Cannabis and Endometriosis: The Roles of the Gut Microbiota and the Endocannabinoid System

Article Obstetrics & Gynecology

Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model

Sabri Berkem Okten et al.

Summary: Through animal experiments, it was found that Cannabidiol (CBD) has anti-inflammatory, antioxidative, and antiangiogenic effects, which may be used in the treatment of endometriosis.

REPRODUCTIVE BIOMEDICINE ONLINE (2023)

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Article Pediatrics

Increased expression of CB2 receptor in the intestinal biopsies of children with inflammatory bowel disease

Caterina Strisciuglio et al.

Summary: This study analyzed the expression of CB2 and factors associated with IBD inflammatory pathways in intestinal biopsies of pediatric CD and UC patients. The results showed an upregulation of CB2 in pediatric IBD, which could have implications for drug discovery.

PEDIATRIC RESEARCH (2023)

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Article Public, Environmental & Occupational Health

A cross-sectional study comparing the inflammatory profile of menstrual effluent vs. peripheral blood

Sara Naseri et al.

Summary: This pilot study investigated the potential of measuring cytokines in menstrual effluent and compared the cytokine profiles of menstrual versus peripheral blood. The results showed a tenuous correlation between menstrual effluent and peripheral blood cytokine profiles, with higher levels detected in menstrual effluent for many cytokines. Further studies are needed to evaluate the relationship between peripheral and menstrual blood cytokines in broader populations.

HEALTH SCIENCE REPORTS (2023)

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Article Obstetrics & Gynecology

Endometriosis research priorities in Australia

Mike Armour et al.

Summary: In Australia, one in nine women and those assigned female at birth are affected by endometriosis. Despite being more common than conditions like diabetes, research funding for endometriosis has been historically low. The National Action Plan for Endometriosis, initiated by the Australian Federal Government, aims to address this imbalance by prioritizing research funding and involving consumer input in determining funding allocation.

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY (2023)

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Article Pharmacology & Pharmacy

Cannabidiol reduces lipopolysaccharide-induced nociception via endocannabinoid system activation

Rafaela Silva dos Santos et al.

Summary: The study found that bacterial LPS can induce pain in mice, but CBD treatment can attenuate this pain by inhibiting the activation of TLR4. CBD may be a potential treatment strategy for controlling LPS-induced pain.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2023)

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Article Obstetrics & Gynecology

Long-term risk of repeated surgeries in women managed for endometriosis: a 1,092 patient-series

Horace Roman et al.

Summary: The objective of this retrospective study was to assess the long-term risk of repeated surgery in women undergoing complete excision of endometriosis by an experienced surgeon and to identify circumstances leading up to repeat surgery. The study found that up to 28% of patients may require a repeated surgical procedure during the 10 years after complete excision of endometriosis. Conservation of the uterus is followed by an increased risk of repeated surgery.

FERTILITY AND STERILITY (2023)

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Article Obstetrics & Gynecology

New concepts on the etiology of endometriosis

Fiona L. Cousins et al.

Summary: Endometriosis is a serious and chronic condition where tissue similar to the lining of the uterus grows outside of it, leading to severe pelvic pain and infertility. It affects 11% of women and has multiple causes, with retrograde menstruation being a major factor. There is a genetic component to endometriosis, with over 40 genetic risk factors identified, although their specific mechanisms are still being understood.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2023)

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Article Cell Biology

Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts

Ayako Muraoka et al.

Summary: Retrograde menstruation is associated with endometriosis, but the mechanisms are not fully understood. This study demonstrated that Fusobacterium infection played a pathogenic role in the formation of ovarian endometriosis. In a mouse model, Fusobacterium infection led to the activation of TGF-13 signaling and the transition of fibroblasts to myofibroblasts, promoting the development of endometriotic lesions. Antibiotic treatment showed potential in preventing and reducing the severity of endometriosis.

SCIENCE TRANSLATIONAL MEDICINE (2023)

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Editorial Material Obstetrics & Gynecology

Cannabis for endometriosis-related pain and symptoms: It's high time that we see this as a legitimate treatment

Mike Armour et al.

