4.7 Article

Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: disease staging by NF-L, p-tau181, and GFAP

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Lecanemab in Early Alzheimer's Disease

Christopher H. van Dyck et al.

Summary: Lecanemab, a humanized monoclonal antibody, reduced amyloid markers and showed improvement in cognition and function in early Alzheimer's disease patients. However, it also resulted in adverse events. Longer trials are needed to determine its efficacy and safety in early Alzheimer's disease.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

Article Medicine, General & Internal

Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease

Nicholas J. Ashton et al.

Summary: CSF p-tau epitopes increase early in the development of AD pathology and are a primary candidate for detecting incipient Aβ pathology.

EBIOMEDICINE (2022)

Article Clinical Neurology

Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change

Denis S. Smirnov et al.

Summary: Plasma biomarkers show promise in identifying the pathological features of Alzheimer's Disease. P-tau181 and P-tau231 are diagnostic biomarkers related to AD neuropathological change and can predict future cognitive decline. NfL can predict cognitive decline and is increased in non-AD cases. Plasma A beta 42/40 is a relatively weak predictor of amyloid pathology and may require different assay methods for improvement.

ACTA NEUROPATHOLOGICA (2022)

Editorial Material Medicine, General & Internal

CSF p-tau231: A biomarker for early preclinical Alzheimer?

Marc Suarez-Calvet

EBIOMEDICINE (2022)

Article Biochemistry & Molecular Biology

Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

Rik Ossenkoppele et al.

Summary: Abnormal amyloid and tau PET in cognitively unimpaired individuals is strongly associated with short-term cognitive decline and subsequent development of dementia.

NATURE MEDICINE (2022)

Article Neurosciences

Phosphatidylethanolamine Binding Protein 1 (PEBP1) in Alzheimer's Disease: ELISA Development and Clinical Validation

Anna Lidia Wojdala et al.

Summary: Phosphatidylethanolamine binding protein 1 (PEBP1) has potential as a biomarker for Alzheimer's disease (AD), but further research is needed to evaluate its diagnostic potential.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Article Clinical Neurology

Multi-Omics Interdisciplinary Research Integration to Accelerate Dementia Biomarker Development (MIRIADE)

Ekaterina Mavrina et al.

Summary: This review discusses the experimental design of the Marie Curie MIRIADE project, which aims to accelerate the validation and implementation of novel biomarkers in clinical practice. The study addresses the technology-translation gap in biomarker discovery and validation, as well as the limited understanding of biomarker protein conformational states in different matrices. The article also describes the decision process of shortlisting biomarkers for development and the development of computational protein state and interaction prediction models.

FRONTIERS IN NEUROLOGY (2022)

Article Clinical Neurology

Longitudinal Blood Biomarker Trajectories in Preclinical Alzheimer’s Disease

Yara Yakoub et al.

Alzheimers & Dementia (2022)

Article Clinical Neurology

Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum

Andrea L. Benedet et al.

Summary: The study suggests that plasma GFAP is a sensitive biomarker for detecting reactive astrogliosis and Aβ pathology in early stages of AD, outperforming CSF GFAP. Plasma GFAP levels accurately discriminate between Aβ-positive and Aβ-negative individuals, with higher accuracy than CSF GFAP.

JAMA NEUROLOGY (2021)

Review Biochemistry & Molecular Biology

Ubiquitin carboxy-terminal hydrolaseL1-physiology and pathology

Ewa Matuszczak et al.

CELL BIOCHEMISTRY AND FUNCTION (2020)

Article Clinical Neurology

UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis

Ruibing Li et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Article Clinical Neurology

Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration

Alberto Benussi et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

Review Clinical Neurology

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Clifford R. Jack et al.

ALZHEIMERS & DEMENTIA (2018)

Review Neurosciences

The Past and the Future of Alzheimer's Disease Fluid Biomarkers

Kaj Blennow et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Clinical Neurology

Plasma tau in Alzheimer disease

Niklas Mattsson et al.

NEUROLOGY (2016)

Article Clinical Neurology

Plasma neurofilament light chain predicts progression in progressive supranuclear palsy

Julio C. Rojas et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2016)

Article Multidisciplinary Sciences

Tissue-based map of the human proteome

Mathias Uhlen et al.

SCIENCE (2015)

Review Clinical Neurology

Classification of primary progressive aphasia and its variants

M. L. Gorno-Tempini et al.

NEUROLOGY (2011)

Review Clinical Neurology

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Clifford R. Jack et al.

LANCET NEUROLOGY (2010)

Article Biotechnology & Applied Microbiology

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

David M. Rissin et al.

NATURE BIOTECHNOLOGY (2010)

Review Medicine, General & Internal

Alzheimer's disease

Kaj Blennow et al.

LANCET (2006)

Article Psychology, Multidisciplinary

A Monte Carlo evaluation of tests for comparing dependent correlations

JB Hittner et al.

JOURNAL OF GENERAL PSYCHOLOGY (2003)

Article Clinical Neurology

Tau and Aβ42 protein in CSF of patients with frontotemporal degeneration

M Riemenschneider et al.

NEUROLOGY (2002)