☆ 4.8 Review

Printed Electronic Devices and Systems for Interfacing with Single Cells up to Organoids

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Multidisciplinary Sciences

Large-scale perfused tissues via synthetic 3D soft microfluidics

Sergei Grebenyuk et al.

Summary: By developing micro-perfused 2-photon printing of 3D microfluidics, the authors have successfully engineered large-scale, viable and functional neural and hepatic 3D tissues. They have achieved the perfusion of multi-mm(3) tissue constructs by generating networks of synthetic capillary-scale 3D vessels, addressing the challenge of vascularization in regenerative medicine.

NATURE COMMUNICATIONS (2023)

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Article Chemistry, Multidisciplinary

Bio-Metamaterials for Mechano-Regulation of Mesenchymal Stem Cells

Natalie Munding et al.

Summary: Cell behaviors depend on the elastic properties of the microenvironments, which differ from polymer-based substrates. Metamaterials, with adjustable elastic properties, offer a promising way to mechanically control stem cells. By designing microstructured bio-metamaterials based on a silicon elastomer-like photoresist and two-photon laser printing, the differential responses of human mesenchymal stem cells (hMSCs) correlate with the calculated elastic properties of the bio-metamaterials, suggesting the potential of using bio-metamaterials for cell behavior regulation.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Pyroelectric Janus nanomotors to promote cell internalization and synergistic tumor therapy

Jie Meng et al.

Summary: The in situ generation of microelectric field on nanoparticles is proposed to overcome the obstacles of tumor diffusion and cell internalization, leading to targeted accumulation, deep tissue penetration, and effective cell interaction. The combination of thermophoresis-driven motion, pyroelectric potential-enhanced cell internalization, and PTT/PEDT/chemotherapy-synergized treatment achieves favorable treatment safety and inhibits tumor growth.

JOURNAL OF CONTROLLED RELEASE (2023)

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Article Physics, Applied

Composite magnetic 3D-printing filament fabrication protocol opens new perspectives in magnetic hyperthermia

A. Makridis et al.

Summary: Three-dimensional (3D) printing technology has shown promise in producing intricately detailed biomimetic 3D structures, particularly magnetic scaffolds for applications in tissue engineering, bone repair, drug delivery, and magnetic hyperthermia. This study presents a fabrication protocol for 3D printed polymer-bonded magnets using the Fused Deposition Modeling method. Different types of filaments with magnetite nanoparticles mixed with polymer binders were successfully fabricated and characterized before the printing process. The results demonstrate that the heating efficiency of the 3D printed magnetic polymer scaffolds can be controlled by adjusting the concentration of magnetite nanoparticles and the type of filament used.

JOURNAL OF PHYSICS D-APPLIED PHYSICS (2023)

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Article Chemistry, Multidisciplinary

Integrated Cardiomyocyte-Based Biosensing Platform for Electroporation-Triggered Intracellular Recording in Parallel with Delivery Efficiency Evaluation

Jiaru Fang et al.

Summary: An integrated cardiomyocyte-based biosensing platform has been developed to record action potential and evaluate the quality of electroporation. This platform shows potential for drug delivery therapy and pathology research in cardiology.

NANO LETTERS (2023)

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Review Engineering, Biomedical

Toxicity and Biocompatibility of Liquid Metals

Sen Chen et al.

Summary: This review provides a comprehensive summary of the current knowledge on liquid metal toxicology and biocompatibility, focusing on Ga and Bi-based liquid metals. It discusses the challenges and suggests further investigation to clarify toxicological mechanisms and strategies to avoid adverse effects. The review aims to promote the healthy and sustainable development of liquid metal-based materials, particularly in healthcare applications.

ADVANCED HEALTHCARE MATERIALS (2023)

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Review Engineering, Biomedical

Catalytic Biomaterials and Nanomedicines with Exogenous and Endogenous Activations

Hui Huang et al.

Summary: Catalytic therapy has shown promise in enhancing therapeutic efficacy and reducing side effects by converting less toxic or nontoxic endogenous substances into highly toxic reactive species to induce cell death. This review summarizes the recent advances in the development and use of catalytic biomaterials and nanomedicines in various biomedical applications. The study focuses on the use of endogenous activators and exogenous stimuli to improve treatment efficacy, and discusses the biosafety and biocompatibility of these materials. The challenges and future opportunities for catalytic biomaterials and nanomedicines are also highlighted.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Chemistry, Multidisciplinary

3D-Printed Piezoelectric Scaffolds with Shape Memory Polymer for Bone Regeneration

Guanlin Li et al.

Summary: Researchers have developed 3D-printed piezoelectric scaffolds using shape memory polymer (SMP) and piezoelectric nanoparticles for bone defect repair. By incorporating Ag-TMSPM-pBT (ATP) nanoparticles, they were able to improve the piezoelectric properties of the scaffolds. In vitro and in vivo experiments showed that the scaffolds promoted osteogenic differentiation of bone cells and facilitated bone defect repair.

SMALL (2023)

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Article Multidisciplinary Sciences

Laser printed microelectronics

Liang Yang et al.

Summary: The authors propose laser printing as a facile process for fabricating printed electronics with minimum feature sizes below 1μm and demonstrate functional diodes, memristors, and physically unclonable functions. Laser printing with different inks, for the semiconductor ZnO and the metals Pt and Ag, is introduced for fabricating printed functional electronic devices with minimum feature sizes below 1μm. The versatility of this approach is demonstrated by showing functional diodes, memristors, and a physically unclonable function.

NATURE COMMUNICATIONS (2023)

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Article Multidisciplinary Sciences

Direct laser writing of 3D electrodes on flexible substrates

Morgan A. Brown et al.

Summary: This report describes the integration of a 3D microelectrode array on a thin-film flexible cable for neural recording. The fabrication process combines traditional thin-film processing techniques and direct laser writing of 3D structures at micron resolution via two-photon lithography. The report provides a method for producing high-aspect-ratio structures.

NATURE COMMUNICATIONS (2023)

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Article Engineering, Biomedical

Printed Silk Microelectrode Arrays for Electrophysiological Recoding and Controlled Drug Delivery

Nouran Adly et al.

Summary: Soft microelectrode arrays made of silk fibroin (SF) films are developed for recording cells' electrical activity and as a drug delivery system. Inkjet printing is used to fabricate carbon microelectrodes for in vitro cell action potential recordings. The study also demonstrates the tuning of SF to produce a permeable layer for on-demand drug delivery systems. This multifunctional MEA can enable in vitro drug screening with time-resolved and localized chemical stimuli.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Engineering, Biomedical

Electrical Stimulation Promotes the Vascularization and Functionalization of an Engineered Biomimetic Human Cardiac Tissue

Bingchuan Lu et al.

Summary: The formation of multiscale vascular networks is essential for the construction of large-scale biomimetic cardiac tissues/organs in vitro. Electrical stimulation is applied to promote the elongation and connection of endothelial cells in engineered cardiac tissue (ECT) and achieve vascularization. The results show that electrical stimulation significantly enhances the elongation, migration, and interconnection of endothelial cells in ECT and increases the expression of related genes. Electrical stimulation also enhances the secretion of signal factors between cardiomyocytes and endothelial cells and contributes to the contractility of cardiac tissue.

