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lncRNA TUG1 as potential novel biomarker for prognosis of cardiovascular diseases

EPIGENOMICS (2023)

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Article Cardiac & Cardiovascular Systems

MEF2 in cardiac hypertrophy in response to hypertension

James D. Cornwell et al.

Summary: Hypertension is a common pathological condition worldwide and a risk factor for cardiac hypertrophy and heart failure. Myocyte enhancer factor 2 (Mef2) has been identified as a key player in the morphological changes of the hypertensive heart, regulating cardiac gene expression through a complex molecular signaling network. This article aims to review the literature on Mef2's involvement in hypertension-induced cardiac hypertrophy, providing insights for understanding and potential treatment of heart failure.

TRENDS IN CARDIOVASCULAR MEDICINE (2023)

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Article Endocrinology & Metabolism

Long Non-Coding RNA TUG1 Attenuates Insulin Resistance in Mice with Gestational Diabetes Mellitus via Regulation of the MicroRNA-328-3p/SREBP-2/ERK Axis

Xuwen Tang et al.

Diabetes & Metabolism Journal (2023)

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Article Biochemistry & Molecular Biology

Urinary Long Non-Coding RNA Levels as Biomarkers of Lupus Nephritis

Cheuk-Chun Szeto et al.

Summary: Through the study of three cohorts of lupus nephritis patients and controls, we identified specific lncRNA targets in urine that are associated with the severity and histological classification of lupus nephritis. These urinary lncRNA levels may serve as biomarkers for the disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Cardiac & Cardiovascular Systems

Research advances on circulating long noncoding RNAs as biomarkers of cardiovascular diseases

Mingyi Cao et al.

Summary: Cardiovascular diseases are associated with increased morbidity and mortality, making it necessary to develop new diagnostic markers. LncRNAs have shown potential as biomarkers for cardiovascular diseases, with the ability to be used for diagnosis, prognosis, and prediction.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Atrial Fibrillation: Pathogenesis, Predisposing Factors, and Genetics

Marios Sagris et al.

Summary: Atrial fibrillation is a common arrhythmia associated with increased risk of death, stroke, and peripheral embolism, leading to a high burden on healthcare systems. Identifying modifiable risk factors and implementing preventive measures are crucial for improving community health and reducing healthcare costs. Various mechanisms contributing to the development of AF, including electrical and structural remodeling of atrial tissue, have been proposed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, General & Internal

Original Article Down-regulation of miR-29c promotes the progression of oral submucous fibrosis through targeting tropomyosin-1

Po-Yu Yang et al.

Summary: This study found that miR-29c expression is downregulated in oral submucous fibrosis (OSF). Transfection of miR-29c mimic reduced the migration ability and collagen gel contractility of fibrotic buccal mucosal fibroblasts (fBMFs), while inhibition of miR-29c induced myofibroblast phenotypes in normal BMFs. TPM1 was identified as a direct target of miR-29c, and its expression was suppressed in fBMFs transfected with miR-29c mimic. These findings suggest that upregulation of miR-29c may ameliorate the progression of OSF.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2022)

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Review Chemistry, Medicinal

The Role of LncRNA TUG1 in Obesity-related Diseases

Mengzhen Xue et al.

Summary: As people's living standards improve, obesity has become a focus. TUG1 is related to the occurrence and development of obesity-related diseases, while exosomes play a role in regulating disease molecular mechanisms.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Differential Expression of Serum TUG1, LINC00657, miR-9, and miR-106a in Diabetic Patients With and Without Ischemic Stroke

Omayma O. Abdelaleem et al.

Summary: The study revealed significant upregulation of LINC00657 and miR-9 in serum of diabetic patients without stroke, and marked increases in serum TUG1, LINC00657, and miR-9, as well as a decrease in serum miR-106a in diabetic patients with stroke. Positive correlations were found between TUG1, LINC00657, miR-9 and the National Institutes of Health Stroke Scale (NIHSS), while a negative correlation was observed between miR-106a and NIHSS. Additionally, a negative correlation between LINC00657 and miR-106a in diabetic patients with stroke was demonstrated.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Review Cardiac & Cardiovascular Systems

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Cun-Cun Hua et al.

Summary: This article reviews the roles of miR-34a in cardiovascular diseases, including cardiovascular fibrosis, apoptosis, autophagy, inflammation, senescence, and remodeling. Further understanding of the effects of miR-34a will aid the development of effective interventions.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Cell Biology

HIF-1α-regulated lncRNA-TUG1 promotes mitochondrial dysfunction and pyroptosis by directly binding to FUS in myocardial infarction

Yong-Wang Wang et al.

Summary: This study investigated the roles of HIF-1 alpha/lncRNA-TUG1 in mitochondrial dysfunction and pyroptosis in myocardial infarction (MI). The results showed that HIF-1 alpha promoted the expression of TUG1 and directly bound to the TUG1 promoter. Silencing of TUG1 inhibited ROS production, mitochondrial damage, and expression of pyroptosis-related proteins. Additionally, TUG1 silencing inhibited FUS expression. In vivo experiments confirmed the inhibitory effect of TUG1 silencing on MI.

