期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 255, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.128189
关键词
Alginate; ZnO nanoparticles; Cancer therapy
This study developed a pH-responsive alginate-based assembly for selective drug delivery in cancer treatment. The assembly disassembles under acidic conditions to release the drug and inhibit tumor growth. These findings inspire the development of drug delivery systems for cancer therapy.
Delivering drugs selectively to tumor tissues is a significant challenge in cancer therapy, and pH-responsive polymeric assemblies have shown great potential in achieving this goal. In this study, we developed a pH responsive alginate-based assemblies, called (amine-modified ZnO)-oxidized alginate-PEG ((ZnO-N)-OAl-PEG), for selective drug delivery in cancer treatment. The incorporation of ZnO-N nanoparticles into the alginate-based assemblies enables pH-responsiveness and maintains stability under physiological conditions. At an acidic pH, (ZnO-N)-OAl-PEG disassembles due to the conversion of ZnO to Zn2+, which triggers the unloading of doxorubicin (DOX) from the imine bond between DOX and alginate. This unloading results in the death of cancer cells and inhibition of tumor growth. The anticancer efficacy of (DOX/ZnO-N)-OAl-PEG was demonstrated in vitro and in vivo, providing promising prospects for cancer treatment based on ZnO-induced pH-responsiveness. These findings may also inspire the development of advanced drug delivery systems (DDSs) for cancer therapy.
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