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Article
Food Science & Technology
Xiaofang Liao et al.
Summary: In this study, a simple and sensitive method using ultrasonication assisted one-step extraction and ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) was developed for simultaneous detection of multiple mycotoxins in medicinal foods. The technique showed excellent analytical performance with low detection and quantitation limits for the mycotoxins tested. Real-world application revealed a high occurrence rate of mycotoxins in the tested medicinal foods, posing potential health risks to consumers. This work provides a robust platform for monitoring mycotoxins in medicinal foods to protect consumer health.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Applied
Daiane Cassia Pereira Abreu et al.
Summary: The aim of this study was to validate and apply an analytical methodology for the simultaneous determination of 34 mycotoxins in cocoa. The results showed that the extraction method used was effective, except for a few specific mycotoxins. The method also had some limitations, such as matrix effect and signal suppression. Positive results were found in the cocoa samples collected in Brazil, with 9 out of 34 investigated mycotoxins detected.
Article
Chemistry, Analytical
Zhichao Yu et al.
Summary: A portable photothermal immunosensing platform supported by a microelectromechanical microsystem (MEMS) was developed for quick and cost-effective identification of acutely toxic and low-fatality mycotoxins, which is critical for reducing population mortality.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yu-Zhuo Guo et al.
Summary: In this study, nitrogen-, sulfur-, and fluorine-codoped carbon dots (NSF-CDs) were developed as high electrochemiluminescence (ECL) emitters for the fabrication of an ECL biosensor to detect matrix metalloproteinase 2 (MMP-2). Compared to previous carbon dots, NSF-CDs with narrow band gap reduced side reactions and damage to biomolecules, and had hydrogen bonds to greatly enhance ECL efficiency. Additionally, an improved nucleic acid amplification method was used to convert trace MMP-2 into a mass of output DNA, significantly improving the target conversion efficiency and ECL signal. The ECL biosensor successfully detected MMP-2 from 10 fg/mL to 10 ng/mL with a limit of detection of 6.83 fg/mL and was applied in the detection of MMP-2 from Hela and MCF-7 cancer cells. This strategy offers novel ECL emitters for sensitive biomarker testing in medical research.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Kaiqing Wu et al.
Summary: Electrochemiluminescence (ECL) has various advantages and is widely used for sensing, imaging, and single cell analysis. Small organic ECL luminophores, with their biocompatibility and easy modification, play a key role in the performance of ECL applications. However, there is a lack of comprehensive reviews on small organic ECL luminophores. This review introduces the advantages, emission mechanisms, types, molecular characteristics, and applications of small organic ECL luminophores, and discusses the challenges and prospects in biosensing applications.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Xiaohui Zhan et al.
Summary: This study developed a novel DNA Tetrahedron (DTN)-supported biosensor based on spatially separated CRISPR Cas self-amplification strategy and multiple-metal-nanoparticle tagging coupled with inductively coupled plasma mass spectrometry (ICP-MS) detection, improving the sensitivity and feasibility of the platform for multiplex detection of HPV-DNA.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Zhuoxin Ye et al.
Summary: In this study, low-toxic quaternary AgInZnS quantum dots were synthesized and used as novel anodic electrochemiluminescence (ECL) emitters. These QDs exhibited strong and stable ECL emission, a low excitation potential, and high ECL efficiency. An on-off-on ECL biosensor for detecting microRNA-141 was designed based on a dual isothermal enzyme-free strand displacement reaction, achieving cyclic amplification of the target and ECL signal, as well as a switch function. The ECL biosensor showed a wide linear range and low detection limit, making it a promising tool for rapid and accurate diagnosis of clinical diseases.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Longfei Tang et al.
Summary: A new nanoprobe (DTAAT) was designed based on DNA tetrahedron supported hybridization chain reaction (HCR) for in situ analysis of bacteria. By coupling antibody-aptamer conjugate (AA) with DNA tetrahedron (DT) and linking it with trigger strand (A), DTAAT can precisely recognize bacteria through dual binding, releasing a trigger strand complementary to the aptamer. The released trigger strand induces efficient HCR at three vertices of DT using proximity effect, with a reaction rate of 359.29 min-1 compared to 212.60 min-1 for free HCR. DTAAT enables in situ imaging and single-cell characterization of bacteria, with high specificity and anti-interference capability for quantitative analysis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biophysics
Jiansen Li et al.
Summary: In this study, a dual-ratiometric electrochemical aptasensor was developed for simultaneous detection of malathion and profenofos. Metal ions, hairpin-tetrahedral DNA nano-structures, and nanocomposites were used to create the sensing framework and signal amplification strategy. The detection limits of the aptasensor for malathion and profenofos were 4.3 pg mL-1 and 13.3 pg mL-1, respectively.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Inorganic & Nuclear
Yanping Li et al.
