☆ 4.3 Article

Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine

STEM CELL REVIEWS AND REPORTS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Gastroenterology & Hepatology

Organoids and regenerative hepatology

Nidhi Jalan-Sakrikar et al.

Summary: The burden of liver diseases is increasing worldwide, and liver transplantation is the only treatment option. Regenerative medicine aims to repair or replace damaged liver tissue with healthy functional cells, offering potential therapeutic benefits. Liver organoids provide an optimal source of cells for regenerative medicine and offer new insights into liver physiology.

HEPATOLOGY (2023)

添加到收藏夹

Article Clinical Neurology

Cerebral organoids containing an AUTS2 missense variant model microcephaly

Summer R. Fair et al.

Summary: Variants in the AUTS2 gene are associated with a broad spectrum of neurological conditions. In this study, a human cerebral organoid model was used to investigate the pathophysiology of a specific variant. The study found that the variant led to reduced growth and disrupted cell proliferation in the organoids. Gene editing was able to correct the variant and restore organoid growth and cell proliferative capacity. Single-cell RNA sequencing revealed changes in gene expression and signaling pathways. These findings highlight the importance of cerebral organoids in studying the molecular mechanisms underlying AUTS2 syndrome.

BRAIN (2023)

添加到收藏夹

Letter Toxicology

Organoid-based 3D in vitro microphysiological systems as alternatives to animal experimentation for preclinical and clinical research

Chrianjay Mukhopadhyay et al.

ARCHIVES OF TOXICOLOGY (2023)

添加到收藏夹

Article Oncology

Melatonin blunted the angiogenic activity in 3D colon cancer tumoroids by the reduction of endocan

Maryam Taghavi Narmi et al.

Summary: This study evaluated the tumoricidal properties of melatonin on colon cancer tumoroids using a reconstructed 3D cell culture model. The results showed that lower doses of melatonin reduced tumor cell viability without affecting the structure of the tumoroids. Higher doses of melatonin caused cell disaggregation and reduction in tumoroid diameter, and inhibited the specific pro-angiogenesis factor. These findings suggest the potential therapeutic value of melatonin in cancer treatment.

CANCER CELL INTERNATIONAL (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases

Yuxiang Liu et al.

Summary: The pancreas is an important organ that has been understudied in various fields. Traditional models have limitations in addressing pancreatic-related diseases due to ethical issues, genetic heterogeneity, and clinical translation challenges. Organoids have been proposed as a novel research model for pancreatic diseases, offering advantages such as minimal harm to donors, fewer ethical concerns, and addressing heterogeneity. This review analyzes studies on the use of pancreatic organoids, discussing their advantages, disadvantages, and future trends.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Current status and prospects of organoid-based regenerative medicine

Woo Hee Choi et al.

Summary: Organoids derived from stem cells or organ-specific progenitors are three-dimensional structures that can mimic the function and structure of derived tissues. They have attracted attention as a promising ex vivo model for drug screening and are being developed for regenerative medicine, with some reaching the clinical trial stage.

BMB REPORTS (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Shi Qiu et al.

Summary: Metabolic abnormalities result in dysfunction of metabolic pathways and the accumulation or deficiency of metabolites, which are hallmarks of diseases. Metabolite signatures closely related to phenotypic information are useful for predicting disease diagnosis, prognosis, and treatment monitoring. Noninvasive diagnosis and monitoring methods with high specificity and selectivity are urgently needed. Small molecule metabolites-based metabolomics has become a specialized tool for the analysis of metabolic biomarkers and pathways, revealing mechanisms of various diseases and therapeutic potential. This review summarizes the potential value of small-molecule candidate metabolites as biomarkers in clinical events, which can improve diagnosis, prognosis, drug screening, and treatment. The challenges to be addressed for future breakthroughs are also discussed.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories

Paulina Nunez Bernal et al.

Summary: Organ- and tissue-level biological functions are closely related to microscale cell-cell interactions and tissue architecture. Biofabrication and organoid technologies have the potential to engineer multi-scale living constructs. This study introduces a volumetric bioprinting technique that captures key liver functions. The bioprinting process shapes organoid-laden gelatin hydrogels into complex 3D structures, allowing for rapid printing. Optically tuned bioresins and low stiffness gelatins enhance the viability and metabolism of the bioprinted constructs. This technology opens up new possibilities for regenerative medicine and personalized drug testing.

