☆ 4.6 Review

Resistance in Pseudomonas aeruginosa: A Narrative Review of Antibiogram Interpretation and Emerging Treatments

ANTIBIOTICS-BASEL (2023)

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Phenotypic and genotypic profile of ceftolozane/tazobactam-non-susceptible, carbapenem-resistant Pseudomonas aeruginosa

Christian M. Gill et al.

Summary: This study evaluated the genotypic and ceftazidime/avibactam-susceptibility profiles of ceftolozane/tazobactam-non-susceptible, MBL-negative Pseudomonas aeruginosa. The results showed that ceftazidime/avibactam remained active against the majority of ceftolozane/tazobactam-non-susceptible, MBL-negative Pseudomonas aeruginosa.

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Summary: This study developed a bioinformatic tool called PorinPredict to predict defects in the outer membrane porin OprD of Pseudomonas aeruginosa, which are strongly associated with reduced carbapenem susceptibility. PorinPredict relies on a database of OprD variants and can identify inactivating mutations in the coding or promoter region. The tool was validated against P. aeruginosa genomes and showed a high correlation between OprD loss and meropenem nonsusceptibility, regardless of the presence of carbapenemases.

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Summary: Bacteria form biofilms to resist antibiotic treatment, and environmental biofilms are hotspots for the spread of antibiotic resistance genes. This review summarizes the latest research on biofilms and the techniques used to visualize horizontal gene transfer mechanisms in biofilms.

ANTIBIOTICS-BASEL (2023)

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Article Infectious Diseases

Intravenous Fosfomycin: A Potential Good Partner for Cefiderocol. Clinical Experience and Considerations

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Summary: Multidrug resistant Gram-negative bacteremia, especially when caused by carbapenem resistant Acinetobacter baumannii or difficult-to-treat Pseudomonas aeruginosa, presents a therapeutic challenge with limited antibiotic choices. Cefiderocol, with its innovative mechanism of action, and intravenous fosfomycin, as a potential partner, have shown promising results in overcoming resistance and treating these infections. This study reports successful treatment of two patients with MDR Gram negative bacteremia using a combination of cefiderocol and fosfomycin.

ANTIBIOTICS-BASEL (2023)

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Worldwide Dissemination of blaKPC Gene by Novel Mobilization Platforms in Pseudomonas aeruginosa: A Systematic Review

Daniela Forero-Hurtado et al.

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Article Infectious Diseases

Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study

Jinnethe Reyes et al.

Summary: This study investigated the characteristics and outcomes of carbapenem-resistant Pseudomonas aeruginosa (CRPA) infections and the distribution and clinical significance of carbapenemases. The results showed that carbapenemase-producing CRPA infections were associated with increased 30-day mortality, and the prevalence of carbapenemase genes varied by region. These findings highlight the therapeutic challenges posed by these carbapenem-resistant organisms.

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In vitro activity of cefiderocol against MBL-producing Gram-negative bacteria collected in North America and Europe in five consecutive annual multinational SIDERO-WT surveillance studies (2014-2019)

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Summary: This study evaluated the in vitro antibacterial activity of siderophore cephalosporin cefiderocol against MBL-producing clinical isolates. The results showed that cefiderocol exhibited potent in vitro activity against MBL-producing strains of different bacterial species.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2023)

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Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa

Thilo Kohler et al.

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Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion

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Summary: This comprehensive review examines the unique attributes, distinctions, and clinical implications of ceftazidime-avibactam (CAZ-AVI) and meropenem-vaborbactam (MEM-VAB) against difficult-to-treat Enterobacterales infections. The review provides valuable insights for healthcare professionals to make informed treatment decisions when combating carbapenem-resistant pathogens.

ANTIBIOTICS-BASEL (2023)

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Multi-drug resistant Pseudomonas aeruginosa: a 2019-2020 single center retrospective case control study

Ann Fan Yang et al.