ADVANCED HEALTHCARE MATERIALS (2023)

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Review Chemistry, Analytical

Organic Bioelectronics Development in Italy: A Review

Matteo Parmeggiani et al.

Summary: In recent years, there has been a constant growth in the studies of Organic Bioelectronics due to the interest in connecting the digital world with the biological one in disciplines such as medicine, biology, and food safety. The focus is on organic neuromorphic devices and organic transistor sensors, which are rapidly growing due to their low cost, high sensitivity, and biocompatibility. This review specifically analyzes the Italian production in this field, highlighting its trend and possible future evolutions.

MICROMACHINES (2023)

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Review Pharmacology & Pharmacy

Piezoelectric Nanomaterials Activated by Ultrasound in Disease Treatment

Shiyuan Yang et al.

Summary: Electric stimulation is used to treat certain diseases by changing cell morphology, status, and life cycle. To minimize side effects, ultrasound is being used to control piezoelectric effects of nano materials. Recent studies have shown that this method can induce biological changes and piezo-chemical reactions. However, technical problems and regulatory processes need to be addressed before widespread use.

PHARMACEUTICS (2023)

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Article Chemistry, Multidisciplinary

4D-Printed Soft and Stretchable Self-Folding Cuff Electrodes for Small-Nerve Interfacing

Lukas Hiendlmeier et al.

Summary: A nerve interface that can fold itself to a cuff around a small nerve has been developed, improving the handling and implantation of electrodes for peripheral nerve interfacing. The self-folding electrodes are robust, stretchable, and can be easily implanted and extracted, showing potential for broader clinical applications.

ADVANCED MATERIALS (2023)

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Article Engineering, Biomedical

Electrical stimulation of piezoelectric BaTiO3 coated Ti6Al4V scaffolds promotes anti-inflammatory polarization of macrophages and bone repair via MAPK/JNK inhibition and OXPHOS activation

Hao Wu et al.

Summary: A piezoelectric BaTiO3/Ti6Al4V (BT/Ti) scaffold was prepared by hydrothermal synthesis of a uniform BaTiO3 layer on three dimensionally printed Ti6Al4V scaffold. The BT/Ti scaffolds exhibited piezoelectricity and favorable biocompatibility, promoting M2 polarization of macrophages and immunoregulatory osteogenesis of osteoblasts. Under low intensity pulsed ultrasound stimulation, a higher proportion of M2 macrophages was observed in the tissues around the poled BT/Ti scaffolds, and improvements in bone regeneration were identified in a sheep cervical corpectomy model.

BIOMATERIALS (2023)

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Article Chemistry, Applied

Design of hyaluronan-based dopant for conductive and resorbable PEDOT ink

Maxime Leprince et al.

Summary: Conformable and biocompatible conductive materials are in high demand for the development of bioelectronics. This study designs hyaluronan derivatives as dopants for poly(3,4-ethylenedioxy)thiophene and demonstrates their potential as transient implantable electronic devices. By optimizing the sulfation protocol, the researchers achieved good control over the polymer sulfation degree while minimizing chain degradation. The resulting material showed excellent conductivity in physiological conditions and was non-cytotoxic, making it a promising candidate for in vivo applications such as inkjet printing.

CARBOHYDRATE POLYMERS (2023)

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Article Materials Science, Multidisciplinary

Imparting High Conductivity to 3D Printed PEDOT:PSS

Ian M. Hill et al.

Summary: Complex 3D geometry and high conductivity have been mutually exclusive characteristics for conducting polymers. However, this study reveals that the reduced conductivity in 3D-printed forms of PEDOT:PSS can be overcome by addressing the ink formulation strategy and lateral phase separation. By optimizing these factors, a significant enhancement in conductivity to 1200 S/cm, higher than the typical 2D-processed PEDOT:PSS, has been achieved.

ACS APPLIED POLYMER MATERIALS (2023)

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Article Materials Science, Multidisciplinary

Printed soft skin electrodes for seamless bio-impedance measurements

Bara Levit et al.

Summary: Contemporary skin electrodes for bio-impedance measurements are inconvenient, and new electrode designs are needed for better usability. This study introduces dry, printed, bio-compatible electrode arrays that measure bio-impedance accurately and stably. The electrodes have unique properties that allow blood pulsation measurement in the face and during muscle activation, with signal stability over many hours.

FLEXIBLE AND PRINTED ELECTRONICS (2023)

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Article Engineering, Biomedical

Tailoring inkjet-printed PEDOT:PSS composition toward green, wearable device fabrication

Marina Galliani et al.

Summary: Inkjet printing is a cost-efficient technique for device prototyping and manufacturing, offering digital design freedom, non-contact, and additive fabrication. This study proposes a tailor-made ink formulation based on non-hazardous materials for developing green electronic devices that interface with humans. The developed ink exhibits high-resolution inkjet printability on multiple wearable substrates, with enhanced electrical properties, mechanical flexibility, and water stability. Cytocompatibility evaluations show no harmful effects on human mesenchymal stem cells. A printed wearable touch sensor capable of tracking human steps is fabricated, demonstrating the viability of materials and processes for biocompatible devices.

APL BIOENGINEERING (2023)

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Article Polymer Science

Fast Visible-Light 3D Printing of Conductive PEDOT:PSS Hydrogels

Naroa Lopez-Larrea et al.

Summary: Functional inks for light-based 3D printing are being explored, and a fast visible-light photopolymerization process of conductive PEDOT:PSS hydrogels is demonstrated. A new Type II photoinitiator system based on riboflavin, triethanolamine, and PEDOT:PSS is investigated, enabling full monomer conversion in less than 2 min using visible light. PEDOT:PSS plays a dual role by speeding up photoinitiation and enhancing the conductivity of the hydrogels.

MACROMOLECULAR RAPID COMMUNICATIONS (2023)

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Article Chemistry, Analytical

Integration of microelectrodes and highly-aligned cardiac constructs for in situ electrophysiological recording

Bingsong Gu et al.

Summary: Recapitulating the morphology and electrophysiological activity of native myocardium is crucial for functional cardiac constructs. This study proposes a strategy to integrate platinum microelectrodes into cell-laden fibrin hydrogel to fabricate highly-aligned cardiac constructs and support electrophysiological recording. The constructs demonstrated close contact between the microelectrodes and cardiomyocytes, resulting in highly-aligned morphology. In addition, the embedded microelectrodes recorded changes in electrophysiological signals and altered cardiac behavior with electrical stimulation.

MICROCHEMICAL JOURNAL (2023)

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Article Chemistry, Multidisciplinary

In Situ Fabrication of Constraints for Multicellular Micro‐Spheroids Using Two‐Photon Lithography

Mohammadreza Taale et al.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Materials Science, Multidisciplinary

Fully Printed Electrolyte-Gated Transistor Formed in a 3D Polymer Reservoir with Laser Printed Drain/Source Electrodes

Gabriel Cadilha Marques et al.

