☆ 4.7 Review

Retinoic acid signaling in development and differentiation commitment and its regulatory topology

CHEMICO-BIOLOGICAL INTERACTIONS (2024)

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Cytoskeletal orchestration of glucose uptake in Sertoli cell to support efferocytosis of apoptotic germ cells

Di Wu et al.

Summary: This study reveals the correlation between beta II-spectrin and glucose metabolism as well as cytoskeletal structure in Sertoli cells. Deficiency of beta II-spectrin impairs glucose uptake and lactate production in Sertoli cells, leading to disrupted cytoskeleton and blood-testis barrier integrity, ultimately affecting efferocytosis. The findings suggest a potential link between beta II-spectrin deregulation and male infertility.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2023)

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BDNF signaling in context: From synaptic regulation to psychiatric disorders

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Summary: This review examines the importance of spatial and temporal factors on BDNF activity, particularly in processes such as synaptogenesis, plasticity, and psychiatric disorder treatment. Understanding the fundamental physiology of BDNF and new approaches to control its signaling in time and space can lead to improved therapeutics and patient outcomes.

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Deneddylation of PML/RARα reconstructs functional PML nuclear bodies via orchestrating phase separation to eradicate APL

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Summary: Acute promyelocytic leukemia (APL) is driven by the oncoprotein PML/RAR alpha, which disrupts the construction of PML nuclear bodies (NBs). The disrupted NB assembly in APL is caused by neddylation-induced aberrant phase separation of PML/RAR alpha. Deneddylation restores the phase separation process, suppresses leukemogenesis, and can be targeted for APL eradication.

CELL DEATH AND DIFFERENTIATION (2022)

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Article Cell & Tissue Engineering

Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity

Katharina Schoenberger et al.

Summary: This study investigates the complex regulatory networks that preserve stemness in hematopoietic stem cells and uncovers a non-classical retinoic acid signaling axis that controls their function. The findings highlight the importance of a single metabolite in controlling stem cell fate through epigenetic and transcriptional attributes.

CELL STEM CELL (2022)

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Article Oncology

Evaluation of a DNA demethylating agent in combination with all-trans retinoic acid for IDH1-mutant gliomas

Marina da Costa Rosa et al.

Summary: In IDH-mutant gliomas, the combination of DNA demethylating agent 5-Azacytidine and retinoic acid (atRA) can reduce cell proliferation, increase differentiation marker expression, and induce apoptosis. However, in an orthotopic mouse model, the combination did not improve survival, highlighting the need for further optimization and preclinical studies.

NEURO-ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Alternative splicing and MicroRNA: epigenetic mystique in male reproduction

Di Wu et al.

Summary: Infertility is a serious global health issue with significant socio-economic impacts, predominantly caused by male factors. The post-transcriptional gene regulation mechanisms of alternative splicing and miRNA-mediated RNA silencing play crucial roles in male infertility, and paternal inputs such as unhealthy lifestyle can influence offspring through miRNA-mediated epigenetic inheritance.

RNA BIOLOGY (2022)

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Article Microbiology

CRISPR Interference Reveals That All-Trans-Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A

Gregory H. Babunovic et al.

Summary: The study found that the application of all-trans-retinoic acid (ATRA) can enhance the control of Mycobacterium tuberculosis (Mtb) by human macrophages, which is achieved by altering macrophage cholesterol trafficking and lipid metabolism. In addition, CRISPR interference screening was used to identify specific genes required for Mtb survival in ATRA-activated macrophages.

MBIO (2022)

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Article Allergy

The bile acid-activated retinoic acid response in dendritic cells is involved in food allergen sensitization

Renlan Wu et al.

Summary: This study demonstrates that depletion of commensal gut bacteria enhances retinoic acid (RA) signaling in mucosal dendritic cells (DCs). RA signaling in DCs is crucial for the production of food allergen-specific IgE and IgG1. Antibiotics induce an enlarged bile acid (BA) pool, leading to dysregulated BA profiles that enhance RA signaling in mucosal DCs.

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Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis

Kaori Endo-Umeda et al.

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Article Hematology

Suppression of MYC by PI3K/AKT/mTOR pathway inhibition in combination with all-trans retinoic acid treatment for therapeutic gain in acute myeloid leukaemia

Sven Stengel et al.

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BRITISH JOURNAL OF HAEMATOLOGY (2022)

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Mouse oocytes develop in cysts with the help of nurse cells

Wanbao Niu et al.

Summary: Research findings show that mouse germline cysts periodically activate nurse cells for cytoplasmic transfer, which leads to shrinkage and turnover within 2 days. Nurse cells cluster with pro-oocyte sisters before initiation of transfer, but separate during the final 2 days. Genes promoting oocyte development and nurse cell programmed cell death (PCD) are upregulated, while genes repressing transfer are under-expressed.

CELL (2022)

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Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease

Rui-Yuan Pan et al.

Summary: The dysregulation of microglial function in Alzheimer's disease is associated with the glycolysis/H4K12la/PKM2 positive feedback loop. Inhibiting this loop can ameliorate pathological changes and cognitive deficits in a mouse model. This suggests that disrupting the positive feedback loop may be a potential therapeutic approach for treating AD.

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The Impact of Vitamin A Deficiency on Tuberculosis Progression

Brendan K. Podell et al.

Summary: This study demonstrates an association between baseline vitamin A deficiency and increased risk of tuberculosis progression among individuals living with HIV. Guinea pigs deficient in vitamin A also exhibited more severe pathological responses and increased bacterial growth after TB infection.

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Article Gastroenterology & Hepatology

Oral Delivery of Encapsulated All-Trans Retinoic Acid Ameliorates Disease in Rodent Models of Colitis

Ferdinando Nicoletti et al.

Summary: A poly(lactic-co-glycolic acid) (PLGA) microsphere encapsulated all-trans retinoic acid (ATRA) formulation was developed to target immune structures in the gut and limit systemic exposure, showing potential for attenuating inflammatory bowel disease (IBD).

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Article Neurosciences

NFkB-signaling promotes glial reactivity and suppresses Muller glia-mediated neuron regeneration in the mammalian retina

Isabella Palazzo et al.

Summary: Muller glia (MG) in mammalian retinas are incapable of regenerating neurons after damage, whereas the MG in lower vertebrates regenerate functional neurons. Identification of cell signaling pathways and gene regulatory networks that regulate MG-mediated regeneration is key to harnessing the regenerative potential of MG. In this study, NFkB signaling was found to play a crucial role in regulating immune cell accumulation and suppressing the neurogenic potential of MG after damage. Inhibition of NFkB enhanced the reprogramming of MG into neuron-like cells. Additionally, TGF beta 2 signaling and suppression of NFI and Id transcription factors were coordinated with NFkB signaling to regulate MG-mediated regeneration.

