4.6 Article

One health transmission of fluoroquinolone-resistant Escherichia coli and risk factors for their excretion by dogs living in urban and nearby rural settings

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ONE HEALTH
卷 17, 期 -, 页码 -

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DOI: 10.1016/j.onehlt.2023.100640

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Zoonosis; Molecular ecology; Phylogenetics

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This study investigated the excretion of fluoroquinolone-resistant E. coli by dogs in rural and urban environments and found that rural dogs tend to excrete bacteria types commonly found in cattle, while urban dogs carry plasmid-mediated quinolone resistance genes similar to those found in human E. coli. Feeding dogs uncooked meat was identified as a potential transmission link for fluoroquinolone-resistant E. coli, emphasizing the importance of enhanced hygiene practices for handling and housing such dogs.
Rates of fluoroquinolone resistance in Escherichia coli, a key opportunistic human pathogen, are problematic. Taking a One Health approach, we investigated the excretion of fluoroquinolone-resistant (FQ-R) E. coli by 600 dogs (303 from rural and 297 from urban environments) recruited from a 50 x 50 km region where we have also surveyed FQ-R E. coli from cattle and from human urine. FQ-R E. coli were detected in faeces from 7.3% (rural) and 11.8% (urban) of dogs. FQ-R E. coli from rural dogs tended to be of sequence types (STs) commonly excreted by cattle, whilst those from urban dogs tended to carry plasmid-mediated quinolone resistance genes, common in human E. coli in our study region. Phylogenetic evidence was obtained for sharing FQ-R E. coli - particularly for STs 10, 162 and 744 - between cattle, dogs and humans. Epidemiological analysis showed a strong association between feeding dogs uncooked meat and the excretion of FQ-R E. coli, particularly for STs 10, 162 and 744. This practice, therefore, could serve as a transmission link for FQ-R E. coli from farmed animals entering the home so we suggest that dogs fed uncooked meat should be handled and housed using enhanced hygiene practices.

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