Summary: During the COVID-19 pandemic, there was an increase in the proportion of MDR P. aeruginosa isolates from hospitalized patients, which was strongly associated with prolonged hospitalization, prior antibiotic use, and respiratory sources. Therefore, improved identification of high-risk patients is necessary for appropriate empiric anti-pseudomonal therapy decisions.

INFECTION PREVENTION IN PRACTICE (2023)

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In Vitro Susceptibility of Gram-Negative Pathogens to Cefiderocol in Five Consecutive Annual Multinational SIDERO-WT Surveillance Studies, 2014 to 2019

James A. Karlowsky et al.

Summary: This study reports the in vitro susceptibility data of Gram-negative clinical isolates from North America and Europe to cefiderocol and comparators. The results indicate that clinical isolates collected from 2014 to 2019 in North America and Europe were highly susceptible to cefiderocol.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

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Assessment of Activity and Resistance Mechanisms to Cefepime in Combination with the Novel β-Lactamase Inhibitors Zidebactam, Taniborbactam, and Enmetazobactam against a Multicenter Collection of Carbapenemase-Producing Enterobacterales

Juan Carlos Vazquez-Ucha et al.

Summary: The global distribution of carbapenemases is a concern due to their resistance to traditional beta-lactamase inhibitors. The development of new inhibitors shows promise in treating multidrug-resistant bacteria. The combination of cefepime with novel beta-lactamase inhibitors, zidebactam, taniborbactam, and enmetazobactam, demonstrated high activity against carbapenemase-producing Enterobacterales, particularly cefepime/zidebactam and cefepime/taniborbactam.

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Cefiderocol for the Treatment of Infections Due to Metallo-B-lactamase-Producing Pathogens in the CREDIBLE-CR and APEKS-NP Phase 3 Randomized Studies

Jean-Francois Timsit et al.

Summary: The CREDIBLE-CR and APEKS-NP studies showed that cefiderocol treatment is effective against gram-negative bacteria producing metallo-B-lactamases, with favorable rates of clinical cure, microbiological eradication, and all-cause mortality compared to other treatment options.

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Occurrence of plasmid-mediated quinolone resistance genes in Pseudomonas aeruginosa strains isolated from clinical specimens in southwest Iran: a multicentral study

Morteza Saki et al.

Summary: This study assessed the presence of qnr genes and quinolone resistance pattern in clinical isolates of P. aeruginosa in Ahvaz, southwest Iran. The results showed a high resistance rate of quinolones in P. aeruginosa, with qnrB gene being the most common.

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Laura J. Sherrard et al.

Summary: This study investigates the emergence and clinical relevance of oprD gene mutations in two prevalent Australian shared CF strains of Pseudomonas aeruginosa. The results show that these mutations are closely associated with reduced carbapenem susceptibility in clinical isolates. People with lower lung function are more likely to be infected with these strains, but it does not indicate a worse clinical outcome.

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Therapeutic Strategies for Emerging Multidrug-Resistant Pseudomonas aeruginosa

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INFECTIOUS DISEASES AND THERAPY (2022)

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Infectious Diseases Society of America 2022 Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa)

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Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

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Review Infectious Diseases

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Angela Raffaella Losito et al.

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ANTIBIOTICS-BASEL (2022)

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Review Biochemistry & Molecular Biology

Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

Andre Bittencourt Lorusso et al.

Summary: Antimicrobial resistance is a global public health crisis caused by the emergence of resistant organisms and different mechanisms of antibiotic resistance. Efflux pumps, particularly in Gram-negative bacteria like Pseudomonas aeruginosa, play a significant role in multidrug resistance and extensively drug-resistant bacteria. Understanding their function, structure, and regulation is essential in combating antibiotic resistance and developing new drugs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Infectious Diseases

Activity of cefiderocol, imipenem/relebactam, cefepime/taniborbactam and cefepime/zidebactam against ceftolozane/tazobactam- and ceftazidime/avibactam-resistant Pseudomonas aeruginosa

Cristina Lasarte-Monterrubio et al.

