Prognostic implications of synaptophysin, CD56, thyroid transcription factor-1, and Ki-67 in pulmonary high-grade neuroendocrine carcinomas

Article Oncology

Pulmonary neuroendocrine tumors: study of 266 cases focusing on clinicopathological characteristics, immunophenotype, and prognosis

Shuwen Zhang et al.

Summary: PNETs are a group of highly heterogeneous tumors with different clinical manifestations, pathological features, and prognoses. Knowing clinicopathological characteristics and immunophenotypes of PNETs is significant for diagnosis.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)

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Article Oncology

Challenges of the eighth edition of the American Joint Committee on Cancer staging system for pathologists focusing on early stage lung adenocarcinoma

Yu-Ting Wang et al.

Summary: This study retrospectively analyzed patients with pulmonary adenocarcinoma who underwent surgical resection and found that patients with completely excised pTis, pT1a(mi), and pT1a tumors had excellent survival. Therefore, staging tumors with a diameter of <= 1 cm and exhibiting lepidic, acinar, or papillary histological patterns may not be necessary.

THORACIC CANCER (2023)

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Article Oncology

PARP inhibitor plus radiotherapy reshapes an inflamed tumor microenvironment that sensitizes small cell lung cancer to the anti-PD-1 immunotherapy

Nannan Zhang et al.

Summary: The combination of PARP inhibitor, radiotherapy, and anti-PD-1 treatment significantly inhibits tumor growth and prolongs survival in syngeneic SCLC models in mice. This combination therapy reshapes the tumor microenvironment, induces immunogenic cell death, and upregulates PD-L1 expression on tumor cells. It also enhances CD8(+) T cell infiltration and activation, leading to improved anti-tumor effects.

CANCER LETTERS (2022)

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Letter Oncology

2021 WHO Classification of Lung Cancer: A Globally Applicable and Molecular Biomarker-Relevant Classification

Andrew G. Nicholson et al.

JOURNAL OF THORACIC ONCOLOGY (2022)

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Review Oncology

Pulmonary Large Cell Neuroendocrine Carcinoma

Lan Yang et al.

Summary: Pulmonary large cell neuroendocrine carcinoma is a rare and aggressive subtype of lung tumor, with similar biological behavior to small cell lung cancer. Diagnosis is mainly based on pathology and immunohistochemistry. The rise of LCNEC molecular typing in recent years may aid in diagnosis and treatment.

PATHOLOGY & ONCOLOGY RESEARCH (2022)

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Review Pathology

Morphologic and molecular classification of lung neuroendocrine neoplasms

Jasna Metovic et al.

Summary: The discussion in the article revolves around the morphological and molecular classification of lung neuroendocrine neoplasms, focusing on supervised and unsupervised approaches. It emphasizes the strengths and weaknesses of the current classification of lung NENs and provides an alternative outlook based on biological data.

VIRCHOWS ARCHIV (2021)

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Article Oncology