☆ 4.6 Review

Changing patterns in the epidemiology of drug allergy

ALLERGY (2023)

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Article Dermatology

Successful rechallenge with pembrolizumab after case of progressive immunotherapy-related mucocutaneous eruption (PIRME), a Stevens-Johnson syndrome-like reaction

Connie R. Shi et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2023)

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Review Allergy

Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions

Andrew Gibson et al.

Summary: Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), have significant impact on health and hinder drug development. Understanding the association between HLA class I alleles and SCARs has helped with prevention efforts and shed light on the immunopathogenesis. However, there is still much unknown about the specific risk alleles and antigens involved. Identifying the MHC-restricted drug-reactive peptides and genetic/environmental risk factors will be crucial for predicting individual and drug-level risks and developing targeted therapeutics.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

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Editorial Material Dermatology

Drug Reaction With Eosinophilia and Systemic Symptoms

Matthew S. S. Krantz et al.

Summary: This article describes the symptoms, diagnosis, and treatment of drug reaction with eosinophilia and systemic symptoms.

JAMA DERMATOLOGY (2023)

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Article Allergy

Open Latin American anaphylaxis registry

Edgardo J. Jares et al.

Summary: This study investigated the clinical features, triggers and management of anaphylaxis in Latin America. The results showed that drug-induced anaphylaxis was the most common, followed by food-induced and venom-induced anaphylaxis. Children and adolescents were more likely to experience food-induced and insect sting-induced anaphylaxis. Less than half of the patients were prescribed epinephrine after emergency treatment. The importance of this study lies in providing updated data on anaphylaxis in Latin America and emphasizing the urgent need to disseminate and implement anaphylaxis guidelines.

WORLD ALLERGY ORGANIZATION JOURNAL (2023)

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Review Allergy

Skin testing as a biomarker in drug allergy

Rebecca R. Saff

Summary: Despite limited diagnostic tests for drug allergies, biomarkers such as skin testing can improve diagnosis and identification. Standardized procedures are necessary to enhance the accuracy and reproducibility of skin testing. Other biomarkers like in vitro testing and genetic factors are being investigated for their potential effectiveness in combination with clinical history and skin testing.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2023)

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Editorial Material Allergy

Recent Updates in Understanding NSAID Hypersensitivity

Ellen Minaldi et al.

Summary: This review provides an overview of recent studies on nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity, particularly emphasizing the importance of oral provocation tests in diagnosis and management, the varying risk of cross-reactivity to COX-2 inhibitors, and effective treatment of NSAID-exacerbated cutaneous disease. The pathophysiology, cross-reactivity, and diagnostic evaluation differ among the five distinct phenotypes of NSAID hypersensitivity, and further research is needed to understand the underlying mechanisms in patients with and without underlying disease.

CURRENT ALLERGY AND ASTHMA REPORTS (2023)

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Review Biotechnology & Applied Microbiology

Hypersensitivity reactions to biologics in children

Leticia de las Vecillas et al.

Summary: Hypersensitivity reactions to biologics in children are poorly understood, and there is a lack of knowledge on management and standardization of protocols. Recent publications have provided insights into managing these reactions and adapting desensitization protocols for pediatric populations. An international consensus is needed to improve personalized management and tailored desensitization in children.

EXPERT OPINION ON BIOLOGICAL THERAPY (2023)

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Article Allergy

Deconstructing adverse reactions to Amoxicillin-Clavulanic Acid: the importance of time of onset

NP Freundt-Serpa et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2023)

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Article Oncology

Drug reactions with eosinophilia and systemic symptoms induced by immune checkpoint inhibitors: an international cohort of 13 cases

Saskia Ingen-Housz-Oro et al.

Summary: This study aimed to investigate the clinical features, treatment, and prognosis of drug reactions with eosinophilia and systemic symptoms (DRESS) induced by immune checkpoint inhibitors (ICI). Thirteen patients were included and showed moderate severity of ICI-related DRESS. Discontinuation of ICI and treatment with systemic steroids were the common strategies, and no deaths were reported.

MELANOMA RESEARCH (2023)

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Article Allergy

Different phenotypes of drug-induced anaphylaxis-Data from the European Anaphylaxis Registry

Theresa Hanschmann et al.

