☆ 4.5 Review

Micromixing within microfluidic devices: Fundamentals, design, and fabrication

BIOMICROFLUIDICS (2023)

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Review Chemistry, Analytical

Paper-based Wearable Electrochemical Sensors: A New Generation of Analytical Devices

Patricia Batista Deroco et al.

Summary: In recent years, electrochemical wearable sensors have gained significant attention for their potential applications in point-of-care testing due to their high sensitivity, simplicity, miniaturization, and low cost. New fabrication approaches and innovative substrates have enabled real-time and on-body measurements. These sensors have also been combined with paper-based substrates for non-invasive analyses. Additionally, they allow monitoring of analytes in different biofluids without complex procedures. The integration of IoT with wearable sensors has attracted interest for real-time data collection in resource-limited conditions. This mini-review highlights the advancements in wearable electrochemical devices and discusses challenges for higher performance.

ELECTROANALYSIS (2023)

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Article Chemistry, Analytical

A Directly Moldable, Highly Compact, and Easy-for-Integration 3D Micromixer with Extraordinary Mixing Performance

Zhenghao Wang et al.

Summary: We reported a 3D PDMS micromixer based on the splitting-stretching-recombination (SSR) of streams, which can effectively and rapidly mix solutions with low Reynolds numbers. The micromixer is conveniently fabricated using two-photon polymerization (2PP) 3D printing and soft lithography, with high resolution, reproducibility, and ease of integration. It has better performance and higher chip miniaturization compared to other micromixers.

ANALYTICAL CHEMISTRY (2023)

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Article Chemistry, Physical

Fabrication and performance of nickel-based composite mold inserts for micro-injection molding

Yilei Wang et al.

Summary: Reducing interfacial interactions is crucial in achieving non-destructive molding of polymer micro/nano structures during demolding in micro-injection molding. This study fabricated Ni-based composite mold inserts with low surface energy and low friction coefficients using polytetrafluoroethylene (PTFE), molybdenum disulfide (MoS2), and tungsten disulfide (WS2) via electroforming. The addition of nanoparticles effectively reduced the surface energy and adhesion of the inserts. Molecular dynamics simulation showed that the water contact angle could be more accurate by considering surface roughness. The use of composite mold inserts with low surface energy and low friction coefficient can prevent microstructure deformation in demolding stage of injection molded polymer microfluidic chips.

APPLIED SURFACE SCIENCE (2023)

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Article Chemistry, Analytical

A multi-vortex micromixer based on the synergy of acoustics and inertia for nanoparticle synthesis

Yuwen Lu et al.

Summary: In this study, we proposed an acoustic-inertial micromixer based on multi-vortex synergy by introducing inertia into acoustic micromixer. The device contains side-wall sharp-edge structure and contraction-expansion array structure to enhance the acoustic streaming with inertial vortices. Rapider mixing and wider operating ranges were achieved in this device at lower driving voltages compared with conventional acoustic micromixers.

ANALYTICA CHIMICA ACTA (2023)

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Article Engineering, Chemical

Mixing Enhancement in a Chaotic Micromixer with Reversed Ridges and Grooves

Shulei Chen et al.

Summary: The reversed ridges and grooves micromixer (RRGM) is a novel micromixer with chaotic and passive characteristics. It achieves excellent mixing performance, especially at low Reynolds numbers. The optimization of design parameters can further enhance the mixing performance.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2023)

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Article Chemistry, Analytical

An overview on state-of-art of micromixer designs, characteristics and applications

Xin Wang et al.

Summary: This paper provides an overview of the design and applications of micromixers, including the typical designs and mixing mechanisms of passive and active micromixers, and application cases in the chemical, biological, and medical fields. The characteristics, advantages, and restrictions of different micromixers are also discussed, along with a proposed future perspective on micromixer design.

ANALYTICA CHIMICA ACTA (2023)

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Article Biochemical Research Methods

On-demand microfluidic mixing by actuating integrated magnetic microwalls

Stef Broeren et al.

Summary: Researchers have developed an on-demand micromixer based on magnetic microwalls, which can achieve controllable mixing and complete mixing shut-off in commercial microfluidic devices. The microwalls can create a meandering path in the main channel to enable mixing or open up the channel to stop mixing, controlled by a simple magnet. Experimental results show that the microwalls can effectively enhance mixing in colored fluids with different flow rates and viscosities.

LAB ON A CHIP (2023)

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Article Engineering, Chemical

Mixing Enhancement in a Chaotic Micromixer with Reversed Ridges and Grooves

Shulei Chen et al.

Summary: A novel micromixer named reversed ridges and grooves micromixer (RRGM) with chaotic and passive characteristics is proposed, which achieves excellent mixing performance at different Reynolds numbers. The chaotic behavior in the mixing process is observed and explained. The mixing performance is further optimized by adjusting the design parameters.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2023)

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Article Engineering, Chemical

Experimental and Numerical Investigation of a Novel Spiral Micromixer with Sinusoidal Channel Walls

Dariush Bahrami et al.