Summary: This article introduces a manufacturing concept and optimized material stack for solution processed electronic devices, which addresses the alignment and compatibility issues. Laser printing of metals and polymer reservoirs is used to achieve shorter channel lengths and improved device performance.

ADVANCED MATERIALS TECHNOLOGIES (2023)

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Article

Multifunctional organic monolayer-based coatings for implantable biosensors and bioelectronic devices: Review and perspectives

Taral Patel et al.

Biosensors and Bioelectronics: X (2023)

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Article Cardiac & Cardiovascular Systems

Membrane remodelling triggers maturation of excitation-contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes

Fatemeh Kermani et al.

Summary: The prospective use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) for cardiac regenerative medicine strongly depends on the electro-mechanical properties of these cells, especially regarding the Ca2+-dependent excitation-contraction (EC) coupling mechanism. Currently, the immature structural and functional features of hiPSC-CM limit the progression towards clinical applications. Here, we show that a specific microarchitecture is essential for functional maturation of hiPSC-CM.

BASIC RESEARCH IN CARDIOLOGY (2023)

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Review Chemistry, Multidisciplinary

Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane

Anna Mariano et al.

Summary: The plasma membrane is a highly dynamic structure that can stretch, bend, and bud to allow cells to respond and adapt to their environment. Biomimetic strategies based on substrate dimensionality, utilizing conductive polymers, and biofunctionalization through ECM proteins or lipid bilayers have been developed to optimize cell-chip coupling and maximize interfacial interactions.

CHEMICAL REVIEWS (2022)

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Article Chemistry, Physical

Equilibrium droplet shapes on chemically patterned surfaces: theoretical calculation, phase-field simulation, and experiments

Yanchen Wu et al.

Summary: The hypothesis of this study is that droplet wetting on a solid substrate is affected by surface heterogeneity, and introducing patterned wettability can manipulate droplet wetting behaviors. The research found various anisotropic wetting shapes on chemically patterned substrates using analytical models, phase-field simulations, and experiments, with excellent agreement between the methods. Additionally, non-rotationally symmetric droplet shapes were observed for the first time, and anisotropic wetting shapes during quasi-equilibrium evaporation were revealed.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Interactions between Liquid Metal Droplets and Bacterial, Fungal, and Mammalian Cells

Samuel Cheeseman et al.

Summary: Liquid metals interact with cells, causing deformation and breakage of the metal surface. The flexible nature of the cells allows for multiple adhesion sites and the application of tensile forces on the metal surface. Molecular dynamics simulations demonstrate that flexible biomolecules on the cell surface can disrupt the oxide layer on the metal surface.

ADVANCED MATERIALS INTERFACES (2022)

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Article Engineering, Manufacturing

4D printing of patterned multimaterial magnetic hydrogel actuators

Julia Siminska-Stanny et al.

Summary: This paper presents a new class of printable magnetic hydrogels for 4D printing of soft actuators. The development of biocompatible bionanocomposites is highlighted. The incorporation of magnetic nanoparticles into the hydrogel enables contactless control of hydrogel motion. The magnetic hydrogels exhibit high porosity, good mechanical stability, and unique magnetic responsiveness.

ADDITIVE MANUFACTURING (2022)

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Review Materials Science, Ceramics

A critical review of bioceramics for magnetic hyperthermia

Omid Sedighi et al.

Summary: The magnetic properties, structure, and synthesis parameters of biocompatible ceramics are crucial for controlled heating of malignant tumors, leading to clinical success. Recent progress in magnetic hyperthermia combined with chemotherapy and phototherapy aims to advance the interdisciplinary applications of bioceramics in cancer therapy.

JOURNAL OF THE AMERICAN CERAMIC SOCIETY (2022)

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Article Multidisciplinary Sciences

Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes

Zeinab Jahed et al.

Summary: This study develops mechanically robust nanocrown electrodes with high success rates achieved through electroporation, and validates their accurate recording of intracellular action potentials through simultaneous patch clamp recording. The study also demonstrates the ability of nanocrown electrodes to enable prolonged recording of the same cells after sequential addition of drugs. This technological advancement is significant for establishing a screening assay for preclinical evaluation of drug-induced arrhythmogenicity.

NATURE COMMUNICATIONS (2022)

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Article Polymer Science

Integration of Biofunctional Molecules into 3D-Printed Polymeric Micro-/Nanostructures

Eider Berganza et al.

Summary: This study demonstrates the use of FluidFM technology to print micro-/nanostructures on surfaces with different wetting properties. Molecules with different functional groups were integrated into the polymer ink, and the effect of substrate wetting properties on printing results was investigated. Ink modification showed minor changes in the stiffness of the printed structures, while the functionality of the structures was retained after UV curing.

POLYMERS (2022)

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Article Multidisciplinary Sciences

Intrinsically stretchable electronics with ultrahigh deformability to monitor dynamically moving organs

Shaolei Wang et al.

Summary: Intrinsically stretchable electronics with liquid metal components have been developed, offering high stretchability and durability, and have potential applications in health monitoring, disease diagnosis, and medical therapies.

SCIENCE ADVANCES (2022)

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Review Medicine, Research & Experimental

Bio-hybrid electronic and photonic devices

Susan T. Sharfstein

Summary: Bio-hybrid devices, which combine electronic and photonic components with cells, tissues, and organs, have the potential to advance our understanding of biology, physiology, and pathologies, as well as treat a wide range of conditions and diseases. This review discusses the devices, materials, and technologies that make bio-hybrid devices possible, and provides examples of their application at various biological scales. It also describes the outcomes of a National Science Foundation (NSF)-funded workshop that envisions the potential applications of these technologies in improving health outcomes and quality of life.

EXPERIMENTAL BIOLOGY AND MEDICINE (2022)

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Review Nanoscience & Nanotechnology

Nanomaterial-Based Electrically Conductive Hydrogels for Cardiac Tissue Repair

Mingyu Lee et al.

Summary: Cardiovascular disease is a leading cause of death, and biomaterial-based tissue engineering approaches have shown promise in cardiac repair. This review focuses on the use of nanomaterial-incorporated conductive hydrogels for improving cardiac function post-myocardial infarction.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Nanoscience & Nanotechnology

3D Printed Piezoelectric Wound Dressing with Dual Piezoelectric Response Models for Scar-Prevention Wound Healing

Jiachen Liang et al.

Summary: In this study, a novel piezoelectric hydrogel scaffold was prepared using 3D printing technology, which can simulate and amplify endogenous bioelectricity to promote wound healing and prevent scar formation. The scaffold exhibited significant acceleration of wound healing and effective prevention of scar tissue formation within 2 weeks.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Superparamagnetic Iron Oxide Nanoparticles for Targeted Cell Seeding: Magnetic Patterning and Magnetic 3D Cell Culture

Mona Kappes et al.