Summary: This study analyzes a large dataset on drug induced anaphylaxis and provides insights into its causes, risk factors, symptoms, and treatment. Drugs, particularly analgesics and antibiotics, are found to be the third most common cause of anaphylactic reactions. Female gender and older age are identified as relevant risk factors, while children are less affected by drug induced anaphylaxis.

ALLERGY (2023)

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Review Allergy

Penicillin allergy delabeling Opportunities for implementation and dissemination

Upeka Samarakoon et al.

Summary: Unconfirmed penicillin allergy labels have negative impact on personal and public health, leading to the emergence and transmission of resistant bacteria. Efforts have been made to promote proactive penicillin allergy evaluations and delabeling to remove inaccurate allergy labels. Access to penicillin allergy evaluation services is limited, but recent studies show the feasibility of expanding these services to a wider range of healthcare professionals.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2023)

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Review Allergy

Drug allergy in primary care: systematic review to support quality improvement initiative of management and optimization of healthcare pathways

Clara Gaudin et al.

Summary: The aim of this study was to review the practice of general practitioners in diagnosing and managing drug hypersensitivity reactions, and to develop decision support tools for GPs. Recent findings suggest that DHRs still present challenges in GP clinical practice, with difficulties in clinical decisions and referral to allergy specialists. Recognizing DHRs and differentiating them from other drug side effects remain difficult, and there is a need for decision aids to support GP management.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2023)

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Article Allergy

Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper

Marek Jutel et al.

Summary: The exponential growth of precision diagnostic tools has led to vast amounts of data enabling in-depth disease characterization. New disease endotypes have been identified, moving from symptom-focused descriptions to identifying biomarkers and intricate pathways. The current disease taxonomy must be revised for better categorization.

ALLERGY (2023)

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Article Anesthesiology

Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study

Paul Michel Mertes et al.

Summary: This study assessed the relationship between pholcodine exposure and NMBA-related anaphylaxis. It found that exposure to pholcodine and other quaternary ammonium compounds in the environment can increase sensitivity to NMBAs. Pholcodine and quaternary ammonium sIgEs have a high negative predictive value but a very low positive predictive value for identifying NMBA-related reactions.

BRITISH JOURNAL OF ANAESTHESIA (2023)

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Article Allergy

Vancomycin-Induced Liver Injury, DRESS, and HLA-A*32:01

Bilal A. Asif et al.

Journal of Allergy and Clinical Immunology-In Practice (2023)

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Article Allergy

Nonsteroidal anti-inflammatory drugs hypersensitivity in chronic spontaneous urticaria in the light of its pathogenesis

R. Asero

Summary: The study suggests that hypersensitivity to NSAIDs in CSU patients is independent of the pathogenic mechanisms of the underlying skin disease.

EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Next-generation sequencing and genotype association studies reveal the association of HLA-DRB3*02:02 with delayed hypersensitivity to penicillins

Antonino Romano et al.

Summary: The study revealed a strong association between the HLA-DRB3 gene locus and an increased risk of delayed penicillin hypersensitivity, with specific alleles increasing the risk of delayed reactions. The potential value of the HLA-DRB3*02:02 allele in the risk management of delayed hypersensitivity to penicillins was suggested for further evaluation in larger population samples of diverse origins.

ALLERGY (2022)

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Article Allergy

Hypersensitivity reactions to chemotherapy: an EAACI Position Paper

Mauro Pagani et al.

Summary: Chemotherapeutic drugs can induce hypersensitivity reactions, being the third leading cause of fatal drug-induced anaphylaxis. Deaths related to chemotherapy have been reported in Europe and the United States. The European Network on Drug Allergy organized a task force to provide data and recommendations regarding allergological work-up in this field.

ALLERGY (2022)

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Article Toxicology

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity

Sean Hammond et al.

Summary: An emerging clinical issue associated with immune-oncology agents is their impact on the tolerability of concomitant medications. This study aimed to investigate the role of T cells in hypersensitivity reactions observed in patients receiving immune checkpoint inhibitors (ICIs) and sulfasalazine (SLZ). The results showed that drug-responsive T cells are effectors of these adverse events, and perturbation of drug-specific T-cell priming may explain the increased incidence of these reactions.

TOXICOLOGICAL SCIENCES (2022)

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Letter Medicine, General & Internal

Estimated Costs of Severe Adverse Drug Reactions Resulting in Hospitalization in the Veterans Health Administration

Sherrie L. Aspinall et al.