Summary: This study evaluated the activity of new drugs against ceftolozane/tazobactam- and ceftazidime/avibactam-resistant Pseudomonas aeruginosa isolates. Cefiderocol and cefepime/taniborbactam were the most active agents. However, resistance was observed in some strains with specific mutations or overexpression of efflux pumps.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

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Review Immunology

What Is New in the Anti-Pseudomonas aeruginosa Clinical Development Pipeline Since the 2017 WHO Alert?

Sebastien Reig et al.

Summary: The spread of antibiotic-resistant bacteria, particularly carbapenem-resistant Pseudomonas aeruginosa (CRPA), poses a significant threat to global morbidity and mortality. Despite ongoing research, there is currently no validated efficacy of a new treatment. However, there are potential new solutions for P. aeruginosa infections that are actively being tested in humans and may be approved for use in the coming years.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Microbiology

Mechanism of action of cefiderocol

Alex Soriano et al.

Summary: Gram-negative bacilli are inherently resistant to many antibiotics due to their low outer membrane permeability. Designing antibiotics that can cross the membrane using specific transport systems has been the most effective strategy to address this issue. Cefiderocol, unlike cefepime or ceftazidime, has a chlorocatechol group at the end of its C-3 side chain, allowing it to be recognized by transporters in the outer membrane and accumulate in the periplasmic space. It is also highly stable against hydrolysis by most clinically relevant beta-lactamases. The importance of iron in bacterial metabolism and the competition for iron between bacteria and the host are also reviewed to better understand the mechanism of action of cefiderocol.

REVISTA ESPANOLA DE QUIMIOTERAPIA (2022)

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Outcomes in participants with failure of initial antibacterial therapy for hospital-acquired/ventilator-associated bacterial pneumonia prior to enrollment in the randomized, controlled phase 3 ASPECT-NP trial of ceftolozane/tazobactam versus meropenem

Marin H. Kollef et al.

Summary: In patients with HABP/VABP who had failed prior antibacterial therapy, treatment with ceftolozane/tazobactam showed lower 28-day all-cause mortality rates compared to meropenem, although there were no significant differences in clinical cure rates.

CRITICAL CARE (2022)

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Article Microbiology

High prevalence of blaVEB, blaGES and blaPER genes in beta-lactam resistant clinical isolates of Pseudomonas aeruginosa

Saboura Haghighi et al.

Summary: Increased prevalence of beta-lactamase is a major factor in resistance to beta-lactams in Pseudomonas aeruginosa. This study investigated the prevalence of bla(VEB), bla(PER), and bla(GES) genes in beta-lactam-resistant P. aeruginosa. The results showed a significant relationship between resistance to tested antibiotics and the presence of these resistance genes.

AIMS MICROBIOLOGY (2022)

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Article Immunology

A Randomized, Double-blind, Multicenter Trial Comparing Efficacy and Safety of Imipenem/Cilastatin/Relebactam Versus Piperacillin/Tazobactam in Adults With Hospital-acquired or Ventilator-associated Bacterial Pneumonia (RESTORE-IMI 2 Study)

Ivan Titov et al.

Summary: The study demonstrated that imipenem/cilastatin/relebactam and piperacillin/tazobactam had similar efficacy in treating hospital-acquired/ventilator-associated bacterial pneumonia. Imipenem/cilastatin/relebactam showed favorable safety profile in treating HABP/VABP patients.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Microbiology

Expression of the MexXY Aminoglycoside Efflux Pump and Presence of an Aminoglycoside-Modifying Enzyme in Clinical Pseudomonas aeruginosa Isolates Are Highly Correlated

Alexander Seupt et al.

Summary: Elevated mexXY gene expression levels in clinical Pseudomonas aeruginosa isolates result in slight increases in aminoglycoside MIC levels, but rarely lead to clinically relevant resistance phenotypes. The main driver of resistance in these clinical isolates is the acquisition of aminoglycoside-modifying enzymes (AMEs), which is strongly associated with mexY overexpression. The introduction of a gentamicin acetyltransferase confers full resistance levels in a P. aeruginosa type strain only if the MexXY efflux pump is active.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Structural basis for plazomicin antibiotic action and resistance

Tolou Golkar et al.

