4.7 Article

Molecular Insights into the MLCK Activation by CaM

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms

Ryan B. Williams et al.

Summary: Calmodulin (CaM) is a calcium-sensing protein that regulates various processes in the body. Mutations in CaM can lead to life-threatening heart disease. This study investigates how disease-associated CaM mutations affect the activity of the phosphatase protein CaN and suggests a potential contribution of altered CaN function to calmodulinopathy.

CELL CALCIUM (2023)

Article Multidisciplinary Sciences

Identification and validation of fusidic acid and flufenamic acid as inhibitors of SARS-CoV-2 replication using DrugSolver CavitomiX

M. Hetmann et al.

Summary: This work presents a computational pipeline for drug repurposing and identifying ligands and inhibitors based on cavity point clouds induced by the protein. It successfully identifies compounds with strong inhibition through cavity point cloud comparisons and performs off-target screening using cavity comparisons.

SCIENTIFIC REPORTS (2023)

Article Biochemistry & Molecular Biology

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

Mihaly Varadi et al.

Summary: AlphaFold DB is an openly accessible database with high-accuracy protein-structure predictions, powered by DeepMind's AlphaFold v2.0. It provides programmatic access to a vast number of predicted structures and is expanding to cover more sequences.

NUCLEIC ACIDS RESEARCH (2022)

Article Chemistry, Medicinal

Non-Canonical Interaction between Calmodulin and Calcineurin Contributes to the Differential Regulation of Plant-Derived Calmodulins on Calcineurin

Bin Sun et al.

Summary: Plant-derived CaM variants sCaM-1 and sCaM-4 exhibit similar Ca2+ and canonical CaMBR binding properties as mammalian CaM (mCaM), but show weakened binding with a secondary region in CaN, suggesting a mechanism for differential regulation of CaN activity that involves interactions beyond traditional Ca2+ and CaMBR binding.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)

Article Medicine, General & Internal

Exploring Obscurin and SPEG Kinase Biology

Jennifer R. Fleming et al.

Summary: The obscurin protein family members obscurin and SPEG, containing tandem kinase domains with signaling functions in cardiac and striated muscles, have specific roles in muscle biology. The study found multiple phosphorylation sites in obscurin's linker but not in SPEG, and suggested potential substrates for kinase domain 1 in obscurin and SPEG based on newly proposed phosphorylation sites. Kinase domain 1 in obscurin may play a role in autophosphorylation and have important catalytic functions.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia

Bence Hegyi et al.

Summary: Diabetic hyperglycemia is associated with cardiac dysfunction and increased arrhythmia risk, where CaMKII plays a role. O-GlcNAcylation of CaMKII appears to be crucial in promoting arrhythmia susceptibility in diabetic hyperglycemia, while an additional Ang II-NOX2-CaMKII MM281/2 oxidation pathway could further exacerbate the condition.

CIRCULATION RESEARCH (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

Article Biochemical Research Methods

The ClusPro web server for protein-protein docking

Dima Kozakov et al.

NATURE PROTOCOLS (2017)

Review Pharmacology & Pharmacy

Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases

Yongjian Xiong et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Multidisciplinary Sciences

Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities

Audrey N. Chang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Chemistry, Physical

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

James A. Maier et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)

Review Biochemistry & Molecular Biology

Structural and functional diversity in the activity and regulation of DAPK-related protein kinases

Koen Temmerman et al.

FEBS JOURNAL (2013)

Article Biochemistry & Molecular Biology

High-Resolution Comparative Modeling with RosettaCM

Yifan Song et al.

STRUCTURE (2013)

Review Biology

Evolution of the eukaryotic protein kinases as dynamic molecular switches

Susan S. Taylor et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2012)

Review Biochemistry & Molecular Biology

Biochemistry of smooth muscle myosin light chain kinase

Feng Hong et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)

Article Multidisciplinary Sciences

RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design

Po-Ssu Huang et al.

PLOS ONE (2011)

Review Cell Biology

Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues

B. Paul Herring et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)

Article Multidisciplinary Sciences

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums

Julia M. Shifman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Activation of smooth muscle myosin light chain kinase by calmodulin -: Role of LYS30 and GLY40

JE Van Lierop et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Activation of myosin light chain kinase requires translocation of bound calmodulin

JK Krueger et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)