☆ 4.7 Review

Improvement of inflammatory bowel disease by lactic acid bacteria-derived metabolites: a review

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Review Food Science & Technology

Impact of lactic acid bacteria and their metabolites on the techno-functional properties and health benefits of fermented dairy products

Heena Sharma et al.

Summary: The fermentation process of lactose to lactic acid in fermented dairy products leads to biochemical changes such as improved protein digestibility, release of fatty acids, and production of bioactive compounds. Various lactic acid bacteria are used to develop fermented dairy products with specific desirable attributes. These bacteria produce bioactive compounds and metabolites using homo-fermentative and heterofermentative pathways. The metabolites generated during fermentation vary with incubation and processing conditions and are analyzed and quantified using advanced instrumentation. The health benefits of fermented dairy products are mainly attributed to the biological roles of these metabolites, which also contribute to technological improvements desired by dairy manufacturers and consumers.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Review Food Science & Technology

Beyond probiotics: a narrative review on an era of revolution

Neha Sharma et al.

Summary: Whether intentionally or not, humans have been consuming probiotic microorganisms through fermented foods for many generations. Probiotics, such as lactic acid bacteria, are generally considered harmless and beneficial for human health. However, their therapeutic use is limited due to being living organisms. As a result, the focus has shifted to non-viable microbes made from probiotics, such as paraprobiotics, postbiotics, psychobiotics, nutribiotics, and gerobiotics, which can still provide health benefits and reveal therapeutic effects. This review summarizes the new terminology, traits, and applications of these microbes.

FOOD SCIENCE AND BIOTECHNOLOGY (2023)

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Article Agriculture, Multidisciplinary

Bifidobacterium longum CCFM1206 Promotes the Biotransformation of Glucoraphanin to Sulforaphane That Contributes to Amelioration of Dextran-Sulfate-Sodium-Induced Colitis in Mice

Jiaying Wu et al.

Summary: This study screened probiotics with the ability to metabolize glucoraphanin and investigated the effects of a combination of B. longum CCFM1206 and BSE on colitis induced by DSS in mice. The results showed that the combination treatment could alleviate colitis symptoms, reduce inflammatory reactions and oxidative stress, and protect the intestinal barrier. Furthermore, the combination increased the production of sulforaphane compounds in the colon and activated genes related to the Nrf2 signaling pathway. These findings suggest that probiotics can enhance the bioactivity of dietary phytochemicals in vivo and have potential therapeutic implications for colitis treatment.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Review Allergy

Dietary fiber and SCFAs in the regulation of mucosal immunity

Jian Kai Tan et al.

Summary: Gut bacterial metabolites, specifically short-chain fatty acids (SCFAs), have significant effects on immune cells and gut health. Insufficient fiber intake hampers the production of SCFAs, leading to compromised immune functions and Western lifestyle diseases. There is a need to reconcile the role of fiber intake and the hygiene hypothesis in the development of these diseases. Mechanisms by which SCFAs influence immunity and gut homeostasis include activation of specific receptors, inhibition of histone deacetylases, and metabolic changes. Modulating SCFA levels through dietary interventions holds potential for prevention and treatment of diseases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

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Article Food Science & Technology

Bifidobacterium lactis IDCC 4301 Exerts Anti-Obesity Effects in High-Fat Diet-Fed Mice Model by Regulating Lipid Metabolism

O-Hyun Ban et al.

Summary: Chronic hypernutrition leads to lipid accumulation and obesity. Recent studies have shown that probiotics can prevent adipose dysfunction by regulating lipid metabolism. However, the mechanisms of action of probiotics in obesity are not fully understood and their usage for treating obesity remains limited.

MOLECULAR NUTRITION & FOOD RESEARCH (2023)

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Review Biochemistry & Molecular Biology

Bile acids and their receptors in regulation of gut health and diseases

Sen Lin et al.

Summary: It is well known that bile acids are crucial for lipid metabolism and can act as signaling molecules through interacting with receptors. Bile acids undergo microbial transformation by gut microbes and have profound effects on liver, intestinal tissues, and the gut microbiota. Farnesoid X receptor and G protein-coupled bile acid receptor 1, highly expressed in the intestine, have emerged as pivotal regulators in bile acid metabolism, innate immunity, and inflammatory responses. Manipulating bile acid metabolism and the expression of bile acid receptors may offer a promising strategy to regulate intestinal health and disease. This review aims to summarize the roles of bile acids and their receptors in the regulation of gut health and diseases.

PROGRESS IN LIPID RESEARCH (2023)

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Editorial Material Pharmacology & Pharmacy

Combining Probiotics and Tryptophan to Increase Efficacy of Melanoma Treatments

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2023)

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Article Cell Biology

Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity

Qingqing Zhang et al.

Summary: Previous studies have shown that probiotics can ameliorate colorectal cancer in a mouse model, but the underlying mechanisms are still unclear. In this study, the researchers found that a specific probiotic strain and its metabolite could improve intestinal inflammation, tumor growth, and gut dysbiosis. Further investigation revealed that the metabolite enhanced the production of IL12a in dendritic cells, priming CD8+ T cell immunity against tumor growth, and also regulated cholesterol metabolism in CD8+ T cells. These findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest potential therapeutic strategies for colorectal cancer patients.

CELL METABOLISM (2023)

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Article Chemistry, Applied

Dynamics changes in physicochemical properties, volatile metabolites, non-volatile metabolites, and physiological functions of barley juice during Bifidobacterium infantis fermentation

Bingyong Mao et al.

Summary: The aim of this study was to investigate the potential of Bifidobacterium infantis fermentation to alter the composition and physiological properties of barley juices. B. infantis JFM12 demonstrated a strong ability to decrease the total sugar content within 24 hours of fermentation. The volatile metabolite profiles were enriched as a result of B. infantis JFM12 fermentation, leading to changes in various compounds. Additionally, the antioxidant and lipase inhibitory activities of fermented barley juice were higher compared to unfermented barley juice.

FOOD CHEMISTRY (2023)

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Article Chemistry, Applied

Dietary Lactobacillus reuteri prevent from inflammation mediated apoptosis of liver via improving intestinal microbiota and bile acid metabolism

Zishen Lin et al.

Summary: L. reuteri can improve liver health by changing the composition of bile acids and reducing cholestasis-associated microbiota. It can also prevent liver inflammation and hepatocyte apoptosis. Furthermore, ursodeoxycholic acid plays a crucial role in protecting the liver during inflammatory stimulation.

FOOD CHEMISTRY (2023)

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Article Immunology

Levetiracetam attenuates experimental ulcerative colitis through promoting Nrf2/HO-1 antioxidant and inhibiting NF-κB, proinflammatory cytokines and iNOS/NO pathways

Keyvan Amirshahrokhi et al.

Summary: This study aimed to investigate the potential protective effect of the antiepileptic drug levetiracetam against ulcerative colitis (UC) in mice. The results showed that levetiracetam can alleviate colonic mucosal injury in UC mice, promote antioxidant responses, reduce lipid peroxidation and myeloperoxidase activity, decrease inflammatory mediator expression, and increase anti-inflammatory cytokine levels.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Review Biochemistry & Molecular Biology

Intestinal Microbiota and miRNA in IBD: A Narrative Review about Discoveries and Perspectives for the Future

Ellen Cristina Souza de Oliveira et al.

Summary: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by an overactive immune response to environmental factors, including gut microbiota and dietary components. MicroRNAs (miRNAs) have been associated with various physiological processes and play a role in the regulation of inflammatory pathways. Differences in miRNA profiles can be used as a diagnostic and prognostic marker in IBD. The interaction between miRNAs and intestinal microbiota is still not fully understood, but recent studies have shown their role in modulating intestinal homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biotechnology & Applied Microbiology

Intestinal Microbiomics and Metabolomics Insights into the Hepatoprotective Effects of Lactobacillus paracasei CCFM1222 Against the Acute Liver Injury in Mice

Weiling Guo et al.

Summary: This study suggests that Lactobacillus paracasei CCFM1222 supplementation may have beneficial effects in preventing acute liver injury (ALI). It can inhibit inflammatory responses, alter intestinal microbiota composition and metabolites to prevent the occurrence and development of ALI.

PROBIOTICS AND ANTIMICROBIAL PROTEINS (2023)

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Article Food Science & Technology

Two doses of Lactobacillus induced different microbiota profiles and serum immune indices in pigs

Dongyan Zhang et al.

