison of methods for administering indocyanine green

Kosuke Kobayashi et al.

Summary: This study evaluated the doses and timing of ICG administration for visualizing liver tumors via fluorescence imaging and found that administering 2.5 mg of ICG one day before surgery can enable the identification of tumors effectively.

HPB (2021)

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Review Anesthesiology

Application of controlled low central venous pressure during hepatectomy: A systematic review and meta-analysis

Tie-shuai Liu et al.

Summary: This systematic review and meta-analysis found that controlled low central venous pressure (CVP) effectively reduces blood loss during liver resection and significantly affects alanine transaminase levels in the early postoperative period. Compared with the control group, the low CVP group had significantly reduced blood transfusion volume and number of patients requiring transfusion. The incidence of complications was similar between the two groups.

JOURNAL OF CLINICAL ANESTHESIA (2021)

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Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Surgery

Milrinone is better choice for controlled low central venous pressure during hepatectomy: A randomized, controlled trial comparing with nitroglycerin

Peng Yang et al.

Summary: The study compared the effects of milrinone and nitroglycerin during hepatectomy. Milrinone was found to reduce blood loss, enhance postoperative recovery, and improve hemodynamics compared to nitroglycerin.

INTERNATIONAL JOURNAL OF SURGERY (2021)

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Article Oncology

FDA Approval Summary: Nivolumab Plus Ipilimumab for the Treatment of Patients with Hepatocellular Carcinoma Previously Treated with Sorafenib

May Tun Saung et al.

Summary: The FDA granted accelerated approval to nivolumab in combination with ipilimumab for the treatment of HCC based on data from cohort 4 of Check-Mate 040, showing comparable BICR-assessed ORR in all three arms at 31%-32%. Adverse events were consistent with known profiles of nivolumab and ipilimumab, with no new safety events identified.

ONCOLOGIST (2021)

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Review Gastroenterology & Hepatology

Current strategies to induce liver remnant hypertrophy before major liver resection

Celeste Del Basso et al.

Summary: Hepatic resection is the preferred treatment for liver tumors, but it carries the risk of post-operative liver failure. Clinical judgement is essential in selecting suitable patients for surgery and implementing effective pre-operative strategies to ensure an adequate future liver remnant.

WORLD JOURNAL OF HEPATOLOGY (2021)

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Article Oncology

Downstaging and Resection of Initially Unresectable Hepatocellular Carcinoma with Tyrosine Kinase Inhibitor and Anti-PD-1 Antibody Combinations

Xiao-Dong Zhu et al.

Summary: Combined therapy with TKIs and anti-PD-1 antibodies showed potential in converting initially unresectable hepatocellular carcinoma to resectable, with some patients achieving R0 resection after a median of 3.2 months. However, one patient experienced immune-related adverse effects leading to death post-hepatectomy. Overall, this study demonstrates the efficacy of this combination therapy in downstaging HCC.

LIVER CANCER (2021)

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Article Oncology

Sustained Complete Response after Biological Downstaging in Patients with Hepatocellular Carcinoma: XXL-Like Prioritization for Liver Transplantation or Wait and See Strategy?

Alessandro Vitale et al.

Summary: This study demonstrates that aggressive surgical downstaging can reduce the failure rate of downstaging, and that applying a wait and see policy can avoid immediate prioritization of transplantation for patients with sustained complete response to downstaging, saving organs without worsening patient outcomes.

CANCERS (2021)

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Article Oncology

Augmented Reality Navigation for Stereoscopic Laparoscopic Anatomical Hepatectomy of Primary Liver Cancer: Preliminary Experience

Weiqi Zhang et al.

Summary: The study evaluated the safety and effectiveness of a laparoscopic augmented reality navigation system in anatomical hepatectomy of primary liver cancer. Results showed that the system helped in identifying anatomical structures, reducing intraoperative bleeding, and accelerating postoperative recovery.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study

Robin Kate Kelley et al.

Summary: This study evaluated the treatment regimens for patients with hepatocellular carcinoma and found that all regimens were tolerable and clinically active, with the T300 + D regimen showing the most favorable benefit-risk profile. Early expansion of CD8+ lymphocytes was associated with treatment response across arms.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Oncology

Chinese Expert Consensus on Multidisciplinary Diagnosis and Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus (2018 Edition)

Shuqun Cheng et al.

LIVER CANCER (2020)

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Article Gastroenterology & Hepatology

Safety and feasibility of laparoscopic liver resection in patients with a history of abdominal surgeries

Linda Feldbruegge et al.

HPB (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Locoregional Therapies in the Treatment of 3-to 5-cm Hepatocellular Carcinoma: Critical Review of the Literature

Shamar Young et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2020)

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Article Oncology

Minimally Invasive Versus Open Liver Resection for Hepatocellular Carcinoma in the Setting of Portal Vein Hypertension: Results of an International Multi-institutional Analysis

Andrea Ruzzenente et al.

ANNALS OF SURGICAL ONCOLOGY (2020)

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Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Gastroenterology & Hepatology

Consensus recommendations of three-dimensional visualization for diagnosis and management of liver diseases

Chihua Fang et al.

