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Article
Multidisciplinary Sciences
Yunlong Cao et al.
Summary: Continuous evolution of Omicron has led to the emergence of multiple variants with growth advantages, and mutations in their receptor-binding domain have converged on several hotspots, allowing them to evade neutralizing antibody drugs and convalescent plasma. Breakthrough infections of BA.2 and BA.5 have reduced the diversity of neutralizing antibody binding sites and promoted convergent evolution in the RBD.
Article
Chemistry, Physical
Ying Yue et al.
Summary: This article introduces an improved method for enhancing fluorescence using plasmonic enhanced fluorescence (PEF) technology. By self-assembling gold nanoparticles (GNPs) and subsequent annealing-assisted regulation, the method achieves fluorescence enhancement and high density electromagnetic coupling in the near-infrared region. The method has high sensitivity and low detection limit, making it valuable for clinical detection and disease diagnosis.
Article
Chemistry, Multidisciplinary
Yajun Wang et al.
Summary: A modular theranostic system combining NIR-II FGS and a sandwiched plasmonic chip (SPC) was developed for intraoperative detection and resection of tumor cells in lymph nodes with high sensitivity and selectivity. The system achieved accurate diagnosis and improved efficiency of cancer therapy.
Article
Chemistry, Multidisciplinary
Fajun Li et al.
Summary: Plasmonic metasurfaces (PMs) functionalized with monoclonal antibodies (mAbs) are promising biophotonic sensors for biomolecular interaction analysis and immunoassay of various biomarkers, such as SARS-CoV-2 variants. We developed a high efficiency affinity testing method using label-free PM sensors with mAbs and studied the binding characteristics between 12 SARS-CoV-2 RBD variants and mAb-functionalized PMs. Our study demonstrates the potential of label-free biosensing using low-cost wafer-scale PMs for high-precision point-of-care testing of emerging SARS-CoV-2 variants.
Article
Cell Biology
Qingwen He et al.
Summary: Emerging Omicron sub-variants are causing global concerns, and their immune evasion should be monitored continuously. An updated atlas of 77 monoclonal antibodies (mAbs) against the emerging sub-variants including BQ.1.1 and XBB revealed further evasion and provided insights into the molecular mechanisms of antibody evasion. By focusing on broadly potent mAbs, a hotspot epitope on the receptor-binding domain (RBD) was identified, which could guide vaccine design and the development of new countermeasures against COVID-19.
CELL REPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jingyun Yang et al.
Summary: The COVID-19 response strategies in Chinese mainland were adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants. In Chengdu, China, an infection wave was predominantly induced by the BA.5 subvariant. It is crucial to determine whether the hybrid anti-SARS-CoV-2 immunity following BA.5 infection is sufficient to shape the immune responses against newly emerged Omicron subvariants, especially for XBB lineages.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Chemistry, Physical
Ying Yue et al.
Summary: This study develops a thermal-annealing gold nanoparticle platform that enhances immunofluorescence microarrays, achieving high sensitivity and low detection limits. This technology can be used for clinical sample detection and has applications in proteomic research and clinical pathology.
Article
Medical Laboratory Technology
Giuseppe Lippi et al.
Summary: Measuring the level of protection provided by anti-SARS-CoV-2 antibodies is a reliable approach for predicting biological protection against COVID-19. However, the vast mutations in SARS-CoV-2 may compromise the reliability of current commercial immunoassays.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Chemistry, Analytical
Wen-Yu Su et al.
Summary: This study utilized a multiplexed spike variant protein microarray (SVPM) to analyze the humoral immune response and neutralizing activity in COVID-19 patients, and found that severe patients had stronger inhibition of ACE2 binding to multiple variants.
ANALYTICAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Jason Z. Zhang et al.
Summary: We developed a protein biosensor that can rapidly and sensitively detect neutralizing antibodies against SARS-CoV-2 variants in serum. The biosensor can accurately differentiate between different samples based on the affinity and abundance of antibody binding, which is superior to traditional competition-based assays.
NATURE BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jingjie Nan et al.
