4.8 Article

Microenvironment responsive charge-switchable nanoparticles act on biofilm eradication and virulence inhibition for chronic lung infection treatment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Lipase-Responsive Amphotericin B Loaded PCL Nanoparticles for Antifungal Therapies

Evelyn Osehontue Uroro et al.

Summary: This report describes the encapsulation of amphotericin B into lipase-sensitive polycaprolactone as a nanocomposite for targeted and controlled drug delivery, reducing cytotoxicity and enhancing antifungal activity against Candida albicans.

NANOMATERIALS (2023)

Article Nanoscience & Nanotechnology

On-Demand Multifunctional Electrostatic Complexation for Synergistic Eradication of MRSA Biofilms

Xinyu Jiang et al.

Summary: In this study, a multifunctional electrostatic complexation was constructed for biofilm combination therapy. The complexation achieved efficient biofilm penetration and retention by regulating the surface charge and particle size under an acidic microenvironment, and achieved sequential release of biofilm dispersal and antibacterial agents. Both in vitro and in vivo experiments demonstrated the superior performance of the complexation in biofilm eradication and MRSA infection treatment.

ACS APPLIED MATERIALS & INTERFACES (2022)

Review Chemistry, Multidisciplinary

Surface Modification of Lipid-Based Nanoparticles

Yining Xu et al.

Summary: This review provides an overview of various methods for lipid nanoparticle grafting and critically examines the usefulness and impact of these modifications in overcoming biological barriers, while predicting future developments in this field.

ACS NANO (2022)

Article Pharmacology & Pharmacy

Elucidating inhaled liposome surface charge on its interaction with biological barriers in the lung

Jing Zhao et al.

Summary: The surface charge of liposomes is a crucial factor in modulating their interaction with biological barriers in the lung and their fate after inhalation. Neutral and negatively charged liposomes show improved safety and lung retention properties, while positively charged liposomes are unstable in the lung microenvironment and may lead to systemic exposure.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

Article Dermatology

Acute and chronic wound infections: microbiological, immunological, clinical and therapeutic distinctions

Jenny Hurlow et al.

Summary: Wound infection is a complex pathology, with significant differences between acute and chronic infections in terms of pathogens, immune responses, and clinical manifestations. Antibiotics are appropriate for acute wound infections, but overuse in chronic wound management contributes to antibiotic resistance.

JOURNAL OF WOUND CARE (2022)

Review Microbiology

Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

Felipe Francisco Tuon et al.

Summary: Pseudomonas aeruginosa is a microorganism associated with various human infections related to healthcare services. It exhibits resistance to multiple antibiotics and forms biofilms, which make treatments challenging.

PATHOGENS (2022)

Article Chemistry, Multidisciplinary

Mucoadhesive, Antibacterial, and Reductive Nanogels as a Mucolytic Agent for Efficient Nebulized Therapy to Combat Allergic Asthma

Dan Zhao et al.

Summary: In this study, cationic nanogels were synthesized through ionic cross-linking and showed potential as a mucolytic agent for the treatment of asthma and other muco-obstructive diseases. The nanogels effectively prevented the formation of large aggregates of mucin and exhibited antibacterial and anti-inflammatory effects.

ACS NANO (2022)

Review Immunology

Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

Chongbing Liao et al.

Summary: Pseudomonas aeruginosa is a pathogen that causes nosocomial infections, particularly in severely ill and immunocompromised patients. It is widely distributed in the environment, especially in hospitals, and poses a major threat to human health due to the emergence of drug-resistant strains. The use of antivirulence treatment or combination therapies can effectively reduce virulence without inducing drug resistance.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Chemistry, Multidisciplinary

Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection

Yanling Hu et al.

Summary: Biofilm infectious diseases have become a growing global health issue, and conventional antibiotic therapy is ineffective due to poor biofilm penetration and antibiotic tolerance. The development of biofilm microenvironment-responsive nanoparticles offers a promising strategy for combating biofilm infection.

NANO TODAY (2022)

Article Chemistry, Multidisciplinary

A Dual-Responsive Antibiotic-Loaded Nanoparticle Specifically Binds Pathogens and Overcomes Antimicrobial-Resistant Infections

Mingzhou Ye et al.

Summary: A novel nanoparticle coated with dextran and carrying an antibiotic shows strong affinity with various pathogens and effectively accumulates in infected tissues, overcoming antimicrobial resistant infections. The nanoparticle is activated in the infectious microenvironment, releasing polymers and antibiotics that synergistically combat resistant pathogens. This nanoparticle formulation demonstrates safety and efficacy in animal infection models against resistant Gram-negative and Gram-positive pathogens.

ADVANCED MATERIALS (2021)

Review Pharmacology & Pharmacy

Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development

Jennifer A. Kricker et al.

Summary: Macrolides, especially azithromycin, are widely prescribed for respiratory infections and exhibit time-dependent immunomodulatory actions that can benefit both infectious and chronic inflammatory diseases. Chronic use of these drugs can lead to bacterial resistance, but they have shown to enhance barrier properties of airway epithelial cells, contributing to therapeutic efficacy. Nonantibacterial macrolides are being studied for their immunomodulatory and barrier-strengthening properties to overcome the issue of resistance, with a focus on their beneficial effects in chronic inflammation and epithelial protection.