Summary: This quality improvement study utilized VHA data to estimate the costs of severe adverse drug reactions leading to or contributing to hospitalizations.

JAMA NETWORK OPEN (2022)

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Article Allergy

Hypersensitivity Reactions to Platinum Agents and Taxanes

Lulu R. Tsao et al.

Summary: Hypersensitivity reactions to chemotherapy agents pose a serious challenge in treating patients with preferred or first-line therapies. Allergic reactions through an immunologic mechanism have been established for platinum and taxane agents, and drug desensitization has been proven to be an effective method for safe reintroduction of both chemotherapeutic agents.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

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Editorial Material Dermatology

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis-Coordinating Research Priorities to Move the Field Forward

Elizabeth J. Phillips et al.

JAMA DERMATOLOGY (2022)

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Review Medicine, General & Internal

Drugs and Vaccines Hypersensitivity in Children with Mastocytosis

Francesca Mori et al.

Summary: Mastocytosis is a heterogeneous disease that includes three different entities. Drug hypersensitivity reactions and anaphylaxis in children with mastocytosis are less studied, but elevated baseline tryptase levels and high disease burden may increase the risk. Some drugs may induce allergic reactions, but they are not contraindicated.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

Drug-Related Hypersensitivity Reactions Leading to Emergency Department: Original Data and Systematic Review

Silvia Pagani et al.

Summary: The aim of this study is to describe the pharmacological characteristics of drug-related allergies and anaphylaxis leading to emergency department visits. Male sex and age classes younger than 65 years were found to have a higher risk of drug-related allergies, while females and adults had a higher risk of anaphylaxis. Antibacterials, analgesics, and radiocontrast agents were identified as the most common triggers of hypersensitivity.

JOURNAL OF CLINICAL MEDICINE (2022)

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Editorial Material Allergy

Iodinated contrast media hypersensitivity reactions: is it time to re-evaluate risk factors?

M. B. Bilo et al.

EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Allergy

Drug hypersensitivity, in vitro tools, biomarkers, and burden with COVID-19 vaccines

Francisca Palomares et al.

Summary: Hypersensitivity reactions to drugs are diverse and impact disease severity and diagnostic procedures. Diagnosis relies on in vitro and in vivo assessments, with biomarkers providing valuable information. The COVID-19 pandemic has prompted updates in managing drug hypersensitivity.

ALLERGY (2022)

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Review Allergy

Global patterns of drug allergy-induced fatalities: a wake-up call to prevent avoidable deaths

Luciana K. Tanno et al.

Summary: The rate of drug-induced anaphylaxis (DAF) is increasing globally, with the main implicated drugs being antibiotics, anaesthetics, radio-contrast media, and NSAIDs. The main manifestations are cardiovascular and respiratory commitments, and those at risk for DAF are patients over 54 years old with a history of drug allergy, cardiovascular disease, and/or asthma. The use of adrenaline is mentioned in only 29% of the articles.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Pharmacology & Pharmacy

Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population

Chuang-Wei Wang et al.

Summary: This study aims to investigate the genetic predisposition of vancomycin-induced DRESS in the Han-Chinese population. Through genetic typing and experimental research on patients and control groups, the study identified that HLA-A*32:01, HLA-B*07:05, HLA-B*40:06, and HLA-B*67:01 are associated with vancomycin-induced DRESS.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pediatrics

Antibiotic allergy in children with cystic fibrosis: A retrospective case-control study

Ayse Suleyman et al.

Summary: The study aims to evaluate predictive factors for confirmed antibiotic hypersensitivity in children with CF. The results showed that beta-lactam antibiotic allergy is the most commonly confirmed drug allergy in CF children.

PEDIATRIC PULMONOLOGY (2022)

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Editorial Material Allergy

Precision Medicine in Allergy and Immunology Through the Lens of Immunogenomics

Elizabeth J. Phillips et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Review Allergy

Anaphylaxis in elderly people

Maria Teresa Ventura et al.

Summary: This review discusses the characteristics of anaphylaxis in old-age adults and emphasizes the importance of adrenaline in its management. Major findings include data from the European Anaphylaxis Registry on elderly patients and new epidemiologic data. It is crucial to prevent anaphylactic reactions in coronavirus disease 2019 vaccination. Anaphylaxis in old-age adults has a more severe outcome than in younger individuals. Adrenaline is a crucial component in the management of anaphylaxis.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Pharmacology & Pharmacy

Associations of HLA and drug-metabolizing enzyme genes in co-trimoxazole-induced severe cutaneous adverse reactions

Nontaya Nakkam et al.