ADVANCED MATERIALS (2022)

添加到收藏夹

Review Neurosciences

Challenges of Organoid Research

Madeline G. Andrews et al.

Summary: Organoids derived from human pluripotent stem cells are valuable tools for studying human brain development and neurological diseases. However, their utility is limited by the lack of high-fidelity cell types, limited maturation, atypical physiology, and lack of arealization.

ANNUAL REVIEW OF NEUROSCIENCE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Proteomics technologies for cancer liquid biopsies

Zhiyong Ding et al.

Summary: The complexity of proteomes in liquid biopsy samples and the limitations of proteomic technologies compared to high-plex sequencing technologies have hindered the development of proteomics. However, novel protein technologies are urgently needed for biomarker discovery in cancer liquid biopsies. Traditional and innovative proteomic technologies are being rapidly developed and have greatly facilitated early detection, diagnosis, prognosis, and monitoring of cancer evolution.

MOLECULAR CANCER (2022)

添加到收藏夹

Review Biophysics

The role of physical cues in the development of stem cell-derived organoids

Ilaria Tortorella et al.

Summary: Organoids are a novel three-dimensional stem cell culture system that mimics the complexity of organ/tissue structure. The balance of microenvironmental components is crucial for successful development, and mechanical forces play a key role in stem cell specification process towards organoid formation.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2022)

添加到收藏夹

Article Biochemical Research Methods

Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells

Jiyoon Lee et al.

Summary: This article describes a detailed protocol for generating hair-bearing skin tissue from human pluripotent stem cells. By using defined culture conditions in a three-dimensional in vitro culture system, skin organoids with hair follicles can be obtained after 60 days and reach full complexity after approximately 130 days.

NATURE PROTOCOLS (2022)

添加到收藏夹

Article Psychiatry

Human forebrain organoids reveal connections between valproic acid exposure and autism risk

Qingtuan Meng et al.

Summary: This study utilizes hFOs to uncover the connection between VPA exposure and ASD pathogenesis, and finds that VPA affects the expression of genes involved in important pathways such as neural development and synaptic transmission. These findings are valuable for understanding the etiology of ASD and identifying potential therapeutic targets.

TRANSLATIONAL PSYCHIATRY (2022)

添加到收藏夹

Article Engineering, Biomedical

Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment

Hyemin Kim et al.

Summary: This study aims to generate liver organoids with high drug metabolic ability using human pluripotent stem cells. The fully differentiated organoids exhibit cellular polarity, hepatobiliary structures, and remarkable drug metabolic function. They can also successfully model Wilson's disease and provide an advanced tool for studying hepatic drug metabolism and diseases.

BIOMATERIALS (2022)

添加到收藏夹

Article Cell & Tissue Engineering

A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery

Tracy Tran et al.

Summary: Human pluripotent stem-cell-derived organoids have been modified to generate thousands of similar kidney organoids, which can be used for modeling human kidney development and disease. The models have been used to study polycystic kidney disease and identify compounds that can block cyst formation. Scaling and further development of this platform will greatly enhance its capabilities for kidney disease modeling and high-throughput drug screening.

CELL STEM CELL (2022)

添加到收藏夹

Review Cell & Tissue Engineering

Organoids: a systematic review of ethical issues

Dide de Jongh et al.

Summary: Organoids, 3D structures grown from pluripotent stem cells derived from human tissue, have the potential to revolutionize biomedical research and clinical care. However, ethical discussions surrounding Organoids, especially in areas like organoid transplantation, are necessary to ensure responsible development and clinical implementation of this technology in the field. Further research is needed in this area.

STEM CELL RESEARCH & THERAPY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

Amy D. Westerling-Bui et al.

Summary: Pharmacodynamic (PD) studies are crucial in preclinical drug discovery, but current approaches limited to animal models lack translatability to humans. To overcome this challenge, researchers developed a novel method using transplanted human kidney organoids for PD studies. By orally administering investigational drug GFB-887 to athymic rats with transplanted organoids, significant protection of kidney filter cells was observed in both the organoids and host kidneys.