PHARMACOLOGICAL REVIEWS (2021)

Review Biochemistry & Molecular Biology

Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

Irene Jurado-Martin et al.

Summary: Pseudomonas aeruginosa is a dominant pathogen in cystic fibrosis patients, with its adaptability and numerous virulence factors contributing to chronic infections. Understanding these virulence mechanisms is crucial for developing therapeutic strategies and vaccines against this multi-resistant pathogen.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pharmacology & Pharmacy

Association of OprF mutant and disturbance of biofilm and pyocyanin virulence in pseudomonas aeruginosa

Sarah Bukhari et al.

SAUDI PHARMACEUTICAL JOURNAL (2020)

Review Microbiology

Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms

Rita M. Pinto et al.

FRONTIERS IN MICROBIOLOGY (2020)

Article Chemistry, Multidisciplinary

Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm

Pengyu Li et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Editorial Material Biochemistry & Molecular Biology

The Scourge of Antibiotic-resistant Infections in Cystic Fibrosis

Erin P. Price et al.

TRENDS IN MICROBIOLOGY (2019)

Article Chemistry, Medicinal

Antibiofilm Efficacy of Nitric Oxide-Releasing Alginates against Cystic Fibrosis Bacterial Pathogens

Mona Jasmine R. Ahonen et al.

ACS INFECTIOUS DISEASES (2019)

Article Nanoscience & Nanotechnology

Hydrophobic Control of the Bioactivity and Cytotoxicity of de Novo-Designed Antimicrobial Peptides

Haoning Gong et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Biotechnology & Applied Microbiology

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

Zheng Pang et al.

BIOTECHNOLOGY ADVANCES (2019)

Article Chemistry, Multidisciplinary

Bacterial biofilm destruction by size/surface charge-adaptive micelles

Maohua Chen et al.

NANOSCALE (2019)

Article Biochemistry & Molecular Biology

Cerium oxide nanoparticles as potential antibiotic adjuvant. Effects of CeO2 nanoparticles on bacterial outer membrane permeability

Pierangelo Bellio et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

Article Infectious Diseases

Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin

Laura Mueller et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

Article Medicine, Research & Experimental

Encapsulation of Azithromycin Ion Pair in Liposome for Enhancing Ocular Delivery and Therapeutic Efficacy on Dry Eye

Tianyang Ren et al.

MOLECULAR PHARMACEUTICS (2018)

Article Multidisciplinary Sciences

Improved method for qualitative screening of lipolytic bacterial strains

Jair Carrazco-Palafox et al.

METHODSX (2018)

Review Infectious Diseases

Azithromycin use in patients with cystic fibrosis

N. Principi et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2015)

Article Chemistry, Multidisciplinary

Bacteria-Triggered Release of Antimicrobial Agents

Vitaly V. Komnatnyy et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Analytical

Poly-ε-Lysine Modified Nanocarbon Film Electrodes for LPS Detection

Dai Kato et al.

ELECTROANALYSIS (2014)

Review Pharmacology & Pharmacy

Azithromycin: Mechanisms of action and their relevance for clinical applications

Michael J. Parnham et al.

PHARMACOLOGY & THERAPEUTICS (2014)

Review Microbiology

Antivirulence activity of azithromycin in Pseudomonas aeruginosa

Francesco Imperi et al.

FRONTIERS IN MICROBIOLOGY (2014)

Review Immunology

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

Shaan L. Gellatly et al.

PATHOGENS AND DISEASE (2013)

Article Biochemistry & Molecular Biology

Mucin Multilayers Assembled through Sugar-Lectin Interactions

Thomas Crouzier et al.

BIOMACROMOLECULES (2012)

Review Biochemistry & Molecular Biology

Cystic fibrosis: a mucosal immunodeficiency syndrome

Taylor Sitarik Cohen et al.

NATURE MEDICINE (2012)

Review Microbiology

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

Anders Folkesson et al.

NATURE REVIEWS MICROBIOLOGY (2012)

Review Biotechnology & Applied Microbiology

Contribution of an arsenal of virulence factors to pathogenesis of Pseudomonas aeruginosa infections

Tanya Strateva et al.

ANNALS OF MICROBIOLOGY (2011)

Review Agricultural Engineering

Microbial synthesis of poly(epsilon-lysine) and its various applications

IL Shih et al.

BIORESOURCE TECHNOLOGY (2006)

Article Biochemical Research Methods

A microtiter-plate screening method for biofilm disinfection and removal

B Pitts et al.

JOURNAL OF MICROBIOLOGICAL METHODS (2003)

Review Immunology

Structure and function of lipopolysaccharides

C Erridge et al.

MICROBES AND INFECTION (2002)

Article Biotechnology & Applied Microbiology

Fluorometric assessment of Gram-negative bacterial permeabilization

IM Helander et al.

JOURNAL OF APPLIED MICROBIOLOGY (2000)