Summary: This study found that the HLA-B*13:01 allele is significantly associated with Co-trimoxazole-induced SCARs, especially DRESS, while the HLA-C*08:01 allele is significantly associated with Co-trimoxazole-induced SJS/TEN in HIV/AIDS patients. The genes involved in the bioactivation and detoxification of Co-trimoxazole investigated in this study do not play a major role in the development of all phenotypes of SCARs.

DRUG METABOLISM AND PHARMACOKINETICS (2022)

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Article Allergy

Drug allergy: A 2022 practice parameter update

David A. Khan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Letter Dermatology

Risk Factors for Vancomycin Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome

Kimberly G. Blumenthal et al.

JAMA DERMATOLOGY (2022)

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Article Allergy

Allergy Electronic Health Record Documentation: A 2022 Work Group Report of the AAAAI Adverse Reactions to Drugs, Biologicals, and Latex Committee

Autumn C. Guyer et al.

Summary: The allergy section of the electronic health record plays a crucial role in clinical decision-making and treatment planning, but current allergy modules do not meet the requirements. We recommend collaboration between EHR vendors and allergists to optimize and modernize allergy documentation, providing meaningful, accurate, timely, and comprehensive allergy information.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Article Allergy

Non-steroidal anti-inflammatory drug-induced anaphylaxis infrequent in 388 patients with mastocytosis: A two-center retrospective cohort study

Patrizia Bonadonna et al.

Summary: A study found that patients with mastocytosis have an approximately 4-fold increased prevalence of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) compared to the general population. However, most reactions were limited to the skin and severe hypersensitivity reactions were infrequent. Patients with a known tolerance to NSAIDs can continue using these medications without special precautions, while those with a prior reaction should undergo a thorough allergy work-up.

FRONTIERS IN ALLERGY (2022)

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Article Allergy

Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort

Paola Nicoletti et al.

Summary: This study identified HLA-DRB1*10:01 as a genetic predisposing factor for immediate hypersensitivity reactions to beta-lactam antibiotics, particularly penicillins. Further research is needed to identify other predisposing HLA and non-HLA loci.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

Emerging Causes of Drug-Induced Anaphylaxis: A Review of Anaphylaxis-Associated Reports in the FDA Adverse Event Reporting System (FAERS)

Roger J. Yu et al.

Summary: Drug-induced anaphylaxis is a well-known adverse drug reaction, with antibiotics, monoclonal antibodies, nonsteroidal anti-inflammatory drugs, and acetaminophen being the top drug classes associated with anaphylaxis. Antibiotics were highly reported for anaphylaxis overall and anaphylaxis followed by death, while an increasing trend was noted for anaphylaxis to monoclonal antibody therapies.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Editorial Material Medicine, General & Internal

Race and Pharmacogenomics-Personalized Medicine or Misguided Practice?

Christopher W. Goodman et al.

Summary: The use of race and ethnicity as surrogates for biology in clinical decisions is flawed and inconsistent, leading to potential consequences for patient care.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Allergy

Utility of drug provocation tests in the evaluation of quinolone hypersensitivity reactions

Anca Mirela Chiriac et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Allergy

Role of nanostructures in allergy: Diagnostics, treatments and safety

Cristobalina Mayorga et al.

Summary: Nanotechnology, conducted at the nanoscale, has led to the development of nanomaterials with wide applications in biomedicine, while facing challenges such as toxicity and hypersensitivity responses that require evaluation and resolution. The application of nanoengineered materials in allergy diagnosis and specific immunotherapy shows promising prospects for improving sensitivity and efficacy.

ALLERGY (2021)

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Article Multidisciplinary Sciences

Analysis of the reporting of adverse drug reactions in children and adolescents in Germany in the time period from 2000 to 2019

Sarah Leitzen et al.

Summary: This study analyzed adverse drug reaction reports related to children and adolescents in Germany, finding that the majority of reports came from healthcare professionals and a significant proportion were classified as serious. The number of reports has been increasing since 2000, although there has been a decline in the pediatric population.

