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Article
Chemistry, Analytical
Miguel Vazquez-Alvarado et al.
Summary: Microfluidic paper-based analytical devices (microPADs) are a promising platform for point-of-care assays. This study evaluated and compared 33 chromogenic substrate solutions for horseradish peroxidase (HRP) in terms of their analytical performance. The results showed that TMB and OPD substrates achieved the best overall performance. The findings of this study will guide the selection and formulation of substrate solutions for future paper-based assays involving HRP.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Jianping Guan et al.
Summary: In this study, a single-atom nanozyme-Rh-N/C with tetra-enzyme mimic activities was constructed. The Rh-N/C showed stable and reusable laccase and oxidase mimic activities, even after 2 months of storage and 10 times of reuse with minimal loss of activity (maintained above 96.0%). Two biosensors were designed based on the versatile enzymatic activities of Rh-N/C, including a colorimetric biosensor for acetylcholinesterase activity determination and a sensitive Rh-N/C-based biosensor for adrenaline detection. This work expands the application of single-atom nanozyme and explores their potential in biosensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Lorena Placer et al.
Summary: This study presents the development of a 3D origami microfluidic paper-based analytical device (3D mu PAD) for the determination of iodide and iodate in edible seaweeds by colorimetric detection using a smartphone. The addition of a methacrylate holder improved the interlayer contact in 3D mu PADs, resulting in enhanced sensitivity and precision, as well as real-time monitoring. The assay relies on the formation of a blue triiodide-starch complex at the detection areas of the 3D mu PAD, providing an affordable, fast, and environmentally friendly method for simultaneous determination of inorganic iodine species. Under optimal conditions, the method achieved low limits of detection and quantification for iodide and iodate.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Multidisciplinary Sciences
Zhiyin Yu et al.
Summary: This study characterizes six karnamicins with fully substituted hydroxypyridine and thiazole moieties from the rare actinobacterium Lechevalieria rhizosphaerae NEAU-A2. The authors propose a programmed assembly pathway of the hydroxypyridine moiety in karnamicin and identify two unusual flavoprotein hydroxylases involved in this process. The karnamicins show significant angiotensin-converting enzyme inhibitory activity, suggesting their potential for hypertension treatment.
NATURE COMMUNICATIONS
(2023)
Article
Biophysics
Yuqing Chen et al.
Summary: To screen active pharmaceutical ingredients used as acetylcholinesterase inhibitors (AChEIs) for Alzheimer's disease treatment, a colorimetric cellulose membrane bioactivity strip (CBS) was developed. The strip enabled rapid and simple screening of AChEIs based on the colorimetric method. Inhibitors decreased the enzyme activity of AChE, resulting in decreased color intensity. The CBS exhibited fast chromogenic time, excellent specificity, and storage stability, making it a promising tool for preliminary screening of AChEIs and inspiring the development of other cellulose membrane-based biosensors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Medicinal
Andreu Vidal-Albalat et al.
Summary: Insecticide resistance poses a threat to the prevention of infectious diseases by controlling disease-transmitting mosquitoes. New insecticidal compounds with minimal adverse effects on humans and the environment are urgently required. In this study, we investigate noncovalent inhibitors of acetylcholinesterase (AChE), a well-established target for insecticides, and find that certain compounds based on a 4-thiazolidinone scaffold effectively inhibit AChE from Anopheles gambiae and Aedes aegypti mosquitoes. The selectivity of these compounds depends on the substitution pattern of the phenyl ring.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Wei Xu et al.
Summary: In this study, a dual-mode approach using multifunctional BSA-MnO2 quantum dots with oxidase-mimetic activity was developed to determine acetylcholinesterase (AChE). This method achieved high sensitivity detection of AChE and exhibited excellent interference tolerance and reliability.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Multidisciplinary Sciences
Wai Cheung Chan et al.
Summary: Deubiquitinating enzymes (DUBs) are a drug target class that regulate cellular processes by cleaving ubiquitin from protein substrates. This study used a diverse chemical library and activity-based protein profiling to identify selective hits against 23 DUBs. Optimization of a hit compound yielded a probe for the understudied DUB VCPIP1 with nanomolar potency and in-family selectivity.
NATURE COMMUNICATIONS
(2023)
Article
Biophysics
Xia Tong et al.
Summary: A cascade reaction system integrated with threaded 3D microfluidic paper analytical device (3D mu PAD) was developed for background-free and visual detection of organophosphorus pesticides (OPs) in agricultural samples. The system utilized a cascade reaction mechanism involving the hydrolysis of acetylcholine by butyrylcholinesterase (BChE), the reduction of MnO2 nanosheets, and the oxidation of o-phenylenediamine. The detection platform showed accurate response, facile operation, and background-free detection, providing a new alternative approach for on-site pesticide detection.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Inorganic & Nuclear
Changyu Cao et al.
