Dual photoresponsive & water-triggered nitric oxide releasing materials based on rhodium-based metal-organic polyhedra

The exogenous administration of nitric oxide (NO) is considered a potential therapeutic treatment against a great variety of diseases due to its significant role in multiple physiological functions. Due to the gaseous nature, short lifetime and dose- and tissue-dependent activity of this molecule, the development of new administration procedures is required to control the NO delivery in terms of dosage, timing, and location. In this work, we propose a new molecular material based on robust metal-organic polyhedra (MOPs) for controlled NO release. We select dirhodium paddlewheel complex-based cuboctahedral MOPs (RhMOP), in which NO can chemically coordinate to the open-metal sites at the axial sites of dirhodium paddlewheel moieties. We further prepare amorphous coordination polymer particles (CPPs) by connecting RhMOP with bis(imidazole) linkers at the external axial sites. Both molecular MOPs and polymeric CPPs show relevant NO payloads and the release of NO can be triggered by two different stimuli: light and humidity. We show that imidazole ligands coordinating to the external axial sites of the paddlewheel moieties tune the light-triggered NO release property. We further demonstrate that the size and the extrinsic pores of CPPs are important for enhanced NO release. Porous materials based on robust rhodium-based metal-organic polyhedra have relevant NO payloads and release them in response to two different stimuli: light and humidity.

Automated summary

In this study, a new molecular material based on metal-organic polyhedra is proposed for controlled release of nitric oxide (NO). These porous materials, with significant NO payloads, can be triggered to release NO by light and humidity, making them potentially effective for treating various diseases.