Three new schinortriterpenoids from the leaves of Schisandra chinensis (Turcz.) Baill

Three undescribed schinortriterpenoids, schinensilactones D-F (1-3), together with five known ones, namely, wuweizidilactone A (4), wuweizidilactone C (5), wuweizidilactone F (6), wuweizidilactone J (7) and wuweizidilactone N (8), were isolated from the leaves of Schisandra chinensis (Turcz.) Baill. The structures of new compounds were established by analysis of their spectroscopic data including MS, IR, 1D- and 2D-NMR spectra. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction and calculated electronic circular dichroism (ECD) spectra. All compounds were evaluated for their neuroprotective effects against H2O2-induced injury in human neuroblastoma SH-SY5Y cell lines. Cell viability was remarkably reduced to 52.33% in H2O2-treated cells. Compounds 5-7 exhibited moderate neuroprotective activities at 50 mu M, with cell viability of 64.84%, 67.34% and 63.73%, respectively.

Automated summary

Three new schinortriterpenoids were identified from the leaves of Schisandra chinensis, along with five known compounds. The structures of the new compounds were determined through various spectroscopic techniques. These compounds showed moderate neuroprotective effects in human neuroblastoma cells.