Summary: Nanozymes, tiny-sized artificial enzymes, show potential in mimicking the catalytic actions of natural enzymes. The intersection between nanozyme and biomedicine has attracted significant interest and extensive research. To better understand this field and facilitate its growth, a comprehensive exposition of nanozyme catalytic chemistry and its biological applications is significant.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biophysics
Yongfeng Zhu et al.
Summary: A novel platform for multiplex enzyme detection was developed based on 3D origami microfluidic paper-based device, allowing simultaneous detection of two enzymes' activities without pretreatment procedures. The platform exhibited excellent selectivity, good precision, favorable linear range, and high accuracy, successfully detecting alkaline phosphatase and butyrylcholinesterase in human serum samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Inorganic & Nuclear
Reddicherla Umapathi et al.
Summary: Due to over application of synthetic pesticides, pesticide residues pose an increasing threat to ecosystems and human health. Electrochemical sensor and biosensor platforms have emerged as powerful analytical methods for detecting pesticide residues, offering advantages such as synergistic aspects, systematic fabrication procedure, ease of detection, sensitivity, and selectivity. Additionally, portable electrochemical devices have been developed for on-site detection of pesticide residues.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Analytical
Jianting Ma et al.
Summary: Enzyme-linked immunosorbent assay (ELISA) and enzyme-linked immunospot (ELISpot) are commonly used methods in biological studies, but they have low sensitivity and can only detect one signal at a time. This study introduces a fluorescence-based oligo-linked immunosorbent assay (FOLISA) and fluorescence-based oligo-linked immunospot (FOLISPOT) that use DNA-barcoded antibodies to achieve highly multiplexed detection and signal amplification.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zahra Shojaeifard et al.
Summary: A novel method has been developed for immobilizing hydrophilic indicators on the surface of paper-based strips in aqueous solution. The method utilizes a hydrophobic deep eutectic solvent (DES) to immobilize the indicators without the need for hydrophobic barriers. The resulting colorimetric strip demonstrates homogeneous color, reversibility, and significant leaching stability over months.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Abderrahman Lamaoui et al.
Summary: In this work, a paper-based analytical device (PAD) utilizing molecularly imprinted polymer (MIP) as the biomimetic receptor and a simple colorimetric assay combined with smartphone readout was developed. The device showed high sensitivity and long-term stability, making it applicable for real-time colorimetric assays in environmental monitoring, public health, and food control.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Pharmacology & Pharmacy
Songtao Dong et al.
Summary: Cancer immunotherapy is a promising anti-tumor treatment that can be enhanced by natural products such as saponins, polysaccharides, and flavonoids. These natural products have shown significant effects in reversing the tumor-immunosuppressive microenvironment, which is crucial for the success of cancer immunotherapy.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Chemistry, Analytical
Ming Mu et al.
Summary: This review systematically presents the recent development of fabrication, properties, and applications of nanozyme-SERS systems. The fundamentals of nanozymes and SERS technique are introduced, followed by the classification of nanozyme-SERS systems. The influence factors on the properties of nanozyme-SERS systems and their applications in various fields are discussed. The challenges and perspectives to construct new nanozyme-SERS systems are also emphasized.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Qilin Zhao et al.
Summary: A facile and sensitive method for sensing alpha-glucosidase and screening its inhibitors based on fluorescence monitoring of water-solute silicon-containing nanoparticles was proposed and demonstrated. The method showed a linear relationship and a low detection limit, and it could be applied in human serum and inhibitor screening.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Inorganic & Nuclear
Miriam Daniel et al.
Summary: Biomolecules play a crucial role in regulating homeostasis, and their accurate detection as biomarkers is of great importance in clinical diagnosis. Electrochemical sensing, a simple and cost-effective method, shows potential for the miniaturization of healthcare devices. Metal-organic frameworks (MOFs), with their unique properties, have emerged as promising candidates for electrochemical sensors to detect biomolecules.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Analytical
Yu Wang et al.
Summary: Alzheimer's disease is a common neurodegenerative disease, and the conventional methods for detecting the activity of acetylcholinesterase (AChE) are not patient-friendly. In this study, 2D Zn-TCPP(Fe) nanosheets were used as a catalyst for a colorimetric assay to measure AChE activity in a convenient and rapid manner. The proposed method showed high selectivity and sensitivity, making it a potential alternative for early diagnosis and drug screening of Alzheimer's disease.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Ge Kang et al.
