☆ 4.7 Review

MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Cardiac & Cardiovascular Systems

miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure

Gyeoung-Jin Kang et al.

Summary: This study revealed that myocardial ischemia results in the downregulation of KCNA4 gene expression and the upregulation of miR-448 gene expression. miR-448 binds to a specific region of KCNA4 gene, leading to the decreased expression of KCNA4 and the alteration of normal cardiac action potential. These findings provide insights into the mechanism of miR-448 regulation of KCNA4 expression during ischemia.

HEART RHYTHM (2023)

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Review Biochemistry & Molecular Biology

MicroRNAs as Biomarkers for Coronary Artery Disease Related to Type 2 Diabetes Mellitus-From Pathogenesis to Potential Clinical Application

Joanna Szydelko et al.

Summary: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with a growing incidence worldwide and a higher risk of developing coronary artery disease (CAD). Current diagnostic methods are inadequate for early detection of CAD, necessitating extensive research on non-invasive blood-based biomarkers. MicroRNAs (miRNAs) show promise as stable and easily detectable biomarkers. Aberrant expression of miRNAs has been implicated in the pathophysiology of atherosclerosis, linking T2DM with CAD. This review discusses the role of miRNAs in diabetic CAD development and highlights their potential as non-invasive biomarkers and therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biochemistry & Molecular Biology

Pacemaker activity and ion channels in the sinoatrial node cells: MicroRNAs and arrhythmia

Wei Fan et al.

Summary: The pacemaking activity of the heart is primarily determined by spontaneous action potentials (APs) within sinoatrial node (SAN) cells, which rely on membrane clocks and calcium clocks. Nonhomologous arrhythmias result from changes in myocardial function and structure. MicroRNAs (miRNAs) are important regulators of gene expression in cardiomyocytes and play a role in regulating cardiac conduction stability and arrhythmia-induced remodeling. Although the mechanisms of miRNA regulation of ion channels in the heart are not yet clear, these mechanisms may support new therapeutic approaches. This study discusses AP generation and spread in the SAN, as well as the regulation of miRNAs and individual ion channels, with the aim of providing a research basis for miRNA modulation as a new therapeutic target for arrhythmias.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2023)

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Article Biochemistry & Molecular Biology

miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives

Francesco Sessa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Public, Environmental & Occupational Health

Estimates of the global, regional, and national burden of atrial fibrillation in older adults from 1990 to 2019: insights from the Global Burden of Disease study 2019

Min Jiao et al.

Summary: This study aimed to explore the burden of atrial fibrillation (AF) in older adults aged 60-89 globally, regionally, and nationally. The results showed that in 2019, there were a total of 33.31 million AF cases, 219.4 thousand deaths, and 65.8 million DALYs globally. The burden of AF varied significantly across different territories and countries, with China having the highest number of cases, deaths, and DALYs. AF in older adults remains a major public health concern worldwide.

FRONTIERS IN PUBLIC HEALTH (2023)

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Review Medicine, General & Internal

MicroRNAs as a Potential Biomarker in the Diagnosis of Cardiovascular Diseases

Dagmar Kramna et al.

Summary: Cardiovascular diseases (CVD) are the leading cause of death in most developed countries. MicroRNAs (miRNAs) are highly investigated molecules not only in CVD but also in other diseases. Several studies on miRNAs continue to reveal novel miRNAs that may play a role in CVD, in their pathogenesis in diagnosis or prognosis, but evidence for clinical implementation is still lacking.

MEDICINA-LITHUANIA (2023)

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Article Cardiac & Cardiovascular Systems

Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction

Thassio Mesquita et al.

Summary: Chronotropic incompetence and sinoatrial node (SAN) dysfunction are common problems in patients with heart failure, but the underlying mechanisms are not yet fully understood. This study identified intrinsic abnormalities in SAN structure and function as the cause of chronotropic incompetence in heart failure patients with preserved ejection fraction (HFpEF).

CIRCULATION (2022)

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Review Cardiac & Cardiovascular Systems

Heart failure with preserved ejection fraction: recent concepts in diagnosis, mechanisms and management

Andreas B. Gevaert et al.