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY (2023)

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Review Medicine, General & Internal

Correlations between Gut Microbial Composition, Pathophysiological and Surgical Aspects in Endometriosis: A Review of the Literature

Irene Iavarone et al.

Summary: Endometriosis is an estrogen-dependent, inflammatory disorder characterized by the migration of endometrial tissue outside the uterus. The human microbiome may play a role in its pathogenesis, particularly before and after laparotomy. This review aims to determine the interaction between endometriosis and gut microbial composition.

MEDICINA-LITHUANIA (2023)

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Article Obstetrics & Gynecology

Endometriosis and the workplace: Lessons from Australia's response to COVID-19

Mike Armour et al.

Summary: The study found that during the COVID-19 pandemic, Australian people with endometriosis reported easier symptom management and increased productivity, mainly due to the flexibility in work hours and increased ability to self-manage their time.

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY (2022)

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Article Obstetrics & Gynecology

The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain

Mary E. Salliss et al.

Summary: The relationship between the microbiome and endometriosis, infertility, and chronic pelvic pain (CPP) is complex and requires further research for a better understanding. Studies have shown a potential link between dysbiotic gut or genital microbiota and gynecologic conditions, highlighting the need for more rigorous study designs and consistent methodology across the field.

HUMAN REPRODUCTION UPDATE (2022)

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Article Biochemistry & Molecular Biology

A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study

Cherry Yin-Yi Chang et al.

Summary: Infection-induced chronic inflammation is common in patients with endometriosis. This study found that the composition of microbial communities in the cervical mucus changed during the development and progression of the disease. Compared to healthy women, patients with endometriosis had increased Lactobacillus, Streptococcus, and decreased Dialister. These changes were frequently associated with advanced disease stages, higher CA125 levels, severe pain, and infertility.

BIOMEDICINES (2022)

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Article Anesthesiology

Association of endocannabinoids with pain in endometriosis

Thomas Andrieu et al.

Summary: This case-control study found that levels of endocannabinoids (eCBs) are significantly influenced by both noncyclic and cyclic abdominal pain, suggesting a potential role of the eCB system in endometriosis-associated pain.

PAIN (2022)

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Article Medicine, General & Internal

Treatment use and satisfaction in Australian women with endometriosis: a mixed-methods study

Subhadra Evans et al.

Summary: The study found that most Australian women with endometriosis use medication for pain relief, and complementary/self-care strategies are less effective. The survey showed that some patients are dissatisfied with treatment, some are satisfied, and there is a need for comprehensive, interdisciplinary care and patient knowledge, advocacy, and resilience.

INTERNAL MEDICINE JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis

Tiziana Genovese et al.

Summary: This study found that cannabidiol (CBD) has anti-inflammatory, antioxidant, and analgesic effects in endometriosis, playing an important role in reducing lesion size, improving lesion morphology, restoring oxidative balance, and reducing inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Multidisciplinary Sciences

An Aotearoa New Zealand survey of the impact and diagnostic delay for endometriosis and chronic pelvic pain

Jordan Tewhaiti-Smith et al.

Summary: Chronic pelvic pain has a significant negative impact on quality of life and endometriosis is the leading cause of this condition among females. However, there is limited data available on the impact of chronic pelvic pain and diagnostic delay in New Zealand.

SCIENTIFIC REPORTS (2022)

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Article Immunology

Detection of Cannabinoid Receptor Expression by Endometriotic Lesions in Women with Endometriosis as an Alternative to Opioid-Based Pain Medication

Sarah Allam et al.

Summary: The study found that ovarian endometriotic lesions express CB1 and CB2 receptors, suggesting that these lesions may respond to cannabinoids as pain medication. This provides a foundation for future clinical studies with larger cohorts.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

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Article Pharmacology & Pharmacy

Cannabinoid Receptor 2 (CB2) Inverse Agonist SMM-189 Induces Expression of Endogenous CB2 and Protein Kinase A That Differentially Modulates the Immune Response and Suppresses Experimental Colitis

Sonia Kiran et al.