Summary: A novel spiral micromixer with sinusoidal channel walls was designed to enhance mixing performance, showing a significant increase in mixing index compared to a simple spiral micromixer through numerical simulations and experimental validation.

CHEMICAL ENGINEERING & TECHNOLOGY (2022)

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Article Engineering, Environmental

Optimum design of micromixer for a non-Newtonian fluid by topology optimization

Xin Dong et al.

Summary: This paper investigates the design of the mixing unit in a T-shape micromixer considering non-Newtonian fluid effects using topology optimization. The optimized structures exhibit superior performance in maximizing mixing quality, especially for non-Newtonian fluids.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Environmental

Fast prototyping using 3D printed templates and flexible fluoropolymer microcapillary films offers enhanced micromixing in immobilised (bio) catalytic reactions

Kirandeep K. Gill et al.

Summary: This study presents a novel approach in fabricating inexpensive non-linear microstructure prototypes using a flexible fluoropolymer microcapillary film and 3D printed templates, which enhance mass transfer efficiency in microreactors. By evaluating different micromixer structures and experimental validation, significant insights into fluid flow distribution were gained.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Chemical

Enhanced Electroosmotic Mixing in a Wavy Micromixer Using Surface Charge Heterogeneity

Sumit Kumar Mehta et al.

Summary: The flow and mixing characteristics of an electroosmotic flow through a wavy micromixer are investigated using surface charge heterogeneity. The results indicate that the phase lag, Debye parameter, geometrical wave number, dimensionless wall amplitude, and diffusive Peclet number significantly influence the flow field and mixing performance.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2022)

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Article Chemistry, Physical

Power-law fluid micromixing enhancement using surface acoustic waves

Vahid Rabiei Faradonbeh et al.

Summary: This study numerically investigates the mixing efficiency of non-Newtonian fluid flow using surface acoustic waves. The results show that the input velocity and power-law index significantly affect the mixing efficiency, and shear-thickening fluids experience a higher rate of increase in mixing efficiency under the pressure of acoustic field.

JOURNAL OF MOLECULAR LIQUIDS (2022)

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Article Mechanics

Investigation of a novel serpentine micromixer based on Dean flow and separation vortices

Zahra Babaie et al.

Summary: Passive micromixers are widely used in various fields due to their high mixing efficiency and simple fabrication. This study investigated a combination of sinusoidal and serpentine microchannels, and found that adding convergent-divergent regions can significantly improve the mixing efficiency. The study also showed that serpentine-sinusoidal mixers achieve the highest mixing efficiency with fewer mixing units compared to serpentine mixers. The performance coefficient of the micromixers is influenced by the amplitude and the number of bumps.

MECCANICA (2022)

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Article Engineering, Electrical & Electronic

A micromixer driven by two valveless piezoelectric pumps with multi-stage mixing characteristics

Guojun Liu et al.

Summary: A novel micromixer driven by valveless piezoelectric pumps with multi-stage mixing characteristics was proposed and studied through numerical simulation and experimental verification, demonstrating optimized structural parameters and enhanced working performance.

SENSORS AND ACTUATORS A-PHYSICAL (2022)

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Article Chemistry, Analytical

Current Development in Interdigital Transducer (IDT) Surface Acoustic Wave Devices for Live Cell In Vitro Studies: A Review

Mazlee Bin Mazalan et al.

Summary: Acoustics has a wide range of applications, and there has been increasing interest in the development of acoustic-based approaches for biological and biomedical purposes in recent years. This review focuses on the use of surface acoustic waves (SAW) based on interdigital transducers (IDT) for live-cell investigations. The article provides an overview of various IDT SAW devices used on cells and discusses the future applications of SAW techniques in live-cell studies.

MICROMACHINES (2022)

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Article Chemistry, Multidisciplinary

Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure

Junyao Wang et al.

Summary: This paper presents a helical three-dimensional passive micromixer fabricated through 3D printing and polymer dissolution technology, which effectively improves the mixing efficiency according to experimental results.

ACS OMEGA (2022)

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Article Engineering, Chemical

Micromixing efficiency intensification of a millimeter channel reactor in the high gravity field

Shun Bai et al.

Summary: This study presents a novel rotating millimeter channel reactor (RMCR) that utilizes centrifugal and Coriolis forces to enhance micromixing performance. Experimental results demonstrate that the micromixing efficiency of the RMCR is improved by 35% compared to the conventional millimeter channel reactor without rotation.

CHEMICAL ENGINEERING SCIENCE (2022)

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Article Thermodynamics

Flow and mixing analysis of a thixotropic fluid in a barrier-emb e dde d partitioned pipe mixer (BPPM): A numerical study

Seon Yeop Jung et al.