Summary: It is estimated that half of heart failure patients have heart failure with preserved ejection fraction (HFpEF), which presents a diagnostic and therapeutic challenge. Recent evidence suggests that the mechanisms, phenotypes, and response to therapies of heart failure gradually change as left ventricular ejection fraction (LVEF) increases. HF hospitalizations and deaths due to cardiac causes decrease as LVEF increases. Medications effective for heart failure with reduced ejection fraction (HFrEF) have less impact on HFpEF patients with higher LVEF. HFpEF is also influenced by non-cardiac comorbidities. Sodium-glucose cotransporter 2 inhibitors reduce the risk of cardiovascular events by reducing HF hospitalizations, while renin-angiotensin-aldosterone blockers and angiotensin-neprilysin inhibitors have smaller effects on HF hospitalizations in HFpEF patients.

HEART (2022)

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Article Cardiac & Cardiovascular Systems

Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure

Liam S. Couch et al.

Summary: The circulating biomarkers miR-16 and miR-26a were found to be involved in the pathophysiology of Takotsubo syndrome (TTS), sensitizing the heart to TTS-like changes produced by adrenaline. These miRs are associated with anxiety and depression and may provide a mechanism whereby previous stress primes the heart, increasing the likelihood of TTS in the future.

CARDIOVASCULAR RESEARCH (2022)

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Review Medicine, General & Internal

Upregulated miR-328-3p and its high risk in atrial fibrillation A systematic review and meta-analysis with meta-regression

Haitao Huang et al.

Summary: This meta-analysis demonstrated a significant association between high levels of miR-328-3p and increased risk of atrial fibrillation, suggesting its potential as an important biomarker for diagnosis.

MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Interplay between PI3K/AKT pathway and heart disorders

Soudeh Ghafouri-Fard et al.

Summary: The PI3K/AKT signaling pathway plays a crucial role in regulating physiological functions and contributing to the pathogenesis of various diseases.

MOLECULAR BIOLOGY REPORTS (2022)

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Review Biochemistry & Molecular Biology

miRNA in Ischemic Heart Disease and Its Potential as Biomarkers: A Comprehensive Review

Amanda Shen-Yee Kong et al.

Summary: Ischemic heart disease is the leading cause of mortality and morbidity globally, and microRNAs play a crucial role in the diagnosis and treatment of this disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cardiac & Cardiovascular Systems

Circulating microRNAs in cellular and antibody- mediated heart transplant rejection

Palak Shah et al.

Summary: By analyzing and studying miR expression data in heart transplant patients, miR panels with high diagnostic accuracy for acute rejection can be developed, providing a new non-invasive method for clinical monitoring of heart transplant.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

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Article Medicine, Research & Experimental

MicroRNAs as therapeutic targets in cardiovascular disease

Bernhard Laggerbauer et al.

Summary: The discovery of microRNAs and their role in cardiovascular diseases has sparked interest in using microRNAs as drug targets. MicroRNA-based drugs have made significant progress in preclinical and clinical testing for cardiovascular diseases, showing great potential in treatment.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Cardiac & Cardiovascular Systems

Atrial fibrillation in the UK: predicting costs of an emerging epidemic recognizing and forecasting the cost drivers of atrial fibrillation-related costs

Paul Burdett et al.

Summary: Atrial fibrillation (AF) is a common sustained heart arrhythmia that imposes a significant cost on the NHS and the wider UK healthcare system. Hospitalizations are the main cost driver, and with an increasing number of AF patients, these costs are expected to rise in the future. By focusing on reducing hospitalizations, healthcare costs related to AF could be substantially reduced for the NHS.

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES (2022)

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Review Cardiac & Cardiovascular Systems

The Role of the VEGF Family in Coronary Heart Disease

Yan Zhou et al.

Summary: The VEGF family, known for its role in regulating blood and lymphatic vessels, shows promise for treating coronary heart disease (CHD) by regulating various functions such as angiogenesis, apoptosis, inflammation, and fibrogenesis. Through binding with different receptors, VEGF proteins can modulate distinct physiological processes, offering potential pathways for treating CHD.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Potential Roles of MyomiRs in Cardiac Development and Related Diseases

Leila Abkhooie et al.

Summary: MyomiRs, known as crucial regulatory elements for cardiovascular development, are abundantly expressed in the myocardium and have been confirmed as promising diagnostic biomarkers for early diagnosis of cardiac disorders. Recent findings have focused on epigenetic modulations of MyomiRs and cardiac regeneration associated with cardiac diseases.

