4.7 Article

Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Microbiology

A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell

Mikha Gabriela et al.

Summary: The malaria parasite Plasmodium falciparum exports a large number of proteins into host erythrocytes, modifying the physiology of the host cells. This study has identified a subcomplex consisting of EXP2 and PTEX150 that facilitates the docking of HSP101. It has also demonstrated that HSP101 can interact with specific cargo proteins in the parasite's ER and guide them to the parasitophorous vacuole membrane. These findings provide insights into the mechanism of how exported proteins are targeted to PTEX.

PLOS PATHOGENS (2022)

Article Biology

Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

Marc A. Schureck et al.

Summary: Malaria parasites use the RhopH complex for erythrocyte invasion and nutrient uptake, with the complex integrating into the erythrocyte membrane through a PTEX translocon-dependent process after transferring to a new host cell. The complex is tightly assembled with extensive disulfide bonding and predicted transmembrane helices, poised for large-scale rearrangements for host membrane insertion.
Review Microbiology

Transport mechanisms at the malaria parasite-host cell interface

Josh R. Beck et al.

Summary: Intracellular malaria parasites reside in a vacuole generated during invasion, utilizing various transport activities at the membrane interface to subvert host cells and support their metabolism. Efforts have been made to understand effector protein translocation and small molecule transport by PTEX and EXP2, with comparisons to related apicomplexans highlighting both similarities and differences in transport mechanisms.

PLOS PATHOGENS (2021)

Article Chemistry, Medicinal

Assessment of Biological Role and Insight into Druggability of the Plasmodium falciparum Protease Plasmepsin V

Alexander J. Polino et al.

ACS INFECTIOUS DISEASES (2020)

Review Biochemistry & Molecular Biology

Malaria parasite plasmepsins: More than just plain old degradative pepsins

Armiyaw S. Nasamu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Biochemical Research Methods

Proteomic Analysis of Plasmodium Merosomes: The Link between Liver and Blood Stages in Malaria

Melanie J. Shears et al.

JOURNAL OF PROTEOME RESEARCH (2019)

Article Biochemistry & Molecular Biology

The malaria PTEX component PTEX88 interacts most closely with HSP101 at the host-parasite interface

Scott A. Chisholm et al.

FEBS JOURNAL (2018)

Article Multidisciplinary Sciences

Malaria parasite translocon structure and mechanism of effector export

Chi-Min Ho et al.

NATURE (2018)

Article Multidisciplinary Sciences

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

David A. Baker et al.

NATURE COMMUNICATIONS (2017)

Review Microbiology

Plasmodium species: master renovators of their host cells

Tania F. de Koning-Ward et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Review Biochemistry & Molecular Biology

Protein Export into Malaria Parasite-Infected Erythrocytes: Mechanisms and Functional Consequences

Natalie J. Spillman et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84 (2015)

Article Biochemistry & Molecular Biology

The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins

Jana Schulze et al.

MOLECULAR MICROBIOLOGY (2015)

Article Multidisciplinary Sciences

PTEX is an essential nexus for protein export in malaria parasites

Brendan Elsworth et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Identification of a Plasmodium falciparum Phospholipid Transfer Protein

Christiaan van Ooij et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemical Research Methods

N-terminal Protein Processing: A Comparative Proteogenomic Analysis

Stefano Bonissone et al.

MOLECULAR & CELLULAR PROTEOMICS (2013)

Article Biochemistry & Molecular Biology

Two putative protein export regulators promote Plasmodium blood stage development in vivo

Joachim M. Matz et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2013)

Article Microbiology

Uncovering Common Principles in Protein Export of Malaria Parasites

Christof Gruering et al.

CELL HOST & MICROBE (2012)

Article Biochemical Research Methods

Protein Export Marks the Early Phase of Gametocytogenesis of the Human Malaria Parasite Plasmodium falciparum

Francesco Silvestrini et al.

MOLECULAR & CELLULAR PROTEOMICS (2010)

Article Multidisciplinary Sciences

An aspartyl protease directs malaria effector proteins to the host cell

Justin A. Boddey et al.

NATURE (2010)

Article Multidisciplinary Sciences

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

Ilaria Russo et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Sequence requirements for the export of the Plasmodium falciparum Maurer's clefts protein REX2

Silvia Haase et al.

MOLECULAR MICROBIOLOGY (2009)

Article Multidisciplinary Sciences

A newly discovered protein export machine in malaria parasites

Tania F. de Koning-Ward et al.

NATURE (2009)

Review Microbiology

Malaria parasite proteins that remodel the host erythrocyte

Alexander G. Maier et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Article Biochemistry & Molecular Biology

N-terminal processing of proteins exported by malaria parasites

Henry H. Chang et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2008)

Article Microbiology

The malaria secretome: From algorithms to essential function in blood stage infection

Christiaan van Ooij et al.

PLOS PATHOGENS (2008)

Article Biotechnology & Applied Microbiology

Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites

TJ Sargeant et al.

GENOME BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Function of the plasmodium export element can be blocked by green fluorescent protein

E Knuepfer et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2005)

Article Multidisciplinary Sciences

Targeting malaria virulence and remodeling proteins to the host erythrocyte

M Marti et al.

SCIENCE (2004)