期刊
TRENDS IN CANCER
卷 9, 期 12, 页码 1006-1018出版社
CELL PRESS
DOI: 10.1016/j.trecan.2023.08.003
关键词
-
类别
This article reviews the biological function of selenium and highlights the role of selenoproteins in cellular antioxidant capacity. It also emphasizes the potential of targeting selenoproteins and the biogenesis of selenocysteine for therapeutic intervention in cancer.
In the past two decades significant progress has been made in uncovering the biological function of selenium. Selenium, an essential trace element, is required for the biogenesis of selenocysteine which is then incorporated into selenoproteins. These selenoproteins have emerged as central regulators of cellular antioxidant capacity and maintenance of redox homeostasis. This review provides a comprehensive examination of the multifaceted functions of selenoproteins with a particular emphasis on their contributions to cellular antioxidant capacity. Additionally, we highlight the promising potential of targeting selenoproteins and the biogenesis of selenocysteine as avenues for therapeutic intervention in cancer. By understanding the intricate relationship between selenium, selenoproteins, and reactive oxygen species (ROS), insights can be gained to develop therapies that exploit the inherent vulnerabilities of cancer cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据