期刊
MEDICAL ONCOLOGY
卷 41, 期 1, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-023-02259-4
关键词
Epithelial-mesenchymal transition (EMT); Metaplastic breast carcinoma; Breast cancer; Phyllodes breast tumors
类别
This review summarizes the role of EMT in the pathogenesis of Metaplastic Breast Carcinoma (MBC) and Phyllodes tumors (PTs), and suggests several anti-EMT targeting strategies as promising therapeutic approaches for patients suffering from these aggressive neoplasms.
Epithelial-mesenchymal transition (EMT), a transdifferentiation program whereby epithelial cells acquire mesenchymal phenotype, is essential during embryonic development. EMT has also been implicated in cancer progression by conferring migratory and metastatic potential, as well as cell plasticity and stem cell like traits, to cancer cells. Metaplastic breast carcinoma (MBC) is a rare aggressive type of breast cancer characterized by the presence of heterologous elements, typically by the existence of epithelial and mesenchymal components. Phyllodes tumors (PTs) are uncommon fibroepithelial neoplasms consisting of epithelial and mesenchymal elements. Although various hypotheses have been proposed on the pathogenesis of these biphasic tumors, there is growing evidence supporting the theory that PTs and MBC could both correlate with cancer related EMT. This review summarizes the existing literature on the emerging role of EMT in the pathogenesis of MBC and PTs. Both malignant PTs and MBC are characterized by poor prognosis. Therefore, several anti-EMT targeting strategies such as blocking upstream signaling pathways, targeting the molecular drivers of EMT and targeting mesenchymal cells and the extracellular matrix, could potentially represent a promising therapeutic approach for patients suffering from these aggressive neoplasms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据