期刊
MOLECULAR BRAIN
卷 9, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s13041-015-0184-0
关键词
Fear memory; Generalization
资金
- World Premier International Research Center Initiative from the Japan Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
- Japan Society for the Promotion of Science [26115502, 25116530]
- Brain Science Foundation
- Research Foundation for Opto-Science and Technology
- Kato Memorial Bioscience Foundation
- Japan Foundation for Applied Enzymology
- BBSRC [BB/M025128/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M025128/1] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [15F15408, 26115502] Funding Source: KAKEN
Background: The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization. Results: Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning. Conclusions: Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.
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