Summary: We studied the impact of Lactobacillus reuteri ZLR003 supplementation on the microbiota and serum immune indices of growing pigs. The Lactobacillus doses had significant effects on the pigs' growth performance. L. reuteri ZLR003 was found in the gastrointestinal tract and showed increased species richness and Bacteroidetes abundance. Several bacterial abundances were significantly altered in the Lactobacillus-treated groups compared to controls. The Lactobacillus-treated pigs also exhibited changes in acid concentrations and serum immune markers. Our findings have implications for the use of Lactobacillus strains in pig production.

JOURNAL OF FUNCTIONAL FOODS (2023)

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Article Multidisciplinary Sciences

Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

Bo Tang et al.

Summary: Intrahepatic cholestasis of pregnancy (ICP) is a liver disease that sometimes develops during pregnancy and is characterized by increased serum bile acid levels. Here the authors report that the gut microbiome species B. fragilis is enriched in patients with ICP and promotes ICP development in mice via inhibition of signalling though the bile acid receptor FXR.

NATURE COMMUNICATIONS (2023)

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Article Medicine, General & Internal

Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019

Rui Wang et al.

Summary: The global burden of inflammatory bowel disease (IBD) is increasing, with higher numbers of cases, deaths, and DALYs among females than males. Understanding the changing epidemiological trends and disease burden of IBD is important for policy makers to develop effective management strategies.

BMJ OPEN (2023)

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Article Microbiology

Administration of Bifidobacterium animalis subsp. lactis strain BB-12® in healthy children: characterization, functional composition, and metabolism of the gut microbiome

Carlotta Vizioli et al.

Summary: This study aimed to investigate the effects of probiotic consumption on the gut microbiome and metabolome of children. The results showed no significant changes in the global metagenomic or metabolomic profiles between the two intervention groups. However, there was a measurable impact on the relative abundance of the probiotics of interest in the gut microbiome. Future research should explore longer probiotic interventions and focus on children at risk for gastrointestinal disorders to further understand the potential protective effects of functional metabolite changes.

FRONTIERS IN MICROBIOLOGY (2023)

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Review Gastroenterology & Hepatology

Inflammation and malnutrition in inflammatory bowel disease

Sara Massironi et al.

Summary: Inflammatory bowel disease (IBD) has been on the rise worldwide, with impaired nutritional status in patients presenting in various forms such as malnutrition, sarcopenia, and micronutrient deficiency, as well as overweight, obesity, and sarcopenic obesity. Malnutrition can disrupt the gut microbiome, leading to an imbalanced state that triggers inflammation. Despite the clear link between IBD and malnutrition, little is known about the underlying mechanisms that promote inflammation and malnutrition. This Review explores the potential mechanisms behind the vicious cycle of malnutrition and inflammation, and their implications for clinical treatment.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2023)

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Review Food Science & Technology

Paraprobiotics and Postbiotics-Current State of Scientific Research and Future Trends toward the Development of Functional Foods

Shenia Santos Monteiro et al.

Summary: The scientific community is gathering information on the bioactivity and production methods of paraprobiotics and postbiotics, recognizing their potential as beneficial agents for human health. Understanding the evolution of scientific research in this area is crucial for future progress. This review utilized bibliometric analysis to improve scientific documentation and provide the scientific community with quantitative analysis of the current literature, focusing on paraprobiotic and postbiotic development. The results indicate that the main studies explore the bioactivity of these compounds, but further research is needed on production methods and their interaction with food, especially in the development of functional foods.

FOODS (2023)

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Review Microbiology

The potential of paraprobiotics and postbiotics to modulate the immune system: A Review

Jeet P. Mehta et al.

Summary: Probiotics are beneficial microorganisms that have positive effects on health when consumed in adequate amounts. They modulate the immune system through their colonization in the gut, interaction with intestinal cells, and production of various metabolites and by-products. Non-viable probiotics and microbial by-products have been proven to provide positive immune responses even in their inactivated form. This review focuses on the immune-modulating ability of different types of non-viable probiotics and their by-products.

MICROBIOLOGICAL RESEARCH (2023)

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Article Cell Biology

Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression

Ting Fu et al.

Summary: Colorectal cancer is driven by genomic alterations and dietary influences, and the gut microbiome and metabolome play important roles in disease progression. A multi-omics study on mice reveals that diet is the major driver of microbiome and metabolome differences, with high-fat diet causing decreased diversity and changes in cecal metabolites.

CELL REPORTS (2023)

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Article Food Science & Technology

Role of intestinal probiotics in the modulation of lipid metabolism: implications for therapeutic treatments

Xiaoran Song et al.

Summary: Accumulating evidence suggests that probiotics in the gastrointestinal tract play an important role in regulating host metabolism, particularly in the treatment of lipid metabolism diseases. However, the relationship between probiotics and abnormal lipid metabolism remains unclear, and the mechanisms of action are the focus of microbiome research. This article explores the connection between intestinal probiotics and lipid metabolism, discusses the underlying mechanisms, and provides therapeutic strategies for abnormal lipid metabolism. It serves as a reference for the utilization of probiotics in functional foods and benefits the clinical diagnosis and treatment of lipid metabolism diseases.

FOOD SCIENCE AND HUMAN WELLNESS (2023)

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Article Biochemistry & Molecular Biology

Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

Mackenzie J. Bender et al.

Summary: The use of probiotics, specifically Lactobacillus reuteri, has been shown to enhance antitumor immunity and facilitate immune checkpoint inhibitor (ICI) treatment in preclinical melanoma. This is achieved through the release of the tryptophan catabolite indole-3-aldehyde (I3A), which promotes interferon-gamma-producing CD8 T cells within the tumor microenvironment. The signaling of the aryl hydrocarbon receptor (AhR) within CD8 T cells is necessary for the antitumor effects of Lactobacillus reuteri and I3A.

CELL (2023)

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Review Gastroenterology & Hepatology

Peptides, Exopolysaccharides, and Short-Chain Fatty Acids from Fermented Milk and Perspectives on Inflammatory Bowel Diseases

Rodrigo Sigala-Robles et al.

Summary: Crohn's disease and ulcerative colitis are characterized by chronic inflammation along the gastrointestinal tract. Fermented milk with specific lactic acid bacteria can alleviate the symptoms through the bioactive compounds it produces.

DIGESTIVE DISEASES AND SCIENCES (2022)

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Article Engineering, Chemical

Production, purification, and structural characteristics of extracellular polysaccharides derived from Lactobacillus acidophilus

Jia-Jun Huang et al.

Summary: This study successfully produced EPSs from Lactobacillus acidophilus BCRC 10695 through optimization of the culture medium composition, purification process, and structural analysis. The experimental results showed that sucrose, yeast extract, and polysorbate 80 were the optimal carbon source, nitrogen source, and surfactant, respectively. The EPSs production reached 923.7 mg/l after 96 hours of cultivation, with high purity.

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS (2022)

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Article Food Science & Technology

Characterization of antimicrobial peptides produced by Lactobacillus acidophilus LA-5 and Bifidobacterium lactis BB-12 and their inhibitory effect against foodborne pathogens

Saber Amiri et al.

Summary: This study optimized the production of antimicrobial peptides (AMPs) by pure and mixed cultures of Lactobacillus acidophilus LA-5 and Bifidobacterium lactis BB-12, and characterized the properties of the produced AMPs. The AMPs showed antimicrobial effects against important food-borne pathogens and had high-temperature stability under optimal conditions.

LWT-FOOD SCIENCE AND TECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis

Pei Li et al.

Summary: In this study, live L. acidophilus (La) showed the best therapeutic effect on ulcerative colitis (UC) rats. It achieved this by regulating SCFAs to balance inflammation and improve intestinal barrier function. These findings provide new theoretical basis for the application of L. acidophilus and its interaction with host immunity.

FOOD & FUNCTION (2022)

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Article Food Science & Technology

Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs

Yuanyuan Zhao et al.

Summary: This study found a dose-dependent relationship between pectin intake and changes in body weight, fat accumulation, serum triglyceride levels, and acetate and propionate concentrations. Additionally, pectin was found to modulate the gut microbiota and enhance short-chain fatty acid production, leading to attenuations in colonic injury and liver steatosis.

FOOD SCIENCE AND HUMAN WELLNESS (2022)

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Review Microbiology

Carbohydrate-active enzymes (CAZymes) in the gut microbiome

Jacob F. Wardman et al.