Summary: The study investigated the effects of the CB2 inverse agonist SMM-189 on experimental colitis induced by DSS. Results showed that SMM-189 effectively attenuated colitis symptoms, reversed pathogenesis, increased body weight and colon length, and altered the immune cell composition in the spleen, MLNs, and LPLs. The findings suggest that SMM-189 may be a potential therapeutic target for IBD by modulating CB2 and PKA expression in LPLs and altering immune cell populations.

PHARMACEUTICS (2022)

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Article Psychology, Multidisciplinary

A day-to-day struggle: A comparative qualitative study on experiences of women with endometriosis and chronic pelvic pain

Alexandra Hawkey et al.

Summary: This study explores the similarities and differences in the experiences of women with different causes of chronic pelvic pain (CPP). Regardless of the cause, women reported significant impacts on their intimate relationships, fertility, and parenting. However, women with non-endometriosis related CPP faced greater challenges in communicating about pelvic pain in the workplace due to the taboo nature of the topic.

FEMINISM & PSYCHOLOGY (2022)

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Article Multidisciplinary Sciences

A microbiome-dependent gut-brain pathway regulates motivation for exercise

Lenka Dohnalova et al.

Summary: This study discovered a gut-brain connection in mice that enhances exercise performance by increasing dopamine signaling during physical activity. The researchers found that gut microbiota-dependent production of endocannabinoid metabolites stimulates sensory neurons, elevating dopamine levels, and improving running capacity. These findings have significant implications for understanding exercise motivation and interindividual differences in exercise performance.

NATURE (2022)

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Article Multidisciplinary Sciences

Effects of active, inactive, and derivatives of Akkermansia muciniphila on the expression of the endocannabinoid system and PPARs genes

Farinaz Ghaderi et al.

Summary: This study investigated the effects of active and heat-inactivated forms of Akkermansia muciniphila, bacterial-derived outer membrane vesicles (OMVs), and cell-free supernatant on gene expression related to the endocannabinoid system (ECS) and peroxisome proliferator-activated receptors (PPARs) in Caco-2 and HepG-2 cell lines. The results showed that both forms of the bacterium, OMVs, and cell-free supernatant significantly affected the expression of the studied genes, indicating their potential as probiotic, paraprobiotic, and postbiotic candidates for the prevention of obesity, metabolic disorders, and liver diseases.

SCIENTIFIC REPORTS (2022)

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Review Medicine, General & Internal

Endometriosis and irritable bowel syndrome: A systematic review and meta-analyses

Michelle Y. Nabi et al.

Summary: The study aimed to estimate the pooled odds ratio of endometriosis and irritable bowel syndrome, and the pooled prevalence of irritable bowel syndrome in patients with endometriosis. The results showed that patients with endometriosis have a threefold increased risk of developing irritable bowel syndrome, and the prevalence of irritable bowel syndrome in women with endometriosis was 23.4%.

FRONTIERS IN MEDICINE (2022)

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Review Gastroenterology & Hepatology

Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis

Hailey Cuddihey et al.

Summary: This review illustrates the role of the endocannabinoid system in regulating intestinal homeostasis, including the regulation of intestinal permeability, fluid secretion, and immune regulation. It also emphasizes the reciprocal regulation between the endocannabinoid system and the gut microbiome.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Review Obstetrics & Gynecology

The Effect of Neuromodulatory Drugs on the Intensity of Chronic Pelvic Pain in Women: A Systematic Review

Marcela Almeida Andrade et al.

Summary: The study evaluated the effect of neuromodulatory drugs on chronic pelvic pain (CPP) in women. Most of the analyzed studies showed pain improvement with the help of neuromodulators, but the study with the highest statistical power did not find improvement. There is currently insufficient evidence to suggest that neuromodulatory drugs reduce the intensity of pain in women with CPP.

REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA (2022)

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Review Pharmacology & Pharmacy

Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications

Harshavardhan Lingegowda et al.

