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Cell-cell communication in kidney fibrosis

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

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Article Cell Biology

Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis

Man J. Livingston et al.

Summary: Following acute kidney injury, autophagy in renal tubular cells leads to the production of FGF2, which acts as a paracrine factor to activate fibroblasts and promote renal fibrosis. This process has been confirmed in renal biopsies from post-AKI patients.

AUTOPHAGY (2023)

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Article Urology & Nephrology

Proteomic landscape of the extracellular matrix in the fibrotic kidney

Li Li et al.

Summary: The extracellular matrix (ECM) is a complex network of proteins that controls various cellular processes. In chronic kidney disease (CKD), the ECM undergoes changes that contribute to kidney fibrosis. Using proteomic analysis, this study identified differentially expressed proteins in the ECM of mice with CKD and found that 9 signature proteins are involved in the fibrogenic microenvironment. Furthermore, the depletion of glutathione peroxidase 3 (GPX3), one of the signature proteins, was shown to promote oxidative stress and kidney fibrosis. These findings highlight the importance of oxidative stress in the fibrogenic microenvironment.

KIDNEY INTERNATIONAL (2023)

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Article Cell Biology

Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes

Xi Liu et al.

Summary: This study found that exosomes derived from stressed/injured tubules play a pivotal role in regulating fibroblast apoptosis and fate. Exosomal-TNFAIP8 promotes p53 degradation, thereby inhibiting fibroblast apoptosis and inducing their proliferation.

CELL DEATH & DISEASE (2023)

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Article Biochemistry & Molecular Biology

Oxidatively stressed extracellular microenvironment drives fibroblast activation and kidney fibrosis

Li Li et al.

Summary: Depletion of GPX3 in the renal tubular epithelium plays a central role in orchestrating an oxidatively stressed extracellular microenvironment, which drives interstitial fibroblast activation and proliferation.

REDOX BIOLOGY (2023)

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Article Medicine, Research & Experimental

Macrophage promotes fibroblast activation and kidney fibrosis by assembling a vitronectin-enriched microenvironment

Yiling Peng et al.

Summary: Macrophages promote fibroblast activation in kidney fibrosis by assembling a vitronectin-enriched extracellular microenvironment.

THERANOSTICS (2023)

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Article Pharmacology & Pharmacy

Secreted protein acidic and rich in cysteine (SPARC) and a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) increments by the renin-angiotensin system induce renal fibrosis in deoxycorticosterone acetate-salt hypertensive rats

Hiroe Toba et al.

Summary: This study investigated the role of SPARC and ADAMTS1 in renal fibrosis using a rat model. The treatment with DOCA and salt induced kidney damage and fibrosis, and increased the expression of SPARC and ADAMTS1, promoting collagen deposition and fibrosis progression. The angiotensin II type-1 receptor blocker losartan suppressed the overexpression of SPARC and ADAMTS1, thereby slowing down fibrosis development.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury

Suravi Majumder et al.

Summary: TLR4 mutation may alleviate hypertension-induced renal injury by activating autophagy and suppressing apoptosis.

PHARMACOLOGICAL RESEARCH (2022)

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Article Biochemistry & Molecular Biology

CCN2 Binds to Tubular Epithelial Cells in the Kidney

Sandra Rayego-Mateos et al.

Summary: This study aimed to locate the cellular binding sites of CCN2/EGFR in the kidney. The results showed that CCN2 primarily binds to tubular epithelial cells, and the activation of CCN2(IV) can promote the progression of kidney damage.

BIOMOLECULES (2022)

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Review Urology & Nephrology

Extracellular vesicles in kidney disease

Cristina Grange et al.

Summary: Extracellular vesicles play significant roles in kidney physiology and pathology by facilitating cell-to-cell communication and modulating gene expression and fate of target cells. They have potential diagnostic, prognostic, and therapeutic applications in kidney diseases, including in the field of kidney regeneration and inflammation reduction. Stem cell-derived extracellular vesicles are considered as promising therapeutic agents, but standardized production strategies are still needed for their clinical application.

NATURE REVIEWS NEPHROLOGY (2022)

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Article Cell Biology

β-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis

Shuangqin Chen et al.

Summary: The activation of beta-catenin in renal tubular cells leads to the release of exosomes containing osteopontin (OPN) that are then taken up by fibroblasts, promoting their proliferation and activation through binding with CD44. Deletion of beta-catenin or CD44 greatly improves renal fibrosis. N-terminal fragment of OPN is secreted into the urine and negatively correlated with kidney function in CKD patients. Urinary exosomes from CKD patients accelerate renal fibrosis, which can be blocked by CD44 deletion.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Cell Biology

Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury

Qionghong Xie et al.