Summary: Food pollution is a major concern for public health and food safety. The development of nanomaterials, photo/electric sensing, and nucleic acid aptamer recognition technology has led to the emergence of electrochemiluminescence (ECL) aptamer sensing technology, which shows promising potential in detecting residual levels of various food pollutants. This review focuses on the latest progress in nanomaterials-driven ECL aptasensors for quantitative detection of food pollutants in the past 5 years, discusses challenges, and explores future prospects.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Applied
Yonghui Li et al.
Summary: Food can be contaminated by hazardous substances at every stage of the supply chain, posing various health risks. Developing sensors capable of selective analysis in complex food matrices is crucial for ensuring food safety. This review discusses biomimetic functional materials commonly used in sensor preparation, including antifouling materials and recognition receptors, and summarizes their mechanisms, advantages, limitations, and applications in food safety analysis.
Article
Chemistry, Applied
Qian Wang et al.
Summary: In this study, methylamine perovskite quantum dots (MP QDs) encapsulated by ZIF-8 metal-organic frameworks (MP QDs@ZIF-8) were prepared for the detection of aflatoxin B1 (AFB1). The constructed electrochemiluminescence (ECL) sensor showed good selectivity and ultra-sensitivity, with a wide linear range for AFB1 quantification. The satisfactory recoveries in corn samples demonstrated the reliable practicability of the proposed sensor for AFB1 assay. This work provided a novel pathway for designing high-performance ECL sensing platforms in food safety.
Article
Chemistry, Applied
Zongbing Li et al.
Summary: The immobilization efficiency of surface-based DNA walker can be improved by fixing three-dimensional (3D) DNAzyme walker on the top of DNA tetrahedral scaffold. With Ferrocene (Fc) labeled at the ends of substrate strand, the electrochemiluminescence (ECL) signal of Ru(bpy)2(cpaphen)2 +/- can be effectively quenched, resulting in a signal-off state of the sensor. Upon the addition of aflatoxin B1 (AFB1), the 3D DNAzyme walker is activated and releases Fc, thus recovering the ECL signal. The high movement efficiency of the 3D DNAzyme walker enables ultrasensitive detection of AFB1 with a detection limit of 0.58 fg mL-1 in the range of 1.0 fg mL- 1-10 ng mL-1. Satisfactory results were also obtained when detecting AFB1 in corn and peanut samples, indicating its potential application in food safety analysis.
Article
Chemistry, Analytical
Jie Liu et al.
Summary: In this study, fluorine-nitrogen co-doped carbon dots (FNCDs) were used as a novel electrochemiluminescence (ECL) emitter for ultrasensitive detection of human immunodeficiency virus (HIV) DNA fragment. The doping of fluorine and nitrogen in carbon dots (CDs) improved the ECL intensity and stability of FNCDs by forming hydrogen bonds and changing the charge distribution. The ECL biosensor fabricated using exonuclease III (Exo III)-assisted amplification achieved ultrasensitive detection of HIV-DNA fragment.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Food Science & Technology
Meera Mohamed Alameri et al.
Summary: Aflatoxins (AFs) are mycotoxins produced by Aspergillus flavus and Aspergillus parasiticus, with significant public health and economic impact globally. Chronic exposure to AFs is associated with liver cancer, oxidative stress, and fetal growth abnormalities. Various detection methods, including cultures, molecular techniques, and chromatographic means, are used to determine AF contamination. Incorporating crops with higher resistance, such as sorghum, into animal feed can reduce the risk of AF contamination in milk and cheese. This review provides an overview of the health risks, detection techniques, and management strategies for AF.
Article
Chemistry, Multidisciplinary
Runran Ma et al.
Summary: A novel ratiometric fluorescent nanosensor combining mesoporous silica spheres-coated nitrogen-doped carbon dots (N-CDs@SiO2) and bovine serum albumin-stabilized gold nanoclusters (BSA-AuNCs) was developed for sensitive detection of glyphosate. The nanosensor showed highly selective differentiation and accurate detection of glyphosate based on the fluorescence quenching of Cu2+ on BSA-AuNCs and the fluorescence recovery induced by glyphosate. It exhibited excellent selectivity, wide detectability, high sensitivity and reliability, making it suitable for applications in the environment and food safety fields.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Sun et al.
Summary: In this study, a simple electrochemical liver-microsome-based biosensor using a composite of gold nanoparticles adsorbed on MXene (Au@MXene) was developed for rapid screening of aflatoxin B1 (AFB1). The metabolic behavior of the biosensor was confirmed and a linear relationship between AFB1 content and electrical signal was established. The sensor showed a limit of detection of 2.8 nM and comparable recovery and accuracy to the UPLC-MS/MS method for corn samples.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Applied
Wenting Li et al.
Review
Chemistry, Multidisciplinary
Lucy F. Yang et al.