Summary: This study numerically investigates the flow and mixing characteristics of a thixotropic fluid in a static mixer. The results show that the characteristics of the thixotropic fluid are influenced by the flow parameters and the thixotropy parameter. As the flow parameters increase, the mixing characteristics become more complex, and the thixotropy parameter significantly affects the average of the structure parameter. From the analysis of the Poincare section and the flux-weighted intensity of segregation, it is found that the mixing performance improves with the increase of the thixotropy parameter in the counter-rotational static mixer, while a more complex trend of the degree of mixing is observed in the co-rotational mixer.

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER (2022)

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Article Engineering, Electrical & Electronic

Enhanced acoustofluidic mixing in a semicircular microchannel using plate mode coupling in a surface acoustic wave device

Jin-Chen Hsu et al.

Summary: This study presents enhanced acoustic mixing inside a semicircular microfluidic channel using acoustic streaming induced by acoustic plate modes (APMs). By exciting APMs on a 500-μm-thick polished lithium-niobate (LiNbO3) substrate, stronger acoustic streaming flow and stirring effects were observed, leading to rapid and enhanced mixing processes. Finite element simulation and experimental validation were performed to investigate the acoustic process and mixing behaviors. The ability of the device to enhance micromixing using APM frequencies was demonstrated, suggesting the potential for integrated design with surface acoustic waves (SAWs) in a single system. The results also highlight the innovative application of conventional SAW acoustofluidic devices to extended frequency regimes via APMs without altering the substrate thickness and interdigitated transducer (IDT) pitch.

SENSORS AND ACTUATORS A-PHYSICAL (2022)

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Article Materials Science, Multidisciplinary

Acoustofluidic micromixers: From rational design to lab-on-a-chip applications

Zhenzhen Chen et al.

Summary: Microfluidics, especially acoustofluidics, offers new opportunities in chemical and biomedical engineering by manipulating fluids at the micrometer or submicrometer scale. This review discusses the utility of acoustofluidic technology, summarizes different types of acoustic micromixers, highlights their applications in various fields, and identifies the practical challenges that need to be addressed. Overall, this review provides valuable insights for both academic research and industrial applications.

APPLIED MATERIALS TODAY (2022)

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Article Biochemical Research Methods

A novel 3D Tesla valve micromixer for efficient mixing and chitosan nanoparticle production

Kefan Guo et al.

Summary: This paper investigates the design, fabrication, and characterization of a novel micromixer that uses a simple spatial Tesla valve design to achieve efficient mixing of multiple solutions. The flow characteristics and mixing efficiencies of the micromixer are investigated using numerical simulations and experiments. The results show that the micromixer can effectively mix viscoelastic solutions with different concentrations and produce smaller and more uniform nanoparticles compared to conventional magnetic stirring.

ELECTROPHORESIS (2022)

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Article Engineering, Chemical

Novel Study on the Mixing Mechanism of Active Micromixers Based on Surface Acoustic Waves

Honglin Lv et al.

Summary: This paper investigates the potential mechanism of using surface acoustic waves (SAW) to drive fluid mixing on a microfluidic chip. Through simulations and experiments, it is found that different types of SAW driving result in different mixing effects, with TSAW driving producing a single vortex flow and SSAW driving producing a symmetric double vortex flow. This study contributes to a better understanding of the SAW-driven effect on flow properties of fluids.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2022)

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Article Chemistry, Analytical

Numerical Analysis of Mixing Performance in an Electroosmotic Micromixer with Cosine Channel Walls

Zhong Chen et al.

Summary: This study presents the design and numerical simulations of a passive micromixer and a novel active electroosmotic micromixer. The results show that electroosmosis can effectively induce fluid mixing. The effects of key parameters on the mixing performance were discussed through numerical analysis. The proposed electroosmotic micromixer has a simple structure, fast response, and high mixing index.

MICROMACHINES (2022)

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Review Chemistry, Physical

Classification, Synthetic, and Characterization Approaches to Nanoparticles, and Their Applications in Various Fields of Nanotechnology: A Review

Yousaf Khan et al.

Summary: Nanotechnology, with its focus on nanoparticles, has attracted significant interest for its wide range of potential applications in various fields. Understanding the size, structure, and properties of nanoparticles is essential for their use in different sectors.

CATALYSTS (2022)

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Article Mechanics

Highly efficient and controllable micromixer through interactions of photothermal multivortices

Fangjing Luo et al.

Summary: This study presents a novel micromixer for efficient and controllable mixing based on photothermal vortices. The vortices, generated from an array of linear heat sources excited by a laser, provide stable disturbance to fluid interfaces and enhance the mixing efficiency. The study reveals the interactions between vortices and the mixing mechanism of fluids, and explores the effects of various factors on the mixing performance.

PHYSICS OF FLUIDS (2022)

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Article Engineering, Electrical & Electronic

A novel design for split-and-recombine micromixer with double-layer Y-shaped mixing units

Guojun Liu et al.