Summary: Noncontact manipulation of cells in regenerative medicine using superparamagnetic iron oxide nanoparticles (SPIONs) allows for new possibilities in tissue engineering. SPIONs can be used as drug transporters, contrast agents, or to make cells maneuverable by magnetic forces. Different SPION coatings, such as PAM and citrate, show good cellular loading and magnetic controllability of cells. This research demonstrates the potential for using SPIONs in 3D cell cultures and highlights their ability to accelerate spheroid formation and micropatterning.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Review Polymer Science

3D printed magnetic polymer composite hydrogels for hyperthermia and magnetic field driven structural manipulation

Sayan Ganguly et al.

Summary: Magnetic hydrogels and soft composites have played a crucial role in the development of biomimetic soft robotics. By trapping magnetic nanoparticles inside polymeric matrices, precise control and non-cytotoxicity can be achieved. These polymeric magnetic soft materials also respond to external magnetic fields, enabling clinical applications and shape morphing behaviors.

PROGRESS IN POLYMER SCIENCE (2022)

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Article Engineering, Biomedical

Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization

Changhao Li et al.

Summary: This study proposes a wireless electrical stimulation strategy to achieve tumor vascular normalization by breaking bioelectric homeostasis within cells. Polarized barium titanate nanoparticles with high mechano-electrical conversion performance are developed, which can generate pulsed open-circuit voltage under low-intensity pulsed ultrasound. Wireless electrical stimulation significantly inhibits endothelial cell migration and differentiation in vitro. In vivo experiments show that wireless electrical stimulation normalizes tumor vasculature by optimizing vascular structure, enhancing blood perfusion, reducing vascular leakage, and restoring local oxygenation.

BIOACTIVE MATERIALS (2022)

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Article Materials Science, Biomaterials

Piezoelectric Hydrogel for Prophylaxis and Early Treatment of Pressure Injuries/Pressure Ulcers

Yuanxing Li et al.

Summary: The study introduces an electroactive hydrogel with large stretchability and skinlike ductility, which exhibits piezoelectric properties and can promote angiogenesis under piezoelectric stimulation. The hydrogel has the potential to form fine vessels for the treatment of pressure injuries/pressure ulcers and is suitable for preventing PIs/PUs by redistributing force, reducing tissue distortion, and maintaining the skin microenvironment.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Multidisciplinary Sciences

Shell microelectrode arrays (MEAs) for brain organoids

Qi Huang et al.

Summary: Researchers have developed miniaturized wafer-integrated caps with multiple electrodes (MEAs) for electrical recording in brain organoids. These MEAs have the ability to adapt to organoids of different sizes through mechanics simulations, and can record electrophysiological data for up to 4 weeks.

SCIENCE ADVANCES (2022)

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Article Materials Science, Multidisciplinary

Digital Light 3D Printing of PEDOT-Based Photopolymerizable Inks for Biosensing

Naroa Lopez-Larrea et al.

Summary: This research optimized short-time photopolymerizable conductive inks for the fabrication of flexible and shape-defined conductive hydrogels and dry conductive PEDOTs using DLP printing. The printed conductive PEDOT-based hydrogels exhibit soft mechanical properties and good conductivity values for biosensing.

ACS APPLIED POLYMER MATERIALS (2022)

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Article

Research Trends of Piezoelectric Nanomaterials in Biomedical Engineering

Jianying Ji et al.

Advanced Nanobiomed Research (2022)

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Article Cell Biology

Cell-substratum and cell-cell adhesion forces and single-cell mechanical properties in mono- and multilayer assemblies from robotic fluidic force microscopy

Agoston G. Nagy et al.

Summary: This study used high-throughput fluidic force microscopy to investigate the cellular adhesion maturation in epithelial cells. The results showed a significant strengthening adhesive tendency during the formation of Vero monolayers, but this step-by-step maturation was absent in HeLa cells. Additionally, cancerous HeLa cells displayed stronger adhesion to the tight Vero monolayer than cells of the same origin, and the mechanical characteristics of Vero monolayers upon cancerous HeLa cell influence were recorded and analyzed.

EUROPEAN JOURNAL OF CELL BIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Multimodal Characterization of Cardiac Organoids Using Integrations of Pressure-Sensitive Transistor Arrays with Three-Dimensional Liquid Metal Electrodes

Moohyun Kim et al.

Summary: In this study, an unconventional method for multimodal characterization of three-dimensional cardiac organoids is presented. The method utilizes an active-matrix array of pressure-sensitive transistors to visualize the local pressure distributions of human-induced pluripotent stem-cell-derived cardiac organoids, and integrates it with three-dimensional electrodes formed by high-resolution printing of liquid metal for simultaneous electrophysiological recording and stimulation. This method enables electrical therapeutics of cardiac organoids without any interference between pressure signals and electrical pulses from pacing electrodes.

NANO LETTERS (2022)

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Article Materials Science, Biomaterials

Electrically Copolymerized Polydopamine Melanin/Poly(3,4-ethylenedioxythiophene) Applied for Bioactive Multimodal Neural Interfaces with Induced Pluripotent Stem Cell-Derived Neurons

Wei-Chen Huang et al.

Summary: Multimodal neural interfaces combine electrical neuromodulation and synchronous monitoring of neurochemical and physiological signals in one device. This study developed PDAM-doped PEDOT (PEDOT/PDAM) as a bioactive neural interface that exhibits robust electrochemical performance, structural stability, analyte-trapping capacity, and neural stem cell affinity. The use of potentiodynamic scans resolved the problem of structural instability and functionalization difficulties commonly found in PEDOT/PSS, leading to improved electrode materials for brain-machine interfaces.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

Blood-Lymphatic Integrated System with Heterogeneous Melanoma Spheroids via In-Bath Three-Dimensional Bioprinting for Modelling of Combinational Targeted Therapy

Won-Woo Cho et al.

Summary: Metastatic melanoma is a challenging form of cancer due to its resistance to therapy and limited understanding of its heterogeneity. A blood-lymphatic integrated system with heterogeneous melanoma spheroids (BLISH) has been developed using in-bath bioprinting process. This system can reproduce key events of metastatic melanoma and has the potential to improve our understanding of its pathophysiology and accuracy of drug response monitoring.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

Jihyun Lee et al.

Summary: The study demonstrates the use of porous Pt-black electrodes arranged in high-density microelectrode arrays to record intracellular-like signals of cardiomyocytes at large scale repeatedly over an extended period of time. This technique enables highly parallelized electroporations using stimulation voltages around 1 V peak-to-peak amplitude, with high success rates and without significant alteration in key electrophysiological features. In a proof-of-concept study, the technique accurately captured electrophysiological modulations induced by two clinically applied drugs, nifedipine and quinidine, showing potential for routine use in in vitro platforms for cardiotoxicity screening.

ACS SENSORS (2022)

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Review Chemistry, Analytical

A review of electrochemical impedance spectroscopy for bioanalytical sensors

Edward P. Randviir et al.