Summary: This review discusses the diversity and functions of carbohydrate-active enzymes (CAZymes) in the human gut microbiota and their roles in human health and disease. It also highlights potential applications of these enzymes, such as improving microbiota health and treating diseases.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Microbiology

Metabolomic Analysis of Lactobacillus acidophilus, L. gasseri, L. crispatus, and Lacticaseibacillus rhamnosus Strains in the Presence of Pomegranate Extract

MaryClaire Chamberlain et al.

Summary: Lactobacillus species are important residents of the human gastrointestinal tract that can be influenced by probiotic supplements and dietary changes, ultimately affecting host health. The growth of four Lactobacillus strains in the presence of pomegranate extract was studied, revealing the production of unique metabolites. Untargeted metabolomics was utilized to further characterize the metabolic profiles of these strains. Understanding these differences is crucial for understanding probiotic function and selecting strains for commercial products.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Chemistry, Applied

Interaction of Companilactobacillus crustorum MN047-derived bacteriocins with gut microbiota

Tao Wang et al.

Summary: The study found that CCDB can alleviate colitis by strengthening the gut barrier, reducing oxidative stress and inflammation, and regulating the composition of gut microbiota.

FOOD CHEMISTRY (2022)

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Article Food Science & Technology

Simple and reliable determination of B group vitamins in various food matrices with the use of the voltammetric sensor based on Ni-zeolite/carbon black nanocomposite

Rados law Porada et al.

Summary: A low-cost and highly selective voltammetric method for the determination of vitamins B-2, B-9, B-12, and B3 using a Ni-zeolite/carbon black modified glassy carbon electrode was presented. The proposed sensor showed an enhancement effect on reduction signals of the studied vitamins. The developed protocol was successfully applied for the direct determination of the above-mentioned vitamins in dietary supplements, multivitamin juices and energy drinks, and food products without laborious sample preparation.

FOOD CONTROL (2022)

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Article Food Science & Technology

Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis

Qinchao Ding et al.

Summary: This study found that Lactobacillus plantarum ZY08 plays a protective role against alcoholic liver disease (ALD) by improving hepatic steatosis, liver injury, and intestinal barrier. It also reduces plasma endotoxin levels and affects hepatic genes related to lipid metabolism. Additionally, Lactobacillus plantarum ZY08 restores intestinal flora homeostasis and increases short-chain fatty acid content, promoting intestinal health. These findings suggest that Lactobacillus plantarum ZY08 has potential in mitigating alcohol-induced hepatic steatosis and liver injury.

FOOD RESEARCH INTERNATIONAL (2022)

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Review Nutrition & Dietetics

Novel Horizons in Postbiotics: Lactobacillaceae Extracellular Vesicles and Their Applications in Health and Disease

Elena Gonzalez-Lozano et al.

Summary: Lactobacillus probiotics have beneficial effects on host health and various pathological conditions, especially in improving inflammatory bowel disease (IBD) and regulating the immune system. Extracellular vesicles (EVs) derived from probiotics play a key role in these interactions and have been proposed as a safe alternative to live bacteria for vulnerable patients. This review provides an updated overview of EVs from different Lactobacillus strains and their potential therapeutic applications.

NUTRIENTS (2022)

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Article Food Science & Technology

Purification and characterization of antioxidative and antimicrobial peptides from lactic-fermented sheep milk

Jodhani Keyur Ashokbhai et al.

Summary: This study investigates the antioxidant and antimicrobial properties of sheep milk fermented using Lactobacillus plantarum (KGL3A). The results demonstrate that the antioxidative and antimicrobial activities increase with increasing fermentation time. The study also identifies peptides with antioxidant and antimicrobial activities in the fermented sheep milk, suggesting it as a potential source of such proteins.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2022)

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Article Agriculture, Multidisciplinary

Exopolysaccharide from Lactobacillus rhamnosus ZFM231 alleviates DSS-induced colitis in mice by regulating gut microbiota

Cheng Wan et al.

Summary: The study found that EPS produced by L. rhamnosus ZFM231 significantly improved the symptoms of mice with inflammatory bowel disease, including weight loss, colonic tissue damage, and disease activity index score. The EPS treatment also effectively modulated the gut microbiota composition and increased the levels of short-chain fatty acids and anti-inflammatory factors in colonic cells.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2022)

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Article Food Science & Technology

The effect of fermentation conditions (temperature, salt concentration, and pH) with lactobacillus strains for producing Short Chain Fatty Acids

Nasrin Hadinia et al.

Summary: This study aimed to evaluate the effects of different fermentation conditions on the production of short-chain fatty acids by different strains of Lactobacillus. The results showed that the fatty acid content was affected by fermentation conditions, and different strains produced different types and levels of short-chain fatty acids.

LWT-FOOD SCIENCE AND TECHNOLOGY (2022)

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Article Nutrition & Dietetics

Therapeutic potential of Short Chain Fatty acid production by gut microbiota in Neurodegenerative disorders

Sarika Yadav et al.

NUTRITION RESEARCH (2022)

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Article Multidisciplinary Sciences

Microbial-derived metabolites induce actin cytoskeletal rearrangement and protect blood-brain barrier function

Emily G. Knox et al.

Summary: The gut microbiota can influence the structure and function of the blood-brain barrier by altering the actin cytoskeleton and tight junction proteins. Short-chain fatty acids (SCFAs) can modulate BBB integrity and mitochondrial dynamics.

ISCIENCE (2022)

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Article Food Science & Technology

Recent insights into the hepatoprotective effects of lactic acid bacteria in alcoholic liver disease

Xiaoqian Sun et al.

Summary: Lactic acid bacteria (LAB) can protect liver health by restoring imbalances in gut microbiota induced by alcohol and increasing intestinal permeability, which leads to a reduction in lipopolysaccharide levels reaching the liver and alleviates liver inflammation directly. Additionally, LAB can decrease oxidative stress, reduce liver fat accumulation, promote nutrient absorption, and protect gastric mucosa, showing excellent protection against ALD.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2022)

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Article Multidisciplinary Sciences

Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation

Yingying Shen et al.

Summary: The compound ursodeoxycholic acid (UDCA) has been found to enhance antitumor immunity by degrading TGF-beta and inhibiting Treg cell differentiation and activation in tumor-bearing mice. It also synergizes with anti-PD-1 to enhance antitumor immunity and tumor-specific immune memory. UDCA phosphorylates TGF-beta and promotes its degradation through a specific pathway, suggesting its potential as a TGF-beta inhibitor.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Co-administration of Lactobacillus gasseri KBL697 and tumor necrosis factor-alpha inhibitor infliximab improves colitis in mice

Dae Hee Han et al.

Summary: This study investigated the effects of co-administration of L. gasseri KBL697 and IFX on colitis in mice. The results showed that the combined treatment improved inflammation symptoms, modulated inflammatory cytokine production, and affected gut microbiota and metabolic pathways.

SCIENTIFIC REPORTS (2022)

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Article Pharmacology & Pharmacy

Bifidobacterium longum CECT 7894 Improves the Efficacy of Infliximab for DSS-Induced Colitis via Regulating the Gut Microbiota and Bile Acid Metabolism

Fangfei Xiao et al.

Summary: This study found that Bifidobacterium longum CECT 7894 can enhance the efficacy of infliximab (IFX) for DSS-induced colitis. This strain of probiotics achieves this effect by altering the composition of gut microbiota and bile acid metabolism.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Microbiology

Lactobacillus rhamnosus HN001 Ameliorates BEZ235-Induced Intestinal Dysbiosis and Prolongs Cardiac Transplant Survival

Xiaolong Miao et al.

Summary: Our study confirms that the combination of BEZ235 and Lactobacillus rhamnosus HN001 significantly prolongs cardiac transplant survival. The main metabolic product of Lactobacillus rhamnosus HN001, propionic acid (PA), enriches regulatory T (Treg) cells and serves as a potent immunomodulatory supplement to BEZ235. This study provides a novel and efficient therapeutic strategy for transplant recipients.

MICROBIOLOGY SPECTRUM (2022)

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Article Nutrition & Dietetics

From Function to Metabolome: Metabolomic Analysis Reveals the Effect of Probiotic Fermentation on the Chemical Compositions and Biological Activities of Perilla frutescens Leaves

Zhenxing Wang et al.