CURRENT CARDIOLOGY REVIEWS (2021)

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Article Biochemistry & Molecular Biology

MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation

Flavia Ravelli et al.

Summary: Atrial fibrillation is a multifactorial disease that often occurs in the presence of underlying cardiac abnormalities and is supported by electrophysiological and structural alterations. MicroRNAs are emerging as potential regulators in the pathogenesis of AF, particularly in modulating atrial electrical and structural remodeling. Abnormal substrates in various conditions such as hypertension, heart failure, obesity, and sleep apnea contribute to the predisposition to AF.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel

Dandan Yang et al.

Summary: This study reveals a novel biophysical action of endogenous miRs in modulating cardiac electrophysiology through noncanonical mechanisms. Endogenous miR1 physically binds with cardiac membrane protein Kir2.1, suppressing I-K1 and affecting action potential of cardiomyocytes. The findings suggest that miRs may be involved in the pathogenesis of cardiac arrhythmias by regulating ion channel physiology and pathology.

CIRCULATION (2021)

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Review Cardiac & Cardiovascular Systems

Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease

Caitlin Hall et al.

Summary: Cardiac fibroblasts play a crucial role in providing support to the heart and are involved in physiological signaling processes, but excessive activation can lead to pathological remodeling. Research is expanding our understanding of cardiac fibroblast activation and their interactions with cardiac myocytes.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Multidisciplinary Sciences

Altered microRNA and mRNA profiles during heart failure in the human sinoatrial node

Ning Li et al.

Summary: Heart failure is often associated with dysfunction of the sinoatrial node (SAN), leading to abnormal heart rhythms and increased mortality. This study analyzed altered microRNAs (miRs) and mRNAs in the SAN of HF patients, with 27 miRs predicted to regulate major ion channels and neurotransmitter receptors involved in SAN functions.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Multidisciplinary

MiR-486-3p and MiR-938-Important Inhibitors of Pacemaking Ion Channels and/or Markers of Immune Cells

Abimbola J. Aminu et al.

Summary: The study confirmed that miR-486-3p significantly downregulates Ca(v)1.3, Ca(v)3.1, and TPSAB1-mediated luciferase activity, while miR-938 only significantly downregulates TPSAB1-mediated luciferase activity. This suggests that miR-486-3p could be a potential therapeutic target for treating sinus node dysfunctions.

APPLIED SCIENCES-BASEL (2021)

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Review Cardiac & Cardiovascular Systems

miR-21 in Human Cardiomyopathies

Surina Surina et al.

Summary: miR-21, a 22-nucleotide long microRNA, plays a crucial role in various cardiomyopathies by regulating gene expression and providing cardiac protection after injury. It is also closely linked to cardiac dysfunctions such as hypertrophy and fibrosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Further insights into the molecular complexity of the human sinus node-The role of 'novel' transcription factors and microRNAs

Abimbola J. Aminu et al.

Summary: The study identified key transcription factors (TFs) and cell markers in the sinus node (SN) that are significantly more expressed compared to the right atrial tissue (RA), which play a role in regulating ion channels and immune cells. Some TFs were predicted to regulate the expression of key ion channel HNC4, while cell markers were found to have complex interactions with these TFs.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2021)

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Review Oncology

Epigenetic Regulation of MicroRNA Clusters and Families during Tumor Development

Jana Gregorova et al.

Summary: This review provides an overview of the history of RNA interference discovery, microRNA biogenesis, and post-transcriptional regulation of gene expression, with a focus on microRNA clusters and families. It also discusses the strong interplay between microRNAs and epigenetic mechanisms such as DNA methylation and histone modifications, and their association with deregulated microRNA expression in tumor development. Furthermore, it explores novel strategies for epigenetic-based therapies.

CANCERS (2021)

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Review Cardiac & Cardiovascular Systems

Role of MicroRNAs in the Pathogenesis of Coronary Artery Disease

Soudeh Ghafouri-Fard et al.

Summary: miRNAs play a crucial role in the pathophysiological process of CAD, with up-regulated and down-regulated miRNAs associated with the development of CAD, which can be utilized for diagnostic and prognostic evaluation of CAD.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Review Toxicology

Systems analysis of miRNA biomarkers to inform drug safety

Amy L. Schofield et al.