Summary: A novel Y-shaped split-and-recombine (SAR) micromixer is proposed, which demonstrates better mixing performance and smaller pressure loss due to its three-dimensional structure, splitting recombination, and chaotic convection mechanism. Simulation and experimental results show that the channel aspect ratio has a significant impact on the mixing performance and pressure loss of the micromixer. The micromixer has broad application prospects in chemical synthesis, biochemical analysis, and biomedicine.

SENSORS AND ACTUATORS A-PHYSICAL (2022)

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Article Chemistry, Analytical

Mixing and Flow Transition in an Optimized Electrokinetic Turbulent Micromixer

Keyi Nan et al.

Summary: This study investigated the effects of electric field intensity, AC frequency, electric conductivity ratio, and channel width at the entrance on the mixing effect of a Y-type electrokinetic turbulent micromixer. It was found that the optimal mixing can be achieved in a 350 μm wide micromixer under specific conditions.

ANALYTICAL CHEMISTRY (2022)

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Article Engineering, Electrical & Electronic

A surface acoustic wave-assisted micromixer with active temperature control

Cheng Bai et al.

Summary: Microfluidic mixing is an important issue in lab-on-a-chip systems and has various biomedical applications. Acoustic wave-based active micromixers have recently been used to increase mixing efficiency. However, these micromixers also generate additional heat. In this study, a thermal control unit was integrated into a surface acoustic wave (SAW)-assisted micromixer to effectively control the temperature in temperature-sensitive biomedical research.

SENSORS AND ACTUATORS A-PHYSICAL (2022)

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Article Chemistry, Analytical

Rapid and Continuous Cryopreservation of Stem Cells with a 3D Micromixer

Lin Ding et al.

Summary: Cryopreservation is the final step of stem cell production, and the conventional methods of mixing cryoprotecting agents (CPA) with cells have limitations. This study introduces a highly efficient micromixer as an alternative solution, which can achieve continuous and automated mixing, while preserving the properties of the cells.

MICROMACHINES (2022)

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Review Chemistry, Analytical

Paper-based Wearable Electrochemical Sensors: a New Generation of Analytical Devices

Patricia Batista Deroco et al.

Summary: In recent years, electrochemical wearable sensors have gained significant attention due to their high sensitivity, simplicity, and low cost. These sensors, coupled with innovative substrates and paper-based substrates, allow real-time and on-body measurements and non-invasive analysis of biofluids. The integration of IoT technology enables remote data collection and processing. The use of paper as an intelligent substrate for electrochemical wearable sensors has advantages and drawbacks. Future advancements in wearable sensors include multiplexed detection of biomarkers, reducing analysis time and cost, and providing comprehensive physiological analysis to the wearer.

ELECTROANALYSIS (2022)

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Article Chemistry, Physical

A novel passive micromixer with array of Koch fractal obstacles in microchannel

Xianchun Shi et al.

Summary: Passive micromixers play a crucial role in microfluidics, and enhancing their mixing efficiency is essential. This paper presents six micromixer models with Koch fractal obstacles on different sides, showing that the Koch obstacle improves mixing efficiency by enhancing chaotic convection in the microchannel. The research provides a new design and theoretical basis for microfluidic micromixer design.

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY (2021)

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Article Engineering, Chemical

Liquid hydrodynamics in a gas-liquid vortex reactor

Yi Ouyang et al.

Summary: The gas-liquid hydrodynamics in a gas-liquid vortex reactor (GLVR) have been investigated by high-speed imaging and digital image analysis, revealing that a high turbulent kinetic energy dissipation rate contributes to a high mixing and mass transfer efficiency in the GLVR.

CHEMICAL ENGINEERING SCIENCE (2021)

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Article Thermodynamics

Numerical simulation of a three dimensional electroosmotic micromixer with a flexible and controllable Rubik's cube module

Qiaoyu Feng et al.

Summary: A new 3D electroosmotic micromixer with variable modules is designed in this paper, with a microchannel throughout the module for improved mixing efficiency. Different parameters were studied to determine the mixing efficiency, with results showing high and stable mixing efficiency under specific conditions.

INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER (2021)

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Article Thermodynamics

New insights into the mechanism of fluid mixing in the micromixer based on alternating current electric heating with film heaters

Honglin Lv et al.

Summary: A new micromixer mixing method based on AC heating effect was designed, which uses internal Joule heat and external heat sources to adjust fluid disturbance and temperature distribution for enhanced mixing efficiency. Structural parameters and voltage amplitude/conductivity were analyzed to optimize micromixer performance, achieving over 90% mixing efficiency.

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER (2021)

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Article Thermodynamics

Mixing performance analysis of the novel passive micromixer designed by applying fuzzy grey relational analysis

Xiangyu Luo et al.

Summary: This paper presents a numerical study on a passive baffled T-micromixer with improvement in mixing efficiency. Through orthogonal experimental design, 16 cases were selected to analyze the optimal structure and influential factors using fuzzy grey relational theory. The results indicate that the incline angle of baffles has the highest impact on mixing performance, leading to the proposal of novel stagger baffles for high mixing ability.