Summary: The approval of plazomicin broadened the clinical library of aminoglycosides available for use against emerging bacterial pathogens, but resistance to plazomicin has been reported in clinical settings. Structural insights into the mechanism of plazomicin action and clinical resistance mechanisms provide a roadmap for next-generation drug development. The study of plazomicin structures in complex with the bacterial ribosome and antibiotic modification enzyme can be useful in the development of newer non-modified aminoglycosides capable of targeting the bacterial ribosome.

COMMUNICATIONS BIOLOGY (2021)

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Article Infectious Diseases

Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial

Richard G. Wunderink et al.

Summary: Cefiderocol was found to be non-inferior to high-dose, extended-infusion meropenem in terms of all-cause mortality on day 14 in patients with Gram-negative nosocomial pneumonia, with similar tolerability. This suggests that cefiderocol is a potential option for the treatment of patients with nosocomial pneumonia, including those caused by multidrug-resistant Gram-negative bacteria.

LANCET INFECTIOUS DISEASES (2021)

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Letter Infectious Diseases

Reassessment of the cooperativity between efflux system MexAB-OprM and cephalosporinase AmpC in the resistance of Pseudomonas aeruginosa to β-lactams

Melanie Grosjean et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

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Article Infectious Diseases

An update on cefepime and its future role in combination with novel beta-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa

Burcu Isler et al.

Summary: Cefepime, a broad-spectrum antibiotic, has undergone significant changes in dosing with the development of new combinations with beta-lactamase inhibitors for the treatment of multidrug-resistant Gram-negative infections. While promising, the full potential of these combinations in clinical practice can only be determined through further studies.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

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Article Microbiology

Ceftolozane-tazobactam: When, how and why using it?

Inmaculada Lopez Montesinos et al.

Summary: Ceftolozane-tazobactam is currently the most active antipseudomonal agent, but resistant mutants have been described. Combination therapies may be a strategy to avoid resistance emergence.

REVISTA ESPANOLA DE QUIMIOTERAPIA (2021)

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Review Microbiology

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

Eun-Jeong Yoon et al.

Summary: This article highlights the challenge of carbapenem-resistant Pseudomonas aeruginosa in clinical settings, focusing on the global mechanisms of carbapenem resistance and the horizontal dissemination of drug resistance determinants through mobile genetic elements. The review also examines the modular mobile elements, including carbapenemase-encoding genes, for their structures and implications in antimicrobial therapy.

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Review Infectious Diseases

Pseudomonas aeruginosa Resistance to Bacteriophages and Its Prevention by Strategic Therapeutic Cocktail Formulation

Andrew Vaitekenas et al.

Summary: Antimicrobial resistance is a significant threat in modern healthcare, particularly for bacterial infections in individuals with chronic conditions like cystic fibrosis. Pseudomonas aeruginosa infections are a major factor in CF lung disease, with high resistance to multiple antimicrobials. Phages show promise as an alternative therapy, but their narrow host range and phage resistance evolution may limit their efficacy. Developing phage mixtures with broad host ranges to prevent resistance evolution is a potential strategy, but further research is needed on CF-derived P. aeruginosa phage resistance mechanisms for effective phage therapy formulations.

ANTIBIOTICS-BASEL (2021)

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Review Microbiology

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

Karl A. Glen et al.

Summary: The article summarizes the resistance of Pseudomonas aeruginosa to beta-lactam antibiotics and the associated health and economic impacts, discusses the multifactorial mechanisms of resistance, and suggests strategies to enhance the effectiveness of beta-lactam antibiotics.

PATHOGENS (2021)

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Expression of RND efflux pumps mediated antibiotic resistance in Pseudomonas aeruginosa clinical strains

Abed Zahedi Bialvaei et al.

Summary: The study identified that clinical isolates of Pseudomonas aeruginosa commonly express RND efflux pumps, leading to antibiotic resistance. Overexpression of mexB and mexY in ICU wards was significantly prevalent in the studied strains, correlating with resistance to most anti-pseudomonal antibiotics.