Summary: miRNAs are short non-coding RNA molecules that have been shown to be dysregulated and released in different organ systems. Circulating miRs are proposed as useful biomarkers for various disease states, potentially replacing existing traditional biomarkers. However, pre-analytical and analytical challenges need to be addressed before their clinical use can be realized.

ARCHIVES OF TOXICOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Dual role of miR-1 in the development and function of sinoatrial cells

P. Benzoni et al.

Summary: miR-1, the most abundant miRNA in the heart, plays a crucial role in modulating the expression of transcription factors and ion channels, influencing the development and function of SAN cells. Overexpression of miR-1 leads to changes in the proportion of SAN precursors and alters the electrical properties of SAN-like cells, primarily through regulating the expression of specific genes involved in pacemaker function.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Circulating microRNA-29-5p can add to the discrimination between dilated cardiomyopathy and ischaemic heart disease

Martin Brundin et al.

Summary: This study compared serum levels of specific miRs and cardiac magnetic resonance imaging parameters between patients with DCM and IHD, finding that miR-29-5p levels were increased in DCM and miR-320a levels were elevated in DCM compared to healthy controls.

ESC HEART FAILURE (2021)

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Review Biochemistry & Molecular Biology

Potential roles of mediator Complex Subunit 13 in Cardiac Diseases

Wenqian Zhou et al.

Summary: MED13 plays critical roles in cell cycle regulation, development, growth, myocardial energy metabolism, and non-metabolic cardiovascular diseases. It is a potential therapeutic target for metabolic disorders and cardiovascular diseases.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Cardiac & Cardiovascular Systems

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Jorg Taubel et al.

Summary: The study evaluated the safety and mechanism of action of CDR132L in patients with chronic ischemic heart failure, showing that CDR132L is safe and well tolerated, effectively reducing miR-132 levels and improving cardiac function.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Jorg Taubel et al.

Summary: The first-in-class miR-132 inhibitor, CDR132L, showed good safety and tolerability in HF patients. It effectively reduced miR-132 levels, decreased NT-proBNP levels, and potentially improved cardiac function.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Regulatory RNAs in Heart Failure

Clarissa Pedrosa da Costa Gomes et al.

CIRCULATION (2020)

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Article Oncology

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

David S. Hong et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Pharmacology & Pharmacy

Metformin ameliorates cardiac conduction delay by regulating microRNA-1 in mice

Lifang Lv et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Editorial Material Pharmacology & Pharmacy

Challenges identifying efficacious miRNA therapeutics for cancer

Meirav Segal et al.

EXPERT OPINION ON DRUG DISCOVERY (2020)

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Article Genetics & Heredity

Circulatory miR-133b and miR-21 as Novel Biomarkers in Early Prediction and Diagnosis of Coronary Artery Disease

Dinesh Kumar et al.

GENES (2020)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms, Diagnostic Aspects and Therapeutic Opportunities of Micro Ribonucleic Acids in Atrial Fibrillation

Allan Bohm et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

Joseph Yanni et al.

SCIENTIFIC REPORTS (2020)

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Article Multidisciplinary Sciences

Sex-specific microRNAs in women with diabetes and left ventricular diastolic dysfunction or HFpEF associate with microvascular injury

Barend W. Florijn et al.

SCIENTIFIC REPORTS (2020)

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Article Cardiac & Cardiovascular Systems

Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node

Maria Petkova et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Review Biochemistry & Molecular Biology

Circulating microRNA as a Biomarker for Coronary Artery Disease

Ibrahim T. Fazmin et al.

BIOMOLECULES (2020)

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Article Cardiac & Cardiovascular Systems

Serum Circulating miR-150 is a Predictor of Post-Acute Myocardial Infarction Heart Failure

Xiaoping Lin et al.

INTERNATIONAL HEART JOURNAL (2019)

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Review Pharmacology & Pharmacy

miR-155 in the Resolution of Atherosclerosis

Robyn Bruen et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation

Chao-Shun Chan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Cell Biology

MicroRNAs in Cardiac Diseases

Robin M. W. Colpaert et al.

