4.6 Article

Oscillatory vs. non-oscillatory subthalamic beta activity in Parkinson's disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Long-Term Recording of Subthalamic Aperiodic Activities and Beta Bursts in Parkinson's Disease

Ghazaleh Darmani et al.

Summary: This study investigates the relationship between aperiodic activity in the subthalamic nucleus (STN) and the pathophysiology of Parkinson's disease (PD). Long-term observations reveal that aperiodic activities in the STN increase over time following deep brain stimulation (DBS) and dopaminergic medications, while beta bursts remain stable and are suppressed by dopaminergic medications. These findings emphasize the distinct roles of oscillations and aperiodic activities in the pathophysiology of PD.

MOVEMENT DISORDERS (2023)

Article Neurosciences

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients

Roxanne Lofredi et al.

Summary: Pathologically increased beta power is a biomarker for Parkinson's disease and is related to prolonged bursts of subthalamic beta synchronization. This study investigates the association between subthalamic beta dynamics and motor impairment in Parkinson's patients, and confirms a correlation between low beta power and burst duration with motor impairment. The findings also demonstrate the effectiveness of dopamine medication in alleviating symptoms and validate the use of different beta burst determination methods.

NPJ PARKINSONS DISEASE (2023)

Article Biology

The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

Christoph Wiest et al.

Summary: Periodic features of neural time-series data, such as LFPs, are quantified using power spectra. The aperiodic exponent of spectra, disregarded in the past, was found to reflect E/I balance in neuronal populations. This study demonstrated that the aperiodic exponent of STN-LFPs reflects E/I balance in Parkinsonism and could serve as a potential biomarker for adaptive DBS.
Review Clinical Neurology

Long-term directional deep brain stimulation: Monopolar review vs. local field potential guided programming

Carla Fernandez-Garcia et al.

Summary: This study evaluated the effectiveness of directional subthalamic stimulation in Parkinson's disease based on intraoperatively recorded beta oscillations. The results showed a strong correlation between clinical efficacy and beta activity, and selecting the contacts with the highest beta peaks improved the therapeutic window. Long-term follow-up showed similar improvements in both groups, validating the efficacy of directional stimulation guided by intraoperative beta oscillations.

BRAIN STIMULATION (2022)

Article Neurosciences

Dopamine depletion can be predicted by the aperiodic component of subthalamic local field potentials

Jinmo Kim et al.

Summary: This study highlights the importance of aperiodic components as electrophysiological biomarkers in reflecting pathological activities in the basal ganglia of Parkinson's disease. The findings suggest that aperiodic parameters may provide a more sensitive measurement for early diagnosis and serve as a potential feedback parameter for adaptive deep brain stimulation.

NEUROBIOLOGY OF DISEASE (2022)

Article Computer Science, Interdisciplinary Applications

Separating Neural Oscillations from Aperiodic 1/f Activity: Challenges and Recommendations

Moritz Gerster et al.

Summary: This article scrutinizes two commonly used methods, FOOOF and IRASA, for separating periodic and aperiodic components in electrophysiological power spectra. The methods are evaluated using diverse spectra obtained from electroencephalography, magnetoencephalography, and local field potential recordings. The article highlights specific spectral features that hinder the separation and quantifies the parameterization error of each method. The advantages of both methods are evaluated based on real and simulated power spectra, and recommendations on how to use them are proposed.

NEUROINFORMATICS (2022)

Article Clinical Neurology

Subthalamic low beta bursts differ in Parkinson's disease phenotypes

Arnaldo Fim Neto et al.

Summary: This study investigated the dynamics of subthalamic nucleus local field potentials (STN-LFP) in Parkinson's disease patients and found differences in low-frequency beta bursts between tremor-dominant and postural instability and gait disorder phenotypes. These differences were correlated with motor symptoms.

CLINICAL NEUROPHYSIOLOGY (2022)

Article Neurosciences

Amplitude and frequency modulation of subthalamic beta oscillations jointly encode the dopaminergic state in Parkinson's disease

Alberto Averna et al.

Summary: This study investigates the dynamics of spontaneous amplitude modulation (AM) and frequency modulation (FM) in Parkinson's disease patients. The results show a negative correlation between AM and FM, which changes after levodopa administration. AM and FM separately and jointly encode the dopaminergic state in patients, with FM being more informative than AM.

NPJ PARKINSONS DISEASE (2022)

Article Neurosciences

Voluntary movements cause beta oscillations increase and broadband slope decrease in the subthalamic nucleus of parkinsonian patients

Elena M. Belova et al.

