期刊
MOLECULAR BRAIN
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13041-016-0211-9
关键词
Nitric oxide; Endothelial nitric oxide synthase; Cerebral blood flow; Cerebrovascular diseases
资金
- National Natural Science Foundation of China [81503279, 81202653]
- Natural Science Foundation of Tianjin City [15JCYBJC54800]
Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential therapeutic target for cerebrovascular diseases. This review summarizes the current evidence supporting the importance of CBF to cerebrovascular function, and the roles of NO and eNOS in CBF regulation.
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