GLIA (2022)

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Dysregulated Retinoic Acid Signaling in the Pathogenesis of Pseudoexfoliation Syndrome

Matthias Zenkel et al.

Summary: This study demonstrates that decreased retinoic acid (RA) signaling in conjunction with hyperactivated TGF-beta1/Smad signaling is a driver of Pseudoexfoliation (PEX)-associated fibrosis. Restoration of RA signaling may be a promising strategy for anti-fibrotic intervention in patients with PEX syndrome and glaucoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Activity-dependent modulation of neuronal KV channels by retinoic acid enhances CaV channel activity

Eric de Hoog et al.

Summary: The metabolite of vitamin A, retinoic acid (RA), influences neuronal firing by inducing spike broadening and complex spiking, and modulates Ca2+ influx through CaV2 channels by enhancing inactivation of delayed rectifier voltage-gated K+ channels.

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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Jia Xiong et al.

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Zinc oxide nanoparticle causes toxicity to the development of mouse oocyte and early embryo

Chunjie Huang et al.

Summary: This study reported the hazardous effects of zinc oxide nanoparticles (ZnO NP) on the development of mouse oocytes and pre-implantation embryos. ZnO NP compromised the meiosis process, caused cellular stress, activated autophagy and apoptosis, disrupted cytoskeleton architecture, and induced DNA damage, leading to developmental arrest and degeneration of oocytes and early embryos. The study suggests that ZnO NP is toxic to oocytes and embryos in mammals, highlighting the need for careful evaluation of human exposure and its impact on reproductive health.

TOXICOLOGY LETTERS (2022)

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Article Multidisciplinary Sciences

Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery

Zhanna Alekseenko et al.

Summary: Stem cell therapies utilizing retinoic acid (RA) signaling have shown promise in providing treatment for Parkinson's disease, by deriving dopamine neurons and restoring motor deficits in animal models.

NATURE COMMUNICATIONS (2022)

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Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling

Dina Rekler et al.

Summary: This study reveals that retinoic acid synthesized in the neural tube regulates the end of neural crest development by inhibiting BMP signaling. The activity of neural crest-specific genes also inhibits retinoic acid synthesis in the roof plate. There is a mutual repressive interaction between neural crest and roof plate traits, compromising the cellular and molecular architecture of the roof plate.

ELIFE (2022)

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Article Biochemistry & Molecular Biology

Retinoic acid restores the levels of cellular cholesterol in Leishmania donovani infected macrophages by increasing npc1 and npc2 expressions

Satya Prakash et al.

Summary: This study observed the loss of cellular cholesterol in infected macrophages in the absence of retinoic acid (RA) and found that Leishmania utilizes host cholesterol for infection. Supplementation of RA restored cellular cholesterol levels and resulted in decreased parasite load. Therefore, RA supplementation could be a potential advancement in the treatment and cure of visceral leishmaniasis (VL) patients.

BIOCHIMIE (2022)

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Article Multidisciplinary Sciences

All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity

Jafar S. Hasbullah et al.

Summary: This study explores the effects of activating the retinoic acid pathway using all-trans retinoic acid (ATRA) on anthracycline-induced cardiotoxicity (ACT). The findings demonstrate that ATRA can reduce the toxicity of anthracyclines on human cardiomyocytes by regulating gene expression and enhancing cell survival. In a mouse model, ATRA treatment improves heart function and reduces pathological changes associated with ACT.

PLOS ONE (2022)

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Article Oncology

Retinoic Acid Receptor Activation Reduces Metastatic Prostate Cancer Bone Lesions by Blocking the Endothelial-to-Osteoblast Transition

Guoyu Yu et al.

Summary: This study provides mechanistic insights into how RAR agonists suppress prostate cancer-induced bone formation and offers a rationale for developing RAR agonists for prostate cancer bone metastasis therapy.

CANCER RESEARCH (2022)

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Article Cell Biology

Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis

Linyi Zhu et al.

Summary: More than 40% of individuals will develop osteoarthritis (OA) during their lifetime, yet there are currently no licensed disease-modifying treatments for this disabling condition. Common polymorphic variants in ALDH1A2, which encodes the key enzyme for synthesis of all-trans retinoic acid (atRA), are associated with severe hand OA. This study confirms the association between ALDH1A2 risk variants and hand OA and identifies retinoic acid metabolism blocking agents (RAMBAs) as potential disease-modifying drugs for OA.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity

Shruti Thapliyal et al.

Summary: Homeostatic synaptic plasticity is a mechanism that adjusts synaptic strength to maintain network stability. This study reveals that synaptic signaling through retinoic acid and its receptor, RAR alpha, regulates presynaptic neurotransmitter release to achieve homeostatic adjustment.

ELIFE (2022)

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Article Cell Biology

Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cells

Di Wu et al.

Summary: This study identifies Smtnl2 as a crucial determinant for Sertoli cells in supporting spermatogenesis by regulating cytoskeleton organization and phagocytosis. Smtnl2-deficient Sertoli cells show defective ability to engulf apoptotic germ cells, accompanied by alterations in glucose metabolism and activation of downstream signaling pathways. In vivo silencing of Smtnl2 disrupts cytoskeleton architecture and blood-testis barrier integrity, leading to the detachment of germ cells into the lumen.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2022)

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Article Cell & Tissue Engineering

All-trans retinoic acid modulates pigmentation, neuroretinal maturation, and corneal transparency in human multiocular organoids

Helena Isla-Magrane et al.

Summary: The study found that ATRA can modulate corneal epithelial integrity and transparency, photoreceptor development and maturation, and the pigmentation of RPE cells in a dose-dependent manner. These experiments revealed the high relevance of ATRA during ocular tissue development and its use as a potential new strategy to better modulate the development and maturation of ocular tissue through temporal and spatial control of ATRA signaling.

STEM CELL RESEARCH & THERAPY (2022)

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Article Cell & Tissue Engineering

Retinoic acid inhibits the angiogenesis of human embryonic stem cell-derived endothelial cells by activating FBP1-mediated gluconeogenesis

Zhuangzhuang Yang et al.

Summary: This study demonstrates that retinoic acid inhibits angiogenesis and suppresses glycolysis in human embryonic stem cell-derived endothelial cells. The inhibitory effect is mediated by upregulation of fructose-1,6-bisphosphatase 1 (FBP1), a key enzyme in gluconeogenesis, and is dependent on the retinoic acid receptor (RAR). These findings suggest that FBP1 may serve as a novel therapeutic target for pathological angiogenesis.

STEM CELL RESEARCH & THERAPY (2022)

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Review Biochemistry & Molecular Biology

Potential Therapeutic Effect of All-Trans Retinoic Acid on Atherosclerosis

Qile Deng et al.

Summary: Atherosclerosis is a major risk factor for heart attacks and stroke, and all-trans retinoic acid (ATRA) plays an important role in inflammatory cells involved in this process.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner

Magda Zachara et al.