HEPATOLOGY INTERNATIONAL (2020)

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Article Oncology

Liver transplantation in hepatocellular carcinoma after tumour downstaging (XXL): a randomised, controlled, phase 2b/3 trial

Vincenzo Mazzaferro et al.

LANCET ONCOLOGY (2020)

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Review Surgery

Outcomes of ex vivo liver resection and autotransplantation: A systematic review and meta-analysis

Michal Zawistowski et al.

SURGERY (2020)

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Review Immunology

Liver Transplantation for Hepatocellular Carcinoma. Working Group Report from the ILTS Transplant Oncology Consensus Conference

Neil Mehta et al.

TRANSPLANTATION (2020)

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Article Multidisciplinary Sciences

Comparative clinical outcomes of robot-assisted liver resection versus laparoscopic liver resection: A meta-analysis

Lilong Zhang et al.

PLOS ONE (2020)

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Article Oncology

Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib The CheckMate 040 Randomized Clinical Trial

Thomas Yau et al.

JAMA ONCOLOGY (2020)

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Article Infectious Diseases

Ex vivo liver resection and autotransplantation versus allotransplantation for end-stage hepatic alveolar echinococcosis

Shu Shen et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2019)

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Article Surgery

Meta-analysis of short- and long-term outcomes after pure laparoscopic versus open liver surgery in hepatocellular carcinoma patients

Jan Witowski et al.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2019)

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Editorial Material Gastroenterology & Hepatology

Three Possible Variations in Ex Vivo Hepatectomy: Achieving R0 Resection by Auto-transplantation

Maria R. Baimas-George et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2019)

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Review Biochemistry & Molecular Biology

Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

Chen Lu et al.

MOLECULAR CANCER (2019)

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Article Medicine, General & Internal

End-stage liver disease score and future liver remnant volume predict post-hepatectomy liver failure in hepatocellular carcinoma

Fan-Hua Kong et al.

WORLD JOURNAL OF CLINICAL CASES (2019)

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Review Oncology

Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence

Jean-Luc Raoul et al.

CANCER TREATMENT REVIEWS (2019)

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Article Gastroenterology & Hepatology

Liver Maximum Capacity: A Novel Test to Accurately Diagnose Different Stages of Liver Fibrosis

Matthias Buechter et al.

DIGESTION (2019)

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Article Gastroenterology & Hepatology

Alpha-Fetoprotein Decrease from > 1,000 to < 500 ng/mL in Patients with Hepatocellular Carcinoma Leads to Improved Posttransplant Outcomes

Neil Mehta et al.

HEPATOLOGY (2019)

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Article Oncology

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial

Andrew X. Zhu et al.

LANCET ONCOLOGY (2019)

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Review Surgery

Associating liver partition and portal vein ligation for staged hepatectomy in Qatar: Initial experience with two case series and review of the literature

Ibnouf Sulieman et al.

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS (2019)

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Article Surgery

Benefits of laparoscopic liver resection in patients with hepatocellular carcinoma and portal hypertension: a case-matched study

Victor Molina et al.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2018)

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Article Surgery

A long-term experience with expansion of Milan criteria for liver transplant recipients

Sarah Jane Commander et al.

CLINICAL TRANSPLANTATION (2018)

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Article Gastroenterology & Hepatology

Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

Jorge A. Marrero et al.

HEPATOLOGY (2018)

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Article Surgery

Laparoscopic Versus Open Hepatic Resection for Solitary Hepatocellular Carcinoma Less Than 5cm in Cirrhotic Patients: A Randomized Controlled Study

Ahmed El-Gendi et al.

JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES (2018)

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Review Surgery

Prolonged operative duration is associated with complications: a systematic review and meta-analysis

Hang Cheng et al.

JOURNAL OF SURGICAL RESEARCH (2018)

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Article Medicine, General & Internal

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

G. K. Abou-Alfa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Oncology

Minimal-invasive versus open hepatectomy for hepatocellular carcinoma: Comparison of postoperative outcomes and long-term survivals using propensity score matching analysis

Andreas Andreou et al.

SURGICAL ONCOLOGY-OXFORD (2018)

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Letter Gastroenterology & Hepatology

Percutaneous cooled-probe microwave versus radiofrequency ablation in early-stage hepatocellular carcinoma: a phase III randomised controlled trial

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Portal Hypertension and the Outcome of Surgery for Hepatocellular Carcinoma in Compensated Cirrhosis: A Systematic Review and Meta-analysis

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Laparoscopic Liver Resection for Malignant and Benign Lesions Ten-Year Norwegian Single-Center Experience

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Prediction of Postoperative Outcome After Hepatectomy With a New Bedside Test for Maximal Liver Function Capacity

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Real-Time Identification of Liver Cancers by Using Indocyanine Green Fluorescent Imaging

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MR Imaging of Liver Fibrosis: Current State of the Art

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Preoperative portal vein embolization for major liver resection - A meta-analysis

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ANNALS OF SURGERY (2008)

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