Summary: This review discusses the discovery process of aptamers, known as systematic evolution of ligands by exponential enrichment (SELEX), and their applications in biosensors and separations. Aptamers, with similar binding affinity and specificity as antibodies, have shown great potential in various fields. They have been utilized in biosensors for virus detection, such as SARS-CoV-2, and in separations for purifying specific molecules or cell types.
Review
Chemistry, Multidisciplinary
Tao Zhang et al.
Summary: This article discusses the strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) and their potential biomedical applications. tFNAs have the ability to scavenge reactive oxygen species, enhance cellular endocytosis and tissue permeability, and promote cell-material interactions. They can be used to treat inflammatory and degenerative diseases, and also have potential applications in targeted therapies, tissue regeneration, antitumor strategies, and antibacterial treatment through their structural programmability.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Yuye Li et al.
Summary: The study reported a novel method for regulating the electrochemiluminescence of Ru(bpy)(3)(2+) by tuning the DNA sequence length, demonstrating the role of Fc in controlling the ECL of SiO2@Ru-NGQDs. A dual-signal readout aptasensor was developed using Fc-apt for AFB1 detection, showing potential for versatile design of aptasensors.
ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Mingxuan Jia et al.
Summary: A CdSe@CdS quantum dots-based label-free ECL aptasensor was developed for specific and sensitive detection of OTA, with excellent stability and strong ECL intensity. The sensor showed superior sensitivity for OTA with a wide linear concentration range after optimizing crucial conditions, demonstrating potential for various applications.
Review
Food Science & Technology
Yujiao Hou et al.
Summary: Aptasensors, with their strong recognition capacity, simple fabrication, rapid response, high sensitivity, low cost, and easy adaptability for in situ measurement, have great potential in food safety inspection and risk assessment.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Review
Engineering, Environmental
Xin Zhang et al.
Summary: This paper provides a comprehensive overview of using carbon dots (CDs) for pesticide monitoring, including their synthesis and modification methods, and recent advances in CDs-based optical sensors for pesticide detection over the past five years. It highlights the integration of various recognition elements and design principles in photoluminescent, electrochemiluminescent, and colorimetric sensors, as well as the novel functions of CDs in constructing optical sensors. Additionally, it discusses the real-world application performances, existing inadequacies, challenges, and future perspectives for pesticide monitoring using CDs-based sensing strategies.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Jiehao Guan et al.
Summary: In this study, a highly sensitive and selective electrochemical probe was designed for detecting antibiotics in foods. By modifying the electrode with nanomaterials and DNA nanotechnology, the conductivity and biocompatibility were improved, and the detection sensitivity was enhanced with the use of self-assembled TDN. The results showed that the electrochemical probe was able to detect antibiotics such as ampicillin in a short time, with high detection limit and stability.
Article
Pharmacology & Pharmacy
Liu Liu et al.
Summary: In this study, a fluorescent aptasensor was developed for on-site detection of live Salmonella typhimurium and Vibrio parahaemolyticus. The sensor utilized encoded probes and dual-stirring-bar-assisted signal amplification for pathogen quantification. The assay has broad application potential for simultaneous on-site detection of various live pathogenic bacteria in water.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Shuting Cheng et al.
Summary: A novel sandwich electrochemiluminescence aptasensor was developed for highly sensitive detection of kanamycin. The aptasensor used PAMAM, molybdenum disulfide, and multi-walled carbon nanotubes as the substrate to improve the ECL intensity. The sandwiched aptasensor formed between aptamer1 and aptamer2 resulted in a proportional increase of ECL intensity. The aptasensor exhibited a wide linear range and low detection limit.
BIOELECTROCHEMISTRY
(2022)
Article
Biophysics
Fubin Pei et al.
Summary: A fast and sensitive detection approach based on a photoelectrochemical immunosensor was developed for the detection of AFB1 contaminant in agricultural products. The sensor showed a wide linear detection range and promising application prospects.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Applied
Boyu Jia et al.
Summary: A quantum dot nanobeads (QBs) based lateral flow fluorescent strip immunosensor was developed for rapid detection and quantitation of aflatoxin B1 (AFB1) in lotus seeds. The sensor showed high sensitivity, with a detection limit of 1 ng/mL and a linear range of 1-19 ng/mL, and accurate results for samples with low, medium, and high spiking concentrations. The method provides a preferred solution for on-site screening and quantitation of AFB1 in a large number of lotus seed samples.
Article
Biophysics
Xiaohui Xiong et al.
BIOSENSORS & BIOELECTRONICS
(2020)
Review
Environmental Sciences
Noreddine Benkerroum
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Chemistry, Analytical
Yan Lu et al.
MICROCHEMICAL JOURNAL
(2020)
Review
Chemistry, Multidisciplinary
Ying Chen et al.
MATERIALS CHEMISTRY FRONTIERS
(2020)
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Chemistry, Analytical
Long Wu et al.
ANALYTICAL CHEMISTRY
(2017)
Article
Chemistry, Analytical
Zhi-hao Gao et al.
ANALYTICAL METHODS
(2016)