Summary: The study compared LFP signals in the STN of Parkinson's patients at rest and during hand, sometimes followed by leg movements. It found a significant increase in synchronization in the low beta range during leg movements, with an increase in gamma range synchronization for both movements. The slope of the aperiodic component may reflect the excitatory/inhibitory projections ratio in the recording site, correlating significantly with motor signs of PD.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Article Clinical Neurology

The Pathophysiological Correlates of Parkinson's Disease Clinical Subtypes

Daniele Belvisi et al.

Summary: The study aimed to identify the pathophysiological substrate of Parkinson's disease subtypes using neurophysiological techniques. Two clinical clusters were identified, with one having milder symptoms and the other having a combination of severe motor and nonmotor manifestations. Differences in motor system dysfunction were observed between the subtypes, while sensory function and sensorimotor integration mechanisms did not differ.

MOVEMENT DISORDERS (2021)

Article Clinical Neurology

Modulation of beta bursts in subthalamic sensorimotor circuits predicts improvement in bradykinesia

Yasmine M. Kehnemouyi et al.

Summary: There is currently no biomarker available for clinicians to adjust chronic therapies for Parkinson's disease. Studies suggest that beta oscillopathy in the subthalamic nucleus is related to motor symptoms in Parkinson's disease, and deep brain stimulation may improve symptoms by modulating this activity.
Article Neurosciences

Spectral characteristics of subthalamic nucleus local field potentials in Parkinson's disease: Phenotype and movement matter

Fabio Godinho et al.

Summary: Parkinson's disease patients exhibit differences in STN-LFP beta-band activity between tremor dominant (TD) and postural instability and gait disorder (PIGD) motor phenotypes, especially during rest and movement states. Movement-induced desynchronization patterns in alpha-beta range vary in TD (10-20 Hz) and PIGD patients (21-28 Hz), leading to improved classification accuracy when considering movement information. These findings suggest that STN-LFP beta-band encodes phenotype-movement dependent information in PD patients.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Review Clinical Neurology

Technology of deep brain stimulation: current status and future directions

Joachim K. Krauss et al.

Summary: Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based neuromodulation and is now commonly used for the treatment of movement disorders such as Parkinson's disease, tremor, and dystonia. Advances in engineering and imaging technologies are expected to enhance the efficacy and tolerability of DBS procedures in the future.

NATURE REVIEWS NEUROLOGY (2021)

Article Neurosciences

Differential Effects of Pathological Beta Burst Dynamics Between Parkinson's Disease Phenotypes Across Different Movements

Raumin S. Neuville et al.

Summary: Resting state beta band oscillations were recorded in PD patients during various movement tasks, showing consistent peak frequencies across activities but differences in oscillatory dynamics between different disease phenotypes.

FRONTIERS IN NEUROSCIENCE (2021)

Article Biochemical Research Methods

Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease

Benoit Duchet et al.

Summary: Parkinson's disease motor symptoms are linked to increased beta oscillatory power in the subthalamic nucleus, particularly the duration of beta bursts may be crucial. Analysis suggests the system generating beta oscillations is more likely non-linear off medication, with changes in non-linearity correlated with motor impairment. The study explores how burst dynamics differ between medication states using various models, providing insights into the mechanism behind beta oscillations.

PLOS COMPUTATIONAL BIOLOGY (2021)

Article Neurosciences

Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts

Matteo Vissani et al.

Summary: This study explores the neural features of excessive beta-band oscillations in the subthalamic nucleus in Parkinson's disease, and their correlations with movement kinematics and striatal dopamine. The results suggest a strong correlation between beta high range bursts, inter-hemispheric striatal dopaminergic tone imbalance, and impaired inter-joint movement coordination, providing new insights into motor control in parkinsonian patients.

NPJ PARKINSONS DISEASE (2021)

Article Clinical Neurology

Modulation of beta bursts in subthalamic sensorimotor circuits predicts improvement in bradykinesia

Yasmine M. Kehnemouyi et al.

Summary: It has been found that improvements in bradykinesia in Parkinson's disease patients undergoing deep brain stimulation are linked to a reduction in beta oscillopathy in the sensorimotor region. The degree of improvement correlates with the reduction in beta power and burst durations, as well as the volume of tissue modulated in the subthalamic nucleus. These findings suggest that beta oscillopathy combined with lead location could potentially serve as a marker for real-time feedback to adjust clinical settings or drive closed-loop deep brain stimulation.
Article Neurosciences

Parkinsonian Beta Dynamics during Rest and Movement in the Dorsal Pallidum and Subthalamic Nucleus

Robert S. Eisinger et al.

JOURNAL OF NEUROSCIENCE (2020)

Article Biochemical Research Methods

Uncoupling the roles of firing rates and spike bursts in shaping the STN-GPe beta band oscillations

Jyotika Bahuguna et al.