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The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies

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Cefiderocol Activity Against Clinical Pseudomonas aeruginosa Isolates Exhibiting Ceftolozane-Tazobactam Resistance

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ANTIBIOTICS-BASEL (2021)

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Summary: This study evaluated the efficacy and safety outcomes of ceftazidime-avibactam in patients with Gram-negative bacteremia associated with various infections, showing favorable clinical and microbiological responses in comparison to standard treatments.

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Activity of imipenem/relebactam against Pseudomonas aeruginosa producing ESBLs and carbapenemases

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Ceftolozane/Tazobactam vs Polymyxin or Aminoglycoside-based Regimens for the Treatment of Drug-resistant Pseudomonas aeruginosa

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Ceftolozane-tazobactam versus meropenem for treatment of nosocomial pneumonia (ASPECT-NP): a randomised, controlled, double-blind, phase 3, non-inferiority trial

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Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

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BIOTECHNOLOGY ADVANCES (2019)

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Evidence-Based Study Design for Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia

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Nicole Gidaya Bonine et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2019)

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Activity of plazomicin in combination with other antibiotics against multidrug-resistant Enterobacteriaceae

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DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2018)

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β-lactam resistance: The role of low molecular weight penicillin binding proteins, β-lactamases and LD-transpeptidases in bacteria associated with respiratory tract infections

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IUBMB LIFE (2018)

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Clinical activity of ceftazidime/avibactam against MDR Enterobacteriaceae and Pseudomonas aeruginosa: pooled data from the ceftazidime/avibactam Phase III clinical trial programme

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KPC-2 carbapenemase-producing Pseudomonas aeruginosa reaching Germany

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JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

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Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

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LANCET INFECTIOUS DISEASES (2018)

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Article Microbiology

Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens

Karl A. Hassan et al.

RESEARCH IN MICROBIOLOGY (2018)

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Review Infectious Diseases

Evaluation of the efficacy and safety of ceftazidime/avibactam in the treatment of Gram-negative bacterial infections: a systematic review and meta-analysis

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Article Microbiology

Oxygen Limitation Enhances the Antimicrobial Activity of Fosfomycin in Pseudomonas aeruginosa Following Overexpression of glpT Which Encodes Glycerol-3-Phosphate/Fosfomycin Symporter

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Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial

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LANCET INFECTIOUS DISEASES (2018)

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Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosa

Gertrudis Horna et al.

SCIENTIFIC REPORTS (2018)

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Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: A Multicenter Study

Jason C. Gallagher et al.

OPEN FORUM INFECTIOUS DISEASES (2018)

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Extended-Spectrum Beta-lactamase Producers: Detection for the Diagnostic Laboratory

Rani Diana Sahni et al.

JOURNAL OF GLOBAL INFECTIOUS DISEASES (2018)

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Article Microbiology

In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria

Akinobu Ito et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

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Article Microbiology

In Vitro Activity of the Siderophore Cephalosporin, Cefiderocol, against Carbapenem-Nonsusceptible and Multidrug-Resistant Isolates of Gram-Negative Bacilli Collected Worldwide in 2014 to 2016

Meredith A. Hackel et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

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International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia

Antoni Torres et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Contamination of hospital tap water: the survival and persistence of Pseudomonas aeruginosa on conventional and 'antimicrobial' outlet fittings

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Review Immunology

Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence

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FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

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Pseudomonas aeruginosa Ventilator-Associated Pneumonia Induces Lung Injury through TNF-α/c-Jun NH2-Terminal Kinase Pathways

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PLOS ONE (2017)

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Antibacterial effect of silver nanoparticles in Pseudomonas aeruginosa

R. Salomoni et al.

NANOTECHNOLOGY SCIENCE AND APPLICATIONS (2017)

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Review Infectious Diseases

Intravenous fosfomycin-back to the future. Systematic review and meta-analysis of the clinical literature

B. Grabein et al.

CLINICAL MICROBIOLOGY AND INFECTION (2017)

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In Vitro Activity of Imipenem-Relebactam against Gram-Negative ESKAPE Pathogens Isolated by Clinical Laboratories in the United States in 2015 (Results from the SMART Global Surveillance Program)

Sibylle H. Lob et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

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Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

Andre C. Kalil et al.