SCIENCE ADVANCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

3D Human Organoids: The Next Viral Model for the Molecular Basis of Infectious Diseases

Shirley Pei Shan Chia et al.

Summary: The COVID-19 pandemic has led to the adoption of efficient and reliable models in the scientific community to combat infectious diseases. Three dimensional human organoid technology, which closely mimics the structure and function of organs, has emerged as an essential tool in infectious disease research. This article compares conventional systems with organoid models, highlights the role of organoids in modeling infectious diseases and understanding the molecular mechanisms behind them, and presents the limitations of current organoid models and innovative strategies to overcome them.

BIOMEDICINES (2022)

添加到收藏夹

Review Engineering, Biomedical

Advancement of Organoid Technology in Regenerative Medicine

Babak Arjmand et al.

Summary: Organoids, three-dimensional cultures of stem cells in an environment similar to the body's extracellular matrix, have shown great potential in regenerative and precision medicine. They can be used as research models for studying diseases, drug discovery, and organ transplantation. However, the lack of standardized protocols and other barriers currently hinder the wider use of this technology.

REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Review Oncology

Genomic and Epigenomic Characterization of Tumor Organoid Models

Chehyun Nam et al.

Summary: The patient-derived organoid (PDO) model is a versatile tool for studying the genomic and epigenomic properties of cancer. PDOs preserve key (epi-)genomic features and can accurately map genetic alterations using next-generation sequencing technology. Due to its advantages, research on PDOs is rapidly growing for genotype-phenotype association and precision oncology.

CANCERS (2022)

添加到收藏夹

Article Biophysics

Micro/nano devices for integration with human brain organoids

Hao Nguyen Tran et al.

Summary: Brain organoids are powerful models for studying neurodevelopmental processes and neurological disorders, but their limited use in biomedicine and clinical research due to complex cellular architecture and lack of vascular networks can be overcome by micro/nanoscale devices. These devices can improve in vitro culture methods, enable physiological recordings, screen drugs, study drug effects, and develop vascular networks in organoids, advancing the potential of brain organoids in clinical research.

BIOSENSORS & BIOELECTRONICS (2022)

添加到收藏夹

Article Biochemical Research Methods

Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids

Junichi Takahashi et al.

Summary: In this study, a robust method was established to differentiate human pluripotent stem cells into suspension-cultured intestinal organoids. The generated spheroids showed reliable growth and could mature into large organoids with supporting mesenchyme. This method has wide applications in regenerative medicine.

CELL REPORTS METHODS (2022)

添加到收藏夹

Review Polymer Science

Current Advances in 3D Dynamic Cell Culture Systems

Xin Huang et al.

Summary: Traditional 2D cell culture methods cannot fully represent physiological conditions, while 3D cell carriers provide a more realistic microenvironment for cell growth in static and dynamic culture conditions.

GELS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Interfacing brain organoids with precision medicine and machine learning

Honghui Zheng et al.

Summary: Brain organoid modeling is an advanced technique for studying brain development, physiology, function, and disease occurrence, with potential for therapy and healthcare management, and establishing communication between human brains and engineered computing machinery.

CELL REPORTS PHYSICAL SCIENCE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Human organoids in basic research and clinical applications

Xiao-Yan Tang et al.

Summary: Organoids are 3D miniature structures cultured in vitro that recapitulate the cellular heterogeneity, structure, and functions of human organs. They have potential applications for studying human physiology and development, as well as for biomedical research and preclinical drug testing.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

添加到收藏夹

Review Medicine, General & Internal

Airway organoids as models of human disease

J. van der Vaart et al.

Summary: Over the past decade, there has been a significant increase in research and application of organoid technology. Organoids are three-dimensional structures established from stem cells, which self-organize through cell sorting and spatially restricted lineage commitment. Particularly in the field of respiratory development and disease, organoid models have shown great potential.

JOURNAL OF INTERNAL MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids

Maria Jose Perez et al.

Summary: Mutations in the PITRM1 gene lead to a slow-progressing syndrome characterized by cerebellar ataxia and cognitive decline. Studies using PITRM1-knockout iPSCs show induction of mitochondrial unfolded protein response and increased mitochondrial clearance in neurons, as well as elevated levels of amyloid precursor protein and amyloid beta. Astrocytes also show dysregulated immune transcriptional signatures in PITRM1-knockout cerebral organoids.