Summary: This article systematically examines the application of electrochemical impedance spectroscopy (EIS) in electrode customization and sensor design. The study finds that immunosensors are the most common quantification technique employing EIS, with bio-based electrodes suitable for detecting complex molecules and non-bio-based sensors more often used for simpler molecules. The article also notes advancements in electrode design for EIS, but inconsistencies remain in equivalent circuit modeling for certain sensor types.

ANALYTICAL METHODS (2022)

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Review Nanoscience & Nanotechnology

Electrohydrodynamic Jet Printing: Introductory Concepts and Considerations

Nhlakanipho Mkhize et al.

Summary: EHD jet printing is an emerging technique in additive manufacturing with the potential for high resolution printing, but achieving high quality results requires understanding of ink properties, printer system, and substrate manipulation.

SMALL SCIENCE (2022)

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Article Materials Science, Biomaterials

Piezoelectric nanocomposite bioink and ultrasound stimulation modulate early skeletal myogenesis

Claudia Paci et al.

Summary: By combining piezoelectric nanoparticles with ultrasound stimulation, early myogenesis in muscle cell-laden hydrogels can be enhanced in 3D bioprinting, promoting cell aggregation and crucial steps for myoblast fusion.

BIOMATERIALS SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Measurement of Electrophysiological Signals In Vitro Using High-Performance Organic Electrochemical Transistors

James E. Tyrrell et al.

Summary: OECTs have proven to be successful in transducing physiological information and measuring high-frequency signals, with significant improvements in key performance parameters like peak transconductance and response time.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Magnetically-driven drug and cell on demand release system using 3D printed alginate based hollow fiber scaffolds

Zhiyong Wang et al.

Summary: The study developed hollow fiber alginate/iron oxide nanoparticles scaffolds for on demand release of drugs, proteins and living cells using magnetic field. The scaffolds showed repeated on demand release capability, which may be useful for tissue engineering and disease therapies.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Multidisciplinary Sciences

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

Hyogeun Shin et al.

Summary: Current technologies for monitoring and controlling neural activities in 3D models are lacking. The authors present a 3D high-density multielectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics in engineered 3D neural tissues, demonstrating accurate measurements of synaptic latencies in 3D neural networks.

NATURE COMMUNICATIONS (2021)

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Review Materials Science, Multidisciplinary

Biomaterials-based bioengineering strategies for bioelectronic medicine

Asish Kumar Panda et al.

Summary: The field of bioelectronic medicine has seen significant advancements in the past two decades, yet precise control over cell functionalities remains a major challenge. Biophysical cues and integrating electronic systems with biomaterials are being explored to modulate cellular functions and monitor cellular physiology. The development of bioresorbable and flexible electronics may lead to next-generation bioelectronic devices with improved biointegration and electrical performance, potentially enabling the development of bioartificial organs.

MATERIALS SCIENCE & ENGINEERING R-REPORTS (2021)

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Article Multidisciplinary Sciences

3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels

Andrew C. Daly et al.

Summary: Cellular models are essential for studying human development and disease, as well as for screening drug toxicity and efficacy. A bioprinting approach has been developed to transfer spheroids into self-healing support hydrogels, enabling their patterning and fusion into high-cell density microtissues.

NATURE COMMUNICATIONS (2021)

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Review Nanoscience & Nanotechnology

Engineering organoids

Moritz Hofer et al.

Summary: This review discusses the application of engineering approaches to enhance the reproducibility and physiological relevance of organoids, including cellular engineering, designer matrices, and microfluidics.

NATURE REVIEWS MATERIALS (2021)

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Review Clinical Neurology

Neurovascular-modulation: A review of primary vascular responses to transcranial electrical stimulation as a mechanism of action

Mersedeh Bahr-Hosseini et al.

Summary: The vascular response to transcranial electrical stimulation (tES) involves both primary and secondary phenomena mediated by four cellular elements, with the nature of the response depending on vessel anatomy and physiology. Further research is needed to explore the mechanisms underlying the vascular response and its impact on neural activity in healthy and pathological conditions.

BRAIN STIMULATION (2021)

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Article Chemistry, Analytical

Cardiac Cell Patterning on Customized Microelectrode Arrays for Electrophysiological Recordings

Jiaying Ji et al.

Summary: The interaction between cardiomyocytes and fibroblast cells can affect cardiac electrophysiology and contribute to cardiac diseases like arrhythmia. A custom-designed MEA device with micropatterning was used to study the electrical activity of rat cardiomyocyte-fibroblast co-cultures, showing that fibroblast bridges can synchronize separate cardiomyocyte clusters. This method allows for the examination of the coupling dynamics in cell networks and could provide insights into heart disease mechanisms.

MICROMACHINES (2021)

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Article Chemistry, Multidisciplinary

Microengineered Hollow Graphene Tube Systems Generate Conductive Hydrogels with Extremely Low Filler Concentration

Christine Arndt et al.

Summary: The study presents a novel approach to fabricate hydrogel composites with outstanding electrical conductivity by microengineering graphene and polyacrylamide. The method allows for combining excellent conductivity of graphene with adaptable mechanical properties of polyacrylamide, while maintaining the original properties of the matrix. This approach shows promise for applications in bioelectronics and biohybrid robotics.

NANO LETTERS (2021)

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Article Engineering, Biomedical

A digital light processing 3D printed magnetic bioreactor system using silk magnetic bioink

Olatunji Ajiteru et al.

Summary: In this study, a magnetic bioreactor system and magnetic hydrogel were fabricated using single-stage three-dimensional printing with digital light processing technique. The system provided mechanical stretching of cells in the hydrogel in 3D ways, promoting differentiation of myoblast cells. The magnetic bioreactor accelerated differentiation of mouse myoblast cells in the hydrogel and increased myotube diameter and length in vitro, demonstrating potential for muscle tissue engineering.

BIOFABRICATION (2021)

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Review Engineering, Biomedical

Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications

Yong Xu et al.

Summary: Conductive hydrogels (CHs) are being increasingly utilized for 3D cell culture and tissue engineering, with dynamic conductive hydrogels (DCHs) offering the ability to provide dynamic environments for cellular functions while maintaining matrix integrity. The reversible linkages in DCHs allow for properties mimicking native tissues, making them well-suited for various biotechnological and medical applications.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Engineering, Biomedical

PEDOT:PSS-Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

Yuanying Liang et al.

Summary: Understanding the physiology and pathology of electrogenic cells requires quantitative investigation of ion transmission and chemical signal release. The use of organic conducting materials, especially organic electrochemical transistors like PEDOT:PSS, shows promise in interfacing electronics and biological matter for recording electrophysiological and biochemical signals.

ADVANCED HEALTHCARE MATERIALS (2021)

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Editorial Material Engineering, Biomedical

Possibilities in bioelectronics: Super humans or science fiction?

Rylie A. Green

Summary: The development of neurotechnologies has brought new hope for the diagnosis and treatment of neurological conditions, as well as sparking the concept of superhuman performance. However, there are still key limitations, such as surgical damage and reactions to devices, which have hindered the clinical translation of high-resolution neural interfaces.