PLOS ONE (2021)

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Letter Allergy

Biological treatments in allergy: prescribing patterns and management of hypersensitivity reactions

Leyla Barakat et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Pharmacology & Pharmacy

Immunopharmacogenomics: Mechanisms of HLA-Associated Drug Reactions

Pooja Deshpande et al.

Summary: The HLA system is highly polymorphic and associated with a wide range of diseases. In the past twenty years, HLA class I alleles have been strongly linked to T-cell-mediated drug hypersensitivity reactions. While specific HLA associations for many drugs remain undefined, the presence of a risk HLA allele is necessary for drug-induced T-cell activation.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Article Oncology

Severe anaphylaxis caused by intravenous anti-cancer drugs

Nobuyuki Horita et al.

Summary: This study examined the incidence and risk factors of severe anaphylaxis induced by intravenous chemotherapy in cancer patients. A total of 27 cases of severe anaphylaxis were observed among 5584 patients, with drugs like carboplatin and paclitaxel being the main culprits. The study highlighted the high-risk settings associated with these severe allergic reactions.

CANCER MEDICINE (2021)

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Article Immunology

Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones

Jessy Elst et al.

Summary: Research has shown that certain neuromuscular blocking agents and fluoroquinolones can cause mast cell-mediated anaphylactic reactions by activating MRGPRX2, while sugammadex can attenuate drug-induced mast cell activation. Some patients treated with rocuronium develop anaphylaxis, with reactions similar to IgE-mediated allergies.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Allergy

Diagnostic Approach of Hypersensitivity Reactions to Cefazolin in a Large Prospective Cohort

Gador Bogas et al.

Summary: This study aimed to characterize patients reporting cefazolin allergic reactions and analyze the diagnostic role of in vivo and in vitro tests. Severe immediate-type reactions were often reported by patients allergic to cefazolin, with skin tests enabling a diagnosis in half of patients, but DPT could not be performed in all patients due to reaction severity. BAT may be a promising diagnostic tool for further research to clarify the underlying mechanisms, especially in severe reactions.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Allergy

Triggers of Exacerbation in Chronic Urticaria and Recurrent Angioedema-Prevalence and Relevance

Anete Sevciovic Grumach et al.

Summary: Patients with urticaria and angioedema should explore potential triggers to better understand and control their conditions. They are advised to avoid known triggers and prepare for appropriate pretreatment in case avoidance is not possible. Various factors such as drugs, food additives, mental stress, and trauma have been identified as potentially exacerbating chronic spontaneous urticaria and angioedema.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Allergy

Anaphylaxis and Pregnancy: A Systematic Review and Call for Public Health Actions

Sophie Carra et al.

Summary: Anaphylaxis during pregnancy is rare but poses risks to both mother and newborn. Identified causes include beta-lactam antibiotics, latex, and anesthetic agents. Most literature suggests similar management and treatment for pregnant and non-pregnant patients experiencing anaphylaxis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Editorial Material Allergy

Reporting of drug reaction with eosinophilia and systemic symptoms from 2002 to 2019 in the US Food and Drug Administration Adverse Event Reporting System

Sara Beth Bluestein et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Allergy

Adverse reactions during procedures Hypersensitivity to contrast agents and dyes

Christine Schoenmann et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2020)

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Letter Allergy

Drug-induced anaphylaxis, elicitors, risk factors, and management in Latin America

Edgardo Jose Jares et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Allergy

The diagnosis of hypersensitivity to antibiotics is rarely confirmed by allergy work-up in cystic fibrosis patients

Camille Braun et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2020)

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Article Allergy

Rapid desensitization to antineoplastic drugs in an outpatient immunoallergology clinic Outcomes and risk factors

Joana Caiado et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2020)

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Review Allergy

NSAID-ERD Syndrome: the New Hope from Prevention, Early Diagnosis, and New Therapeutic Targets

Tanya M. Laidlaw et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2020)

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Review Allergy

Drug-Induced Anaphylaxis: An Update on Epidemiology and Risk Factors

Frederico S. Regateiro et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2020)

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Article Allergy

Clinical Characterization and Diagnostic Approaches for Patients Reporting Hypersensitivity Reactions to Quinolones

Inmaculada Dona et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Editorial Material Allergy

Diagnosis and treatment of drug hypersensitivity reactions to biologicals: Medical algorithm

Barbara Carolyn Yang et al.

ALLERGY (2020)

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Article Allergy

Practical Guidelines for the Evaluation and Management of Drug Hypersensitivity: General Concepts

Ana Dioun Broyles et al.

