Moslosooflavone protects against brain injury induced by hypobaric hypoxic via suppressing oxidative stress, neuroinflammation, energy metabolism disorder, and apoptosis

Article Biochemistry & Molecular Biology

Effect of Non-Volatile Constituents of Elsholtzia ciliata (Thunb.) Hyl. from Southern Vietnam on Reactive Oxygen Species and Nitric Oxide Release in Macrophages

Dieu T. X. Nguyen et al.

Summary: Fifteen compounds were isolated from the extract of Elsholtzia ciliata aerial parts, including eleven flavonoids, three hydroxycinnamic acid derivatives, and one fatty acid. Biological evaluation showed that all of these compounds exhibited good antioxidant and anti-inflammatory activities, with compound 13 showing particularly promising results.

CHEMISTRY & BIODIVERSITY (2021)

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Article Multidisciplinary Sciences

Global and country-level estimates of human population at high altitude

Joshua C. Tremblay et al.

Summary: Global estimates of human population living at high altitude vary widely, with limited data available at the country level. A GIS-based approach was used to quantify human population at 500-m elevation intervals for each country. The study found that high altitude presents environmental stresses impacting physiological responses and disease prevalence.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Physiology

Hypoxic Hypoxia and Brain Function in Military Aviation: Basic Physiology and Applied Perspectives

David M. Shaw et al.

Summary: Acute hypobaric hypoxia poses a major threat to military aviation, affecting brain function and operational performance at high altitudes. Recognizing and effectively managing hypoxia is crucial for ensuring flight safety and mission success.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Integrative & Complementary Medicine

Norwogonin attenuates hypoxia-induced oxidative stress and apoptosis in PC12 cells

Linlin Jing et al.

Summary: Norwogonin attenuates hypoxia-induced injury in PC12 cells by scavenging ROS, maintaining the activities of antioxidant enzymes, and inhibiting mitochondrial apoptosis pathway.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

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Article Pharmacology & Pharmacy