MOLECULAR PSYCHIATRY (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells

Mesude Bicer et al.

Summary: As populations age, osteoporosis and osteoporosis-related fractures are becoming increasingly prevalent degenerative bone diseases. Three-dimensional cell culture technology may serve as an alternative therapeutic approach to tackle osteoporosis, allowing for more physiological expansion and differentiation of stem cells.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Organoid Cultures Derived From Patients With Papillary Thyroid Cancer

Dong Chen et al.

Summary: Researchers established patient-derived PTC organoids as a promising new preclinical model for personalized therapy, demonstrating preservation of biological characteristics and genomic heterogeneity from the originating tumors and patient-specific drug responses.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Organoid technology: Current standing and future perspectives

Laleh Shariati et al.

Summary: Organoid technology is a powerful tool for personalized treatments and drug development, enabling the modeling of organ complexity and diseases. However, it also encounters challenges and limitations in its applications.

STEM CELLS (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Lung organoids, useful tools for investigating epithelial repair after lung injury

Jing Kong et al.

Summary: Organoids derived from stem cells or organ-specific progenitors display structures and functions consistent with organs in vivo. Lung organoids are widely used in modeling injury to and repair of lungs, as well as understanding the mechanisms of epithelial repair.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Review Microbiology

Refining Host-Pathogen Interactions: Organ-on-Chip Side of the Coin

Buket Baddal et al.

Summary: Bioinspired organ-level in vitro platforms, particularly organ-on-chip microfluidic devices, have emerged as effective technologies for infectious disease research, drug discovery, and personalized medicine. By bridging the gap between in vitro experimental models and human pathophysiology, these platforms offer alternatives for animal models and contribute to major advances in various research areas. The recent development of plug-and-play organ chips may hold promise for addressing unmet clinical needs in the development of effective therapeutic strategies, particularly in the context of host-pathogen interactions.

PATHOGENS (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Veronica Krenn et al.

Summary: Viral infection in early pregnancy can lead to microcephaly, with distinct mechanisms observed in Zika virus and herpes simplex virus-induced brain organoid models. This study highlights the importance of organoid models in understanding virus-specific mechanisms and immune responses associated with virus-induced microcephaly.

CELL STEM CELL (2021)

添加到收藏夹

Review Medicine, Research & Experimental

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

Hongbing Wang et al.

Summary: Nonclinical testing is crucial for evaluating potential risks and effectiveness of new drugs. Current 2D in vitro systems lack accuracy in simulating in vivo processes, while animal studies have limitations. Researchers are developing novel 3D models to improve drug safety and efficacy predictions.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids

Takahiro Suezawa et al.

Summary: The study established a novel in vitro pulmonary fibrosis model using alveolar organoids made up of human pluripotent stem cell-derived alveolar epithelial cells and primary human lung fibroblasts. The findings suggest that blocking ALK5 or integrin alpha V beta 6 can ameliorate fibrogenic changes in the alveolar organoids, indicating the potential for targeting alveolar epithelial cells and epithelial-mesenchymal interactions to treat pulmonary fibrosis.

STEM CELL REPORTS (2021)

添加到收藏夹

Review Cell Biology

Generation of Skin Organoids: Potential Opportunities and Challenges

Hui Sun et al.

Summary: Current human skin substitutes lack important skin appendages and cells, highlighting the need for improvement; skin organoids generated from stem cells are expected to possess the complexity and function of natural skin.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Blastocyst-like structures generated from human pluripotent stem cells

Leqian Yu et al.

Summary: The study developed an effective three-dimensional culture strategy to generate blastocyst-like structures in vitro which resemble human blastocysts. These structures, termed 'human blastoids', are readily accessible, scalable, versatile, and perturbable alternative to blastocysts for studying early human development, understanding early pregnancy loss, and gaining insights into early developmental defects.

NATURE (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Advances in development and application of human organoids

Abhijith Shankaran et al.

Summary: The advancement in organoid culture technologies has improved the mimicry of organ reconstruction. Organoids mimic the cellular microenvironment of tissues and represent tissue physiology. Patient-derived organoid culture provides a unique perspective for personalized treatment modalities.