Journal of Allergy and Clinical Immunology-In Practice (2020)

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Article Genetics & Heredity

Genome-wide Study Identifies Association between HLA-B*55:01 and Self-Reported Penicillin Allergy

Kristi Krebs et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2020)

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Article Pharmacology & Pharmacy

Hypersensitivity Reactions to Multiple Iodinated Contrast Media

Inmaculada Dona et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Platelet-Adherent Leukocytes Associated With Cutaneous Cross-Reactive Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs

Raquel Jurado-Escobar et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Allergy

Chronic Urticaria with NSAID-Exacerbated Cutaneous Disease: A (NSAID) Challenge Worth Taking

Kevin A. Cook et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Allergy

Drug-Induced Anaphylaxis Documented in Electronic Health Records

Neil Dhopeshwarkar et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

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Review Anesthesiology

Comparative epidemiology of suspected perioperative hypersensitivity reactions

Paul Michel Mertes et al.

BRITISH JOURNAL OF ANAESTHESIA (2019)

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Article Allergy

HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

Katherine C. Konvinse et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Allergy

Nanoallergen platform for detection of platin drug allergies

Peter E. Deak et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Oncology

Evaluation of Readministration of Immune Checkpoint Inhibitors After Immune-Related Adverse Events in Patients With Cancer

Audrey Simonaggio et al.

JAMA ONCOLOGY (2019)

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Letter Allergy

Sensitization to amoxicillin/clavulanic acid may underlie severe rashes in children treated for infectious mononucleosis

Francesca Mori et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

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Article Allergy

Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology

Melody C. Carter et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Allergy

Controversies in drug allergy: Testing for delayed reactions

Elizabeth J. Phillips et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Review Medicine, General & Internal

Antibiotic allergy

Kimberly G. Blumenthal et al.

LANCET (2019)

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Article Allergy

Drug Hypersensitivity Reactions Documented in Electronic Health Records within a Large Health System

Adrian Wong et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

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Article Allergy

Interleulen-10 is increased in successful drug desensitization regardless of the hypersensitivity reaction type

Asli Gelincik et al.

ASIA PACIFIC ALLERGY (2019)

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Article Cardiac & Cardiovascular Systems

Severe adverse events following benzathine penicillin G injection for rheumatic heart disease prophylaxis: cardiac compromise more likely than anaphylaxis

Shannon Marantelli et al.

HEART ASIA (2019)

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Article Pharmacology & Pharmacy

Drug-induced anaphylaxis in China: a 10year retrospective analysis of the Beijing Pharmacovigilance Database

Ying Zhao et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY (2018)

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Article Anesthesiology

Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6)

N. J. N. Harper et al.

BRITISH JOURNAL OF ANAESTHESIA (2018)

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Article Allergy

Hypersensitivity reactions to therapeutic monoclonal antibodies: Phenotypes and endotypes

Ghislaine Annie C. Isabwe et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Review Allergy

Are Cephalosporins Safe for Use in Penicillin Allergy without Prior Allergy Evaluation?

Eric Macy et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2018)

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Review Allergy

What can we learn in drug allergy management from World Health Organization's international classifications?

L. K. Tanno et al.

ALLERGY (2018)

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Article Allergy

Drug-induced anaphylaxis: seven-year single-center survey

I. Mota et al.

EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Public, Environmental & Occupational Health

Overview of Pharmacovigilance System in Vietnam: Lessons Learned in a Resource-Restricted Country

Khac-Dung Nguyen et al.

DRUG SAFETY (2018)

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Article Allergy

Mastocytosis and Anaphylaxis

Anna Schuch et al.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2017)

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Review Allergy

Diagnosis and management of anaphylaxis in precision medicine

Mariana Castells

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Review Immunology

Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis

Maria Isabel Montanez et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Allergy

Severe Delayed Cutaneous and Systemic Reactions to Drugs: A Global Perspective on the Science and Art of Current Practice

Jonathan Grant Peter et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

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Article Allergy

Adverse and Hypersensitivity Reactions to Prescription Nonsteroidal Anti-Inflammatory Agents in a Large Health Care System

Kimberly G. Blumenthal et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

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Review Allergy

Frequency of self-reported drug allergy A systematic review and meta-analysis with meta-regression

Bernardo Sousa-Pinto et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2017)