Summary: This study investigated the impact of probiotic fermentation on the active components and functions of Perilla frutescens leaves (PFL). The results showed that most of the active component contents and functional activities of PFL exhibited an increasing and then decreasing trend during fermentation. Different probiotics had distinguishable effects on PFL, and fermentation with ATCC 53013 for 1 day showed the highest enhancement effect. Metabolomic analysis revealed significant metabolite changes under the best fermentation condition, involving the generation of fatty acids and their conjugates, flavonoids. The study provides insights into the action mechanism of probiotic fermentation on the chemical composition and biological activity of PFL.

FRONTIERS IN NUTRITION (2022)

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Article Nutrition & Dietetics

Lactobacillus plantarum Alleviates Obesity by Altering the Composition of the Gut Microbiota in High-Fat Diet-Fed Mice

Yong Ma et al.

Summary: Lactobacillus plantarum can regulate lipid metabolism by modulating the structure of intestinal microbiota and increasing the production of short-chain fatty acids (SCFAs), thereby alleviating obesity and metabolic disorders.

FRONTIERS IN NUTRITION (2022)

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Article Food Science & Technology

Modulation of the Gut Microbiota and Glycometabolism by a Probiotic to Alleviate Amyloid Accumulation and Cognitive Impairments in AD Rats

Yuanwang Wang et al.

Summary: Regulating the gut microecology with probiotics is an effective strategy for the prevention and treatment of Alzheimer's disease (AD). This study demonstrates that a functional probiotic, Lactobacillus plantarum MA2, isolated from traditional Chinese Tibetan kefir grains, can improve cognitive deficits and anxiety-like behaviors in AD rats. It also attenuates neuronal degeneration and Aβ accumulation in the brain. Furthermore, the study shows that MA2 alleviates intestinal mucosal impairments and inhibits microglia activation and neuroinflammation through the TLR4/MYD88/NLRP3 signaling pathway. The findings suggest that MA2 reshapes the gut microbiota and modulates glycometabolism, and its exopolysaccharides (EPS) have inhibitory effects on Aβ aggregation and cytotoxicity induced by amyloid.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

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Article Food Science & Technology

Bifidobacterium animalis subsp. lactis A12 prevents obesity- associated dyslipidemia by modulating gut microbiota-derived short-chain fatty acid production and energy metabolism in high-fat diet-fed mice

Tong Li et al.

Summary: The present study elucidated the mechanisms by which B. lactis A12 prevents obesity, including downregulation of sterol regulatory element binding protein-1 mRNA levels in the liver, modulation of the gut microbiota structure, and upregulation of the SCFA-producing bacteria-related G protein-coupled receptor 43 pathway.

FOOD & NUTRITION RESEARCH (2022)

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Article Food Science & Technology

Biodiversity of exopolysaccharide-producing lactic acid bacteria from Iranian traditional Kishk and optimization of EPS yield by Enterococcus spp.

Paria Rahnama Vosough et al.

Summary: This study focuses on the production of polysaccharides derived from Iranian Kishk by isolating and culturing lactic acid bacteria. The optimal conditions for EPS production were determined using optimization design methods, resulting in the identification of three strains with high EPS yield. The EPSs produced by these native LAB strains have potential industrial applications or can be used as functional food ingredients.

FOOD BIOSCIENCE (2022)

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Article Food Science & Technology

Effects of Lactiplantibacillus plantarum WLPL01 fermentation on antioxidant activities, bioactive compounds, and flavor profile of Artemisia argyi

Hui Zhan et al.

Summary: This study found that fermentation of Artemisia argyi using the strain Lactiplantibacillus plantarum WLPL01 can improve its bioactive compounds and flavor characteristics. It increases antioxidant activity, reduces bitterness, and enhances fruity, sweet, and flora notes.

FOOD BIOSCIENCE (2022)

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Article Food Science & Technology

Metabolomic Characteristics of Liver and Cecum Contents in High-Fat-Diet-Induced Obese Mice Intervened with Lactobacillus plantarum FRT10

Hongying Cai et al.

Summary: This study used liver and cecum contents metabonomics to analyze the metabolic profiles of obese mice and revealed the potential functions of Lactobacillus plantarum FRT10 in regulating liver and cecum contents metabolism. The results suggest that the anti-obesity effects of FRT10 may be related to alterations in glycerophospholipid metabolism, primary bile acid biosynthesis, amino metabolism, and purine and pyrimidine metabolism.

FOODS (2022)

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Article Multidisciplinary Sciences

Isolation, characterization and anti-UVB irradiation activity of an extracellular polysaccharide produced by Lacticaseibacillus rhamnosus VHPriobi O17

Shudong Peng et al.

Summary: This study aimed to evaluate the anti-UVB viability of exopolysaccharides (EPS) isolated from lactic acid bacteria (LAB). A LAB strain, Lacticaseibacillus rhamnosus VHPriobi O17, with high EPS production was selected. The purified EPS (OP-2) was identified as a novel Man-like polysaccharide with potential anti-UVB effects. It effectively alleviated cell apoptosis and reactive oxygen species production induced by UVB, inhibited the release of pro-inflammatory cytokines, and suppressed the phosphorylation cascade to prevent cell apoptosis. These findings suggest that EPS produced by L. rhamnosus VHPriobi O17 may be useful for human protection against UVB irradiation.

HELIYON (2022)

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Article Food Science & Technology

Fructooligosaccharides (FOS) significantly increased the relative abundance of intestinal B. pseudolongum in mice with different genotypes

Jiayu Gu et al.

Summary: Fructooligosaccharides (FOS) promote the proliferation of Bifidobacterium, especially Bifidobacterium pseudo-longum, in C57BL/6J mice. However, the response of intestinal microbes to FOS is influenced by host genotypes. The study compared the intestinal microbiota of four commonly used mice before and after FOS intervention and found differences in the abundance of certain bacteria among different genotypes.

CURRENT RESEARCH IN FOOD SCIENCE (2022)

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Article Agriculture, Multidisciplinary

Characterization of Antimicrobial Peptide Fraction Producing Lactobacillus spp. Based on LC/MS-MS and Determination of ACE-inhibitory Activity in Kefir

Merve Atalay et al.

Summary: This study investigated the bioactive properties of kefir using different Lactobacillus strains, including ACE-I activity and antimicrobial activity. Proteolysis was also studied. The results showed that kefir manufactured with Lactobacillus had a stronger antibacterial effect and increased ACE-I activity. Therefore, the addition of Lactobacillus can enhance the functional value of kefir.

JOURNAL OF AGRICULTURAL SCIENCES-TARIM BILIMLERI DERGISI (2022)

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Article Biochemistry & Molecular Biology

Strains producing different short-chain fatty acids alleviate DSS-induced ulcerative colitis by regulating intestinal microecology

Shuo Yang et al.

Summary: This study demonstrates the roles of probiotics and their metabolites, short-chain fatty acids, in the treatment of ulcerative colitis. The results show that these substances can modulate inflammatory factors, intestinal barrier function, intestinal microbiome composition, and SCFA content. Bifidobacterium bifidum H3-R2 and Propionibacterium freudenreichii B1 play crucial roles through TLRs/RHO kinase and Wnt/beta-catenin pathways.

FOOD & FUNCTION (2022)

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Article Biotechnology & Applied Microbiology

Cultivation of Lactic Acid Bacteria and Evaluation of the Antimicrobial Potential of Partially Purified Bacteriocin-like Inhibitory Substances against Cariogenic and Food Pathogens

Amanda Romana Santos da Silva et al.

Summary: Lactic acid bacteria (LAB) can produce bacteriocin-like inhibitory substances (BLIS) that have potential antimicrobial effects against dental caries causing pathogens. This study aimed to isolate and purify BLIS from different LAB strains and evaluate their antimicrobial potential against various pathogens.

FERMENTATION-BASEL (2022)

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Article Biochemistry & Molecular Biology

Bifidobacterium animalis subsp. lactis XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora

Baofeng Xu et al.

Summary: In this study, the regulatory effect of Bifidobacterium animalis subsp. lactis XLTG11 on antibiotic-induced diarrhea in mice was evaluated. The results showed that B. lactis XLTG11 had a better therapeutic effect, reducing intestinal pathologies, improving intestinal permeability, increasing anti-inflammatory cytokine levels, and enhancing the abundance and diversity of the gut microbiota.

