☆ 4.5 Article

Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease

NEUROSCIENCE (2024)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Neurosciences

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

Dylan V. Neel et al.

Summary: Mitochondrial dysfunction and axon loss are key features of neurologic diseases, and Gasdermin (GSDM) proteins, including GSDME, play a role in these processes. Proteins associated with FTD/ALS, such as TDP-43 and PR-50, induce GSDME-mediated damage to mitochondria and neurite loss. Knockdown of GSDME protects against neurite loss in ALS patient iPSC-derived motor neurons, and knockout of GSDME in SOD1G93A ALS mice improves survival, motor function, and reduces neuroinflammation, highlighting the importance of GSDME in neuro-degeneration.

NEURON (2023)

添加到收藏夹

Article Clinical Neurology

Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons

Sebastiaan Moonen et al.

Summary: The study investigated the contribution of pyroptosis, a pro-inflammatory mechanism of cell death downstream of the inflammasome, to neurodegeneration in Alzheimer's disease (AD). The findings suggest the activation of pyroptosis in specific cell types and its potential link to neuron death in AD.

ACTA NEUROPATHOLOGICA (2023)

添加到收藏夹

Review Neurosciences

Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

Lina Gao et al.

Summary: Synaptic abnormalities are a key aspect of Alzheimer's disease, connecting pathological changes to cognitive impairment. Brain-derived neurotrophic factors are crucial in synaptic plasticity for learning and memory, and have potential as diagnostic biomarkers and therapeutic molecules for AD. The exact mechanisms underlying the effects of impaired BDNF signaling on AD are still unclear.

TRANSLATIONAL NEURODEGENERATION (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The synapse as a treatment avenue for Alzheimer's Disease

Lin Peng et al.

Summary: Alzheimer's disease is a neurodegenerative disorder that severely impairs memory and cognition. It is characterized by Aβ deposition, tau tangles, synaptic abnormalities, and dysfunctions. Targeting the synapse and early treatment windows hold promise for finding effective treatments for AD patients.

MOLECULAR PSYCHIATRY (2022)

添加到收藏夹

Letter Biochemistry & Molecular Biology

Clusterin transduces Alzheimer-risk signals to amyloidogenesis

Xi Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation

Qiuyang Zheng et al.

Summary: Down syndrome is one of the critical risk factors for early-onset Alzheimer's disease, and the DS-related gene USP25 has been identified as a critical regulator of AD pathology, potentially serving as a pharmacological target for AD drug development.

JOURNAL OF CLINICAL INVESTIGATION (2022)

添加到收藏夹

Article Immunology

Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer's disease

Wenjuan Rui et al.

Summary: The study revealed that canonical inflammasome signaling and GSDMD-induced pyroptosis were activated in PBMCs of aMCI and AD patients. Additionally, the proinflammatory cytokine IL-1 beta was strongly associated with the pathophysiology of aMCI and AD.

JOURNAL OF NEUROINFLAMMATION (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy

Yinshuang Li et al.

Summary: The study revealed that TNF alpha/Casp3/GSDME-mediated pyroptosis plays a key role in obstructive nephropathy, promoting renal fibrogenesis through inflammatory responses.

CELL DEATH AND DIFFERENTIATION (2021)

添加到收藏夹

Article Behavioral Sciences

Pyroptosis executive protein GSDMD as a biomarker for diagnosis and identification of Alzheimer's disease

Heping Shen et al.

Summary: The levels of GSDMD, T-Tau, and Tau181p were higher in AD patients compared to VD patients and healthy controls, while A beta(1-42) levels were lower in AD patients. GSDMD showed good diagnostic accuracy in AD and good discrimination accuracy between AD and VD. The expression levels of inflammatory factors (IL-1 beta and IL-6) in the cerebrospinal fluid were higher in AD patients and positively correlated with GSDMD expression.

BRAIN AND BEHAVIOR (2021)

添加到收藏夹

Article Cell Biology

Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

Ya-Jen Chiu et al.

Summary: The traditional Chinese herbal medicine SG-Tang shows potential in treating Alzheimer's disease by reducing Aβ aggregation, oxidative stress, and inflammatory responses.

AGING-US (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Charles L. Evavold et al.

Summary: The Ragulator-Rag complex is found to be necessary for GSDMD pore formation and pyroptosis in macrophages, promoting GSDMD oligomerization on the plasma membrane. Defects in GSDMD oligomerization and pore formation can be rescued by mitochondrial poisons that stimulate ROS production, and ROS modulation impacts the ability of inflammasome pathways to promote pore formation downstream of GSDMD cleavage.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ1-42-Induced Alzheimer's Disease

Sareer Ahmad et al.

Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling

Shuting Zhang et al.

MOLECULAR PSYCHIATRY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Antioxidative and antiapoptosis: Neuroprotective effects of dauricine in Alzheimer's disease models

Lingfeng Wang et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

添加到收藏夹

Article Cell Biology

New mechanism of nerve injury in Alzheimer's disease: β-amyloid-induced neuronal pyroptosis

Chenyang Han et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

添加到收藏夹

Article Oncology

HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

Gao Tan et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Article Neurosciences

BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis

Shuting Zhang et al.

JOURNAL OF NEUROSCIENCE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Jianjin Shi et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

添加到收藏夹

Article Immunology

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

C. Dempsey et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Alzheimer's Amyloid-β Sequesters Caspase-3 in Vitro via Its C-Terminal Tail

Yu-Jen Chang et al.

ACS CHEMICAL NEUROSCIENCE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding et al.

NATURE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

添加到收藏夹

Review Immunology

Pyroptotic cell death defends against intracellular pathogens

Ine Jorgensen et al.

IMMUNOLOGICAL REVIEWS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

添加到收藏夹

Review Cell Biology

Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation

Maja Jazvinscak Jembrek et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

添加到收藏夹

Article Otorhinolaryngology

DFNA5, a Gene Involved in Hearing Loss and Cancer: A Review

Ken Op de Beeck et al.

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY (2014)

添加到收藏夹

Article Cell Biology

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease

M-S Tan et al.

CELL DEATH & DISEASE (2014)

添加到收藏夹

Article Neurosciences

Amyloid- protein (A) Glu11 is the major -secretase site of -site amyloid- precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to A Asp1 contributes to Alzheimer pathogenesis

Yu Deng et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2013)

添加到收藏夹

Article Medicine, Research & Experimental

Inhibition of GSK3 beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes

Philip T. T. Ly et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

添加到收藏夹

Article Multidisciplinary Sciences

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka et al.

NATURE (2013)

添加到收藏夹

Review Neurosciences

Caspase-3 activation as a bifurcation point between plasticity and cell death

Shikha Snigdha et al.

NEUROSCIENCE BULLETIN (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulator of Calcineurin 1 (RCAN1) Facilitates Neuronal Apoptosis through Caspase-3 Activation

Xiulian Sun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

添加到收藏夹

Article Neurosciences

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

Marcello D'Amelio et al.

NATURE NEUROSCIENCE (2011)

添加到收藏夹

Article Pathology

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

Natalia Louneva et al.

AMERICAN JOURNAL OF PATHOLOGY (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

Xiulian Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

XL Sun et al.

FASEB JOURNAL (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.