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER (2021)

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Article Energy & Fuels

Twisted architecture for enhancement of passive micromixing in a wide range of Reynolds numbers

Shima Akar et al.

Summary: The study introduces a novel twisted microstructure design to enhance the mixing efficiency of micromixers. Results show that the twisted structure can significantly increase mixing efficiency while maintaining a low pressure drop, indicating promising performance in microfluidic systems.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2021)

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Article Nanoscience & Nanotechnology

Simulation and experimental research of an effective SAR multilayer interlaced micromixer based on Koch fractal geometry

Siyue Xiong et al.

Summary: This study designed a three-dimensional micromixer based on Koch fractal and SAR channel, which was verified to have high mixing efficiency through experiments and simulations. Manufactured using a CO2 laser system, parameters for laser power and cutting times were determined after investigating their effects on micromixer quality.

MICROFLUIDICS AND NANOFLUIDICS (2021)

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Article Mechanics

Numerical and experimental investigations of interdigital transducer configurations for efficient droplet streaming and jetting induced by surface acoustic waves

Mehdi H. Biroun et al.

Summary: Surface acoustic wave (SAW) based technologies have been explored for sensing and microfluidic applications, but the large deformation of droplet interface actuated by SAWs has not been widely studied. In this paper, a computational interface tracking method is developed to simulate the interactions between liquid and acoustic waves. By analyzing energy terms within the liquid medium, it was found that two perfectly aligned interdigital transducers (IDTs) are optimal for mixing applications, while two offset IDTs are optimal for concentration and separation applications.

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW (2021)

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Article Biotechnology & Applied Microbiology

Numerical study of a three-dimensional electroosmotic micromixer with Koch fractal curve structure

Siyue Xiong et al.

Summary: The results of the simulation show that the irregular alternating vortices generated in the microchannel under the combined action of fractal and electric field can greatly improve the mixing of fluids in the electroosmotic micromixer. Specifically, the mixing efficiency can reach 98% when the direct current voltage is 10 V, the electrode spacing is 0.15 mm, and the electroosmotic micromixer has three groups of alternately placed electrode pairs.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2021)

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Article Chemistry, Analytical

Acoustically-actuated bubble-powered rotational micro-propellers

Sumit Mohanty et al.

Summary: This article introduces two bubble-powered micro-propeller designs that autonomously rotate under the excitation of sound waves, serving as both mobile microfluidic mixers and autonomous microrobots for targeted manipulation.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Engineering, Chemical

Micromixing in a gas-liquid vortex reactor

Yi Ouyang et al.

Summary: The gas-liquid vortex reactor shows great potential in intensifying micromixing processes for multiphase reactions. Introducing liquid into the reactor suppresses gas flow, and factors affecting micromixing efficiency include gas flow rate, liquid flow rate, and liquid viscosity. The micromixing time of the GLVR is determined to be comparable to a rotating packed bed and superior to a static mixer.

AICHE JOURNAL (2021)

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Article Chemistry, Analytical

A cost-effective serpentine micromixer utilizing ellipse curve

Xin Wang et al.

Summary: The serpentine micromixer with ellipse curve design shows improved mixing performance and reduced pressure drop compared to traditional zigzag and square-wave designs. By utilizing Dean vortices induced by the continuous change in flow direction through ellipse curves, this novel micromixer is more cost-effective for rapid mixing in complex microfluidic systems.

ANALYTICA CHIMICA ACTA (2021)

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Article Engineering, Chemical

Simple structured and highly efficient passive T-type micromixer with circumferential in-step at entry

Manoj Dundi et al.

Summary: The study evaluated the performance of T and T-T mixers with and without circumferential in-step, showing a significant improvement in mixing at higher Re. The T-mixer outperformed the T-T mixer at Re above 100, exhibiting shorter mixing lengths.

ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING (2021)

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Article Energy & Fuels

On the quality of micromixing in an oxy-fuel micromixer burner for gas turbine applications: A numerical study

A. A. Araoye et al.

Summary: The study found that increasing the tube length and optimizing the size and number of fuel holes can significantly improve the mixing quality of oxy-fuel reactants.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2021)

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Article Engineering, Chemical

Design and evaluation of a 3D multi-manifold micromixer realized by a double-Archimedes-screw for rapid mixing within a short distance

Chow-Shing Shin et al.

Summary: A single 3D multi-manifold micromixer composed of a double Archimedes screw was developed for rapidly mixing within a short distance; Numerical simulations showed satisfactory mixing efficiency can be achieved at a distance of approximately twice the microchannel width; Experimental demonstration by an ASM fabricated by two-photon stereolithography showed good agreement with simulation findings.

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS (2021)

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Article Nanoscience & Nanotechnology

Towards a microfluidics platform for the continuous manufacture of organic and inorganic nanoparticles

Diti Desai et al.