APL BIOENGINEERING (2021)

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Article Multidisciplinary Sciences

Intracellular action potential recordings from cardiomyocytes by ultrafast pulsed laser irradiation of fuzzy graphene microelectrodes

Michele Dipalo et al.

Summary: Researchers have successfully recorded intracellular cardiac action potentials with high signal-to-noise ratio using a microelectrode platform made of three-dimensional fuzzy graphene (3DFG). By utilizing ultrafast pulsed laser for porating the cell membrane, an intimate contact between the 3DFG electrodes and the intracellular domain was created, enabling the detection of drug effects on human-derived cardiomyocytes' action potential shape. This approach may be applied to monitor cellular electrophysiological states, especially for studying the impact of drugs on cardiac cells.

SCIENCE ADVANCES (2021)

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Review Chemistry, Multidisciplinary

Piezoelectric Nanomaterials Activated by Ultrasound: The Pathway from Discovery to Future Clinical Adoption

Andrea Cafarelli et al.

Summary: Piezoelectric nanomaterials offer the potential for wireless electrical stimulation in biomedical applications. However, challenges remain in translating this technology into clinical practice, including issues with measurement of piezoelectric properties, control of ultrasound dose, and understanding of bioeffects. Addressing these challenges will be crucial for advancing the use of piezoelectric stimulation in the clinical setting.

ACS NANO (2021)

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Article Chemistry, Analytical

Inkjet-Printed and Electroplated 3D Electrodes for Recording Extracellular Signals in Cell Culture

Leroy Grob et al.

Summary: Recent investigations into cardiac or nervous tissues require 3D electrical recording, leading to the fabrication of 3D microelectrode arrays using additive manufacturing technology. The user-defined 3D electrodes were produced by adjusting the number of deposited silver nanoparticle ink droplets. The functionality of the array was confirmed through impedance spectroscopy, cyclic voltammetry, and recordings of extracellular potentials from HL-1 cells.

SENSORS (2021)

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Article Biology

Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics

Kai Weissenbruch et al.

Summary: Nonmuscle myosin II (NM II) plays a crucial role in cellular adhesion and migration, with its isoforms NM IIA and IIB essential for generating and stabilizing cellular tension. This study demonstrated that in a structured environment, cells can exhibit invaginated actin arcs even without NM IIA-induced contractility. Additionally, a novel role for NM IIC in establishing tensional homeostasis was identified through dynamic cell stretch/release experiments in a three-dimensional scaffold.

ELIFE (2021)

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Article Materials Science, Multidisciplinary

High-Resolution Capillary Printing of Eutectic Gallium Alloys for Printed Electronics

Navid Hussain et al.

Summary: A versatile liquid metal printing process is introduced for fabrication of various fully printed devices, compatible with digital printing and thin film structuring methods for integration. The research demonstrates successful fabrication of resistors, p-n diodes, and field effect transistors, showing the potential of liquid metal printing in exceeding conventional electronic devices in printed electronics.

ADVANCED MATERIALS TECHNOLOGIES (2021)

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Article Engineering, Mechanical

Programmable shape transformation of 3D printed magnetic hydrogel composite for hyperthermia cancer therapy

Jingda Tang et al.

Summary: The recent development of soft magnetic nanocomposites has enabled the programmable shape transformation of magnetic robots, which shows promise for various biomedical applications. By fabricating composite structures of magnetic hydrogels and elastomers using extrusion-based 3D printing, researchers have demonstrated the potential for complex shape transformation and targeted cancer cell killing through magnetic hyperthermia. This approach may open up new opportunities for applications in medicine and bioengineering.

EXTREME MECHANICS LETTERS (2021)

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Article Engineering, Biomedical

Controlled Surface Adhesion of Macrophages via Patterned Antifouling Polymer Brushes

Johannes Striebel et al.

Summary: Macrophages are crucial in cancer diagnostics and immunotherapies, but capturing and sorting different subpopulations remains a challenge due to their innate ability to bind to various interfaces indiscriminately. By patterning interfaces and constructing arrays of binding sites, researchers have successfully demonstrated the selective capture of macrophages, particularly M2 macrophages. This innovative approach shows promise for further therapeutic or diagnostic purposes in the future.

ADVANCED NANOBIOMED RESEARCH (2021)

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Article Multidisciplinary Sciences

Electrolyte-gated transistors for enhanced performance bioelectronics

Fabrizio Torricelli et al.

Summary: This primer discusses the various architectures and mechanisms of electrolyte-gated transistors (EGTs), as well as their applications in bioelectronics. It covers the materials and fabrication methods used in EGT structures, as well as the integration of functional bio-layers and biosystems. The primer also explores the advantages, limitations, possible optimizations, and future directions of EGTs in the field of bioelectronics.

NATURE REVIEWS METHODS PRIMERS (2021)

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Article Multidisciplinary Sciences

Electrochemical impedance spectroscopy

Shangshang Wang et al.

Summary: This paper introduces the application of electrochemical impedance spectroscopy (EIS), analyzes the error structure and sensitivity of impedance measurements in the reduction of ferricyanide process, and provides guidelines for experimental design. The relevance of accuracy contour plots to wiring and instrumentation selection is highlighted, as well as the importance of the Kramers-Kronig relations to data validation and analysis.

NATURE REVIEWS METHODS PRIMERS (2021)

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Review Chemistry, Multidisciplinary

Flexible Hybrid Electronics for Digital Healthcare

Yinji Ma et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Magnetic Hyperthermia-Synergistic H2O2 Self-Sufficient Catalytic Suppression of Osteosarcoma with Enhanced Bone-Regeneration Bioactivity by 3D-Printing Composite Scaffolds

Shaojie Dong et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Acoustic Holographic Cell Patterning in a Biocompatible Hydrogel

Zhichao Ma et al.

ADVANCED MATERIALS (2020)

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Review Chemistry, Multidisciplinary

4D Printing at the Microscale

Christoph A. Spiegel et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Wireless Manipulation of Magnetic/Piezoelectric Micromotors for Precise Neural Stem-Like Cell Stimulation

Lu Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Biomedical

Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds

Nicole Silbernagel et al.

BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

NanoMEA: A Tool for High-Throughput, Electrophysiological Phenotyping of Patterned Excitable Cells

Alec S. T. Smith et al.

NANO LETTERS (2020)

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Review Nanoscience & Nanotechnology

3D printed nanomaterial-based electronic, biomedical, and bioelectronic devices

Samuel Hales et al.

NANOTECHNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Intracellular Recording of Human Cardiac Action Potentials on Market-Available Multielectrode Array Platforms

Giovanni Melle et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Nanopatterned Nafion Microelectrode Arrays for In Vitro Cardiac Electrophysiology

Jong Seob Choi et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Polymer Science

Stimuli-responsive hydrogels as a model of the dynamic cellular microenvironment

Motomu Tanaka et al.

POLYMER JOURNAL (2020)

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Article Chemistry, Physical

3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering

Christian Polley et al.

MATERIALS (2020)

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Article Chemistry, Physical

Enhancement-mode ion-based transistor as a comprehensive interface and real-time processing unit for in vivo electrophysiology

Claudia Cea et al.