3 BIOTECH (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Review on the Vascularization of Organoids and Organoids-on-a-Chip

Xingli Zhao et al.

Summary: The use of human cells for constructing 3D organ models in vitro has become more popular, but these organoids face challenges in forming complex vascular networks. Organoids-on-a-chip offer a more controllable platform for co-culturing different cells and tissues, but still struggle with simulating signal communications between bionic microenvironments and multiple organs.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation

Sarah E. Blutt et al.

Summary: The use of human tissue stem cell-derived organoids has advanced our understanding of human physiological and pathophysiological processes. This study demonstrates that coupling of ex vivo human intestine and liver epithelial organoid cultures recapitulates in vivo interorgan bile acid signaling, providing new models to investigate interorgan communication. These results suggest that organoid cultures can be used to study and therapeutically modulate interorgan interactions and advance the development of personalized medical care.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Use of Stem Cell-Derived Organoids in Disease Modeling: An Update

Joseph Azar et al.

Summary: Organoids, three-dimensional in vitro culturing models that mimic the structural and functional specificities of body organs, have great potential for disease modeling and clinical applications. However, challenges such as high cost, variability in efficiency, genetic stability, and clinical applications still exist in their culturing process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Engineering, Biomedical

3D Cell Culture-Can It Be As Popular as 2D Cell Culture?

Miao Sun et al.

Summary: The rapid development of 3D cell culture aims to simulate key features of an in vivo environment, including cell-cell, cell-ECM, and cell-organ interactions. It is influenced by biomaterial systems, biomanufacturing technology, and culture device systems. The future popularity of 3D cell culture may depend on the development of simple and standard protocols.

ADVANCED NANOBIOMED RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

Yonatan R. Lewis-Israeli et al.

Summary: The study presents a method to generate human heart organoids using pluripotent stem cells, which are comparable to fetal cardiac tissues at transcriptomic, structural, and cellular levels. These organoids exhibit sophisticated internal chambers, well-organized cardiac cell types, heart field formation, atrioventricular specification, and a complex vasculature, with robust functional activity. Additionally, the organoid platform can reproduce metabolic disorders associated with congenital heart defects, such as pregestational diabetes-induced congenital heart defects.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Engineering, Biomedical

Prospects for 3D bioprinting of organoids

Preety Rawal et al.

Summary: Three-dimensional bioprinting technology is emerging to address limitations in current organoid technologies, showing success in printing stem cells and organoids. Vascularization strategies for bioprinted organoids are critical for achieving complex tissue organization. Harnessing and directing advancements in 3D bioprinting is essential for realizing the translational applications of organoids in disease modeling and regenerative medicine.

BIO-DESIGN AND MANUFACTURING (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

Ye Yao et al.

CELL STEM CELL (2020)

添加到收藏夹

Article Oncology

Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer

Ruoshi Shi et al.

CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development

Shannon R. Nelson et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Cell Biology

A brief history of organoids

Claudia Corro et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

添加到收藏夹

Article Cell Biology

Human Cardiac Organoids for Modeling Genetic Cardiomyopathy

Michele Filippo Buono et al.

CELLS (2020)

添加到收藏夹

Review Cell Biology

Human organoids: model systems for human biology and medicine

Jihoon Kim et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Comparison of senescence-related changes between three- and two-dimensional cultured adipose-derived mesenchymal stem cells

Qiliang Yin et al.

STEM CELL RESEARCH & THERAPY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative Medicine

Cristina Olgasi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Nanoscience & Nanotechnology

Microtechnology-based methods for organoid models

Vanessa Velasco et al.

MICROSYSTEMS & NANOENGINEERING (2020)

添加到收藏夹

Review Immunology

Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?

Florian Tran et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Ethics

Human cerebral organoids and consciousness: a double-edged sword

Andrea Lavazza

MONASH BIOETHICS REVIEW (2020)

添加到收藏夹

Review Cell Biology

Organoid technology for tissue engineering

Juan He et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Is It Time to Start Transitioning From 2D to 3D Cell Culture?

Caleb Jensen et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Human gastric cancer modelling using organoids

Therese Seidlitz et al.

GUT (2019)

添加到收藏夹

Review Cell & Tissue Engineering

Stem cells: past, present, and future

Wojciech Zakrzewski et al.