Summary: This study characterizes the different subpopulations of adipose stem and precursor cells (ASPCs) and focuses on the CD142(+) ASPCs, which demonstrate non-adipogenic and anti-adipogenic properties. These characteristics are age-dependent and regulated by secretory factors and the retinoic acid signaling pathway.

EMBO JOURNAL (2022)

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Review Endocrinology & Metabolism

Understanding lactate sensing and signalling

Michelangelo Certo et al.

Summary: Metabolites generated from cellular and tissue metabolism, such as lactate, have been found to have signaling functions and play important roles in various physiological and pathological processes.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2022)

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Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation

Wenzhe Luo et al.

Summary: This study reveals the importance of retinoic acid signaling in the maintenance of the quiescent state of satellite cells, achieved through regulation of protein translation initiation.

CELL DEATH & DISEASE (2022)

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Article Oncology

The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation

Ruth Meier et al.

Summary: The combination of DAC and ATRA shows cooperative antileukemic effects in AML, leading to the derepression of commonly regulated transcripts and changes in overall chromatin accessibility. This synergy is demonstrated through gene expression studies and transcriptional induction, as well as derepression of transposable elements resulting in a viral mimicry response.

BLOOD CANCER JOURNAL (2022)

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Article Cell & Tissue Engineering

Retinoic acid delays initial photoreceptor differentiation and results in a highly structured mature retinal organoid

Carla Sanjurjo-Soriano et al.

Summary: This study demonstrates the importance of supplemented media for culturing retinal organoids and shows that retinoic acid plays a crucial role in inducing rod cell fate and enhancing the organization of the photoreceptor layer.

STEM CELL RESEARCH & THERAPY (2022)

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Article Cell Biology

Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice

Fathima N. Cassim Bawa et al.

Summary: The study reveals the important role of macrophage retinoic acid receptor alpha (RARα) in regulating atherosclerosis. It protects against atherosclerosis by inducing cholesterol efflux and inhibiting inflammation.

CELLS (2022)

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Article Microbiology

Retinoic Acid Increases Cellular Cholesterol in Leishmania donovani-Infected Macrophages in an mTOR-Independent Manner

Satya Prakash et al.

Summary: Infection with Leishmania donovani reduces cellular cholesterol levels, but retinoic acid (RA) can restore cholesterol levels and reduce parasite burden in macrophages.

MICROBIOLOGY SPECTRUM (2022)

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Article Multidisciplinary Sciences

Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration

Michael Telias et al.

Summary: Rod and cone photoreceptors degenerate in retinitis pigmentosa (RP). However, downstream neurons survive and undergo physiological changes. Retinoic acid (RA) is identified as the molecular trigger for hyperactivity in retinal ganglion cells (RGCs). Inhibiting RA synthesis with disulfiram improves visual perception in vision-impaired mice.

SCIENCE ADVANCES (2022)

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Article Endocrinology & Metabolism

Identification of a regulatory pathway inhibiting adipogenesis via RSPO2

Hua Dong et al.

Summary: Dong and Sun et al. demonstrate the inhibitory role of adipogenesis regulatory cells in murine white adipose tissue through RSPO2. They show that RSPO2 regulates the maturation of early progenitor cells via Lgr4. This study highlights the importance of cellular crosstalk in adipogenesis and its impact on adipose tissue homeostasis.

NATURE METABOLISM (2022)

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Article Hematology

A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia

Yun Tan et al.

Summary: The activation function of PML/RAR alpha through recruiting P300 and HDAC1 and forming super-enhancers, and its synergistic effects with all-trans retinoic acid and arsenic trioxide in controlling super-enhancer-associated PML/RAR alpha-regulated targets in APL cells are highlighted. The study demonstrated the necessity of the PML/RAR alpha-activated target gene GFI1 for maintaining APL cells and the interplay between GFI1 and PML/RAR alpha in coregulating target genes on chromatin. Genomic insight into the dual role of fusion transcription factors in transcriptional deregulation to drive leukemia development is provided, emphasizing the importance of globally dissecting regulatory circuits.

BLOOD (2021)

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An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

Eugen Dhimolea et al.

Summary: Our study reveals that treatment-persistent tumor cells in cancer patients adopt a reversible transcriptional program similar to embryonic diapause, which allows them to resist chemotherapy-induced cytotoxicity. Inhibiting Myc activity or interfering with the diapause-like adaptation could be potential therapeutic strategies against chemotherapy-persistent tumor cells.

CANCER CELL (2021)

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Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution

Anitta Kinga Sarvari et al.

Summary: The study utilized single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose tissue in response to high-fat-diet-induced obesity, revealing changes in adipocyte subpopulations and increased lipid-handling genes in macrophages with obesity.

CELL METABOLISM (2021)

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Review Ophthalmology

Pseudoexfoliation syndrome and glaucoma: from genes to disease mechanisms

Ursula Schloetzer-Schrehardt et al.

Summary: Recent research has identified seven loci associated with the risk of PEX that surpass genome-wide significance. The main genetic effect locus is LOXL1, with common risk variants showing reversed effects in different ethnicities. Other PEX-associated genetic variants have provided insights into additional disease processes and pathways, including ubiquitin-proteasome function, calcium signaling, and lipid biosynthesis. Integration of multiomics data has further contributed to understanding the complex etiology underlying PEX syndrome and glaucoma.

CURRENT OPINION IN OPHTHALMOLOGY (2021)

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Article Cell Biology

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Brennan D. Gerlach et al.

Summary: This study demonstrates that nucleotides derived from apoptotic cell DNA hydrolysis by phagolysosomal DNase2a activate a pathway promoting non-inflammatory macrophage proliferation. The findings suggest that these nucleotides can amplify the resolution benefit by increasing the number of efferocytosing macrophages, thus enhancing tissue resolution in various experimental models including peritonitis, thymocyte apoptosis, and atherosclerosis regression.

CELL METABOLISM (2021)

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Acute Myeloid Leukemia, Version 2.2021 Featured Updates to the NCCN Guidelines

Daniel A. Pollyea et al.

Summary: The NCCN Guidelines for Acute Myeloid Leukemia provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment. Recent updates focus on familial genetic alterations, treatment strategies for low-risk and favorable-risk AML, venetoclax-based therapies, and considerations for patients who prefer not to receive blood transfusions.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

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Article Environmental Sciences

Effect of Radiation on the Essential Nutrient Homeostasis and Signaling of Retinoids in a Non-human Primate Model with Minimal Bone Marrow Sparing

Jianshi Yu et al.

Summary: High-dose radiation exposure can lead to hematopoietic and gastrointestinal acute radiation syndromes, followed by delayed effects such as damage to various tissues and inflammation. Radiation may disrupt retinoid metabolism, playing a crucial role in inhibiting inflammation and fibrosis development.