CLINICAL INFECTIOUS DISEASES (2016)

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A two-centre evaluation of RAPIDEC® CARBA NP for carbapenemase detection in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp.

Muhammad Humaun Kabir et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)

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Article Infectious Diseases

Ceftazidime-avibactam or best available therapy in patients with ceftazidime-resistant Enterobacteriaceae and Pseudomonas aeruginosa complicated urinary tract infections or complicated intra-abdominal infections (REPRISE): a randomised, pathogen-directed, phase 3 study

Yehuda Carmeli et al.

LANCET INFECTIOUS DISEASES (2016)

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Tripartite assembly of RND multidrug efflux pumps

Laetitia Daury et al.

NATURE COMMUNICATIONS (2016)

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β-Lactams and β-Lactamase Inhibitors: An Overview

Karen Bush et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

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Antimicrobial agents targeting bacterial cell walls and cell membranes

K. BUSH

REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES (2016)

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Ceftolozane-tazobactam: A new-generation cephalosporin

David Cluck et al.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2015)

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Article Microbiology

Role of Pseudomonas aeruginosa Low-Molecular-Mass Penicillin-Binding Proteins in AmpC Expression, β-Lactam Resistance, and Peptidoglycan Structure

Alaa Ropy et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

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Article Microbiology

Mutations in β-Lactamase AmpC Increase Resistance of Pseudomonas aeruginosa Isolates to Antipseudomonal Cephalosporins

M. Berrazeg et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

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Review Pharmacology & Pharmacy

The increasing threat of Pseudomonas aeruginosa high-risk clones

Antonio Oliver et al.

DRUG RESISTANCE UPDATES (2015)

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Association of overexpression of efflux pump genes with antibiotic resistance in Pseudomonas aeruginosa strains clinically isolated from urinary tract infection patients

Katsumi Shigemura et al.

JOURNAL OF ANTIBIOTICS (2015)

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Article Microbiology

The absence of the Pseudomonas aeruginosa OprF protein leads to increased biofilm formation through variation in c-di-GMP level

Emeline Bouffartigues et al.

FRONTIERS IN MICROBIOLOGY (2015)

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Review Infectious Diseases

Alarming and increasing prevalence of multidrug-resistant Pseudomonas aeruginosa among healthcare-associated infections in China: A meta-analysis of cross-sectional studies

Yang Peng et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2015)

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What It Takes to Be a Pseudomonas aeruginosa? The Core Genome of the Opportunistic Pathogen Updated

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PLOS ONE (2015)

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Transcriptional Analysis of MexAB-OprM Efflux Pumps System of Pseudomonas aeruginosa and Its Role in Carbapenem Resistance in a Tertiary Referral Hospital in India

Debarati Choudhury et al.

PLOS ONE (2015)

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Article Microbiology

The Pseudomonas aeruginosa CreBC Two-Component System Plays a Major Role in the Response to β-Lactams, Fitness, Biofilm Growth, and Global Regulation

Laura Zamorano et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

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Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations

Jingjing Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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OXA β-Lactamases

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CLINICAL MICROBIOLOGY REVIEWS (2014)

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Ceftolozane/Tazobactam: A Novel Cephalosporin/beta-Lactamase Inhibitor Combination with Activity Against Multidrug-Resistant Gram-Negative Bacilli

George G. Zhanel et al.

DRUGS (2014)

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Investigation of plasmid-mediated quinolone resistance in Pseudomonas aeruginosa clinical isolates

Y. Tanriverdi Cayci et al.

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY (2014)

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Article Infectious Diseases

OprD mutations and inactivation in imipenem-resistant Pseudomonas aeruginosa isolates from China

Zhi-li Fang et al.