CELLS (2019)

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Article Cardiac & Cardiovascular Systems

MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels

Jin Zhang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

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Article Medicine, Research & Experimental

Value of the expression of miR-208, miR-494, miR-499 and miR-1303 in early diagnosis of acute myocardial infarction

Ping Li et al.

LIFE SCIENCES (2019)

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Article Cardiac & Cardiovascular Systems

MicroRNA-200a-3p Is a Positive Regulator in Cardiac Hypertrophy Through Directly Targeting WDR1 as Well as Modulating PTEN/PI3K/AKT/CREB/WDR1 Signaling

Xiaomei Yang et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

miRBase: from microRNA sequences to function

Ana Kozomara et al.

NUCLEIC ACIDS RESEARCH (2019)

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Review Pharmacology & Pharmacy

The Role of Angiogenesis in Coronary Artery Disease: A Double-edged Sword: Intraplaque Angiogenesis in Physiopathology and Therapeutic Angiogenesis for Treatment

Wen Wu et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

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Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Editorial Material Cardiac & Cardiovascular Systems

Finding Ms or Mr Right: Which miRNA to target in AF?

Cristina E. Molina et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

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Meeting Abstract Cardiac & Cardiovascular Systems

MIR-499 PROTECTS THE RAT HEART AGAINST ISCHEMIA/REPERFUSION INJURY THROUGH PDCD4 DURING ISCHEMIC POSTCONDITIONING-REGULATED

Jianbing Zhu et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Multidisciplinary Sciences

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling

Robert S. Stephenson et al.

SCIENTIFIC REPORTS (2017)

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Article Cardiac & Cardiovascular Systems

Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia

Alicia D'Souza et al.

CIRCULATION RESEARCH (2017)

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Review Biochemistry & Molecular Biology

The role of microRNAs in heart failure

Hongjiang Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

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Review Cardiac & Cardiovascular Systems

MicroRNAs in heart failure: from biomarker to target for therapy

Eline L. Vegter et al.

EUROPEAN JOURNAL OF HEART FAILURE (2016)

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Review Biochemistry & Molecular Biology

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

Caterina Catalanotto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Cardiac & Cardiovascular Systems

Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation

Takeshi Soeki et al.

JOURNAL OF CARDIOLOGY (2016)

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Review Cardiac & Cardiovascular Systems

Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction)

Dimitry A. Chistiakov et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

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Review Pharmacology & Pharmacy

MicroRNA-Based Therapy in Animal Models of Selected Gastrointestinal Cancers

Jana Merhautova et al.

FRONTIERS IN PHARMACOLOGY (2016)

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Review Cardiac & Cardiovascular Systems

MicroRNAs in cardiovascular disease: an introduction for clinicians

Simon P. R. Romaine et al.

HEART (2015)

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Review Cardiac & Cardiovascular Systems

Sick sinus syndrome and atrial fibrillation in older persons - A view from the sinoatrial nodal myocyte

O. Monfredi et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

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Article Oncology

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and-133 in patients with age-associated atrial fibrillation

Yao-Dong Li et al.

MOLECULAR MEDICINE REPORTS (2015)

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Review Genetics & Heredity

miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants

T. Desvignes et al.

TRENDS IN GENETICS (2015)

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Article Anesthesiology

Tachycardia-bradycardia syndrome in a patient with atrial fibrillation - a case report

Sung Hwan Choi et al.

KOREAN JOURNAL OF ANESTHESIOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

MicroRNAs in Heart Failure Is the Picture Becoming Less miRky?

Yonathan F. Melman et al.

CIRCULATION-HEART FAILURE (2014)

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Article Multidisciplinary Sciences

Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation

Jun Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Pathology

MicroRNAs: History, Biogenesis, and Their Evolving Role in Animal Development and Disease

M. Bhaskaran et al.

VETERINARY PATHOLOGY (2014)

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Review Physiology

Atrial fibrillation and microRNAs

Gaetano Santulli et al.

FRONTIERS IN PHYSIOLOGY (2014)

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Comparison of plasma microRNA-1 and cardiac troponin T in early diagnosis of patients with acute myocardial infarction

Li-ming Li et al.

WORLD JOURNAL OF EMERGENCY MEDICINE (2014)

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Article Hematology

MicroRNAs in Myocardial Infarction

Jan Fiedler et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

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Article Hematology

MicroRNA-126,-145, and -155 A Therapeutic Triad in Atherosclerosis?