HEALTH PHYSICS (2021)

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Article Multidisciplinary Sciences

Arsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial)

Li Chen et al.

Summary: This study found that the combination of all-trans retinoic acid and arsenic trioxide in treating acute promyelocytic leukemia during consolidation therapy is not inferior to traditional chemotherapy regimens and shows better outcomes in reducing relapse and toxicity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Oncology

All-trans retinoic acid induces leukemia resistance to NK cell cytotoxicity by down-regulating B7-H6 expression via c-Myc signaling

Guoshuai Cao et al.

Summary: This study revealed that all-trans retinoic acid (atRA) promotes leukemia cell resistance against NK cell-mediated lysis by down-regulating B7-H6 expression, while epigenetic modifications such as DNA methylation and histone deacetylase were not responsible for this down-regulation. Additionally, the c-Myc signaling pathway was found to be involved in atRA-induced tumor resistance against NK cells.

CANCER COMMUNICATIONS (2021)

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Article Biology

PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling

Mamta Verma et al.

Summary: This study demonstrates that protein arginine methyltransferase 3 (PRMT3) interacts with and inhibits retinal dehydrogenase ALDH1A1, negatively regulating the expression of retinoic acid responsive genes. PRMT3 affects diverse biological processes not only by globally regulating protein function through methylation but also by regulating gene expression.

COMMUNICATIONS BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Calcitriol and Retinoic acid antagonize each other to suppress the production of IL-9 by Th9 cells

Shachi Pranjal Vyas et al.

Summary: Vitamins play a crucial role in regulating the differentiation of T helper cells, with calcitriol and retinoic acid exhibiting hormone-like properties and antagonizing each other in this process. The recruitment of PU.1 to the Il9 gene is significantly impaired in the presence of either vitamin alone, but their combined treatment increases the recruitment. Interestingly, retinoic acid dampens the binding of VDR on the Il9 gene, negating the effect of calcitriol.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Article Multidisciplinary Sciences

Symmetry breaking in the female germline cyst

D. Nashchekin et al.

Summary: By recruiting Patronin to the fusome and stabilizing more MTs, a polarized MT network is formed, along which Dynein transports oocyte determinants into the presumptive oocyte, breaking symmetry and selecting the oocyte.

SCIENCE (2021)

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Article Multidisciplinary Sciences

All-trans-retinoic acid ameliorates atherosclerosis, promotes perivascular adipose tissue browning, and increases adiponectin production in Apo-E mice

Malgorzata Kalisz et al.

Summary: The findings suggest that atRA ameliorates atherosclerosis in Apo-E mice, induces browning of PVAT, and increases adiponectin production in PVAT. Furthermore, atRA increases nitric oxide levels in the aorta of Apo-E mice without affecting adiponectin concentration.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action

Kanzo Suzuki et al.

Summary: Acute inhibition of eEF2K activity induces rapid synaptic scaling in the hippocampus, while RA signaling pathway can also elicit similar synaptic scaling independently of eEF2K function. Activation of RAR alpha by retinoic acid leads to rapid antidepressant effects similar to ketamine.

CELL REPORTS (2021)

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Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis

Anna Heinrich et al.

Summary: Cdc42 is essential for Sertoli cell polarity and sperm production, as its deletion leads to increased apoptosis and disrupted polarity in the testes, ultimately affecting the progression of spermatogenesis.

CELL REPORTS (2021)

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Evolving concepts in NAD+ metabolism

Claudia C. S. Chini et al.

Summary: NAD and NADP have diverse roles beyond co-factors in oxidation-reduction reactions, including signaling pathways, post-translational modifications, epigenetic changes, and RNA regulation. Recent studies have shown that NAD metabolism is highly dynamic with a short halflife in some tissues, and new concepts are emerging in the roles of NAD pathway metabolites in various disease states. Resolving open questions in NAD biology will lead to significant advancements in the field.

CELL METABOLISM (2021)

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Article Cell Biology

Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation

Long Shen et al.

Summary: Deficiencies in serine metabolism enhance antiviral immunity, with PHGDH playing a key role in regulating IFN-beta production to boost the body's defense against viruses.

CELL METABOLISM (2021)

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Article Endocrinology & Metabolism

Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis

Megan J. Ritter et al.

Summary: NCOR1 and SMRT play critical and specific roles in nuclear receptor action, with some overlapping functions. While SMRT plays little role in thyroid hormone signaling in the liver, it is involved in hepatic metabolism and lipogenesis.

MOLECULAR METABOLISM (2021)

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Review Oncology

Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies

Julia Stomper et al.

Summary: Aberrant DNA methylation is crucial in tumor development and progression. DNA hypomethylating agents can reverse DNA methylation and re-program tumor cells, but long-term use leads to resistance. First-generation HMAs are now standard for treating acute myeloid leukemia and myelodysplastic syndromes, but resistance is a growing concern.

LEUKEMIA (2021)

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Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

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Article Medicine, Research & Experimental

Cardiac retinoic acid levels decline in heart failure

Ni Yang et al.

Summary: The study showed that there is a decline in cardiac ATRA in heart failure, despite sufficient reserves of cardiac vitamin A. Strategies to normalize ATRA metabolism, such as CYP26 inhibition, may have therapeutic potential in preventing cardiac remodeling and functional decline. This suggests that low cardiac ATRA attenuates critical gene expression programs in heart failure.

JCI INSIGHT (2021)

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Article Chemistry, Multidisciplinary

Retinoic Acid-Loaded Dendritic Polyglycerol-Conjugated Gold Nanostars for Targeted Photothermal Therapy in Breast Cancer Stem Cells

Yuanwei Pan et al.

Summary: A targeted and RA-loaded nanoplatform was developed to effectively suppress the growth of breast cancer stem cells and tumor formation through multivalent targeted capability and synergistic effect of photothermal therapy.

ACS NANO (2021)

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Article Hematology

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative

Sabine Kayser et al.

Summary: This study characterized 154 patients with acute promyelocytic leukemia and evaluated the real-life outcome after treatment with arsenic trioxide and all-trans retinoic acid. The treatment showed good efficacy and durability in adults with low/intermediate-risk acute promyelocytic leukemia, with age above 70 years associated with shorter overall survival. No relapses have been observed so far.

HAEMATOLOGICA (2021)

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Article Hematology

A Pin1/PML/P53 axis activated by retinoic acid in NPM-1c acute myeloid leukemia

Rita Hleihel et al.

Summary: The study indicates that PML is essential for RA-induced NPM-1c degradation, P53 activation, and cell death, with RA enhancing PML basal expression by inhibiting Pin1. This PML induction helps promote P53 activation, leading to a response to chemotherapy or arsenic in acute myeloid leukemia.

HAEMATOLOGICA (2021)

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Article Cell Biology

A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength

Patricia M. Horvath et al.