INFECTION GENETICS AND EVOLUTION (2014)

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Characterization of a novel Zn2+-dependent intrinsic imipenemase from Pseudomonas aeruginosa

Alicia Fajardo et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)

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Article Microbiology

Outbreak of PER-1 and diversity of β-lactamases among ceftazidime-resistant Pseudomonas aeruginosa clinical isolates

Yun Qing et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2014)

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Article Microbiology

Prevalence of Extended-Spectrum and Metallo β-Lactamase Production in AmpC β-Lactamase Producing Pseudomonas aeruginosa Isolates From Burns

Roya Rafiee et al.

JUNDISHAPUR JOURNAL OF MICROBIOLOGY (2014)

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Review Microbiology

A new strategy to fight antimicrobial resistance: the revival of old antibiotics

Nadim Cassir et al.

FRONTIERS IN MICROBIOLOGY (2014)

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Review Infectious Diseases

Acquired Class D β-Lactamases

Nuno T. Antunes et al.

ANTIBIOTICS-BASEL (2014)

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Metallo-beta-lactamase structure and function

Timothy Palzkill

ANTIMICROBIAL THERAPEUTICS REVIEWS: THE BACTERIAL CELL WALL AS AN ANTIMICROBIAL TARGET (2013)

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Article Microbiology

Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in β-Lactam Resistance

Jeffrey D. Smith et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

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Pseudomonas in augmented care: should we worry?

Michael Kelsey

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2013)

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Study on drug resistance of Pseudomonas aeruginosa plasmid-mediated AmpC β-lactamase

Bin Zhu et al.

MOLECULAR MEDICINE REPORTS (2013)

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Pan-β-Lactam Resistance Development in Pseudomonas aeruginosa Clinical Strains: Molecular Mechanisms, Penicillin-Binding Protein Profiles, and Binding Affinities

Bartolome Moya et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

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Article Infectious Diseases

Detection of P. aeruginosa harboring blaCTX-M-2, blaGES-1 and blaGES-5, blaIMP-1 and blaSPM-1 causing infections in Brazilian tertiary-care hospital

Milena Polotto et al.

BMC INFECTIOUS DISEASES (2012)

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Review Microbiology

Structure and function of OprD protein in Pseudomonas aeruginosa: From antibiotic resistance to novel therapies

Hui Li et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2012)

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Review Microbiology

From the regulation of peptidoglycan synthesis to bacterial growth and morphology

Athanasios Typas et al.

NATURE REVIEWS MICROBIOLOGY (2012)

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Molecular Epidemiology of a Pseudomonas aeruginosa Hospital Outbreak Driven by a Contaminated Disinfectant-Soap Dispenser

Simone Lanini et al.

PLOS ONE (2011)

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Review Biochemistry & Molecular Biology

Pseudomonas aeruginosa: all roads lead to resistance

Elena B. M. Breidenstein et al.

TRENDS IN MICROBIOLOGY (2011)

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Pseudomonas aeruginosa: resistance to the max

Keith Poole

FRONTIERS IN MICROBIOLOGY (2011)

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Nosocomial Pneumonia in the Intensive Care Unit Acquired by Mechanically Ventilated versus Nonventilated Patients

Mariano Esperatti et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

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Review Microbiology

Diversity, Epidemiology, and Genetics of Class D beta-Lactamases

Laurent Poirel et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

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Article Infectious Diseases

Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues

V. Miriagou et al.

CLINICAL MICROBIOLOGY AND INFECTION (2010)

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Review Microbiology

Three Decades of beta-Lactamase Inhibitors

Sarah M. Drawz et al.

CLINICAL MICROBIOLOGY REVIEWS (2010)

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Review Microbiology

How antibiotics kill bacteria: from targets to networks

Michael A. Kohanski et al.

NATURE REVIEWS MICROBIOLOGY (2010)

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Efflux Unbalance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

Lucie Vettoretti et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

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Article Microbiology

Extended-Spectrum Cephalosporinases in Pseudomonas aeruginosa

Jose-Manuel Rodriguez-Martinez et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

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Review Microbiology

Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms

Philip D. Lister et al.

