相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Tackling the Behavior of Cancer Cells: Molecular Bases for Repurposing Antipsychotic Drugs in the Treatment of Glioblastoma
Michele Persico et al.
CELLS (2022)
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine
Carlos Sebastian et al.
NATURE COMMUNICATIONS (2022)
Disconnecting multicellular networks in brain tumours
Varun Venkataramani et al.
NATURE REVIEWS CANCER (2022)
Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response
Silvia Matteoni et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)
Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
Fadi Almouhanna et al.
CANCER & METABOLISM (2021)
Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro
Silvia Matteoni et al.
FRONTIERS IN ONCOLOGY (2021)
Diagnostic and prognostic potential of the proteomic profiling of serum-derived extracellular vesicles in prostate cancer
Michele Signore et al.
CELL DEATH & DISEASE (2021)
Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect
Elizabeth K. Wiese et al.
NATURE METABOLISM (2021)
PLIP 2021: expanding the scope of the protein-ligand interaction profiler to DNA and RNA
Melissa F. Adasme et al.
NUCLEIC ACIDS RESEARCH (2021)
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
Charles P. Couturier et al.
NATURE COMMUNICATIONS (2020)
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation
Suparno Nandi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
The small molecule SI113 hinders epithelial-to-mesenchymal transition and subverts cytoskeletal organization in human cancer cells
Claudia Abbruzzese et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells
Silvia Matteoni et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer
Ryan C. Gimple et al.
GENES & DEVELOPMENT (2019)
Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells
Zhifen Zhou et al.
CANCER RESEARCH (2018)
Drug repurposing for the treatment of glioblastoma multiforme
Claudia Abbruzzese et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
Xiaoyang Lan et al.
NATURE (2017)
Tumour acidosis: from the passenger to the driver's seat
Cyril Corbet et al.
NATURE REVIEWS CANCER (2017)
Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoy1)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator
Yumi Matsui et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2017)
Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics
Oleg I. Barygin et al.
BRAIN RESEARCH (2017)
PRODIGY: a web server for predicting the binding affinity of protein-protein complexes
Li C. Xue et al.
BIOINFORMATICS (2016)
Epidemiology of Brain Tumors
Katharine A. McNeill
NEUROLOGIC CLINICS (2016)
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
Ji Liang et al.
NATURE COMMUNICATIONS (2016)
Long-term survival in a patient with glioblastoma on antipsychotic therapy for schizophrenia: a case report and literature review
Shahdabul Faraz et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2016)
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
Eva M. Palsson-McDermott et al.
CELL METABOLISM (2015)
Drug repositioning and repurposing: terminology and definitions in literature
Joris Langedijk et al.
DRUG DISCOVERY TODAY (2015)
Brain tumour cells interconnect to a functional and resistant network
Matthias Osswald et al.
NATURE (2015)
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
Hua Yu et al.
NATURE REVIEWS CANCER (2014)
The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells
Soon Young Shin et al.
CARCINOGENESIS (2013)
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
Weiwei Yang et al.
CELL (2012)
Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
Xueliang Gao et al.
MOLECULAR CELL (2012)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
Weiwei Yang et al.
NATURE CELL BIOLOGY (2012)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Dimitrios Anastasiou et al.
NATURE CHEMICAL BIOLOGY (2012)
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
Roman A. Laskowski et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
Weiwei Yang et al.
NATURE (2011)
The Physiology, Signaling, and Pharmacology of Dopamine Receptors
Jean-Martin Beaulieu et al.
PHARMACOLOGICAL REVIEWS (2011)
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Residual Tumor Cells Are Unique Cellular Targets in Glioblastoma
Martin Glas et al.
ANNALS OF NEUROLOGY (2010)
Identification of small molecule inhibitors of pyruvate kinase M2
Matthew G. Vander Heiden et al.
BIOCHEMICAL PHARMACOLOGY (2010)
AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility
Garrett M. Morris et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)
MGMT gene silencing and benefit from temozolomide in glioblastoma
ME Hegi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Drug repositioning: Identifying and developing new uses for existing drugs
TT Ashburn et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Molecular mechanisms of glioma invasiveness: The role of proteases
JS Rao
NATURE REVIEWS CANCER (2003)