Summary: Microfluidics has opened up new possibilities for the synthesis of nanomaterials in the past decade, but its adoption has been limited by technical factors and the lack of a unified platform. This work highlights a micro-mixing platform capable of producing a wide range of organic and inorganic nanoparticles with predictable and reproducible size and shape control. The platform has the potential to accelerate the adoption of nanomaterials in various industries like pharmaceuticals, diagnostics, and cosmeceuticals.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Article Engineering, Chemical

Effect of Thermal Energy and Ultrasonication on Mixing Efficiency in Passive Micromixers

Fahizan Mahmud et al.

Summary: This study simplifies the manufacturing process and improves mixing performance by externally applying ultrasound and thermal energy upstream of the micromixer. The Dean micromixer shows higher mixing performance compared to T- and Y-micromixers, with about 27% improvement for Reynolds numbers between 40 and 100.

PROCESSES (2021)

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Article Engineering, Mechanical

Simulation analysis of micromixer with three-dimensional fractal structure with electric field effect

Siyue Xiong et al.

Summary: In this study, a micromixer with Koch fractal under electric field effect is simulated, and the effects of different fractal parameters on the mixing process are studied. The results show that increasing the number of electrode pairs and increasing the fractal size are beneficial to fluid mixing, and the optimal fractal spacing is 0.75 mm. The Koch fractal structure and the electric field effect can effectively improve the flow state of the fluid and increase the mixing index of the fluid.

JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING (2021)

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Article Engineering, Electrical & Electronic

Fabrication and characteristic study on mixing enhancement of a magnetofluidic mixer

Ran Zhou et al.

Summary: A new magnetofluidic mixer was developed for rapid and efficient mixing of two miscible fluids, utilizing magnetic field. Experimental and simulation results showed that the mixing efficiency was highest at specific angle and magnet width, providing great potential for optimization of biomedical and chemical mixing devices in the future.

SENSORS AND ACTUATORS A-PHYSICAL (2021)

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Article Materials Science, Multidisciplinary

Functionalization of microfluidic devices by microstructures created with proton beam lithography

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Summary: A new fabrication approach integrating PDMS microstructures into PDMS microdevices for passive mixing was introduced, involving computer simulation, optimization, and analysis of the mixing efficiency.

VACUUM (2021)

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Facile engineering and interfacing of styrenic block copolymers devices for low-cost, multipurpose microfluidic applications

Hugo Salmon et al.

Summary: This study explores the prototyping potential of a commercially available SBC material, Flexdym, for microfluidic chip fabrication, showcasing its reversible and permanent self-adhesion properties that allow for rapid and adaptive chip production. The interfaces fabricated using this method can withstand different pressures under continuous flow conditions and enable rapid mixing and local enrichment.

ENGINEERING REPORTS (2021)

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Article Chemistry, Analytical

Mass transfer in a novel passive micro-mixer: Flow tortuosity effects

Arash Haghighinia et al.

ANALYTICA CHIMICA ACTA (2020)

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Review Electrochemistry

Paper-Based Microfluidics for Electrochemical Applications

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CHEMELECTROCHEM (2020)

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Review Energy & Fuels

Active and passive micromixers: A comprehensive review

Morteza Bayareh et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2020)

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Article Engineering, Chemical

Effects of flexibility of conductive plate on efficiency of an induced-charge electrokinetic micro-mixer under constant and time-varying electric fields-A comprehensive parametric study

Morteza Nazari et al.

CHEMICAL ENGINEERING SCIENCE (2020)

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Article Engineering, Chemical

Investigation of Mixing Performance of Two-Dimensional Micromixer Using Tesla Structures with Different Shapes of Obstacles

Shakhawat Hossain et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2020)

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Article Computer Science, Interdisciplinary Applications

Single phase nanofluids in fluid mechanics and their hydrodynamic linear stability analysis

Mustafa Turkyilmazoglu

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2020)

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Article Thermodynamics

A new design of induced-charge electrokinetic micromixer with corrugated walls and conductive plate installation

Soroush Najjaran et al.

INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER (2020)

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Article Chemistry, Analytical

Implementation of a Single Emulsion Mask for Three-Dimensional (3D) Microstructure Fabrication of Micromixers Using the Grayscale Photolithography Technique

Intan Sue Liana Abdul Hamid et al.

MICROMACHINES (2020)

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Review Chemistry, Analytical

A Review of Passive Micromixers with a Comparative Analysis

Wasim Raza et al.

MICROMACHINES (2020)

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Article Engineering, Chemical

Simulation of micromixing in a T -mixer under laminar flow conditions

Claudio P. Fonte et al.

CHEMICAL ENGINEERING SCIENCE (2020)

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Article Thermodynamics

Mechanism of temperature-difference-induced spiral flow in microchannel and investigation of mixing performance of a non-invasive micromixer

Keiko Ishii et al.