CLINICAL MICROBIOLOGY REVIEWS (2009)

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Review Pharmacology & Pharmacy

Efflux-Mediated Drug Resistance in Bacteria An Update

Xian-Zhi Li et al.

DRUGS (2009)

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Article Microbiology

The Glycerol-3-Phosphate Permease GlpT Is the Only Fosfomycin Transporter in Pseudomonas aeruginosa

Alfredo Castaneda-Garcia et al.

JOURNAL OF BACTERIOLOGY (2009)

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Mechanistic Basis for the Emergence of Catalytic Competence against Carbapenem Antibiotics by the GES Family of β-Lactamases

Hilary Frase et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Microbiology

Sensitive Screening Tests for Suspected Class A Carbapenemase Production in Species of Enterobacteriaceae

Fernando Pasteran et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2009)

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Article Microbiology

β-Lactam Resistance Response Triggered by Inactivation of a Nonessential Penicillin-Binding Protein

Bartolome Moya et al.

PLOS PATHOGENS (2009)

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Review Microbiology

The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

Eric Sauvage et al.

FEMS MICROBIOLOGY REVIEWS (2008)

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Review Microbiology

Carbapenemases:: the versatile β-lactamases

Anne Marie Queenan et al.

CLINICAL MICROBIOLOGY REVIEWS (2007)

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Article Infectious Diseases

Evolution of antimicrobial resistance among Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumonide in Brooklyn, NY

David Landman et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)

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Article Microbiology

First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing β-lactamase

Maria Virginia Villegas et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)

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Review Microbiology

Multidrug-resistance efflux pumps - not just for resistance

Laura J. V. Piddock

NATURE REVIEWS MICROBIOLOGY (2006)

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Article Microbiology

Class II transposon-borne structure harboring metallo-β-lactamase gene blaVIM-2 in Pseudomonas putida

Laurent Poirel et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)

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Article Biochemistry & Molecular Biology

Pseudomonas aeruginosa porin OprF exists in two different conformations

Etsuko Sugawara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Microbiology

BEL-1, a novel clavulanic acid-inhibited extended-spectrum β-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa

L Poirel et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)

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Letter Infectious Diseases

Is it necessary to change the classification of β-lactamases?

JM Frère et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)

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Review Microbiology

Metallo-β-lactamases:: the quiet before the storm?

TR Walsh et al.

CLINICAL MICROBIOLOGY REVIEWS (2005)

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Letter Infectious Diseases

Combination antibiotic therapy for Pseudomonas aeruginosa bacteraemia

M Paul et al.

LANCET INFECTIOUS DISEASES (2005)

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Article Biochemistry & Molecular Biology

Phosphonoformate: A minimal transition state analogue inhibitor of the fosfomycin resistance protein, FosA

RE Rigsby et al.

BIOCHEMISTRY (2004)

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Review Infectious Diseases

Integrons and β-lactamases -: a novel perspective on resistance

GF Weldhagen

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2004)

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Article Microbiology

Biochemical characterization of the naturally occurring oxacillinase OXA-50 of Pseudomonas aeruginosa

D Girlich et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)

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Article Biochemistry & Molecular Biology

On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps:: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

WM Mao et al.

MOLECULAR MICROBIOLOGY (2002)

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Article Microbiology

Constitutive high expression of chromosomal β-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD

N Bagge et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)

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Article Infectious Diseases

Cefepime, piperacillin/tazobactam, gentamicin, ciprofloxacin, and levofloxacin alone and in combination against Pseudomonas aeruginosa

DS Burgess et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2002)

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Article Multidisciplinary Sciences

Critical involvement of a carbamylated lysine in catalytic function of class D β-lactamases

D Golemi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Review Medicine, General & Internal

Antibiotic resistance of bacteria in biofilms

PS Stewart et al.

LANCET (2001)

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Article Microbiology

Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics:: Penem resistance mechanisms and their interplay

K Okamoto et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)

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Article Microbiology

Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa

D Aubert et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)

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Article Multidisciplinary Sciences

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

CK Stover et al.

NATURE (2000)

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