期刊
JOURNAL OF CLINICAL ANESTHESIA
卷 93, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinane.2023.111326
关键词
Blood loss; Surgical; Blood transfusion; Hemoglobins; Noncardiac surgery; Noninvasive hemoglobin monitoring
In major noncardiac surgeries with a potential risk of hemorrhage, SpHb-guided management can significantly reduce the rate of hemoglobin deviation outside the target range intraoperatively.
Study objective: The effect of noninvasive CO-oximetry hemoglobin (SpHb) monitoring on the clinical outcomes of patients undergoing surgery remains unclear. This trial aimed to evaluate whether SpHb monitoring helps maintain hemoglobin levels within a predefined target range during major noncardiac surgeries with a potential risk of intraoperative hemorrhage.Design: A single-center, prospective, randomized controlled trial. Setting: University hospital. Patients: One hundred and thirty patients undergoing elective noncardiac surgery with a potential risk of hemorrhage.Interventions: Patients were randomly allocated to undergo either SpHb-guided management (SpHb group) or usual care (control group).Measurements: The primary outcome was the rate of deviation of the total hemoglobin concentration (determined from laboratory testing) from a pre-specified target range (8-14 g/dL). This was defined as the number of laboratory tests revealing such deviations divided by the total number of laboratory tests performed during the surgery.Main results: The primary outcome occurred significantly less frequently in the SpHb group as compared to that in the control group (15/555 [2.7%]) vs. 68/598 [11.4%]; relative risk, 0.24; 95% confidence interval, 0.13-0.41; P < 0.001). Fewer point-of-care blood tests were performed in the SpHb group than in the control group (median [interquartile range], 2 [1-4] vs. 4 [2-5]; P < 0.001). There were no significant intergroup differences in the number of patients who received red blood cell transfusions during surgery (SpHb vs. control, 33.8% vs. 46.2%; P = 0.201). The incidence of unnecessary red blood cell preparation (>2 units) was lower in the SpHb group than in the control group (3.1% vs. 16.9%; P = 0.024).Conclusions: Compared with routine care, SpHb-guided management resulted in significantly lower rates of hemoglobin deviation outside the target range intraoperatively in patients undergoing major noncardiac surgeries with a potential risk of hemorrhage.
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