Mechanochemical Pd-Catalyzed Amino- and Oxycarbonylations using FeBr2(CO)4 as a CO Source

Herein, we describe the development of mechanochemical amino- and oxycarbonylation employing FeBr2(CO)(4) as a solid CO source. This Pd/XantPhos-catalyzed reaction affords a range of carboxamides and esters from aryl iodides and various amines or phenols. Both primary and secondary amines, including amino acids, can be employed as N-nucleophiles.

Automated summary

Here, we present the development of mechanochemical amino- and oxycarbonylation reactions using FeBr2(CO)(4) as a solid CO source. This Pd/XantPhos-catalyzed reaction enables the synthesis of a wide range of carboxamides and esters from aryl iodides and various amines or phenols. Notably, both primary and secondary amines, including amino acids, can be used as N-nucleophiles.