APPLIED THERMAL ENGINEERING (2020)

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Article Engineering, Biomedical

A hybrid electrically-and-piezoelectrically driven micromixer built on paper for microfluids mixing

Yanfang Guan et al.

BIOMEDICAL MICRODEVICES (2020)

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Article Thermodynamics

Application of pressure-sensitive paint for the characterization of mixing with various gases in T-type micromixers

Chih-Yung Huang et al.

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER (2020)

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Article Engineering, Chemical

Controllable synthesis of hierarchical micro/nano structured FePO4 particles under synergistic effects of ultrasound irradiation and impinging stream

Bin Dong et al.

ADVANCED POWDER TECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Fabrication of Stiffness Gradients of GelMA Hydrogels Using a 3D Printed Micromixer

Antonina Lavrentieva et al.

MACROMOLECULAR BIOSCIENCE (2020)

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Article Thermodynamics

On-chip mixing of liquids with high-performance embedded barrier structure

Arash Haghighinia et al.

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER (2020)

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Article Engineering, Electrical & Electronic

Micropillar based active microfluidic mixer for the detection of glucose concentration

Roer Eka Pawinanto et al.

MICROELECTRONIC ENGINEERING (2020)

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Article Materials Science, Multidisciplinary

3D printing enables the rapid prototyping of modular microfluidic devices for particle conjugation

Steven A. Vasilescu et al.

APPLIED MATERIALS TODAY (2020)

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Article Physics, Fluids & Plasmas

Unveiling of the mechanisms of acoustic streaming induced by sharp edges

Chuanyu Zhang et al.

PHYSICAL REVIEW E (2020)

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Article Biochemical Research Methods

An acoustofluidic device for efficient mixing over a wide range of flow rates

Hunter Bachman et al.

LAB ON A CHIP (2020)

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Proceedings Paper Materials Science, Multidisciplinary

Fabrication of wavy micromixer using soft lithography technique

Bappa Mondal et al.

MATERIALS TODAY-PROCEEDINGS (2020)

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Article Engineering, Chemical

Numerical investigation of flow regimes in T-shaped micromixers: Benchmark between finite volume and spectral element methods

Chiara Galletti et al.

CANADIAN JOURNAL OF CHEMICAL ENGINEERING (2019)

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Article Engineering, Environmental

Experimental and numerical analysis of Y-shaped split and recombination micro-mixer with different mixing units

Imran Shah et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Article Engineering, Chemical

Computational Evaluation of Mixing Performance in 3-D Swirl-Generating Passive Micromixers

Mahmut Burak Okuducu et al.

PROCESSES (2019)

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Review Nanoscience & Nanotechnology

Continuous Flow Methods of Fabricating Catalytically Active Metal Nanoparticles

Emily J. Roberts et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Environmental Sciences

Micromixing Efficiency of Particles in Heavy Metal Removal Processes under Various Inlet Conditions

Evangelos Karvelas et al.

WATER (2019)

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Article Engineering, Electrical & Electronic

Development of a valveless piezoelectric pump with vortex diodes

Jun Huang et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2019)

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Article Engineering, Chemical

Numerical Investigation and Estimating Correlation of Micromixing Performance of Coaxial Mixers

Baoqing Liu et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2019)

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Article Thermodynamics

Mixing performance of a fractal-like tree network micromixer based on Murray's law

Jiajia Xu et al.

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER (2019)

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Article Chemistry, Analytical

Micromixers and their applications in kinetic analysis of biochemical reactions

Chao Liu et al.

TALANTA (2019)

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Article Thermodynamics

Parameterization investigation on the microchannel heat sink with slant rectangular ribs by numerical simulation

Rui-jin Wang et al.

APPLIED THERMAL ENGINEERING (2018)

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Article Energy & Fuels

Numerical simulation for electro-osmotic mixing under three types of periodic potentials in a T-shaped micro-mixer

Youliang Cheng et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2018)

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Article Energy & Fuels

Analyzing mixing quality in a T-shaped micromixer for different fluids properties through numerical simulation

A. S. Lobasov et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2018)

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Article Energy & Fuels

Development of an efficient uniflow comb micromixer for biodiesel production at low Reynolds number

Mohamed Nabil Sabry et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2018)

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Article Engineering, Environmental

Optimization of a split and recombine micromixer by improved exploitation of secondary flows

Pascal Hermann et al.

CHEMICAL ENGINEERING JOURNAL (2018)

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Article Mechanics

Newtonian and generalized Newtonian reacting flows in serpentine microchannels: Pressure driven and centrifugal microfluidics

Masoud Madadelahi et al.

JOURNAL OF NON-NEWTONIAN FLUID MECHANICS (2018)

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Article Biochemical Research Methods

A robust, portable and backflow-free micromixing device based on both capillary- and vacuum-driven flows

Yaguang Zhai et al.

