4.2 Article

Mechanism of simulated lunar dust-induced lung injury in rats based on transcriptomics

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors

Tamera D. Hughes et al.

Summary: Under inflammatory conditions, the upregulation of kynurenine 3-monooxygenase (KMO) enzyme leads to the production of toxic metabolites associated with various diseases. Developing KMO inhibitors to reduce the production of these toxic metabolites is necessary. The KMO crystal structure provides an opportunity for structure-based inhibitor design. This review discusses the kynurenine pathway, KMO enzyme, and the potential clinical use of KMO inhibitors.

MOLECULES (2022)

Article Environmental Sciences

Gene expression in human umbilical vein endothelial cells exposed to fine particulate matter: RNA sequencing analysis

Zhixiang Zhou et al.

Summary: Exposure to PM2.5 is linked to cardiovascular diseases, and this study investigated the molecular mechanisms of PM2.5-induced CVDs toxicity in HUVECs. RNA sequencing revealed differential expression of genes involved in metabolism, oxidative stress, inflammation, and vascular dysfunction. The findings contribute to a better understanding of the mechanisms underlying PM2.5-induced cardiovascular diseases.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2022)

Review Immunology

Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system

Moein Ala

Summary: This review explores the three metabolic pathways of tryptophan in the intestines and their impact on IBD and colorectal cancer. Indole metabolites can alleviate colitis and protect against colorectal cancer, while the serotonin system follows a more complex and receptor-specific pattern. The interactions between tryptophan metabolites and intracellular signaling pathways are crucial for understanding the pathophysiology of these diseases.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2022)

Article Chemistry, Multidisciplinary

BAFF, involved in B cell activation through the NF-κB pathway, is related to disease activity and bone destruction in rheumatoid arthritis

Ling-ling Zhang et al.

Summary: The study found that the serum BAFF level is significantly higher in rheumatoid arthritis patients, and is positively correlated with clinical variables, laboratory parameters, and X-ray scores. BAFF is involved in the differentiation, proliferation, and activation of B cells in rheumatoid arthritis through the NF-kappa B signaling pathway.

ACTA PHARMACOLOGICA SINICA (2021)

Article Environmental Sciences

Exposure to PM2.5 during pregnancy causes lung inflammation in the offspring: Mechanism of action of mogrosides

Renshi Li et al.

Summary: Exposure to PM2.5 during pregnancy can cause inflammation in the lungs of the offspring in rats, but this effect can be significantly alleviated by intervention with MGs. The study suggests that MGs may target Pla2g2d to improve PM2.5-induced lung injury.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Transcriptomics changes and the candidate pathway in human macrophages induced by different PM2.5 extracts*

Jing An et al.

Summary: PM2.5 is a global environmental issue that poses a serious threat to human health. Analysis of different PM2.5 extracts on macrophages revealed that water extracts influence oxidative stress and inflammation, while dichloromethane extracts are related to cell cycle processes. Seasonal variations in PM2.5 extracts may be influenced by contents of PAHs and metal ions, with potential implications for biological effects.

ENVIRONMENTAL POLLUTION (2021)

Article Multidisciplinary Sciences

Investigating the microwave heating behaviour of lunar soil simulant JSC-1A at different input powers

Sungwoo Lim et al.

Summary: Our experiment found that higher microwave powers can generate materials with the highest yields and strongest microstructures in the shortest fabrication times. Thermal runaway improves the efficiency of microwave heating once triggered, which is crucial for future lunar ISRU demonstration missions.

SCIENTIFIC REPORTS (2021)

Article Environmental Sciences

Olivine Dissolution in Simulated Lung and Gastric Fluid as an Analog to the Behavior of Lunar Particulate Matter Inside the Human Respiratory and Gastrointestinal Systems

Donald A. Hendrix et al.

Summary: This study investigated the dissolution of olivine in simulated lung and gastric fluids, revealing that inhaled olivine particles may release toxic substances in lung fluid for up to 5-6 days. It was found that inhaled lunar dust containing olivine could settle in the human lungs for years and potentially induce long-term health effects.

GEOHEALTH (2021)

Article Environmental Sciences

Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats

Yan Sun et al.

ENVIRONMENTAL TOXICOLOGY (2019)

Article Medicine, General & Internal

Research on rat's pulmonary acute injury induced by lunar soil simulant

Yan Sun et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2018)

Review Immunology

BAFF and BAFF-Receptor in B Cell Selection and Survival

Cristian R. Smulski et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Gastroenterology & Hepatology

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

Susanna Nikolaus et al.

GASTROENTEROLOGY (2017)

Letter Allergy

Does size really matter?: Relationship of particle size to lung deposition and exhaled fraction

Sunny Jabbal et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases

Ping Song et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Article Engineering, Aerospace

A lunar dust simulant: CLDS-i

Hong Tang et al.

ADVANCES IN SPACE RESEARCH (2017)

Review Rheumatology

The BAFF/APRIL system in SLE pathogenesis

Fabien B. Vincent et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

Article Toxicology

Toxicity of lunar dust assessed in inhalation-exposed rats

Chiu-wing Lam et al.

INHALATION TOXICOLOGY (2013)

Review Biochemistry & Molecular Biology

TNFR1-induced activation of the classical NF-κB pathway

Harald Wajant et al.

FEBS JOURNAL (2011)

Article Multidisciplinary Sciences

Regulation of type 17 helper T-cell function by nitric oxide during inflammation

Wanda Niedbala et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Food Science & Technology

Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells

Leonie E. C. van Meijl et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2010)

Article Engineering, Aerospace

CAS-1 lunar soil simulant

Zheng Yongchun et al.

ADVANCES IN SPACE RESEARCH (2009)

Article Engineering, Electrical & Electronic

Particle removal by electrostatic and dielectrophoretic forces for dust control during lunar exploration missions

C. I. Calle et al.

JOURNAL OF ELECTROSTATICS (2009)

Article Geochemistry & Geophysics

Lunar dust and lunar simulant activation' and monitoring

William T. Wallace et al.

METEORITICS & PLANETARY SCIENCE (2009)

Review Immunology

NF-kappa B Signaling Pathway and Its Therapeutic Implications in Human Diseases

Fazlul H. Sarkar et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2008)

Article Engineering, Aerospace

Characterization of lunar dust for toxicological studies. I: Particle size distribution

Jaesung Park et al.

JOURNAL OF AEROSPACE ENGINEERING (2008)

Review Nutrition & Dietetics

Amino acids and immune function

Peng Li et al.

BRITISH JOURNAL OF NUTRITION (2007)

Article Nutrition & Dietetics

Effect of aspartate and asparagine supplementation on fatigue determinants in intense exercise

ML Marquezi et al.

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM (2003)