FOOD & FUNCTION (2022)

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Article Food Science & Technology

Pediococcus acidilactici FZU106 alleviates high-fat diet-induced lipid metabolism disorder in association with the modulation of intestinal microbiota in hyperlipidemic rats

Qing Zhang et al.

Summary: This study investigated the effects of Pediococcus acidilactici FZU106, isolated from traditional brewing of Hongqu rice wine, on lipid metabolism and intestinal microbiota in high-fat diet-induced hyperlipidemic rats. The results showed that the intervention of P. acidilactici FZU106 effectively improved body weight, serum and liver parameters related to lipid metabolism and oxidative stress. It also demonstrated positive effects on the composition and metabolism of gut microbiota. Additionally, P. acidilactici FZU106 regulated the expression of liver genes involved in lipid metabolism and bile acid homeostasis. These findings suggest that P. acidilactici FZU106 has the potential to reduce disturbances in lipid metabolism by modulating both intestinal microflora and liver gene expression profiles.

CURRENT RESEARCH IN FOOD SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Lactobacillus kefiranofaciens JKSP109 and Saccharomyces cerevisiae JKSP39 isolated from Tibetan kefir grain co-alleviated AOM/DSS induced inflammation and colorectal carcinogenesis

Xuejun Zeng et al.

Summary: This study investigated the therapeutic effects of Lactobacillus kefiranofaciens JKSP109 (LK) and Saccharomyces cerevisiae JKSP39 (SC) on colon inflammation and colorectal carcinogenesis. The results showed that administration of LK, SC, and their combination improved body weight, decreased disease activity index, and reduced tumor multiplicity. These treatments also positively regulated gut microbiota, enhanced gut barrier function, reduced inflammation, and promoted apoptosis of tumor cells. The combination of LK and SC showed superior effects compared to single strain groups.

FOOD & FUNCTION (2022)

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Article Nutrition & Dietetics

Probiotic Effects of Lactobacillus fermentum ZJUIDS06 and Lactobacillus plantarum ZY08 on Hypercholesteremic Golden Hamsters

Dongting Yang et al.

Summary: The study evaluated the probiotic effects of Lactobacillus fermentum ZJUIDS06 and Lactobacillus plantarum ZY08 on hyperlipidemic golden hamsters, demonstrating that Lactobacillus fermentum ZJUIDS06 increased colon SCFA levels, reduced serum LDL, total cholesterol, and triglycerides, and altered the cecum microbiota. Particularly, Lactobacillus fermentum ZJUIDS06 increased the abundance of Parabacteroides, indicating its potential in lowering cholesterol levels.

FRONTIERS IN NUTRITION (2021)

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Review Food Science & Technology

Microbial Metabolites, Postbiotics, and Intestinal Epithelial Function

Aida Mayorgas et al.

Summary: Chronic inflammatory disorders are on the rise globally, with implications of the microbiota in persistent inflammation still being studied. Intestinal epithelial cells are important in forming a protective barrier to harmful components, and strategies like probiotics and postbiotics are being explored to combat bacterial imbalance during inflammation.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Article Food Science & Technology

Metabolomic changes and biological activities during the lacto-fermentation of jackfruit juice using Lactobacillus casei ATCC334

Belal J. Muhialdin et al.

Summary: This study demonstrated the potential for developing a probiotic beverage using jackfruit juice via lacto-fermentation, which resulted in increased viable cell count, enhanced antioxidant and antimicrobial activities, and decreased sugar content. The overall sensory properties showed no significant differences between fermented and non-fermented products.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice

Vivian Gonzalez-Perez et al.

Summary: Y goblet cells (GCs) in the intestinal epithelium play a key role in mucosal homeostasis by producing and secreting MUC2. The association between LRRC26 and BK channels is crucial for maintaining intestinal mucosal function.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Food Science & Technology

Benefits of bacteria-derived exopolysaccharides on gastrointestinal microbiota, immunity and health

Marjolein M. P. Oerlemans et al.

Summary: Bacterial exopolysaccharides (EPS) play a crucial role in intestinal health by influencing bacterial interactions with the host, with specific monosaccharides or linkages possibly being related to their effects.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Agriculture, Multidisciplinary

Bifidobacterium longum Ameliorates Dextran Sulfate Sodium-Induced Colitis by Producing Conjugated Linoleic Acid, Protecting Intestinal Mechanical Barrier, Restoring Unbalanced Gut Microbiota, and Regulating the Toll-Like Receptor-4/Nuclear Factor-κB Signaling Pathway

Yang Chen et al.

Summary: Bifidobacterium longum CCFM681 alleviated colitis by protecting the intestinal mechanical barrier, modulating gut microbiota, inhibiting the TLR4/NF-kappa B pathway, and increasing colonic CLA concentrations. The effectiveness of relieving colitis showed a significantly positive correlation with CLA concentrations.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Microbiology

Antimicrobial Potential of Food Lactic Acid Bacteria: Bioactive Peptide Decrypting from Caseins and Bacteriocin Production

Stefano Nebbia et al.

Summary: The study found that lactic acid bacteria have great potential in the food industry and biotechnological sector, especially in combating food-borne infections. Through the production of antimicrobial compounds, these LAB strains may serve as a powerful weapon against multidrug resistant strains. Additionally, some LAB strains are able to release bioactive peptides with antimicrobial, antihypertensive, and opioid activities.

MICROORGANISMS (2021)

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Article Food Science & Technology

Changes in the chemical and sensory profile of ripened Italian salami following the addition of different microbial starters

Gabriele Rocchetti et al.

Summary: The study revealed that the use of different microbial starters in the production of salami can lead to distinct metabolomic profiles, such as the accumulation of compounds related to lipid oxidation and gamma-glutamyl peptides, ultimately affecting the taste and aroma.

MEAT SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Contributions of exopolysaccharides from lactic acid bacteria as biotechnological tools in food, pharmaceutical, and medical applications

Ghoson M. Daba et al.

Summary: Exopolysaccharides (EPS) produced by some genera of lactic acid bacteria have diverse applications in food, pharmaceuticals, and diagnostics, contributing to improved shelf-life, enhanced functionalities, and various targeted drug delivery systems. Future prospects focus on enhancing EPS production, reducing production costs, and exploring their potential in further applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Food Science & Technology

Effects of exopolysaccharide from Lactobacillus rhamnosus on human gut microbiota in in vitro fermentation model

Yuzhu Zhu et al.

Summary: The study identified four types of EPS with different molecular composition from Lactobacillus rhamnosus ZFM231, and evaluated their potential impact on the human gut microbiota through in vitro fermentation model. Results showed that EPS could be effectively degraded by human gut microbiota and fermented to produce short chain fatty acids. Furthermore, EPS mainly increased the abundance of beneficial bacteria such as Ruminococcus, Dorea, Butyricicoccus, and Blautia. This research provides valuable insights into the mechanisms of Lactobacillus rhamnosus EPS in the gastrointestinal tract of the human body.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Article Food Science & Technology

Anti-osteoporotic potential of Lactobacillus plantarum AR237 and AR495 in ovariectomized mice

Jing Yu et al.

Summary: The study found that the strain AR495 of Lactobacillus plantarum significantly inhibited osteoporosis and improved intestinal health in ovx mice. AR495 modulated bone resorption and intestinal inflammatory responses, as well as enhanced intestinal microbial stability and short-chain fatty acid production in ovx mice.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Biochemistry & Molecular Biology

Protective effect of exopolysaccharide fraction from Bacillus subtilis against dextran sulfate sodium-induced colitis through maintenance of intestinal barrier and suppression of inflammatory responses

Kyung-Sook Chung et al.

Summary: B-EPS can improve immune function and contribute to maintaining intestinal barrier integrity in a DSS-induced colitis mouse model, alleviating colonic inflammation in IBD.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD

Adrian Martyniak et al.

Summary: The increasing incidence of inflammatory bowel diseases necessitates new methods of therapy, with the gut microbiome being studied extensively as a key factor. The composition of intestinal microbiota can be modified by diet and probiotics, and enhanced by the use of paraprobiotics and postbiotics. This study summarizes recent works on various microbiome-altering methods in IBD.

BIOMOLECULES (2021)

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Article Microbiology

Alleviative Effects of Exopolysaccharide Produced by Lactobacillus helveticus KLDS1.8701 on Dextran Sulfate Sodium-Induced Colitis in Mice

Yin Liu et al.

Summary: The study demonstrated that EPS-1 significantly alleviated the damage caused by DSS-induced UC by reducing intestinal inflammation, improving mucosal barrier function, and modulating gut microbiota composition.