Summary: Accumulating evidence suggests that the extracellular matrix (ECM) plays a role in both the outcome and progression of fibrosis, offering a profibrotic microenvironment. This study demonstrates that the matrix protein Tenascin-C (TNC) contributes to kidney fibrosis by promoting the proliferation of kidney interstitial cells via STAT3 activation. The findings highlight TNC as a potential therapeutic target for interstitial fibrosis and chronic kidney disease progression.

CELL DEATH & DISEASE (2022)

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Review Urology & Nephrology

The fibrogenic niche in kidney fibrosis: components and mechanisms

Li Li et al.

Summary: Kidney fibrosis, the final outcome of chronic kidney diseases, is characterized by excessive deposition of extracellular matrix (ECM). The fibrogenic niche, a unique tissue microenvironment, plays a crucial role in promoting fibroblast activation and organ fibrosis. Understanding the composition and mechanisms of the fibrogenic niche may lead to the development of non-invasive biomarkers and novel therapies for kidney diseases.

NATURE REVIEWS NEPHROLOGY (2022)

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Review Pharmacology & Pharmacy

The IL-18/IL-18R1 signalling axis: Diagnostic and therapeutic potential in hypertension and chronic kidney disease

Jordyn M. Thomas et al.

Summary: Chronic kidney disease (CKD) is an inflammatory condition, and the inflammasome and pro-inflammatory cytokine IL-18 play important roles in its development. Regulating the signaling pathways of the inflammasome and IL-18 may serve as potential targets for CKD treatment.

PHARMACOLOGY & THERAPEUTICS (2022)

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Article Medicine, Research & Experimental

Mecp2 protects kidney from ischemia-reperfusion injury through transcriptional repressing IL-6/STAT3 signaling

Jiao Wang et al.

Summary: This study reveals a protective role of Mecp2 in acute kidney injury (AKI) induced by ischemia-reperfusion, suggesting that it inhibits renal tubular damage, inflammation, and fibrosis by suppressing the Il-6/STAT3 signaling pathway.

THERANOSTICS (2022)

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Review Urology & Nephrology

WNT-β-catenin signalling - a versatile player in kidney injury and repair

Stefan J. Schunk et al.

Summary: The WNT-beta-catenin pathway plays a critical role in kidney development and repair, with transient activation aiding in tissue regeneration after acute kidney injury, but uncontrolled signalling can lead to kidney fibrosis and other kidney diseases.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Biochemistry & Molecular Biology

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Yunfan Sun et al.

Summary: This study showed that early-relapse hepatocellular carcinoma (HCC) tumors exhibit innate-like CD8(+) T cells with overexpression of KLRB1 (CD161) and a low cytotoxic state, unlike the exhausted state seen in primary HCC. These cells were associated with a worse prognosis. Additionally, potential immune evasion mechanisms were identified in recurrent tumor cells, which dampen dendritic cell antigen presentation and recruit innate-like CD8(+) T cells.

CELL (2021)

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Article Cell Biology

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

Uta Erdbrugger et al.

Summary: Urine is commonly used for clinical diagnosis and biomedical research, and the discovery of extracellular vesicles (EV) in urine has opened a new scientific field. However, methods for isolating and characterizing urinary extracellular vesicles (uEVs) need further optimization and standardization to advance scientific research and translation into clinical practice. Recommendations for improved rigor, reproducibility, and interoperability in uEV research are provided to address current challenges and gaps in the field.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Multidisciplinary Sciences

Fibrillin-1-enriched microenvironment drives endothelial injury and vascular rarefaction in chronic kidney disease

Li Li et al.

Summary: This study demonstrates the crucial role of FBN1 in mediating vascular rarefaction in CKD by orchestrating a hostile microenvironment for endothelial cells. The upregulation of FBN1 in fibrotic kidney tissue was found in animal models and patients, leading to apoptosis and inhibition of proliferation in endothelial cells. RNA sequencing identified the activated integrin alpha(v)beta(6)/transforming growth factor-beta signaling as the key pathway in FBN1-induced endothelial injury, and blocking this pathway ameliorated renal fibrosis and vascular rarefaction in a mouse model of CKD.

SCIENCE ADVANCES (2021)

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Article Multidisciplinary Sciences

Decoding myofibroblast origins in human kidney fibrosis

Christoph Kuppe et al.

Summary: Using single-cell RNA sequencing, researchers profiled the transcriptomes of healthy and fibrotic human kidneys, identifying distinct subpopulations of pericytes and fibroblasts as the main sources of scar-forming myofibroblasts during kidney fibrosis. This study shed light on the cellular origins and differentiation of myofibroblasts in human kidney fibrosis, identifying potential therapeutic targets such as NKD2.