Summary: Recent studies have shown that protein translation can be regulated by spontaneous excitatory neurotransmission, while the impact of spontaneous neurotransmitter release on gene transcription remains unclear. Blocking spontaneous inhibitory events increases the transcription of BDNF and Npas4 through altered synaptic calcium signaling, which can be prevented by antagonism of NMDA receptors or L-type voltage-gated calcium channels. Transcription can be bidirectionally altered by manipulating spontaneous inhibitory, but not excitatory, currents. Moreover, blocking spontaneous inhibitory events results in multiplicative downscaling of excitatory synaptic strength, dependent on transcription and BDNF signaling. These findings highlight the role of spontaneous inhibitory neurotransmission in setting excitatory synaptic strength at rest.

CELL REPORTS (2021)

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Article Immunology

Clickable Vitamins as a New Tool to Track Vitamin A and Retinoic Acid in Immune Cells

Amelie V. Bos et al.

Summary: The uptake and metabolism of vitamin A within human immune cells has been difficult to study due to the small, lipophilic nature of retinoids. By synthesizing novel bio-orthogonal retinoid-based probes, researchers were able to monitor retinoid molecules in real-time in immune cells, revealing that various immune cell subsets have the capacity to internalize and metabolize retinoids. This study sheds light on the mechanism of vitamin A metabolism and its importance for human adaptive immunity.

FRONTIERS IN IMMUNOLOGY (2021)

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Letter Oncology

All-trans retinoic acid 45 mg/m2 is superior to 25 mg/m2 as the first induction regimen for the treatment of acute promyelocytic leukaemia: a retrospective analysis in a real-world clinical setting

Xinhui Zhang et al.

BLOOD CANCER JOURNAL (2021)

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Review Oncology

Emerging Players in Prostate Cancer-Bone Niche Communication

Giulia Furesi et al.

Summary: Patients with advanced prostate cancer often develop skeletal metastases that can lead to fractures, disability, and increased mortality. Interactions between tumor cells and osteoblasts are believed to play a major role in the osteotropism of prostate cancer. Prostate cancer-derived extracellular vesicles (EVs) are emerging as key players in reprogramming osteoblasts and supporting the formation of premetastatic niches, explaining the complexity of prostate cancer osteotropism.

TRENDS IN CANCER (2021)

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Review Oncology

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Xi Chen et al.

Summary: This review explores how ER stress in the tumor microenvironment can influence the functions of cancer cells and immune cells, leading to vulnerabilities that could be targeted by emerging therapeutic strategies. The tightly regulated processes of protein handling, modification, and folding in the ER determine cell function and survival, and disruptions in ER homeostasis can result in a state of persistent ER stress with pro-tumoral effects in cancer cells and immunomodulatory effects in immune cells.

NATURE REVIEWS CANCER (2021)

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Review Andrology

Cycles, waves, and pulses: Retinoic acid and the organization of spermatogenesis

Rachel Gewiss et al.

ANDROLOGY (2020)

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Article Cell & Tissue Engineering

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

Ashwini Hinge et al.

CELL STEM CELL (2020)

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Review Cardiac & Cardiovascular Systems

The Role of the Epicardium During Heart Development and Repair

Pearl Quijada et al.

CIRCULATION RESEARCH (2020)

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Article Oncology

Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 x 2, Phase II Trial

Michael Luebbert et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Review Biochemistry & Molecular Biology

Generation of Retinaldehyde for Retinoic Acid Biosynthesis

Olga V. Belyaeva et al.

BIOMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression

Samir Devalaraja et al.

CELL (2020)

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Editorial Material Cardiac & Cardiovascular Systems

New ACC Global Heart Attack Treatment Initiative Improving STEMI Care Worldwide

Benny Levenson et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Multidisciplinary Sciences

Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary

Anne-Amandine Chassot et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors

Nadege Vernet et al.

SCIENCE ADVANCES (2020)

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Article Cell Biology

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

Fuming Li et al.

NATURE CELL BIOLOGY (2020)

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Review Cell Biology

The clearance of dead cells by efferocytosis

Emilio Boada-Romero et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Cell Biology

Mechanisms, regulation and functions of the unfolded protein response

Claudio Hetz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Pharmacology & Pharmacy

NKp30-A prospective target for new cancer immunotherapy strategies

Pedro F. Pinheiro et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Vitamin A and Retinoic Acid in Cognition and Cognitive Disease

Marta U. Woloszynowska-Fraser et al.

ANNUAL REVIEW OF NUTRITION, VOL 40, 2020 (2020)

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Article Biochemistry & Molecular Biology

Expression and localization of retinoid receptors in the testis of normal and infertile men

Gui-Shuan Wang et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2020)

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Article Multidisciplinary Sciences

Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary

Wanbao Niu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis

Anna Shcherbina et al.

CELL REPORTS (2020)

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Article Immunology

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

Jacob A. Turner et al.

IMMUNITY (2020)

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Article Biochemistry & Molecular Biology

The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis

Natalie Bruiners et al.

JOURNAL OF LIPID RESEARCH (2020)

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Article Developmental Biology

Reduced retinoic acid synthesis accelerates prophase I and follicle activation

Roseanne Rosario et al.

REPRODUCTION (2020)

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Article Multidisciplinary Sciences

Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer

Hemant M. Kocher et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation

In Ha Cho et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells

LiangYu Zhao et al.

NATURE COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons

Bristol Denlinger et al.

JCI INSIGHT (2020)

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Article Reproductive Biology

Sources of all-trans retinal oxidation independent of the aldehyde dehydrogenase 1A isozymes exist in the postnatal testis

My-Thanh Beedle et al.

BIOLOGY OF REPRODUCTION (2019)

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Article Hematology

Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet

Miguel A. Sanz et al.

BLOOD (2019)

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Article Cell & Tissue Engineering

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

Nicola Vannini et al.

CELL STEM CELL (2019)

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Article Hematology

All-trans retinoic acid protects mesenchymal stem cells from immune thrombocytopenia by regulating the complement-interleukin-1β loop

Xiaolu Zhu et al.

HAEMATOLOGICA (2019)

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Article Neurosciences

Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration

Michael Telias et al.

NEURON (2019)

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Article Multidisciplinary Sciences

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

Qilin Gu et al.

SCIENCE (2019)

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Article Biochemistry & Molecular Biology

The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome

Daniel Berner et al.

HUMAN MOLECULAR GENETICS (2019)

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Article Biochemistry & Molecular Biology

Retinoid receptor-based signaling plays a role in voltage-dependent inhibition of invertebrate voltage-gated Ca2+ channels

Eric de Hoog et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Multidisciplinary Sciences

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

David Merrick et al.

SCIENCE (2019)

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Article Biology

Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice

Mina L. Kojima et al.