Summary: Patients with endometriosis require an effective and economical therapeutic strategy to manage symptoms, and endocannabinoids and phytocannabinoids may have potential benefits in this regard. However, the understanding of the pathophysiology and treatment options for endometriosis remains limited.

JOURNAL OF CANNABIS RESEARCH (2022)

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Article Pharmacology & Pharmacy

Symptoms and Extraintestinal Manifestations in Active Cannabis Users with Inflammatory Bowel Disease

Matthew D. Coates et al.

Summary: An analysis of 383 IBD patients found that active cannabis users were more likely to report various symptoms, such as abdominal pain, gas, tenesmus, and arthralgias. However, these patients did not show increased frequency of active disease or IBD-associated complications compared to nonusers.

CANNABIS AND CANNABINOID RESEARCH (2022)

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Article Obstetrics & Gynecology

Prevalence and incidence of endometriosis in Australian women: a data linkage cohort study

I. J. Rowlands et al.

Summary: A national study in Australia of 13,508 women found that approximately one in nine women were diagnosed with clinically confirmed or suspected endometriosis by age 44, with the majority being diagnosed in their early thirties after a 20-year follow-up.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2021)

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Review Biology

The Endocannabinoid System: A Bridge between Alzheimer's Disease and Gut Microbiota

Tiziana Bisogno et al.

Summary: Alzheimer's disease is a neurodegenerative disease that progresses from mild cognitive impairment to severe dementia, with the endocannabinoid system and gut microbiome believed to play important roles in influencing disease development. Therefore, exploring the roles of these two systems in AD and their potential interactions is the aim of this review.

LIFE-BASEL (2021)

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Review Biochemistry & Molecular Biology

GnRH Antagonists with or without Add-Back Therapy: A New Alternative in the Management of Endometriosis?

Jacques Donnez et al.

Summary: Oral gonadotropin-releasing hormone (GnRH) antagonists have shown effectiveness in managing endometriosis-associated symptoms, especially in patients who do not respond well to traditional treatments. Research needs to take into account the different phenotypes of the disease and propose novel treatment algorithms in order to improve management strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Public, Environmental & Occupational Health

Chronic opioid use and complication risks in women with endometriosis: A cohort study in US administrative claims

Stephanie E. Chiuve et al.

Summary: Women with endometriosis are at greater risk for chronic opioid use, dependence, and overdose compared to those without the condition. Chronic users often exhibit dose escalation and co-prescribing with benzodiazepines and sedatives. Factors such as younger age, comorbidities, depression, and anxiety are associated with a higher risk of developing chronic opioid use among endometriosis patients.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2021)

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Article Multidisciplinary Sciences

Macrophages inhibit and enhance endometriosis depending on their origin

Chloe Hogg et al.

Summary: Macrophages play an important role in the pathophysiology of endometriosis, with lesion-resident macrophages derived from eutopic endometrial tissue, infiltrating large peritoneal macrophages, and monocytes. Continuous recruitment of monocytes and expansion of CCR2+ large peritoneal macrophages are triggered by endometriosis. Depletion of eutopic endometrial macrophages results in smaller lesions, while inhibiting monocyte recruitment reduces macrophage populations and increases lesion number. Reprogramming the ontogeny of peritoneal macrophages decreases lesion development. The study suggests a model where endometrial macrophages promote endometriosis while newly recruited monocyte-derived macrophages, possibly in large peritoneal macrophage form, have antiendometriotic effects.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Medicine, General & Internal

Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review

Jacques Donnez et al.

Summary: Oral contraceptive pills and progestogens are effective in treating most women with endometriosis, but alternative options are needed for those who fail treatment due to progesterone resistance or intolerance. Effective long-term oral treatment is necessary for managing endometriosis symptoms while minimizing side effects. Research on progesterone resistance and new treatment options should be further explored.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Obstetrics & Gynecology

Associations Between Endometriosis and Gut Microbiota

Agnes Svensson et al.

Summary: This study investigated the association between endometriosis and gut microbiota and found differences in microbial diversity between patients and controls. Significantly different abundances of 12 bacterial classes were observed between patients and controls, but these differences disappeared after false discovery rate calculation. These findings suggest that the gut microbiota may be altered in endometriosis patients.