NATURE MATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Trapping and Manipulation of Single Cells in Crowded Environments

Qian Zhao et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Bioprinting Cell- and Spheroid-Laden Protein-Engineered Hydrogels as Tissue-on-Chip Platforms

Daniela F. Duarte Campos et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Engineering, Manufacturing

3D printed stimuli-responsive magnetic nanoparticle embedded alginate-methylcellulose hydrogel actuators

Daria Podstawczyk et al.

ADDITIVE MANUFACTURING (2020)

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Article Chemistry, Multidisciplinary

Electromagnetized-Nanoparticle-Modulated Neural Plasticity and Recovery of Degenerative Dopaminergic Neurons in the Mid-Brain

Di Zhao et al.

ADVANCED MATERIALS (2020)

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Article Biochemical Research Methods

Orthogonal Blue and Red Light Controlled Cell-Cell Adhesions Enable Sorting-out in Multicellular Structures

Samaneh Rasoulinejad et al.

ACS SYNTHETIC BIOLOGY (2020)

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Article Engineering, Biomedical

Tailoring Common Hydrogels into 3D Cell Culture Templates

Aurelien Pasturel et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Multidisciplinary Sciences

Mechanical stimulation of single cells by reversible host-guest interactions in 3D microscaffolds

Marc Hippler et al.

SCIENCE ADVANCES (2020)

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Article Materials Science, Multidisciplinary

Fabrication and Magnetic Actuation of 3D-Microprinted Multifunctional Hybrid Microstructures

Victor Vieille et al.

ADVANCED MATERIALS TECHNOLOGIES (2020)

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Article Nanoscience & Nanotechnology

Electrochemical Stability Investigations and Drug Toxicity Tests of Electrolyte-Gated Organic Field-Effect Transistors

Yu Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Engineering an Injectable Electroactive Nanohybrid Hydrogel for Boosting Peripheral Nerve Growth and Myelination in Combination with Electrical Stimulation

Liumin He et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biochemical Research Methods

Development of a cardiac-and-piezoelectric hybrid system for application in drug screening

Yun-Han Huang et al.

LAB ON A CHIP (2020)

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Article Chemistry, Multidisciplinary

Monitoring supported lipid bilayers with n-type organic electrochemical transistors

Malak Kawan et al.

MATERIALS HORIZONS (2020)

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Article Chemistry, Analytical

Engineering anisotropic cardiac monolayers on microelectrode arrays for non-invasive analyses of electrophysiological properties

Ahmad Alassaf et al.

ANALYST (2020)

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Review Materials Science, Multidisciplinary

Liquid Metal Composites

Sen Chen et al.

MATTER (2020)

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Article Nanoscience & Nanotechnology

Microelectrode arrays for monitoring neural activity in neural stem cells with modulation by glutamate in vitro

Fei Gao et al.

NANOTECHNOLOGY AND PRECISION ENGINEERING (2020)

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Article Engineering, Biomedical

Electrically stimulable indium tin oxide plate for long-term in vitro cardiomyocyte culture

Sung-Hwan Moon et al.

BIOMATERIALS RESEARCH (2020)

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Article Neurosciences

Single-Cell Electrical Stimulation Using CMOS-Based High-Density Microelectrode Arrays

Silvia Ronchi et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Review Chemistry, Multidisciplinary

Development of Dip-Pen Nanolithography (DPN) and Its Derivatives

Guoqiang Liu et al.

SMALL (2019)

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Review Neurosciences

Technologies to Study Action Potential Propagation With a Focus on HD-MEAs

Vishalini Emmenegger et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Chemistry, Multidisciplinary

Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network

Yong Xu et al.

ADVANCED SCIENCE (2019)

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Article Nanoscience & Nanotechnology

Fully Printed μ-Needle Electrode Array from Conductive Polymer Ink for Bioelectronic Applications

Sabine Zips et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Nanoscience & Nanotechnology

Bioprinting of a Cell-Laden Conductive Hydrogel Composite

Andrew R. Spencer et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Intracellular Recording of Cardiomyocyte Action Potentials with Nanopatterned Volcano-Shaped Microelectrode Arrays

B. X. E. Desbiolles et al.

NANO LETTERS (2019)

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Article Multidisciplinary Sciences

Organ-on-e-chip: Three-dimensional self-rolled biosensor array for electrical interrogations of human electrogenic spheroids

Anna Kalmykov et al.

SCIENCE ADVANCES (2019)

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Article Nanoscience & Nanotechnology

Real-Time Monitoring of Cellular Cultures with Electrolyte-Gated Carbon Nanotube Transistors

Francesca Scuratti et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Nanoscience & Nanotechnology

MEA Recordings and Cell-Substrate Investigations with Plasmonic and Transparent, Tunable Holey Gold

Timm J. J. Hondrich et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Biophysics

A Microwell Cell Capture Device Reveals Variable Response to Dobutamine in Isolated Cardiomyocytes

J. Alexander Clark et al.

BIOPHYSICAL JOURNAL (2019)

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Review Engineering, Electrical & Electronic

CMOS based capacitive sensors for life science applications: A review

Saghi Forouhi et al.

SENSORS AND ACTUATORS A-PHYSICAL (2019)

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Article Multidisciplinary Sciences

Controlling the shape of 3D microstructures by temperature and light

Marc Hippler et al.

NATURE COMMUNICATIONS (2019)

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Review Materials Science, Biomaterials

Recent Strategies in Extrusion-Based Three-Dimensional Cell Printing toward Organ Biofabrication

Ge Gao et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Chemistry, Multidisciplinary

3D-Printed Biodegradable Microswimmer for Theranostic Cargo Delivery and Release

Hakan Ceylan et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

3D Printing of Multifunctional Hydrogels

Zhe Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

3D Scaffolds to Study Basic Cell Biology

Marc Hippler et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Progress Report on From Printed Electrolyte-Gated Metal-Oxide Devices to Circuits

Gabriel Cadilha Marques et al.

ADVANCED MATERIALS (2019)

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Article Biochemical Research Methods

Inkjet-printed PEDOT:PSS multi-electrode arrays for low-cost in vitro electrophysiology

Leonardo D. Garma et al.

LAB ON A CHIP (2019)

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Article Materials Science, Biomaterials

Manipulation of Single Cells Using a Ferromagnetic Nanorod Cluster Actuated by Weak AC Magnetic Fields

Lu Zhu et al.

ADVANCED BIOSYSTEMS (2019)

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Review Chemistry, Multidisciplinary

Hydrogel bioelectronics

Hyunwoo Yuk et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

A Practical Beginner's Guide to Cyclic Voltammetry

Noemie Elgrishi et al.