STEM CELL RESEARCH & THERAPY (2019)

添加到收藏夹

Review Genetics & Heredity

Genome to Phenome: Improving Animal Health, Production, and Well-Being - A New USDA Blueprint for Animal Genome Research 2018-2027

Caird Rexroad et al.

FRONTIERS IN GENETICS (2019)

添加到收藏夹

Review Cell & Tissue Engineering

Engineering Stem Cell Self-organization to Build Better Organoids

Jonathan A. Brassard et al.

CELL STEM CELL (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

Kyu Shik Mun et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Biochemical Research Methods

Generation of blood vessel organoids from human pluripotent stem cells

Reiner A. Wimmer et al.

NATURE PROTOCOLS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Human blood vessel organoids as a model of diabetic vasculopathy

Reiner A. Wimmer et al.

NATURE (2019)

添加到收藏夹

Article Cell & Tissue Engineering

Engineered Microenvironment for Manufacturing Human Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells

Haishuang Lin et al.

STEM CELL REPORTS (2019)

添加到收藏夹

Article Neurosciences

State-level prevalence, health service use, and spending vary widely among Medicare beneficiaries with Parkinson disease

Sneha Mantri et al.

NPJ PARKINSONS DISEASE (2019)

添加到收藏夹

Article Cell & Tissue Engineering

Three-dimensional hydrogel culture conditions promote the differentiation of human induced pluripotent stem cells into hepatocytes

Ying Luo et al.

CYTOTHERAPY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Use and application of 3D-organoid technology

Benedetta Artegiani et al.

HUMAN MOLECULAR GENETICS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions?

Jessica Hoarau-Vechot et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Biochemical Research Methods

Genetically engineered cerebral organoids model brain tumor formation

Shan Bian et al.

NATURE METHODS (2018)

添加到收藏夹

Article Biochemical Research Methods

Generation of human brain region-specific organoids using a miniaturized spinning bioreactor

Xuyu Qian et al.

NATURE PROTOCOLS (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Use of bioreactors for culturing human retinal organoids improves photoreceptor yields

Patrick Ovando-Roche et al.

STEM CELL RESEARCH & THERAPY (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors

Tyler DiStefano et al.

STEM CELL REPORTS (2018)

添加到收藏夹

Article Cell & Tissue Engineering

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells

Aneta Przepiorski et al.

STEM CELL REPORTS (2018)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

THE THIRD DIMENSION IN STEM-CELL CULTURE

C. Y. Tachibana

NATURE (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

Sandra Haider et al.

STEM CELL REPORTS (2018)

添加到收藏夹

Editorial Material Urology & Nephrology

Kidney organoids-a new tool for kidney therapeutic development

Joseph V. Bonventre

KIDNEY INTERNATIONAL (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Trophoblast organoids as a model for maternal-fetal interactions during human placentation

Margherita Y. Turco et al.

NATURE (2018)

添加到收藏夹

Article Neurosciences

Vascularization and Engraftment of Transplanted Human Cerebral Organoids in Mouse Cortex

Nicolas Daviaud et al.

ENEURO (2018)

添加到收藏夹

Article Biology

Three-dimensional cell culture model utilization in cancer stem cell research

Zofia F. Bielecka et al.

BIOLOGICAL REVIEWS (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

Meike Hohwieler et al.

GUT (2017)

添加到收藏夹

Review Cell Biology

Organoids: A historical perspective of thinking in three dimensions

Marina Simian et al.

JOURNAL OF CELL BIOLOGY (2017)

添加到收藏夹

Article Cell Biology

A three-dimensional model of human lung development and disease from pluripotent stem cells

Ya-Wen Chen et al.

NATURE CELL BIOLOGY (2017)

添加到收藏夹

Article Chemistry, Physical

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

Nelly M. Cruz et al.

NATURE MATERIALS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Progress and challenges in large-scale expansion of human pluripotent stem cells

Christina Kropp et al.

PROCESS BIOCHEMISTRY (2017)

添加到收藏夹

Review Multidisciplinary Sciences

Human tissues in a dish: The research and ethical implications of organoid technology

Annelien L. Bredenoord et al.