ELIFE (2019)

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Article Biochemistry & Molecular Biology

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

Weina Zhang et al.

CELL (2019)

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Article Developmental Biology

Retinoic acid signaling pathways

Norbert B. Ghyselinck et al.

DEVELOPMENT (2019)

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Article Biochemistry & Molecular Biology

The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance

Guo Zhong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Oncology

Connections between metabolism and epigenetics in cancers

Chitra Thakur et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Review Immunology

The Metabolic Signature of Macrophage Responses

Antonella Viola et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Medicine, Research & Experimental

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

C. Ronald Kahn et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Review Cell & Tissue Engineering

Endothelial progenitor cell therapy for chronic wound tissue regeneration

Komal Kaushik et al.

CYTOTHERAPY (2019)

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Article Multidisciplinary Sciences

Metabolic regulation of gene expression by histone lactylation

Di Zhang et al.

NATURE (2019)

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Article Food Science & Technology

The success and the challenge of all-trans retinoic acid in the treatment of cancer

Xiaoling Ni et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

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Article Immunology

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology

Daniella M. Schwartz et al.

IMMUNITY (2019)

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Article Biochemistry & Molecular Biology

Healthy infants harbor intestinal bacteria that protect against food allergy

Taylor Feehley et al.

NATURE MEDICINE (2019)

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Article Parasitology

Leishmania donovani reduces the levels of retinoic acid-synthesizing enzymes in infected macrophages and favoring its own survival

Pankaj Verma et al.

PARASITOLOGY RESEARCH (2019)

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Review Cell & Tissue Engineering

Endothelial Progenitor Cells Biology in Diabetes Mellitus and Peripheral Arterial Disease and their Therapeutic Potential

Anna Pysna et al.

STEM CELL REVIEWS AND REPORTS (2019)

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Review Genetics & Heredity

Genetics and functions of the retinoic acid pathway, with special emphasis on the eye

Brian Thompson et al.

HUMAN GENOMICS (2019)

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Review Immunology

Patrolling the vascular borders: platelets in immunity to infection and cancer

Florian Gaertner et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Oncology

Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress

S. Masciarelli et al.

LEUKEMIA (2018)

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Review Gastroenterology & Hepatology

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Wei Jia et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Article Cell & Tissue Engineering

Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Muller Glia-Derived Progenitor Cells in the Avian Retina

Levi Todd et al.

STEM CELLS (2018)

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Review Reproductive Biology

50 years of spermatogenesis: Sertoli cells and their interactions with germ cells

Michael D. Griswold

BIOLOGY OF REPRODUCTION (2018)

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Letter Hematology

Oral arsenic and all-trans retinoic acid for high-risk acute promyelocytic leukemia

Hong-Hu Zhu et al.

BLOOD (2018)

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Review Hematology

When the good go bad: Mutant NPM1 in acute myeloid leukemia

Preethi Kunchala et al.

BLOOD REVIEWS (2018)

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Article Cell Biology

Retinoic acid inhibits neuronal voltage-gated calcium channels

Eric de Hoog et al.

CELL CALCIUM (2018)

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Article Endocrinology & Metabolism

All-trans retinoic acid improves the viability of ischemic skin flaps in diabetic rat models

Zhenjun Weng et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

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Article Biochemistry & Molecular Biology

Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells

Suya Wang et al.

FASEB JOURNAL (2018)

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Article Biochemistry & Molecular Biology

The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis

Piyali Basu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Oncology

Oral arsenic plus retinoic acid versus intravenous arsenic plus retinoic acid for non-high-risk acute promyelocytic leukaemia: a non-inferiority, randomised phase 3 trial

Hong-Hu Zhu et al.

LANCET ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

Denise R. Minton et al.

MOLECULAR CELL (2018)

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Review Physiology

ENDOTHELIAL CELL METABOLISM

Guy Eelen et al.

PHYSIOLOGICAL REVIEWS (2018)

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Review Cell Biology

Rethinking Phagocytes: Clues from the Retina and Testes

Kristen K. Penberthy et al.

TRENDS IN CELL BIOLOGY (2018)

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Review Immunology

Antibiotics as Instigators of Microbial Dysbiosis: Implications for Asthma and Allergy

Tomasz P. Wypych et al.

TRENDS IN IMMUNOLOGY (2018)

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Review Immunology

Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism

Davide G. Franchina et al.

TRENDS IN IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia

Jacqueline Lehmann-Che et al.

NATURE COMMUNICATIONS (2018)

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Review Nutrition & Dietetics

The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis

Wishal D. Ramdas et al.

NUTRIENTS (2018)

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Review Immunology

Complement and the Regulation of T Cell Responses

Erin E. West et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

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Review Medicine, General & Internal

Leishmaniasis

Sakib Burza et al.

LANCET (2018)

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Article Multidisciplinary Sciences

A stromal cell population that inhibits adipogenesis in mammalian fat depots

Petra C. Schwalie et al.

NATURE (2018)

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Review Medicine, Legal

A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes

Qing Zhou et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2018)

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Article Multidisciplinary Sciences

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Shingo Kozono et al.

NATURE COMMUNICATIONS (2018)

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Article Microbiology

Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice

Joseph H. Skalski et al.

PLOS PATHOGENS (2018)

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Article Microbiology

Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance

Nathan D. Hicks et al.

NATURE MICROBIOLOGY (2018)

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Article Developmental Biology

Lens-regulated retinoic acid signalling controls expansion of the developing eye

Jonathan N. Smith et al.

DEVELOPMENT (2018)

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Review Oncology

Differentiation therapy revisited

Hugues de The

NATURE REVIEWS CANCER (2018)

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Article Endocrinology & Metabolism

Cellular Retinoic Acid-Binding Protein 1 Modulates Stem Cell Proliferation to Affect Learning and Memory in Male Mice

Yu-Lung Lin et al.

ENDOCRINOLOGY (2017)

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Review Immunology

Immunology of Food Allergy

Leticia Tordesillas et al.

IMMUNITY (2017)

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Article Immunology

Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages

Christel Goudot et al.

IMMUNITY (2017)

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Article Immunology

PML is a ROS sensor activating p53 upon oxidative stress

Michiko Niwa-Kawakita et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Medicine, General & Internal

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

Stephen Russell et al.

LANCET (2017)

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Article Biochemical Research Methods

Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

Sara Nolbrant et al.

NATURE PROTOCOLS (2017)

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Review Pharmacology & Pharmacy

Modulating putative endothelial progenitor cells for the treatment of endothelial dysfunction and cardiovascular complications in diabetes

Julien Wils et al.

PHARMACOLOGY & THERAPEUTICS (2017)

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Article Multidisciplinary Sciences

Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence

Antoine de Morree et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Review Immunology

Retinoic Acid and Immune Homeostasis: A Balancing Act

Martje N. Erkelens et al.