MICROORGANISMS (2021)

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Article Food Science & Technology

Development of multi-strain probiotic cheese: Nisin production in food and gut

S. Langa et al.

Summary: Three strains with technological and probiotic properties were used as adjunct cultures for the manufacture of pasteurized ewe's milk cheese, showing good viability during production and ripening, as well as survival in an in vitro colonic model. The nisin-producing strain was able to produce the antimicrobial peptide nisin in both cheese production and the colonic model. The addition of these strains as adjunct cultures did not negatively impact the physicochemical or sensory characteristics of the cheese, demonstrating the suitability of cheese as a carrier for a multi-strain combination with potential dual effects.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Article Food Science & Technology

A novel bacteriocin from Lactobacillus salivarius against Staphylococcus aureus: Isolation, purification, identification, antibacterial and antibiofilm activity

Hong-Wei Li et al.

Summary: The study identified a novel bacteriocin XJS01 with potential activity against foodborne Staphylococcus aureus. XJS01 exhibited low minimum inhibitory concentration and good resistance to heat treatment, leading to significant inhibition of both planktonic cells and biofilm formation of S. aureus. The bacteriocin impaired membrane permeability, caused cytoplasmic content leakage, and induced cell deformation in S. aureus.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Article Microbiology

Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Daotong Li et al.

Summary: Our study demonstrates that the gut microbiota-inosine-A(2A)R/PPAR gamma axis is crucial in maintaining intestinal homeostasis and may offer a novel approach for preventing colitis through manipulation of gut microbial purine metabolite. Additionally, dietary supplementation of barley leaf improves intestinal mucosal barrier functions and induces metabolic reprogramming in colonic tissues by enhancing the glycolysis process. Furthermore, the enrichment of microbiota-derived purine metabolite inosine from BL supplementation activates PPAR gamma signaling in human colon epithelial cells.

MICROBIOME (2021)

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Review Medicine, Research & Experimental

Role of microbiota-derived short-chain fatty acids in cancer development and prevention

Rasoul Mirzaei et al.

Summary: Recent studies have indicated the significant roles of gut microbiota and SCFAs in cancer development, affecting cell survival, differentiation, proliferation, and death. Manipulating the microbiota structure to regulate SCFA levels could potentially offer new strategies for cancer treatment/prevention.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Immunology

Regulation of host physiology and immunity by microbial indole-3-aldehyde

Teresa Zelante et al.

Summary: The review explores the multifaceted role of indole-3-aldehyde in host physiology, pathology, and immunity, and discusses its potential as a valuable therapeutic strategy.

CURRENT OPINION IN IMMUNOLOGY (2021)

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Article Food Science & Technology

Moringa oleifera leaves alleviated inflammation through downregulation of IL-2, IL-6, and TNF-α in a colitis-associated colorectal cancer model

M. L. Cuellar-Nunez et al.

Summary: Moringa oleifera leaves have shown chemopreventive properties against inflammatory response and colon carcinogenesis by modulating gene expression and reducing proinflammatory mediators.

FOOD RESEARCH INTERNATIONAL (2021)

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Article Agriculture, Multidisciplinary

Exopolysaccharides from Lactobacillus plantarum NCU116 Facilitate Intestinal Homeostasis by Modulating Intestinal Epithelial Regeneration and Microbiota

Xingtao Zhou et al.

Summary: EPS116 promotes intestinal epithelial regeneration by increasing the number of intestinal stem cells and modulating the gut microbiota profile, thereby maintaining intestinal barrier and homeostasis.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Agriculture, Multidisciplinary

Protective Effects of Microbiome-Derived Inosine on Lipopolysaccharide-Induced Acute Liver Damage and Inflammation in Mice via Mediating the TLR4/NF-κB Pathway

Weiling Guo et al.

Summary: The research assessed the protective effects of inosine on liver injury and inflammation by modulating the intestinal microbiota structure and TLR4/NF-kappa B signaling pathway in LPS-treated mice. Inosine pretreatment significantly reduced inflammatory factors secretion, ALT and AST levels, and improved antioxidant enzyme activity and relative abundance of certain genera. The results suggest that inosine pretreatment has the potential for preventing LPS-induced acute liver damage through its regulatory effects on both intestinal microbiota and hepatic signaling pathways.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Nutrition & Dietetics

Bifidobacterium animalis subsp. lactis BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome

Daniel Merenstein et al.

Summary: Probiotic Bifidobacterium animalis subsp. lactis BB-12 demonstrates protection against antibiotic-induced disruptions in gut microbiota and short-chain fatty acids, enhancing microbial recovery. Compared to the control group, the BB-12 group showed smaller changes in fecal acetate levels and less loss in gut microbiota diversity after antibiotic treatment.

NUTRIENTS (2021)

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Article Biochemistry & Molecular Biology

Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism

Caixin Ni et al.

Summary: This study demonstrated the therapeutic effects of several LAB strains on a mouse model of hyperuricaemia by promoting the production of short-chain fatty acids, leading to reduced uric acid levels. Importantly, this effect was independent of purine degradation, providing a novel therapeutic approach for hyperuricaemia.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

Protective effect of Bifidobacterium bifidum FSDJN7O5 and Bifidobacterium breve FHNFQ23M3 on diarrhea caused by enterotoxigenic Escherichia coli

Bo Yang et al.

Summary: This study demonstrated that Bifidobacterium could alleviate diarrhea caused by ETEC infection, promote the restoration of gut microbiota balance and intestinal tissue structure. B. breve FHNFQ23M3 and B. bifidum FSDJN7O5 showed significant improvements in diarrhea symptoms.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

Lactobacillus rhamnosus from human breast milk ameliorates ulcerative colitis in mice via gut microbiota modulation

Bing Pang et al.

Summary: This study demonstrates that L. rhamnosus SHA113 relieves ulcerative colitis (UC) by modulating gut microbiota, leading to increased production of SCFAs and gut microbial diversity, as well as reduced levels of UC-related genera. Additionally, it regulates the levels of intestinal inflammatory factors and enhances the expression of anti-inflammatory cytokines.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

Daily intake of Lactobacillus alleviates autistic-like behaviors by ameliorating the 5-hydroxytryptamine metabolic disorder in VPA-treated rats during weaning and sexual maturation

Qingmin Kong et al.

Summary: Probiotic therapy targeting the gut-brain axis has shown efficacy in improving autistic-like behavioral symptoms in VPA-treated rats, with L. helveticus CCFM1076 proving more beneficial. This probiotic strain helps regulate the 5HT system, increase OT synthesis, improve neurotransmitter balance, and influence gut microbiota and SCFA levels.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

Characterization, bioactivities, and rheological properties of exopolysaccharide produced by novel probiotic Lactobacillus plantarum C70 isolated from camel milk

Mutamed Ayyash et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Applied

Physicochemical, bioactive and rheological properties of an exopolysaccharide produced by a probiotic Pediococcus pentosaceus M41

Mutamed Ayyash et al.

CARBOHYDRATE POLYMERS (2020)

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Article Biochemistry & Molecular Biology

Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway

Ji Hyun Choi et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Agriculture, Multidisciplinary

c9, t11, c15-CLNA and t9, t11, c15-CLNA from Lactobacillus plantarum ZS2058 Ameliorate Dextran Sodium Sulfate-Induced Colitis in Mice

Qing Ren et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Nutrition & Dietetics

Lactobacillus rhamnosus GG Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction by Regulating MAPK/NF-κB Signaling and Modulating Metabolome in the Piglet Intestine

Jiangdi Mao et al.

JOURNAL OF NUTRITION (2020)

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Review Gastroenterology & Hepatology

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

Aonghus Lavelle et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Cell Biology

Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury

Bejan J. Saeedi et al.

CELL METABOLISM (2020)

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Article Multidisciplinary Sciences

JNK-dependent intestinal barrier failure disrupts host-microbe homeostasis during tumorigenesis

Jun Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Food Science & Technology

Bifidobacterium affected the correlation between gut microbial composition, SCFA metabolism, and immunity in mice with DNFB-induced atopic dermatitis

Zhifeng Fang et al.

Food Bioscience (2020)

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Article Neurosciences

Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice

Peijun Tian et al.

NEUROBIOLOGY OF STRESS (2020)

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Article Biochemistry & Molecular Biology

Impact of Lactobacillus paracasei IMC502 in coculture with traditional starters on volatile and non-volatile metabolite profiles in yogurt

Yuxiang Gu et al.