SCIENCE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Moritz Schuette et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment

Angela Babetski Holton et al.

PLOS ONE (2017)

添加到收藏夹

Article Engineering, Biomedical

Regulating dynamic signaling between hematopoietic stem cells and niche cells via a hydrogel matrix

Shushan P. Mahadik et al.

BIOMATERIALS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dawn of the organoid era: 3D tissue and organ cultures revolutionize the study of development, disease, and regeneration

Ninouk Akkerman et al.

BIOESSAYS (2017)

添加到收藏夹

Review Cell & Tissue Engineering

Engineering Stem Cell Organoids

Xiaolei Yin et al.

CELL STEM CELL (2016)

添加到收藏夹

Review Cell Biology

Organoids: Modeling Development and the Stem Cell Niche in a Dish

Kai Kretzschmar et al.

DEVELOPMENTAL CELL (2016)

添加到收藏夹

Article Biochemical Research Methods

Organoid culture systems for prostate epithelial and cancer tissue

Jarno Drost et al.

NATURE PROTOCOLS (2016)

添加到收藏夹

Article Health Care Sciences & Services

The Flaws and Human Harms of Animal Experimentation

Aysha Akhtar

CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS (2015)

添加到收藏夹

Article Cell Biology

Three-dimensional spheroid culture of human umbilical cord mesenchymal stem cells promotes cell yield and stemness maintenance

Yi Li et al.

CELL AND TISSUE RESEARCH (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Minoru Takasato et al.

NATURE (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

Ryuji Morizane et al.

NATURE BIOTECHNOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

Ling Huang et al.

NATURE MEDICINE (2015)

添加到收藏夹

Review Cell Biology

3D Cell Culture Systems: Advantages and Applications

Maddaly Ravi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Dong Gao et al.

CELL (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

Kyle W. McCracken et al.

NATURE (2014)

添加到收藏夹

Review Chemistry, Physical

Materials as stem cell regulators

William L. Murphy et al.

NATURE MATERIALS (2014)

添加到收藏夹

Article Biochemical Research Methods

Generation of cerebral organoids from human pluripotent stem cells

Madeline A. Lancaster et al.

NATURE PROTOCOLS (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Meritxell Huch et al.

EMBO JOURNAL (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

In vitro three-dimensional (3D) models in cancer research: An update

Lauren C. Kimlin et al.

MOLECULAR CARCINOGENESIS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Meritxell Huch et al.

NATURE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Vascularized and functional human liver from an iPSC-derived organ bud transplant

Takanori Takebe et al.

NATURE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Cerebral organoids model human brain development and microcephaly

Madeline A. Lancaster et al.

NATURE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

Taisuke Kadoshima et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Jason R. Spence et al.

NATURE (2011)

添加到收藏夹

Article Biochemical Research Methods

Matrigel: A complex protein mixture required for optimal growth of cell culture

Chris S. Hughes et al.

PROTEOMICS (2010)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Cell-interactive 3D-scaffold; advances and applications

Ranjna C. Dutta et al.

BIOTECHNOLOGY ADVANCES (2009)

添加到收藏夹

Article Cell Biology

Cellular observations enabled by microculture: paracrine signaling and population demographics

Maribella Domenech et al.

INTEGRATIVE BIOLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato et al.

NATURE (2009)

添加到收藏夹

Article Cell & Tissue Engineering

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Mototsugu Eiraku et al.

CELL STEM CELL (2008)

添加到收藏夹

Article Medicine, Research & Experimental

Strategies for Therapeutic Repair: The R3 Regenerative Medicine Paradigm

Timothy J. Nelson et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2008)

添加到收藏夹

Review Pediatrics

Stem cells bioprocessing: An important milestone to move regenerative medicine research into the clinical arena

Julia M. Polak et al.

PEDIATRIC RESEARCH (2008)

添加到收藏夹

Article Immunology

Regenerative medicine: An insight

M. Muraca et al.

TRANSPLANTATION PROCEEDINGS (2007)

添加到收藏夹

Article Anatomy & Morphology

Optimization of hepatocyte spheroid formation for hepatic tissue engineering on three-dimensional biodegradable polymer within a flow bioreactor prior to implantation

E Torok et al.

CELLS TISSUES ORGANS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.