TRENDS IN IMMUNOLOGY (2017)

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Article Cell Biology

Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation

Bo Wang et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2017)

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Article Multidisciplinary Sciences

Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1

Francesca Pasutto et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells

Subbarayalu Panneerdoss et al.

NATURE COMMUNICATIONS (2017)

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Review Nutrition & Dietetics

Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis

Ana Canete et al.

NUTRIENTS (2017)

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Article Cell Biology

Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex

Haider M. Hassan et al.

CELL REPORTS (2017)

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Article Endocrinology & Metabolism

Novel concepts in the aetiology of male reproductive impairment

Herman Tournaye et al.

LANCET DIABETES & ENDOCRINOLOGY (2017)

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Review Public, Environmental & Occupational Health

Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis

Rupert R. A. Bourne et al.

LANCET GLOBAL HEALTH (2017)

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Article Hematology

Oral all-trans retinoic acid plus danazol versus danazol as second-line treatment in adults with primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial

Fei-Er Feng et al.

LANCET HAEMATOLOGY (2017)

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Article Multidisciplinary Sciences

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease

M. M. Mariani et al.

SCIENTIFIC REPORTS (2017)

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Article Immunology

Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression

Omowunmi Aibana et al.

CLINICAL INFECTIOUS DISEASES (2017)

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Article Biochemistry & Molecular Biology

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Luisa Cimmino et al.

CELL (2017)

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Article Pharmacology & Pharmacy

Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling

Faith Stevison et al.

DRUG METABOLISM AND DISPOSITION (2017)

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Article Cell Biology

Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina

Susana da Silva et al.

DEVELOPMENTAL CELL (2017)

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Article Cell Biology

Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer

Song-Chang Lin et al.

DEVELOPMENTAL CELL (2017)

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Article Biochemistry & Molecular Biology

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy

Nina Cabezas-Wallscheid et al.

CELL (2017)

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Article Developmental Biology

Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary

Anna Minkina et al.

DEVELOPMENTAL BIOLOGY (2017)

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Review Immunology

Dendritic cells in cancer: the role revisited

Filippo Veglia et al.

CURRENT OPINION IN IMMUNOLOGY (2017)

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Article Immunology

Macrophage and dendritic cell subsets in IBD: ALDH(+) cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation

M. K. Magnusson et al.

MUCOSAL IMMUNOLOGY (2016)

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Article Biology

Dynamics of BMP and Hes1/Hairy1 signaling in the dorsal neural tube underlies the transition from neural crest to definitive roof plate

Erez Nitzan et al.

BMC BIOLOGY (2016)

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Review Cell Biology

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

Annika Wahlstrom et al.

CELL METABOLISM (2016)

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Article Cell & Tissue Engineering

Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal

Victoria Zismanov et al.

CELL STEM CELL (2016)

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Article Endocrinology & Metabolism

Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells

Kosuke Takeda et al.

DIABETES (2016)

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Peripheral Lymphoid Volume Expansion and Maintenance Are Controlled by Gut Microbiota via RALDH+ Dendritic Cells

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Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer

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Article Immunology

Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia

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JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Regulation of vitamin D receptor expression by retinoic acid receptor alpha in acute myeloid leukemia cells

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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2016)

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Article Hematology

Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets

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JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2016)

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Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

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NATURE CELL BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

The E3 ubiquitin protein ligase MDM2 dictates all-trans retinoic acid-induced osteoblastic differentiation of osteosarcoma cells by modulating the degradation of RARα

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Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy (Publication with Expression of Concern. See vol. 365, pg. 991, 2019)

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Mouse oocytes differentiate through organelle enrichment from sister cyst germ cells

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The Warburg Effect: How Does it Benefit Cancer Cells?

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TRENDS IN BIOCHEMICAL SCIENCES (2016)

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ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries

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Article Clinical Neurology

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease

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JCI INSIGHT (2016)

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Role of retinoic acid receptor (RAR) signaling in post-natal male germ cell differentiation

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Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells

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Article Biochemistry & Molecular Biology

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

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CELLULAR & MOLECULAR IMMUNOLOGY (2015)

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Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program

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Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

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Mechanisms of retinoic acid signalling and its roles in organ and limb development

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Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis

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Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

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Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium's Metabolism Is Constrained by the Intracellular Environment

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ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Nuclear Receptor Coactivators: Master Regulators of Human Health and Disease

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ANNUAL REVIEW OF MEDICINE, VOL 65 (2014)

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Editorial Material Hematology

AML drug resistance: c-Myc comes into play

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Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

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CELL METABOLISM (2014)

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Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor α

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FEBS JOURNAL (2014)

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The Pathophysiology and Treatment of Glaucoma A Review

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

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NATURE (2014)

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Article Genetics & Heredity

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31

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Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure

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NATURE MEDICINE (2014)

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Muller glial cell reprogramming and retina regeneration

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NATURE REVIEWS NEUROSCIENCE (2014)

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NEUROPHARMACOLOGY (2014)

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Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

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SCIENCE (2014)

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Review Cell Biology

Sertoli cells - Immunological sentinels of spermatogenesis

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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)

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Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

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LANCET GLOBAL HEALTH (2014)

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Article Hematology

Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions

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Article Oncology

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

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Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development

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Retinoid Acid Specifies Neuronal Identity through Graded Expression of Ascl1

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CURRENT BIOLOGY (2013)

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Therapeutic Potential of the Inhibition of the Retinoic Acid Hydroxylases CYP26A1 and CYP26B1 by Xenobiotics

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CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)

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Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control

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DEVELOPMENTAL CELL (2013)

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Article Biochemistry & Molecular Biology

The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development

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FASEB JOURNAL (2013)

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Article Gastroenterology & Hepatology

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

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GASTROENTEROLOGY (2013)

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Article Cell Biology

Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3

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GENES & DEVELOPMENT (2013)

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Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet

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GENES AND NUTRITION (2013)

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Review Biochemistry & Molecular Biology

Retinoic acid signaling in spinal cord development

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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

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Article Immunology

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells

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JOURNAL OF EXPERIMENTAL MEDICINE (2013)

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Article Immunology

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation

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JOURNAL OF EXPERIMENTAL MEDICINE (2013)

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Article Cell Biology

Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation

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MOLECULAR AND CELLULAR ENDOCRINOLOGY (2013)

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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NATURE CELL BIOLOGY (2013)

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Oocyte differentiation is genetically dissociable from meiosis in mice

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NATURE GENETICS (2013)

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Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

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NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Medicine, General & Internal

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

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NEW ENGLAND JOURNAL OF MEDICINE (2013)

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An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

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Editorial Material Oncology

Retinoic acid-producing DCs and gut-tropic FOXP3+ regulatory T cells in the induction of oral tolerance

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Review Biochemistry & Molecular Biology

Lipid metabolism in mammalian tissues and its control by retinoic acid

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

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CANCER LETTERS (2012)