PROCESS BIOCHEMISTRY (2020)

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Article Multidisciplinary Sciences

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Lukas F. Mager et al.

SCIENCE (2020)

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Review Cell Biology

Tight Junction Structure and Function Revisited

Tetsuhisa Otani et al.

TRENDS IN CELL BIOLOGY (2020)

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Article Immunology

Bifidobacterium animalisssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells

Hongxia Zhang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Chemistry, Applied

Exopolysaccharide produced by the potential probiotic Lactococcus garvieae C47: Structural characteristics, rheological properties, bioactivities and impact on fermented camel milk

Mutamed Ayyash et al.

FOOD CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Lactobacillus plantarum relieves diarrhea caused by enterotoxin-producing Escherichia coli through inflammation modulation and gut microbiota regulation

Yue Yue et al.

FOOD & FUNCTION (2020)

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Article Cell Biology

Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study

Cristina Alcon-Giner et al.

CELL REPORTS MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manners

Gang Wang et al.

FOOD & FUNCTION (2020)

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Article Biochemistry & Molecular Biology

Oral administration of Lactobacillus fermentum CRL1446 improves biomarkers of metabolic syndrome in mice fed a high-fat diet supplemented with wheat bran

M. Russo et al.

FOOD & FUNCTION (2020)

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Article Chemistry, Applied

Characterization and Bifidobacterium sp. growth stimulation of exopolysaccharide produced by Enterococcus faecalis EJRM152 isolated from human breast milk

Wiratchanee Kansandee et al.

CARBOHYDRATE POLYMERS (2019)

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Article Chemistry, Applied

Exopolysaccharides produced by lactic acid bacteria and Bifidobacteria: Structures, physiochemical functions and applications in the food industry

Yuanmei Xu et al.

FOOD HYDROCOLLOIDS (2019)

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Article Agriculture, Multidisciplinary

Exopolysaccharides from Lactobacillus plantarum NCU116 Enhances Colonic Mucosal Homeostasis by Controlling Epithelial Cell Differentiation and c-Jun/Muc2 Signaling

Xingtao Zhou et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Medicine, General & Internal

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naive type 2 diabetics

Huanzi Zhong et al.

EBIOMEDICINE (2019)

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Article Biotechnology & Applied Microbiology

Characterization and antioxidant activity of an acidic exopolysaccharide from Lactobacillus plantarum JLAU103

Wei-Hong Min et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2019)

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Article Immunology

In vitro evaluation of adherence and anti-infective property of probiotic Lactobacillus plantarum DM 69 against Salmonella enterica

Debapriya Mohanty et al.

MICROBIAL PATHOGENESIS (2019)

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Article Microbiology

Gut microbiome structure and metabolic activity in inflammatory bowel disease

Eric A. Franzosa et al.

NATURE MICROBIOLOGY (2019)

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Review Gastroenterology & Hepatology

Environmental triggers in IBD: a review of progress and evidence

Ashwin N. Ananthakrishnan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Article Chemistry, Applied

Exopolysaccharide produced by Streptococcus thermophiles S-3: Molecular, partial structural and rheological properties

Zhiyuan Xu et al.

CARBOHYDRATE POLYMERS (2018)

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Article Biotechnology & Applied Microbiology

Molecular Characterization and Identification of Bioactive Peptides Producing Lactobacillus sps. Based on 16S rRNA Gene Sequencing

Priyanka Chandra et al.

FOOD BIOTECHNOLOGY (2018)

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Article Chemistry, Applied

Characterization of a yogurt-quality improving exopolysaccharide from Streptococcus thermophilus AR333

Hui Zhang et al.

FOOD HYDROCOLLOIDS (2018)

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Article Biochemistry & Molecular Biology

Characterization of a novel exopolysaccharide produced by Lactobacillus gasseri FR4 and demonstration of its in vitro biological properties

Rizwana Parveen Rani et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

Production and structural characterization of exopolysaccharides from newly isolated probiotic lactic acid bacteria

Yousra Abid et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Agriculture, Multidisciplinary

Analysis of Improved Nutritional Composition of Potential Functional Food (Okara) after Probiotic Solid-State Fermentation

Sulagna Gupta et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Layilin is critical for mediating hyaluronan 35 kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo

Yeojung Kim et al.

MATRIX BIOLOGY (2018)

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Article Agriculture, Multidisciplinary

Exopolysaccharides from Lactobacillus plantarum NCU116 Regulate Intestinal Barrier Function via STAT3 Signaling Pathway

Xingtao Zhou et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Agriculture, Dairy & Animal Science

Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease

M. K. Seo et al.

JOURNAL OF DAIRY SCIENCE (2018)

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Article Allergy

Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles

Min-Hye Kim et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2018)

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Article Microbiology

A metabolomics and proteomics study of the Lactobacillus plantarum in the grass carp fermentation

Tinghong Ming et al.

BMC MICROBIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

Ara Koh et al.

CELL (2018)

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Article Food Science & Technology

Purification and partial characterization of M1-UVs300, a novel bacteriocin produced by Lactobacillus plantarum isolated from fermented sausage

Yu An et al.

FOOD CONTROL (2017)

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Article Agriculture, Dairy & Animal Science

Characterization and bioactivities of the exopolysaccharide from a probiotic strain of Lactobacillus plantarum WLPL04

Zhengqi Liu et al.

JOURNAL OF DAIRY SCIENCE (2017)

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Article Biochemistry & Molecular Biology

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

Nathaniel R. West et al.

NATURE MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism

Gang Wang et al.

FOOD & FUNCTION (2017)

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Article Multidisciplinary Sciences

Exopolysaccharides from Lactobacillus plantarum NCU116 induce c-Jun dependent Fas/Fasl-mediated apoptosis via TLR2 in mouse intestinal epithelial cancer cells

Xingtao Zhou et al.

SCIENTIFIC REPORTS (2017)

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Article Food Science & Technology

Safety evaluation and antimicrobial properties of Lactobacillus pentosus 22C isolated from traditional yogurt

Paria Motahari et al.

JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION (2017)

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Article Chemistry, Applied

Chemical and biological properties of the novel exopolysaccharide produced by a probiotic strain of Bifidobacterium longum

Rosanna Inturri et al.

CARBOHYDRATE POLYMERS (2017)

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Article Chemistry, Applied

Structural characterization and antioxidant property of released exopolysaccharides from Lactobacillus delbrueckii ssp bulgaricus SRFM-1

Weizhi Tang et al.

CARBOHYDRATE POLYMERS (2017)

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Article Chemistry, Applied

Physicochemical characterization and antitumour activity of exopolysaccharides produced by Lactobacillus casei SB27 from yak milk

Wei Di et al.

CARBOHYDRATE POLYMERS (2017)

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Review Multidisciplinary Sciences

Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation

Vicky Garcia-Hernandez et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

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Article Chemistry, Applied

Exopolysaccharides of Lactobacillus reuteri: Their influence on adherence of E. coli to epithelial cells and inflammatory response

Petra Ksonzekova et al.

CARBOHYDRATE POLYMERS (2016)

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Article Food Science & Technology

Impact of starch and exopolysaccharide-producing lactic acid bacteria on the properties of set and stirred yoghurts

Marie-Claude Gentes et al.

INTERNATIONAL DAIRY JOURNAL (2016)

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Article Biotechnology & Applied Microbiology

Complete genome sequence of Lactobacillus plantarum LZ95, a potential probiotic strain producing bacteriocins and B-group vitamin riboflavin

Ping Li et al.

JOURNAL OF BIOTECHNOLOGY (2016)

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Article Food Science & Technology

Characterization, Anti-Inflammatory and Antiproliferative Activities of Natural and Sulfonated Exo-Polysaccharides from Streptococcus thermophilus ASCC 1275

Siqian Li et al.

JOURNAL OF FOOD SCIENCE (2016)

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Editorial Material Multidisciplinary Sciences

A SLOW-MOTION EPIDEMIC

Michael Eisenstein

NATURE (2016)

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Article Multidisciplinary Sciences

Genome Analysis and Characterisation of the Exopolysaccharide Produced by Bifidobacterium longum subsp longum 35624™

Friedrich Altmann et al.

PLOS ONE (2016)

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Review Gastroenterology & Hepatology

Consequences of bile salt biotransformations by intestinal bacteria

Jason M. Ridlon et al.