Summary: The study demonstrates the exceptional oxidase-like activity of single-atom Pt catalysts, which enhances the generation of H2O2 and 1O2 species, facilitating the chromogenic reaction. Based on this, a novel colorimetric assay for α-Glu is designed and successfully applied to serum samples, showing excellent analytical performance.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Zhihui Mao et al.
Summary: By mimicking active catalytic sites of natural enzymes and combining them with distinct channels of metal organic frameworks, an active copper mimetic oxidase enzyme (Cu-MOF) was designed and synthesized with good structure and clear catalytic sites, showing excellent oxidase-like activity and antibacterial efficacy.
Article
Chemistry, Analytical
Abderrahman Lamaoui et al.
Summary: The study developed a paper-based MIP-PAD utilizing MIP as the receptor for simple colorimetric assay, offering a platform for real-time, selective, rapid, and low-cost environmental monitoring and food control.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Parham Taslimi et al.
Summary: Sulfonamide derivatives have a wide range of biological activities and potential as medical molecules in drug development. Studies have shown that these compounds have an impact on various enzymes. The synthesized derivatives demonstrate inhibitory effects on AChE, GST, and α-GLY enzymes, with stronger inhibition observed at lower concentrations through the addition of functional electronegative groups.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Analytical
Yunyi Zhang et al.
Summary: This sensor utilizes the specific interaction between Ag+ and GSH to achieve portable detection of silver ions, exhibiting high selectivity and making it a sensitive, portable, and accurate new Ag+ detection system.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Environmental Sciences
Younhee Kang et al.
Summary: The study identified that nurses caring for dementia patients face significant workloads and mental stress, in addition to difficulties in playing a mediator role and lack of systematic support. To reduce the burden on nurses, supportive measures tailored to their occupational characteristics should be developed based on workload estimates that consider the unique attributes of dementia patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Chemistry, Analytical
Yue Cai et al.
Summary: A fluorescence-colorimetric dual-signal biosensor was developed for monitoring organophosphorus pesticides by encapsulating AuNCs in a metal-organic framework. This biosensor combines fluorescence and colorimetric signals based on the enzymolysis product of AChE and CHO, allowing detection through the inhibition of AChE activity. Additionally, colorimetric paper strips and a smartphone APP were utilized for visual semiquantitative detection and real-time supervision of pesticide contamination.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xia Tong et al.
Summary: A new strategy based on dual-emission carbon dots has been developed for simultaneous monitoring of GGT and ALP activity, showing high sensitivity and wide linear ranges. Detection of GGT and ALP activity can be achieved through IFE and SQE of blue and red channels of CDs, meeting the monitoring needs in human serum samples.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Multidisciplinary
Eka Noviana et al.
Summary: Microfluidic paper-based analytical devices (muPADs) have gained significant interest as a promising analytical platform in the past decade, offering unique advantages over traditional microfluidics. This comprehensive Review highlights fabrication methods, device designs, and detection strategies, as well as the growing applications of muPADs, while discussing the field's need for further advancement to realize its full potential.
Article
Chemistry, Analytical
Sumaira Nishat et al.
Summary: Paper-based microfluidics is a branch of microfluidics that uses paper or other porous membranes to wick fluids, offering advantages like simpler fabrication, lower cost, and ease of disposal. Its most common application is in the development of point-of-care diagnostic devices, potentially replacing costly and time-consuming laboratory procedures.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Dong-Mei Liu et al.
Summary: Acetylcholinesterase (AChE) is widely used in biological and chemical sensors, assisting in the treatment of neurodegenerative diseases and detection of pesticides and heavy metals; Colorimetric method is a popular strategy for AChE assay, known for its low cost, practicality, and simplicity.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yingying Guo et al.
Summary: This study successfully extracted bioactive polysaccharides from poria cocos using a new method with a yield of 55.02%. The extraction mechanism was thoroughly investigated, and a life cycle assessment showed significant environmental benefits compared to traditional methods.
Review
Chemistry, Analytical
Xia Tong et al.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Xianlong Zhang et al.
Article
Chemistry, Multidisciplinary
Lei Han et al.
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Chemistry, Analytical
Luhong Sun et al.
ANALYTICA CHIMICA ACTA
(2018)
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Endocrinology & Metabolism
N. H. Cho et al.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2018)
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Plant Sciences
Huijun Wang et al.
JOURNAL OF ETHNOPHARMACOLOGY
(2018)
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Chemistry, Multidisciplinary
Xu Yan et al.
Article
Nanoscience & Nanotechnology
Lizeng Gao et al.
NATURE NANOTECHNOLOGY
(2007)