Summary: In this study, a sandwiched plasmonic biosensor was developed for rapid, label-free, and naked-eye detection of targeted biomolecular species, such as SARS-CoV-2 antibodies. The sensor demonstrated a broad dynamic range and low limit of detection.
Article
Biotechnology & Applied Microbiology
Ruibin Hu et al.
Summary: This study developed a platform for the multiplexed evaluation of SARS-CoV-2 neutralizing antibodies against various variants. It was found that individuals recovered from Omicron variant infection showed weak binding strength against non-Omicron variants, while vaccination could enhance antibody avidity more efficiently.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Virology
Kuan-Ting Liu et al.
Summary: This article reviewed the different types of neutralization assays and international standards for SARS-CoV-2. The authors comprehensively summarized the serological assays for detecting neutralizing antibodies against SARS-CoV-2 and highlighted the importance of international standards for calibrating the measurement of neutralizing antibodies.
Article
Multidisciplinary Sciences
Rafael R. de Assis et al.
Summary: Diagnosis of COVID-19 by PCR testing may underestimate the true prevalence of infection; serologic methods are more accurate and versatile for monitoring disease burden and epidemiology. A protein microarray with antigens from SARS-CoV-2, SARS-CoV, MERS-CoV, and common human respiratory viruses has been reported as a diagnostic, epidemiologic, and research tool.
NATURE COMMUNICATIONS
(2021)
Letter
Medicine, General & Internal
Riccardo Laterza et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Jacob T. Heggestad et al.
Summary: CoVariant-SCAN is a rapid test developed to detect neutralizing antibodies against different SARS-CoV-2 variants, showing consistent results with live virus neutralization assays and aiding in the rapid assessment of antibody response.
Article
Medicine, Research & Experimental
Jo-Lewis Banga Ndzouboukou et al.
Summary: Neutralizing antibody assays are crucial in managing the COVID-19 pandemic, aiding in protection assessment, donor screening, therapy testing, and vaccine efficacy prediction. This review compares different detection methods to enhance their clinical application.
CURRENT MEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Zoe Swank et al.
Summary: A novel microfluidic nanoimmunoassay technology has been developed for high-throughput detection of anti-SARS-CoV-2 IgG antibodies in human blood samples, showing high specificity and sensitivity. Using two commercial devices and a blood glucose test strip, a low-cost and ultralow-volume whole blood sampling method without the need for venipuncture has been successfully achieved. This technology is expected to be applicable to current and future SARS-CoV-2 related serological studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Rafael Assis et al.
Summary: A coronavirus antigen microarray (COVAM) was constructed to measure immunoglobulin responses to different coronavirus antigens in serum samples, showing high concordance with FDA authorized diagnostic tests. This method could help group convalescent plasma based on antibody reactivity patterns, improving therapeutic efficacy and assessing vaccine performance.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Patthara Kongsuphol et al.
Summary: An easy-to-use, rapid cellulose-based test has been developed to detect neutralizing antibodies against SARS-CoV-2, providing results in just 10 minutes with comparable performance to lab-based tests. This test could be valuable for large-scale monitoring of immunity, especially in populations without routine access to a laboratory.
COMMUNICATIONS MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Jingjie Nan et al.
ADVANCED MATERIALS
(2020)
Article
Multidisciplinary Sciences
Fan Wu et al.
Article
Biotechnology & Applied Microbiology
Chee Wah Tan et al.
NATURE BIOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
He-wei Jiang et al.
NATURE COMMUNICATIONS
(2020)
Review
Materials Science, Multidisciplinary
Zhen Qin et al.
Review
Biochemical Research Methods
Huan Qi et al.
EXPERT REVIEW OF PROTEOMICS
(2019)
Article
Chemistry, Multidisciplinary
Ozlem Yavas et al.
Article
Chemistry, Multidisciplinary
Pengyu Chen et al.
Article
Biochemistry & Molecular Biology
Bo Zhang et al.
Article
Nanoscience & Nanotechnology
Ryan T. Hill et al.
Article
Chemistry, Multidisciplinary
Ryan T. Hill et al.
Article
Chemistry, Analytical
A Bernard et al.
ANALYTICAL CHEMISTRY
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