GUT MICROBES (2016)

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Article Biochemistry & Molecular Biology

Lactobacillus plantarum NCU116 attenuates cyclophosphamide-induced intestinal mucosal injury, metabolism and intestinal microbiota disorders in mice

Jun-Hua Xie et al.

FOOD & FUNCTION (2016)

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Article Gastroenterology & Hepatology

A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients

Jonathan P. Jacobs et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2016)

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Article Chemistry, Applied

Characterization of an exopolysaccharide produced by Lactobacillus plantarum YW11 isolated from Tibet Kefir

Ji Wang et al.

CARBOHYDRATE POLYMERS (2015)

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Article Food Science & Technology

Biopreservative effect of the natural antimicrobial substance from Lactobacillus paracasei subsp tolerans FX-6 on fresh pork during chilled storage

Jianyin Miao et al.

FOOD CONTROL (2015)

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Article Food Science & Technology

Purification and characteristics of bifidocin A, a novel bacteriocin produced by Bifidobacterium animals BB04 from centenarians' intestine

Guorong Liu et al.

FOOD CONTROL (2015)

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Article Food Science & Technology

Edible kefiran films as vehicle for probiotic microorganisms

J. Piermaria et al.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2015)

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Article Biochemistry & Molecular Biology

Characterization and bioactivities of an exopolysaccharide produced by Lactobacillus plantarum YW32

Ji Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Food Science & Technology

Short-chain fatty acids produced by synbiotic mixtures in skim milk differentially regulate proliferation and cytokine production in peripheral blood mononuclear cells

M. Asarat et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2015)

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Article Agriculture, Multidisciplinary

Structural Characterization and Anticancer Activity of Cell-Bound Exopolysaccharide from Lactobacillus helveticus MB2-1

Wei Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

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Article Food Science & Technology

Antilisterial Bacteriocin from Lactobacillus rhamnosus CJNU 0519 Presenting a Narrow Antimicrobial Spectrum

Ye-Jin Jeong et al.

KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES (2015)

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Article Food Science & Technology

Characterization of an exopolysaccharide with potential health-benefit properties from a probiotic Lactobacillus plantarum RJF4

Sasidharan Vasanthakumari Dilna et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2015)

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Article Food Science & Technology

Optimization of culture conditions for the production of antimicrobial substances by probiotic Lactobacillus paracasei subsp Tolerans FX-6

Jianyin Miao et al.

JOURNAL OF FUNCTIONAL FOODS (2015)

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Article Multidisciplinary Sciences

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Laurence Macia et al.

NATURE COMMUNICATIONS (2015)

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Article Multidisciplinary Sciences

Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community

Hirosuke Sugahara et al.

SCIENTIFIC REPORTS (2015)

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Article Gastroenterology & Hepatology

Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD

Vicky De Preter et al.

GUT (2015)

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Article Biochemistry & Molecular Biology

Characterization of a novel exopolysaccharide with antitumor activity from Lactobacillus plantarum 70810

Kun Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2014)

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Review Biotechnology & Applied Microbiology

Bacteriocin production by Bifidobacterium spp. A review

Fabio Andres Castillo Martinez et al.

BIOTECHNOLOGY ADVANCES (2013)

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Article Biochemistry & Molecular Biology

Structure determination of the exopolysaccharide of Lactobacillus fermentum TDS030603-A revision

Gerrit J. Gerwig et al.

CARBOHYDRATE RESEARCH (2013)

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Article Biochemistry & Molecular Biology

The structure and immunoreactivity of exopolysaccharide isolated from Lactobacillus johnsonii strain 151

Sabina Gorska-Fraczek et al.

CARBOHYDRATE RESEARCH (2013)

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Review Biotechnology & Applied Microbiology

Lactobacillus salivarius: Bacteriocin and probiotic activity

S. Messaoudi et al.

FOOD MICROBIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Antioxidant activity of an exopolysaccharide isolated from Lactobacillus plantarum C88

Li Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2013)

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Article Chemistry, Applied

Emulsifying, rheological and physicochemical properties of exopolysaccharide produced by Bifidobacterium longum subsp infantis CCUG 52486 and Bifidobacterium infantis NCIMB 702205

P. H. P. Prasanna et al.

CARBOHYDRATE POLYMERS (2012)

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Article Biochemistry & Molecular Biology

Structure of the high molecular weight exopolysaccharide produced by Bifidobacterium animalis subsp lactis IPLA-R1 and sequence analysis of its putative eps cluster

Shaun Leivers et al.

CARBOHYDRATE RESEARCH (2011)

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Article Food Science & Technology

Chemical characterization and antioxidant activity of an exopolysaccharide fraction isolated from Bifidobacterium animalis RH

Rihua Xu et al.

EUROPEAN FOOD RESEARCH AND TECHNOLOGY (2011)

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Article Gastroenterology & Hepatology

Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives

Marie Joossens et al.

GUT (2011)

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Article Agriculture, Multidisciplinary

Fermentation of β-Glucans Derived from Different Sources by Bifidobacteria: Evaluation of Their Bifidogenic Effect

Jinyang Zhao et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

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Article Chemistry, Multidisciplinary

The partial characterization of the antibacterial peptide bacteriocin G(2) produced by the probiotic bacteria Lactobacillus plantarum G(2)

Svetlana L. Seatovic et al.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY (2011)

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Review Multidisciplinary Sciences

Intestinal homeostasis and its breakdown in inflammatory bowel disease

Kevin J. Maloy et al.

NATURE (2011)

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Review Food Science & Technology

New Developments and Applications of Bacteriocins and Peptides in Foods

S. Mills et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 2 (2011)

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Article Microbiology

Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene

Petra Louis et al.

ENVIRONMENTAL MICROBIOLOGY (2010)

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Article Food Science & Technology

Studies on antibacterial activity and antibacterial mechanism of a novel polysaccharide from Streptomyces virginia H03

Feng He et al.

FOOD CONTROL (2010)

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Article Food Science & Technology

Diversity of stress tolerance in Lactobacillus plantarum, Lactobacillus pentosus and Lactobacillus paraplantarum: A multivariate screening study

Eugenio Parente et al.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2010)

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Article Biochemistry & Molecular Biology

Classification of Fermented Soymilk during Fermentation by H-1 NMR Coupled with Principal Component Analysis and Elucidation of Free-Radical Scavenging Activities

Seung-Ok Yang et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2009)

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Article Biochemistry & Molecular Biology

TNF-α induces two distinct caspase-8 activation pathways

Lai Wang et al.

CELL (2008)

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Review Food Science & Technology

Use of nisin and other bacteriocins for preservation of dairy products

A. Sobrino-Lopez et al.

INTERNATIONAL DAIRY JOURNAL (2008)

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Article Agriculture, Multidisciplinary

Synthesis of conjugated linoleic acid by human-derived Bifidobacterium breve LMC 017:: Utilization as a functional starter culture for milk fermentation

Soo Hyun Chung et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

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Article Food Science & Technology

Metabolomics: applications to food science and nutrition research

David S. Wishart

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2008)

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Article Gastroenterology & Hepatology

Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection

Maria Van der Sluis et al.

GASTROENTEROLOGY (2006)

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Letter Biotechnology & Applied Microbiology

Untitled

L. Makras et al.

JOURNAL OF APPLIED MICROBIOLOGY (2006)

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Article Biotechnology & Applied Microbiology

Production of organic acids from fermentation of mannitol, fructooligosaccharide and inulin by a cholesterol removing Lactobacillus acidophilus strain

MT Liong et al.

JOURNAL OF APPLIED MICROBIOLOGY (2005)

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Article Biotechnology & Applied Microbiology

Growth and exopolysaccharide production during free and immobilized cell chemostat culture of Lactobacillus rhamnosus RW-9595M

D Bergmaier et al.

JOURNAL OF APPLIED MICROBIOLOGY (2005)

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Article Nutrition & Dietetics

Physiology of folate and vitamin B12 in health and disease

PJ Stover

NUTRITION REVIEWS (2004)

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Article Multidisciplinary Sciences

Complete genome sequence of Lactobacillus plantarum WCFS1

M Kleerebezem et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Food Science & Technology

Exopolysaccharide-producing Streptococcus thermophilus strains as functional starter cultures in the production of fermented milks

L De Vuyst et al.

INTERNATIONAL DAIRY JOURNAL (2003)

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