REPRODUCTIVE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin

Yanxin Li et al.

Summary: TRPV1 ion channel serves as a detector for noxious temperature, pungent chemicals, and acidic pH, and functions as an ionotropic cannabinoid receptor. While the high-resolution structures of TRPV1 have been solved, the mechanism of how endocannabinoids bind and activate this channel remains largely unknown. The study found that endocannabinoids bind to TRPV1 in a different configuration compared to capsaicin, suggesting a unique structural mechanism for activation.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Review Cell Biology

Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism

Volatiana Rakotoarivelo et al.

Summary: The endocannabinoid system plays an important role in controlling processes such as energy acquisition and expenditure, and interacts with hormones like leptin and ghrelin. In addition to being present in the central nervous system, the endocannabinoid system is also found in peripheral tissues, particularly adipose tissues. The inhibitory effect of the CB1 antagonist on fat mass indicates that the endocannabinoid system may have a peripheral action beyond its appetite reduction effect.

CELLS (2021)

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Article Gastroenterology & Hepatology

The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids

Amrita Vijay et al.

Summary: The endocannabinoid system plays a key role in energy homeostasis and metabolic disorders, mediating the relationship between gut microbiota and host metabolism. This study found functional interactions between the endocannabinoid system and gut microbiome in modulating inflammatory markers, with short-chain fatty acids potentially mediating anti-inflammatory effects through the EC system.

GUT MICROBES (2021)

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Review Obstetrics & Gynecology

Endometriosis and the microbiome: a systematic review

M. Leonardi et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

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Review Obstetrics & Gynecology

When to Do Surgery and When Not to Do Surgery for Endometriosis: A Systematic Review and Meta-analysis

Mathew Leonardi et al.

JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY (2020)

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Review Obstetrics & Gynecology

The role of the endocannabinoid system in aetiopathogenesis of endometriosis: A potential therapeutic target

Keisuke Tanaka et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Obesity Affects the Microbiota-Gut-Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators

Nicola Forte et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Obstetrics & Gynecology

Effect of hysterectomy on pain in women with endometriosis: a population-based registry study

A. Sandstrom et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

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Article Biology

Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain

Alejandra Escudero-Lara et al.

ELIFE (2020)

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Article Economics

Healthcare utilization and cost burden among women with endometriosis by opioid prescription status in the first year after diagnosis: a retrospective claims database analysis

S. As-Sanie et al.

JOURNAL OF MEDICAL ECONOMICS (2020)

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Review Medicine, General & Internal

Endometriosis

Krina T. Zondervan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Endometriosis and chronic pelvic pain have similar impact on women, but time to diagnosis is decreasing: an Australian survey

Mike Armour et al.

SCIENTIFIC REPORTS (2020)

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Review Biochemistry & Molecular Biology

The Immune Endocannabinoid System of the Tumor Microenvironment

Melanie Kienzl et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Gastroenterology & Hepatology

Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians

Celeste Allaband et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Article Cell Biology

Cellular localization and regulation of receptors and enzymes of the endocannabinoid system in intestinal and systemic inflammation

Magdalena Grill et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2019)

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Article Biochemical Research Methods

Construction of a Model Culture System of Human Colonic Microbiota to Detect Decreased Lachnospiraceae Abundance and Butyrogenesis in the Feces of Ulcerative Colitis Patients

Kengo Sasaki et al.

BIOTECHNOLOGY JOURNAL (2019)

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Review Obstetrics & Gynecology

Endometriosis and nuclear receptors

Bahar D. Yilmaz et al.

HUMAN REPRODUCTION UPDATE (2019)

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Article Biochemistry & Molecular Biology

Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis

Rachel Forster et al.

FASEB JOURNAL (2019)

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Article Obstetrics & Gynecology

Patterns of Prescription Opioid Use in Women With Endometriosis

Georgine Lamvu et al.