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Review Allergy

Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group

E. R. Gomes et al.

ALLERGY (2016)

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Article Allergy

Drug allergies documented in electronic health records of a large healthcare system

L. Zhou et al.

ALLERGY (2016)

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Article Allergy

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA2LEN) survey

J. S. Makowska et al.

ALLERGY (2016)

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Review Allergy

The role of IgE recognition in allergic reactions to amoxicillin and clavulanic acid

M. J. Torres et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2016)

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Review Pharmacology & Pharmacy

Safety of metamizole: a systematic review of the literature

S. Andrade et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2016)

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Review Allergy

Clinical Practice Guidelines for Diagnosis and Management of Hypersensitivity Reactions to Contrast Media

A. Rosado Ingelmo et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2016)

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Review Allergy

Mechanisms of Anaphylaxis Beyond IgE

R. Munoz-Cano et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2016)

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Article Genetics & Heredity

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

Jonathan J. Lyons et al.

NATURE GENETICS (2016)

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Article Allergy

Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies

David Sloane et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2016)

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Article Allergy

IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity and tolerability of alternative cephalosporins

Antonino Romano et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Article Allergy

Adverse reactions associated with oral and parenteral use of cephalosporins: A retrospective population-based analysis

Eric Macy et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Article Infectious Diseases

Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis

Martin H. Thornhill et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2015)

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Review Dermatology

Acute generalized exanthematous pustulosis (AGEP): A review and update

Jesse Szatkowski et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Public, Environmental & Occupational Health

Reporting rates for severe hypersensitivity reactions associated with prescription-only drugs in outpatient treatment in Germany

Bernhardt Sachs et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2015)

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Review Medicine, General & Internal

Evaluation and management of hypersensitivity reactions to chemotherapy agents

Elizabeth Huiwen Tham et al.

POSTGRADUATE MEDICAL JOURNAL (2015)

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Review Allergy

Hypersensitivity to Biological Agents-Updated Diagnosis, Management, and Treatment

Violeta Regnier Galvao et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2015)

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Article Allergy

Drug-Induced Anaphylaxis in Latin American Countries

Edgardo Jose Jares et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2015)

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Article Multidisciplinary Sciences

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

Benjamin D. McNeil et al.

NATURE (2015)

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Article Allergy

International Consensus on drug allergy

P. Demoly et al.

ALLERGY (2014)

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Article Pharmacology & Pharmacy

Adverse Drug Reactions Causing Hospital Admissions in Childhood: A Prospective, Observational, Single-Centre Study

Petra Langerova et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)

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Review Allergy

Penicillin and Beta-Lactam Allergy: Epidemiology and Diagnosis

Eric Macy

CURRENT ALLERGY AND ASTHMA REPORTS (2014)

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Article Allergy

Fatal anaphylaxis in the United States, 1999-2010: Temporal patterns and demographic associations

Elina Jerschow et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Allergy

Beta-lactam hypersensitivity in children with cystic fibrosis: a study in a specialized pediatric center for cystic fibrosis and drug allergy

Rania Matar et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2014)

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Article Allergy

Nonsteroidal Anti-Inflammatory Drugs are Major Causes of Drug-Induced Anaphylaxis

Marcelo Vivolo Aun et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2014)

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Letter Allergy

Iodinated contrast media-induced acute generalized exanthematous pustulosis confirmed by delayed skin tests

Aurelie Grandvuillemin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2014)

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Article Allergy

Categorization of allergic disorders in the new World Health Organization International Classification of Diseases

Luciana Kase Tanno et al.

CLINICAL AND TRANSLATIONAL ALLERGY (2014)

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Article Allergy

Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010

J. -M. Renaudin et al.

ALLERGY (2013)

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Article Medicine, General & Internal

Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions

Signe Thiesen et al.

BMC MEDICINE (2013)

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Article Anesthesiology

Anaphylaxis to neuromuscular blocking drugs: incidence and cross-reactivity in Western Australia from 2002 to 2011

P. H. M. Sadleir et al.

BRITISH JOURNAL OF ANAESTHESIA (2013)

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Article Pharmacology & Pharmacy

Drug-induced anaphylaxis: a decade review of reporting to the Portuguese Pharmacovigilance Authority

Ines Ribeiro-Vaz et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2013)

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Article Critical Care Medicine

Recurrent Toxic Epidermal Necrolysis Secondary to Iopromide Contrast

Matthew Brown et al.