JOURNAL OF CHEMICAL EDUCATION (2018)

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Article Chemistry, Physical

Three-Dimensional Nanoprinting via Direct Delivery

Joao Ventrici de Souza et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2018)

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Article Nanoscience & Nanotechnology

Ultrasound-activated piezoelectric P(VDF-TrFE)/boron nitride nanotube composite films promote differentiation of human SaOS-2 osteoblast-like cells

Giada Graziana Genchi et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

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Article Nanoscience & Nanotechnology

Cytotoxicity of Gallium-Indium Liquid Metal in an Aqueous Environment

Ji-Hye Kim et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Physical

New Algorithm to Enable Construction and Display of 3D Structures from Scanning Probe Microscopy Images Acquired Layer-by-Layer

William Nanqiao Deng et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2018)

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Article Chemistry, Multidisciplinary

Liquid Metal-Based Multifunctional Micropipette for 4D Single Cell Manipulation

Yu Ting Chow et al.

ADVANCED SCIENCE (2018)

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Article Chemistry, Multidisciplinary

Electroconductive Biohybrid Hydrogel for Enhanced Maturation and Beating Properties of Engineered Cardiac Tissues

Kaveh Roshanbinfar et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Physics, Applied

Tin oxide coating by nonvacuum-based mist chemical vapor deposition on stainless steel separators for polymer electrolyte fuel cells

Kentaro Kaneko et al.

JAPANESE JOURNAL OF APPLIED PHYSICS (2018)

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Article Physics, Applied

Microelectrode array for noninvasive analysis of cardiomyocytes at the single-cell level

Tomi Ryynanen et al.

JAPANESE JOURNAL OF APPLIED PHYSICS (2018)

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Article Multidisciplinary Sciences

3D Inkjet Printing of Complex, Cell-Laden Hydrogel Structures

Andrea Negro et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Transistor in a tube: A route to three-dimensional bioelectronics

C. Pitsalidis et al.

SCIENCE ADVANCES (2018)

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Article Chemistry, Multidisciplinary

Flexible Modulation of Electronic Band Structures of Wide Band Gap GaN Semiconductors Using Bioinspired, Nonbiological Helical Peptides

Sven Mehlhose et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Guiding Cell Attachment in 3D Microscaffolds Selectively Functionalized with Two Distinct Adhesion Proteins

Benjamin Richter et al.

ADVANCED MATERIALS (2017)

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Article Chemistry, Multidisciplinary

Piezoelectric nanotransducers: The future of neural stimulation

Attilio Marino et al.

NANO TODAY (2017)

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Article Chemistry, Physical

Designer biomaterials for mechanobiology

Linqing Li et al.

NATURE MATERIALS (2017)

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Review Chemistry, Analytical

Capacitive Biosensors and Molecularly Imprinted Electrodes

Gizem Erturk et al.

SENSORS (2017)

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Article Multidisciplinary Sciences

Dynamic Mechano-Regulation of Myoblast Cells on Supramolecular Hydrogels Cross-Linked by Reversible Host-Guest Interactions

Marcel Hoerning et al.

SCIENTIFIC REPORTS (2017)

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Article Engineering, Electrical & Electronic

Implantable liquid metal-based flexible neural microelectrode array and its application in recovering animal locomotion functions

Rui Guo et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2017)

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Article Materials Science, Multidisciplinary

All-inkjet-printed gold microelectrode arrays for extracellular recording of action potentials

Bernd Bachmann et al.

FLEXIBLE AND PRINTED ELECTRONICS (2017)

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Review Engineering, Biomedical

Laser-based cell printing techniques for additive biomanufacturing

Benjamin T. Vinson et al.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2017)

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Article Biophysics

PEDOT:PSS organic electrochemical transistor arrays for extracellular electrophysiological sensing of cardiac cells

Felix Hempel et al.

BIOSENSORS & BIOELECTRONICS (2017)

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Article Chemistry, Multidisciplinary

Supported Lipid Bilayer Assembly on PEDOT:PSS Films and Transistors

Yi Zhang et al.

ADVANCED FUNCTIONAL MATERIALS (2016)

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Review Chemistry, Multidisciplinary

Organic Bioelectronics: Bridging the Signaling Gap between Biology and Technology

Daniel T. Simon et al.

CHEMICAL REVIEWS (2016)

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Article Materials Science, Biomaterials

Cardiomyocyte behavior on biodegradable polyurethane/gold nanocomposite scaffolds under electrical stimulation

Yasaman Ganji et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

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Review Biochemical Research Methods

A practical guide to hydrogels for cell culture

Steven R. Caliari et al.

NATURE METHODS (2016)

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Article Engineering, Electrical & Electronic

An impedance biosensor for monitoring cancer cell attachment, spreading and drug-induced apoptosis

Tien Anh-Nguyen et al.

SENSORS AND ACTUATORS A-PHYSICAL (2016)

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Article Engineering, Biomedical

Flexible Inkjet-Printed Multielectrode Arrays for Neuromuscular Cartography

Timothee Roberts et al.

ADVANCED HEALTHCARE MATERIALS (2016)

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Article Materials Science, Biomaterials

3D-printed bioceramic scaffolds with a Fe3O4/graphene oxide nanocomposite interface for hyperthermia therapy of bone tumor cells

Yongliang Zhang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Article Engineering, Biomedical

Inkjet-Print Micromagnet Array on Glass Slides for Immunomagnetic Enrichment of Circulating Tumor Cells

Peng Chen et al.

ANNALS OF BIOMEDICAL ENGINEERING (2016)

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Article Nanoscience & Nanotechnology

Two-Photon Lithography of 3D Nanocomposite Piezoelectric Scaffolds for Cell Stimulation

Attilio Marino et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Chemistry, Physical

Synthesis and characterization of bicontinuous cubic poly(3,4-ethylene dioxythiophene) gyroid (PEDOT GYR) gels

Whirang Cho et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2015)

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Article Multidisciplinary Sciences

Transformable liquid-metal nanomedicine

Yue Lu et al.

NATURE COMMUNICATIONS (2015)

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Review Physics, Applied

Fundamentals and advances in magnetic hyperthermia

E. A. Perigo et al.

APPLIED PHYSICS REVIEWS (2015)

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Large-Scale Parallel Surface Functionalization of Goblet-type Whispering Gallery Mode Microcavity Arrays for Biosensing Applications

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Magnetically shaped cell aggregates: from granular to contractile materials

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3D-printed magnetic Fe3O4/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia

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Substrate dependent stability of conducting polymer coatings on medical electrodes

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Cell patterning using magnetite nanoparticles and magnetic force

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Massively parallel dip-pen nanolithography of heterogeneous supported phospholipid multilayer patterns

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Polymer-supported membranes as models of the cell surface

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NATURE (2005)

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Silicon chip interfaced with a geometrically defined net of snail neurons

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Scientific importance, properties and growing applications of poly( 3,4-ethylenedioxythiophene)

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JOURNAL OF MATERIALS CHEMISTRY (2005)

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Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2004)

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Fabrication of BaTiO3 dielectric films by direct ink-jet printing

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CERAMICS INTERNATIONAL (2004)

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Use of conducting electroactive polymers for drug delivery and sensing of bioactive molecules. A redox chemistry approach

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JOURNAL OF PHYSICAL CHEMISTRY B (2000)

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