OBSTETRICS AND GYNECOLOGY (2019)

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Article Pharmacology & Pharmacy

The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients

E. Pagano et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Multidisciplinary Sciences

The cost of illness and economic burden of endometriosis and chronic pelvic pain in Australia: A national online survey

Mike Armour et al.

PLOS ONE (2019)

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Article Integrative & Complementary Medicine

Self-management strategies amongst Australian women with endometriosis: a national online survey

Mike Armour et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Review Reproductive Biology

The role of the endocannabinoid system in female reproductive tissues

O' Llenecia S. Walker et al.

JOURNAL OF OVARIAN RESEARCH (2019)

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Review Obstetrics & Gynecology

Assessing research gaps and unmet needs in endometriosis

Sawsan As-Sanie et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2019)

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Article Multidisciplinary Sciences

The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls

Baris Ata et al.

SCIENTIFIC REPORTS (2019)

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Article Obstetrics & Gynecology

From pathogenesis to clinical practice: Emerging medical treatments for endometriosis

Sara Clemenza et al.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2018)

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Article Obstetrics & Gynecology

Fatigue-a symptom in endometriosis

Annika Ramin-Wright et al.

HUMAN REPRODUCTION (2018)

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Article Substance Abuse

Potential risk for fatal drug overdose perceived by people using opioid drugs

Daryle E. A. Deering et al.

DRUG AND ALCOHOL REVIEW (2018)

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Article Obstetrics & Gynecology

Factors Associated with Severity of Irritable Bowel Syndrome Symptoms in Patients with Endometriosis

Caroline E. Lee et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA (2018)

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Article Obstetrics & Gynecology

Epidemiology of endometriosis and its comorbidities

F. Parazzini et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2017)

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Article Obstetrics & Gynecology

Partial suppression of estradiol: a new strategy in endometriosis management?

Jacques Donnez et al.

FERTILITY AND STERILITY (2017)

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Review Neurosciences

The cannabinoid system and pain

Stephen G. Woodhams et al.

NEUROPHARMACOLOGY (2017)

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Article Psychology, Biological

Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity

Donovan A. Argueta et al.

PHYSIOLOGY & BEHAVIOR (2017)

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Article Multidisciplinary Sciences

Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches

Giorgia Gioacchini et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity

Pegah Mehrpouya-Bahrami et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

Endocannabinoids modulate apoptosis in endometriosis and adenomyosis

Elif Bilgic et al.

ACTA HISTOCHEMICA (2017)

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Article Obstetrics & Gynecology

Dysbiosis of Gut Microbiota Contributes to Chronic Stress in Endometriosis Patients via Activating Inflammatory Pathway

Jing Xu et al.

REPRODUCTIVE AND DEVELOPMENTAL MEDICINE (2017)

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Article Obstetrics & Gynecology

Endometriosis in patients with irritable bowel syndrome: Specific symptomatic and demographic profile, and response to the low FODMAP diet

Judith S. Moore et al.

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY (2017)

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Review Obstetrics & Gynecology

Anxiety and depression in patients with endometriosis: impact and management challenges

Antonio Simone Lagana et al.

INTERNATIONAL JOURNAL OF WOMENS HEALTH (2017)

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Review Endocrinology & Metabolism

Endocannabinoids - at the crossroads between the gut microbiota and host metabolism

Patrice D. Cani et al.

NATURE REVIEWS ENDOCRINOLOGY (2016)

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Article Public, Environmental & Occupational Health

Increasing Benzodiazepine Prescriptions and Overdose Mortality in the United States, 1996-2013

Marcus A. Bachhuber et al.

AMERICAN JOURNAL OF PUBLIC HEALTH (2016)

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Article Obstetrics & Gynecology

Molecular detection of intrauterine microbial colonization in women with endometriosis

Khaleque N. Khan et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2016)

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Article Obstetrics & Gynecology

Endometriosis and fertility: women's accounts of healthcare

K. Young et al.

HUMAN REPRODUCTION (2016)

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Cannabis and Endometriosis: The Roles of the Gut Microbiota and the Endocannabinoid System

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