PLoS Computational Biology (2020)

Review Neurosciences

Using Bayes factor hypothesis testing in neuroscience to establish evidence of absence

Christian Keysers et al.

NATURE NEUROSCIENCE (2020)

Article Neurosciences

Striatal Oscillations in Parkinsonian Non-Human Primates

Arun Singh et al.

NEUROSCIENCE (2020)

Editorial Material Behavioral Sciences

Dissecting Transient Burst Events

Catharina Zich et al.

TRENDS IN COGNITIVE SCIENCES (2020)

Article Neurosciences

Parameterizing neural power spectra into periodic and aperiodic components

Thomas Donoghue et al.

NATURE NEUROSCIENCE (2020)

Article Clinical Neurology

Changing views of the pathophysiology of Parkinsonism

Thomas Wichmann

MOVEMENT DISORDERS (2019)

Review Clinical Neurology

Focused ultrasound in Parkinson's disease: A twofold path toward disease modification

Guglielmo Foffani et al.

MOVEMENT DISORDERS (2019)

Article Clinical Neurology

Pallidal Beta Bursts in Parkinson's Disease and Dystonia

Roxanne Lofredi et al.

MOVEMENT DISORDERS (2019)

Editorial Material Neurosciences

Neural Oscillations: Sustained Rhythms or Transient Burst-Events?

Freek van Ede et al.

TRENDS IN NEUROSCIENCES (2018)

Article Multidisciplinary Sciences

Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease

Ilknur Telkes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Neurosciences

Nonsinusoidal Beta Oscillations Reflect Cortical Pathophysiology in Parkinson's Disease

Scott R. Cole et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Neurosciences

Inferring synaptic excitation/inhibition balance from field potentials

Richard Gao et al.

NEUROIMAGE (2017)

Article Clinical Neurology

Clinical criteria for subtyping Parkinson's disease: biomarkers and longitudinal progression

Seyed-Mohammad Fereshtehnejad et al.

Review Neurosciences

When brain rhythms aren't 'rhythmic': implication for their mechanisms and meaning

Stephanie R. Jones

CURRENT OPINION IN NEUROBIOLOGY (2016)

Article Clinical Neurology

Adaptive deep brain stimulation in Parkinson's disease

M. Beudel et al.

PARKINSONISM & RELATED DISORDERS (2016)

Article Multidisciplinary Sciences

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits

Krishnakanth Kondabolu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Neurosciences

Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations

Alejo J. Nevado-Holgado et al.

JOURNAL OF PHYSIOLOGY-LONDON (2014)

Article Clinical Neurology

Calculating clinical progression rates in Parkinson's disease: Methods matter

Johan Marinus et al.

PARKINSONISM & RELATED DISORDERS (2014)

Review Neurosciences

Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations

Alberto Priori et al.

EXPERIMENTAL NEUROLOGY (2013)

Article Clinical Neurology

The functional role of beta oscillations in Parkinson's disease

Simon Little et al.

PARKINSONISM & RELATED DISORDERS (2013)

Article Multidisciplinary Sciences

Theoretical Analysis of the Local Field Potential in Deep Brain Stimulation Applications

Scott F. Lempka et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease

Coralie de Hemptinne et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Neurosciences

The origin of extracellular fields and currents - EEG, ECoG, LFP and spikes

Gyoergy Buzsaki et al.

NATURE REVIEWS NEUROSCIENCE (2012)

Article Multidisciplinary Sciences

Striatal origin of the pathologic beta oscillations in Parkinson's disease

M. M. McCarthy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Mathematical & Computational Biology

FieldTrip: Open Source Software for Advanced Analysis of MEG, EEG, and Invasive Electrophysiological Data

Robert Oostenveld et al.

COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE (2011)

Article Biochemistry & Molecular Biology

Boosting Cortical Activity at Beta-Band Frequencies Slows Movement in Humans

Alek Pogosyan et al.

CURRENT BIOLOGY (2009)

Article Neurosciences

Dopamine-dependent non-linear correlation between subthalamic rhythms in Parkinson's disease

S Marceglia et al.

JOURNAL OF PHYSIOLOGY-LONDON (2006)

Article Clinical Neurology

300-Hz subthalamic oscillations in Parkinson's disease

G Foffani et al.

Article Neurosciences

Activity patterns in a model for the subthalamopallidal network of the basal ganglia

D Terman et al.

JOURNAL OF NEUROSCIENCE (2002)

Article Computer Science, Software Engineering

Estimation of parameters and eigenmodes of multivariate autoregressive models

A Neumaier et al.

ACM TRANSACTIONS ON MATHEMATICAL SOFTWARE (2001)