Yuanyuan Wei et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

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Biomarkers and diagnostics in heart failure

Hanna K. Gaggin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

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Article Cardiac & Cardiovascular Systems

MicroRNA29 A Mechanistic Contributor and Potential Biomarker in Atrial Fibrillation

Kristin Dawson et al.

CIRCULATION (2013)

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Article Cardiac & Cardiovascular Systems

MiR-378 Controls Cardiac Hypertrophy by Combined Repression of Mitogen-Activated Protein Kinase Pathway Factors

Jayavarshni Ganesan et al.

CIRCULATION (2013)

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Article Medicine, General & Internal

Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction

Ying-Qing Li et al.

CLINICS (2013)

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Article Cardiac & Cardiovascular Systems

Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction

Fabiola Olivieri et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction

Ingo Eitel et al.

AMERICAN HEART JOURNAL (2012)

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Review Medicine, Research & Experimental

MicroRNA therapeutics in cardiovascular medicine

Thomas Thum

EMBO MOLECULAR MEDICINE (2012)

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Review Cardiac & Cardiovascular Systems

MicroRNAs and atrial fibrillation: new fundamentals

Zhiguo Wang et al.

CARDIOVASCULAR RESEARCH (2011)

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Article Urology & Nephrology

TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

Wei Qin et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

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Review Multidisciplinary Sciences

Pervasive roles of microRNAs in cardiovascular biology

Eric M. Small et al.

NATURE (2011)

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Review Chemistry, Multidisciplinary

The Therapeutic Potential of MicroRNAs: Disease Modulators and Drug Targets

Ailbhe M. McDermott et al.

PHARMACEUTICAL RESEARCH (2011)

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Article Cardiac & Cardiovascular Systems

MicroRNA-328 Contributes to Adverse Electrical Remodeling in Atrial Fibrillation

Yanjie Lu et al.

CIRCULATION (2010)

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Article Cardiac & Cardiovascular Systems

MiR423-5p As a Circulating Biomarker for Heart Failure

Anke J. Tijsen et al.

CIRCULATION RESEARCH (2010)

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Review Cardiac & Cardiovascular Systems

The Anatomy and Physiology of the Sinoatrial Node-A Contemporary Review

Oliver Monfredi et al.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2010)

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Review Cardiac & Cardiovascular Systems

MicroRNA Regulation of Cardiovascular Development

Kimberly R. Cordes et al.

CIRCULATION RESEARCH (2009)

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Article Surgery

MicroRNAs: Control and Loss of Control in Human Physiology and Disease

Min Li et al.

WORLD JOURNAL OF SURGERY (2009)

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Review Cardiac & Cardiovascular Systems

The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure

Vijay Divakaran et al.

CIRCULATION RESEARCH (2008)

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Article Biochemistry & Molecular Biology

Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart

Xiaobin Luo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Multidisciplinary Sciences

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

Tamia A. Harris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Review Medicine, General & Internal

MicroRNAs in the broken heart

J. Bauersachs et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2007)

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Article Biochemistry & Molecular Biology

Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2

Yong Zhao et al.

CELL (2007)

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Article Biochemistry & Molecular Biology

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

Baofeng Yang et al.

NATURE MEDICINE (2007)

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Review Pharmacology & Pharmacy

The funny current - Cellular basis for the control of heart rate

Dario DiFrancesco et al.

DRUGS (2007)

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Article Cardiac & Cardiovascular Systems

Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine

M Weber et al.

HEART (2006)

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Review Cardiac & Cardiovascular Systems

Hypertrophy of the heart - A new therapeutic target?

N Frey et al.

CIRCULATION (2004)

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Article Cardiac & Cardiovascular Systems

Impact of beta-myosin heavy chain expression on cardiac function during stress

M Krenz et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)

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Article Medicine, Research & Experimental

Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression

J Miake et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

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Article Cardiac & Cardiovascular Systems

Inflammation and atherosclerosis

P Libby et al.

CIRCULATION (2002)

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Article Multidisciplinary Sciences

Identification of novel genes coding for small expressed RNAs

M Lagos-Quintana et al.

SCIENCE (2001)

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