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Retinoic acid signaling in Sertoli cells regulates organization of the blood-testis barrier through cyclical changes in gene expression

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DEVELOPMENT (2012)

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Article Public, Environmental & Occupational Health

Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study

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GSK3 is a regulator of RAR-mediated differentiation

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LEUKEMIA (2012)

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Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Endocrinology & Metabolism

Vitamin D metabolism and signaling in the immune system

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REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2012)

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

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Article Genetics & Heredity

Craniosynostosis and Multiple Skeletal Anomalies in Humans and Zebrafish Result from a Defect in the Localized Degradation of Retinoic Acid

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AMERICAN JOURNAL OF HUMAN GENETICS (2011)

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Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway: Findings from in vitro and ex vivo studies

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ATHEROSCLEROSIS (2011)

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Article Reproductive Biology

Vitamin A Deficiency Results in Meiotic Failure and Accumulation of Undifferentiated Spermatogonia in Prepubertal Mouse Testis

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BIOLOGY OF REPRODUCTION (2011)

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Article Gastroenterology & Hepatology

Retinoic Acid-Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt-β-Catenin Signaling to Slow Tumor Progression

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GASTROENTEROLOGY (2011)

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Article Cell Biology

FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk

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JOURNAL OF CELL BIOLOGY (2011)

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Article Cell Biology

TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription

Tomonobu Sato et al.

JOURNAL OF CELL SCIENCE (2011)

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Article Neurosciences

Decrease in Calcium Concentration Triggers Neuronal Retinoic Acid Synthesis during Homeostatic Synaptic Plasticity

Hui-Li Wang et al.

JOURNAL OF NEUROSCIENCE (2011)

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Article Multidisciplinary Sciences

Retinoic Acid Signalling and the Control of Meiotic Entry in the Human Fetal Gonad

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PLOS ONE (2011)

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Article Multidisciplinary Sciences

Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Hematology

Complement activation on platelets correlates with a decrease in circulating immature platelets in patients with immune thrombocytopenic purpura

Ellinor I. B. Peerschke et al.

BRITISH JOURNAL OF HAEMATOLOGY (2010)

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Article Obstetrics & Gynecology

Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis

R. Le Bouffant et al.

HUMAN REPRODUCTION (2010)

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Article Neurosciences

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid

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MOLECULAR AND CELLULAR NEUROSCIENCE (2010)

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Article Developmental Biology

Disulfide isomerase glucose-regulated protein 58 is required for the nuclear localization and degradation of retinoic acid receptor alpha

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REPRODUCTION (2010)

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Article Reproductive Biology

Vitamin A Deficiency Blocks the Initiation of Meiosis of Germ Cells in the Developing Rat Ovary In Vivo

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BIOLOGY OF REPRODUCTION (2009)

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Article Hematology

Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production

Chongyun Fang et al.

BLOOD (2009)

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Article Biochemistry & Molecular Biology

A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARα to target promoters

Nathalie Bruck et al.

EMBO JOURNAL (2009)

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Article Endocrinology & Metabolism

Small Ubiquitin-Like Modifier-2 Modification of Retinoic Acid Receptor-alpha Regulates Its Subcellular Localization and Transcriptional Activity

Li Zhu et al.

ENDOCRINOLOGY (2009)

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Article Hematology

Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis

Lauren C. Goldie et al.

BLOOD (2008)

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Review Biochemistry & Molecular Biology

Hematopoiesis: An evolving paradigm for stem cell biology

Stuart H. Orkin et al.

CELL (2008)

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Article Biochemistry & Molecular Biology

Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism

X. Pares et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

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Article Developmental Biology

Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development

Kathrin Laue et al.

DEVELOPMENT (2008)

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Article Biochemistry & Molecular Biology

ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

Nan Wang et al.

FASEB JOURNAL (2008)

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Article Endocrinology & Metabolism

Methyl donor supplementation prevents transgenerational amplification of obesity

R. A. Waterland et al.

INTERNATIONAL JOURNAL OF OBESITY (2008)

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Article Dermatology

Retinoic acid metabolism blocking agents (RAMBAs): a new paradigm in the treatment of hyperkeratotic disorders

Christel J. Verfaille et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2008)

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Article Cell Biology

STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation

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JOURNAL OF CELL SCIENCE (2008)

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Article Immunology

Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-β-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

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JOURNAL OF IMMUNOLOGY (2008)

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Article Cell Biology

Arsenic degrades PML or PML - RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

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NATURE CELL BIOLOGY (2008)

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Article Neurosciences

Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity

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NEURON (2008)

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Article Developmental Biology

Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation

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REPRODUCTION (2008)

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Review Immunology

Vitamin effects on the immune system: vitamins A and D take centre stage

J. Rodrigo Mora et al.

NATURE REVIEWS IMMUNOLOGY (2008)

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Article Multidisciplinary Sciences

RARα-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Biochemistry & Molecular Biology

Asymmetric self-renewal and commitment of satellite stem cells in muscle

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CELL (2007)

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Article Multidisciplinary Sciences

A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A

Riki Kawaguchi et al.

SCIENCE (2007)

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Review Immunology

T-cell regulation: with complements from innate immunity

Claudia Kemper et al.

NATURE REVIEWS IMMUNOLOGY (2007)

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Article Biochemistry & Molecular Biology

Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells

Nadege Vernet et al.

EMBO JOURNAL (2006)

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Article Biochemistry & Molecular Biology

A CK2-dependent mechanism for degradation of the PML tumor suppressor

Pier Paolo Scaglioni et al.

CELL (2006)

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Phosphorylation by PKA potentiates retinoic acid receptor α activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7

Emilie Gaillard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Multidisciplinary Sciences

Retinoid signaling determines germ cell fate in mice

J Bowles et al.

SCIENCE (2006)

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Article Endocrinology & Metabolism

Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis

N Vernet et al.

ENDOCRINOLOGY (2006)

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Article Biochemistry & Molecular Biology

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver

SL Sabol et al.

JOURNAL OF LIPID RESEARCH (2005)

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Article Biochemistry & Molecular Biology

c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor α

H Srinivas et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

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Article Multidisciplinary Sciences

All-trans retinoic acid/AS2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia

ZX Shen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Multidisciplinary Sciences

13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice

J Crandall et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Hematology

Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells

Y Suzuki et al.

BLOOD (2004)

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Article Cell Biology

Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation

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Article Endocrinology & Metabolism

1α,25-dihydroxyvitamin D3 transrepresses retinoic acid transcriptional activity via vitamin D receptor in myeloid cells

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Activation of retinoic acid receptor-dependent transcription by all-trans-retinoic acid metabolites and isomers

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Regulation and perturbation of testicular functions by vitamin A

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

M Pearson et al.

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Article Biochemistry & Molecular Biology

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation

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