LAB ON A CHIP (2018)

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Article Engineering, Electrical & Electronic

Manipulation schemes and applications of liquid marbles for micro total analysis systems

Jing Jin et al.

MICROELECTRONIC ENGINEERING (2018)

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Article Instruments & Instrumentation

Fabrication and performance evaluation of two multi-layer passive micromixers

Xueye Chen et al.

SENSOR REVIEW (2018)

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Article Chemistry, Analytical

Recent advances and applications of micromixers

Chia-Yen Lee et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

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Article Chemistry, Analytical

Mixing Enhancement in Serpentine Micromixers with a Non-Rectangular Cross-Section

Joshua Clark et al.

MICROMACHINES (2018)

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Article Chemistry, Analytical

On AC-Field-Induced Nonlinear Electroosmosis next to the Sharp Corner-Field-Singularity of Leaky Dielectric Blocks and Its Application in on-Chip Micro-Mixing

Yukun Ren et al.

MICROMACHINES (2018)

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Article Nanoscience & Nanotechnology

Soft lithography based on photolithography and two-photon polymerization

Yang Lin et al.

MICROFLUIDICS AND NANOFLUIDICS (2018)

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Article Engineering, Electrical & Electronic

Novel solvent bonding method for creation of a three-dimensional, non-planar, hybrid PLA/PMMA microfluidic chip

Lynh Huyen Duong et al.

SENSORS AND ACTUATORS A-PHYSICAL (2018)

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Article Chemistry, Analytical

Asymmetrical Induced Charge Electroosmotic Flow on a Herringbone Floating Electrode and Its Application in a Micromixer

Qingming Hu et al.

MICROMACHINES (2018)

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Article Energy & Fuels

Investigation of mixing efficiency and pressure drop in T-shaped micromixers

A. S. Lobasov et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2018)

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Article Chemistry, Multidisciplinary

Numerical and Experimental Investigations of a Micromixer with Chicane Mixing Geometry

Valentin Khaydarov et al.

APPLIED SCIENCES-BASEL (2018)

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Article Chemistry, Multidisciplinary

Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery

Niko Kimura et al.

ACS OMEGA (2018)

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Review Engineering, Multidisciplinary

A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects

Bruce K. Gale et al.

INVENTIONS (2018)

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Article Energy & Fuels

Analyzing mixing quality in a curved centrifugal micromixer through numerical simulation

Amir Shamloo et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2017)

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Article Engineering, Biomedical

Electrically conductive graphene/polyacrylamide hydrogels produced by mild chemical reduction for enhanced myoblast growth and differentiation

Hyerim Jo et al.

ACTA BIOMATERIALIA (2017)

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Article Engineering, Electrical & Electronic

Rapid microfluidic mixing via rotating magnetic microbeads

Drew Owen et al.

SENSORS AND ACTUATORS A-PHYSICAL (2016)

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Article Biochemical Research Methods

Effect of the crossing-structure sequence on mixing performance within three-dimensional micromixers

Xiangsong Feng et al.

BIOMICROFLUIDICS (2014)

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Article Nanoscience & Nanotechnology

Unsteady pulsating characteristics of the fluid flow through a sudden expansion microvalve

Amir Nejat et al.

MICROFLUIDICS AND NANOFLUIDICS (2014)

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Review Pharmacology & Pharmacy

Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

Goran T. Vladisavljevic et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Article Biochemical Research Methods

An effective splitting-and-recombination micromixer with self-rotated contact surface for wide Reynolds number range applications

Xiangsong Feng et al.

BIOMICROFLUIDICS (2013)

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Article Thermodynamics

Mixing efficiency of Y-type micromixers with different angles

Shou-Shing Hsieh et al.

INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW (2013)

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Article Polymer Science

Polymer micromixers bonded to thermoplastic films combining soft-lithography with plasma and aptes treatment processes

Michael Lee et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2013)

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Article Engineering, Environmental

Passive split and recombination micromixer with convergent-divergent walls

Arshad Afzal et al.

CHEMICAL ENGINEERING JOURNAL (2012)

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Article Engineering, Chemical

Mixing of a split and recombine micromixer with tapered curved microchannels

Tsung Sheng Sheu et al.

CHEMICAL ENGINEERING SCIENCE (2012)

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Article Engineering, Chemical

Design and Fabrication of an Affordable Polymer Micromixer for Medical and Biomedical Applications

Lei Li et al.

POLYMER ENGINEERING AND SCIENCE (2010)

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Article Engineering, Chemical

Fluid mixing in a T-shaped micro-mixer

D Bothe et al.

CHEMICAL ENGINEERING SCIENCE (2006)

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Article Physics, Applied

High-frequency surface acoustic wave device based on thin-film piezoelectric interdigital transducers

AKS Kumar et al.

APPLIED PHYSICS LETTERS (2004)

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Article Multidisciplinary Sciences

Chaotic mixer for microchannels

AD Stroock et al.

SCIENCE (2002)

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