NATURE (2021)

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Article Urology & Nephrology

Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling.

Haili Zhu et al.

KIDNEY INTERNATIONAL (2020)

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Article Urology & Nephrology

Tubule-derived exosomes play a central role in fibroblast activation and kidney fibrosis

Xi Liu et al.

KIDNEY INTERNATIONAL (2020)

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Review Biochemistry & Molecular Biology

Osteopontin: The Molecular Bridge between Fat and Cardiac-Renal Disorders

Elena Vianello et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Urology & Nephrology

The current and future landscape of dialysis

Jonathan Himmelfarb et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Article Multidisciplinary Sciences

Calcium and hydroxyapatite binding site of human vitronectin provides insights to abnormal deposit formation

Kyungsoo Shin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Cell Biology

Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery

Zihao Chen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Cell Biology

Thrombospondin 1 and Its Diverse Roles as a Regulator of Extracellular Matrix in Fibrotic Disease

Joanne E. Murphy-Ullrich

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2019)

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Article Urology & Nephrology

Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome

Yue Zhao et al.

KIDNEY INTERNATIONAL (2019)

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Article Urology & Nephrology

Tenascin-C protects against acute kidney injury by recruiting Wnt ligands

Shuangqin Chen et al.

KIDNEY INTERNATIONAL (2019)

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Editorial Material Urology & Nephrology

Single-cell genomics and gene editing: implications for nephrology

Parker C. Wilson et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Article Oncology

Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation

Sandra Rayego-Mateos et al.

JOURNAL OF PATHOLOGY (2018)

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Review Urology & Nephrology

Renal tubule injury: a driving force toward chronic kidney disease

Bi-Cheng Liu et al.

KIDNEY INTERNATIONAL (2018)

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Article Physiology

Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease

Archana Raman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Urology & Nephrology

Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis

Haiyan Fu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Article Urology & Nephrology

Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis

Dong Zhou et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Review Medicine, General & Internal

Chronic kidney disease

Angela C. Webster et al.

LANCET (2017)

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Article Multidisciplinary Sciences

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

Yalin Zhang et al.

NATURE (2017)

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Review Urology & Nephrology

Of Inflammasomes and Alarmins: IL-1β and IL-1α in Kidney Disease

Hans-Joachim Anders

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Review Urology & Nephrology

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

Maria Edeling et al.

NATURE REVIEWS NEPHROLOGY (2016)

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Review Urology & Nephrology

TGF-β: the master regulator of fibrosis

Xiao-ming Meng et al.

NATURE REVIEWS NEPHROLOGY (2016)

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Review Biology

Sonic hedgehog signaling in kidney fibrosis: a master communicator

Dong Zhou et al.

SCIENCE CHINA-LIFE SCIENCES (2016)

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Review Urology & Nephrology

Signaling Crosstalk between Tubular Epithelial Cells and Interstitial Fibroblasts after Kidney Injury

Roderick J. Tan et al.

KIDNEY DISEASES (2016)

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Review Urology & Nephrology

TNF receptors: signaling pathways and contribution to renal dysfunction

Rafia S. Al-Lamki et al.

KIDNEY INTERNATIONAL (2015)

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Article Cell Biology

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

Wenchao Zhou et al.

NATURE CELL BIOLOGY (2015)

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Article Medical Laboratory Technology

Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells

John J. Gildea et al.

CLINICAL BIOCHEMISTRY (2014)

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Article Urology & Nephrology

Thrombospondin-1 Activation of Signal-Regulatory Protein-α Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury

Mingyi Yao et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Sonic Hedgehog Is a Novel Tubule-Derived Growth Factor for Interstitial Fibroblasts after Kidney Injury

Dong Zhou et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Urology & Nephrology

Inhibition of Periostin Expression Protects against the Development of Renal Inflammation and Fibrosis

Mouna Mael-Ainin et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Review Urology & Nephrology

Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease

Helena M. Kok et al.

NATURE REVIEWS NEPHROLOGY (2014)

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Article Pathology

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

Ching-Fang Wu et al.

AMERICAN JOURNAL OF PATHOLOGY (2013)

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Review Pharmacology & Pharmacy

ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis

A. C. Simoes e Silva et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

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Article Pathology

Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension

Matthew J. Socha et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

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Review Biotechnology & Applied Microbiology

The integrins

Yoshikazu Takada et al.

GENOME BIOLOGY (2007)

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Review Physiology

Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action

YH Liu

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)

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Hepatocyte growth factor in renal failure: Promise and reality

GA Vargas et al.

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