JOURNAL OF BURN CARE & RESEARCH (2013)

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Article Public, Environmental & Occupational Health

US-based emergency department visits for fluoroquinolone-associated hypersensitivity reactions

S. Christopher Jones et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2013)

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Article Allergy

Undernotification of anaphylaxis deaths in Brazil due to difficult coding under the ICD-10

L. K. Tanno et al.

ALLERGY (2012)

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Article Pharmacology & Pharmacy

Epidemiology and risk factors for drug allergy

Bernard Y-H. Thong et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2011)

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Article Allergy

Characteristics of subjects experiencing hypersensitivity to non-steroidal anti-inflammatory drugs: patterns of response

I. Dona et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2011)

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Letter Allergy

Selective allergic reactions to clavulanic acid: A report of 9 cases

Leticia Sanchez-Morillas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Letter Allergy

Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions

Maria Jose Torres et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Medicine, General & Internal

Self-reported Antibiotic Allergy Incidence and Prevalence: Age and Sex Effects

Eric Macy et al.

AMERICAN JOURNAL OF MEDICINE (2009)

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Article Allergy

Immunogloblin E-mediated immediate allergic reactions to dipyrone: value of basophil activation test in the identification of patients

E. Gomez et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2009)

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Article Allergy

Anaphylaxis fatalities and admissions in Australia

Woei Kang Liew et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Article Immunology

High sensitivity of human leukocyte antigen-B*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients

Michael Saag et al.

CLINICAL INFECTIOUS DISEASES (2008)

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Article Allergy

Hypersensitivity reactions to chemotherapy: Outcomes and safety of rapid desensitization in 413 cases

Mariana C. Castells et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

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Article Medicine, General & Internal

HLA-B*5701 screening for hypersensitivity to abacavir

Simon Mallal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Pharmacology & Pharmacy

Allergic reactions to oral drugs: A case/non-case study from an Italian spontaneous reporting database (GIF)

Francesco Salvo et al.

PHARMACOLOGICAL RESEARCH (2008)

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Letter Infectious Diseases

Results of a UK survey of fatal anaphylaxis after oral amoxicillin

Paul Lee et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)

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Review Allergy

Drug hypersensitivity in HIV

Elizabeth Phillips et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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Review Allergy

Desensitization for drug aflergy

Mariana Castells

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2006)

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Article Anesthesiology

Anaesthetist's responses to patients' self-reported drug allergies

R. D. MacPherson et al.

BRITISH JOURNAL OF ANAESTHESIA (2006)

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Review Pharmacology & Pharmacy

Hypersensitivity reactions associated with oxaliplatin

M. Wasif Saif

EXPERT OPINION ON DRUG SAFETY (2006)

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Article Pediatrics

Early presentation with angioedema and urticaria in cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs among young, asian, atopic children

MI Kidon et al.

PEDIATRICS (2005)

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Article Public, Environmental & Occupational Health

Drug-induced anaphylaxis - Case/non-case study based on an Italian pharmacovigilance database

R Leone et al.

DRUG SAFETY (2005)

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Article Allergy

Represcription of penicillin after allergic-like events

AJ Apter et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

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Article Allergy

Self-reported drug allergy in a general adult Portuguese population

E Gomes et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2004)

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Article Pharmacology & Pharmacy

Adverse reactions to trimethoprim/sulfamethoxazole in AIDS

MA Floris-Moore et al.

ANNALS OF PHARMACOTHERAPY (2003)

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Article Medicine, General & Internal

Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics

BL Strom et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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Review Medicine, General & Internal

Delayed drug hypersensitivity reactions

WJ Pichler

ANNALS OF INTERNAL MEDICINE (2003)

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Article Public, Environmental & Occupational Health

Risk of anaphylaxis in a hospital population in relation to the use of various drugs: an international study

JR Laporte et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2003)

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Article Allergy

Inpatient consultation of allergy/immunology in a tertiary care setting

RW England et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2003)

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Article Allergy

Atopy is a risk factor for non-steroidal anti-inflammatory drug sensitivity

N Sanchez-Borges et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2000)

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Article Allergy

Evidence for familial aggregation of immunologic drug reactions

KM Kurtz et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2000)

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Article Oncology

Oxaliplatin-induced fever and release of IL-6

H Ulrich-Pur et al.

ONCOLOGY (2000)

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