期刊
OPEN BIOLOGY
卷 6, 期 4, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.160003
关键词
m(6)A; mRNA; methylation
资金
- Howard Hughes Medical Institute
- National Natural Science Foundation of China [31420103901]
- NIH [T32 2T32DK007356]
The identification of m(6)A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m(6)A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m(6)A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the 'writers', 'erasers' and 'readers' of m(6)A RNA modification. Moreover, we emphasize recent advances of biological functions of m(6)A and conceive the possible roles of m(6)A in the regulation of immune response and related diseases.
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