CELL DEATH DISCOVERY (2022)

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Article Multidisciplinary Sciences

Defining the timeline of periostin upregulation in cardiac fibrosis following acute myocardial infarction in mice

Hadas Gil et al.

Summary: After myocardial infarction, cardiac fibrosis occurs, leading to changes in cardiac structure and impaired function. Recent studies have identified the matricellular protein periostin as a potential therapeutic target for post-MI fibrosis. This study found that cellular periostin expression significantly increased during days 2-7 post-infarct and peaked on day 7, regardless of mouse strain. This finding provides important insights for the development of periostin-targeted gene therapy for post-MI fibrosis.

SCIENTIFIC REPORTS (2022)

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Article Cardiac & Cardiovascular Systems

Impact of lactate dehydrogenase on prognosis of patients undergoing cardiac surgery

Yu Zeng et al.

Summary: In this study, the prognostic effects of preoperative lactate dehydrogenase (LDH) on adverse outcomes in cardiac surgery patients were explored. The analysis of retrospective data from two large medical databases showed that elevated LDH was independently correlated with increased risk of adverse outcomes. Subgroup analyses demonstrated consistent association between high LDH and primary endpoint. Moreover, LDH had the highest predictive ability for the primary endpoint compared to other indicators. The results were further confirmed in a separate dataset.

BMC CARDIOVASCULAR DISORDERS (2022)

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Review Medicine, Research & Experimental

Functional roles of lncRNA-TUG1 in hepatocellular carcinoma

Maryam Farzaneh et al.

Summary: This review summarizes the potential roles of long non-coding RNA TUG1 in hepatocellular carcinoma (HCC), including mediating HCC cell growth, EMT, and metastasis.

LIFE SCIENCES (2022)

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Article Multidisciplinary Sciences

Aging-regulated TUG1 is dispensable for endothelial cell function

Anna Theresa Gimbel et al.

Summary: Despite the high expression and strong evolutionary conservation of TUG1, it does not seem to play a major role in basic endothelial cell function.

PLOS ONE (2022)

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Review Oncology

The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer

Shirin Azizidoost et al.

Summary: Colorectal cancer is a gastrointestinal tumor with unsatisfactory prognosis. Research has shown that the long non-coding RNA TUG1 plays a role in the pathogenesis of CRC and may serve as a predictive/prognostic biomarker for diagnosis of CRC.

CANCER CELL INTERNATIONAL (2022)

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Review Cardiac & Cardiovascular Systems

Cardiac Fibrosis: Cellular Effectors, Molecular Pathways, and Exosomal Roles

Wenyang Jiang et al.

Summary: Cardiac fibrosis, a common pathophysiologic process in most heart diseases, involves multiple cell types, with exosomes playing a crucial role in intercellular communication.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

LncRNA TUG1 Regulates Proliferation of Cardiac Fibroblast via the miR-29b-3p/TGF-β1 Axis

Yini Guo et al.

Summary: TUG1 was found to play a crucial role in the proliferation of cardiac fibroblasts, acting as a competing endogenous RNA for miR-29b-3p and regulating the miR-29b-3p/TGF-beta 1 axis. Knockdown of TUG1 inhibited CF proliferation induced by AngII, and miR-29b-3p targeted directly to TGF-beta 1.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Review Cell Biology

Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response

Ana Catarina Silva et al.

Summary: The extracellular matrix (ECM) plays a crucial role in heart development and disease, with fibrosis being a major manifestation of many cardiovascular diseases. Effective treatments for managing fibrosis and promoting ECM repair are currently lacking. Understanding ECM composition and function is important for developing more efficient therapies for heart conditions.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Pivotal Role of TGF-β/Smad Signaling in Cardiac Fibrosis: Non-coding RNAs as Effectual Players

Somayeh Saadat et al.

Summary: TGF-β induces cardiac fibrosis through activation of cytokines and growth factors, stimulating fibroblast proliferation and ECM protein production via canonical and non-canonical signaling pathways. Non-coding RNAs play crucial roles in regulating these processes, suggesting potential for new diagnostic and therapeutic approaches for cardiac disorders.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Foam Cells as Therapeutic Targets in Atherosclerosis with a Focus on the Regulatory Roles of Non-Coding RNAs

Amin Javadifar et al.

Summary: This study focuses on the role of foam cells in the development of atherosclerosis, with a special emphasis on non-coding RNAs and their regulation of lipid metabolism, inflammatory pathways, and foam cell formation. Important preclinical evidence is reviewed regarding therapeutic targeting of non-coding RNAs in atherosclerosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

Serum NT-proBNP and TUG1 as novel biomarkers for elderly hypertensive patients with heart failure with preserved ejection fraction

Shuang Zhang et al.

Summary: The study found that NT-proBNP and TUG1 levels were increased in the serum of hypertensive patients with HFPEF, and were correlated with various parameters related to cardiac function. Both NT-proBNP and TUG1 were confirmed as useful biomarkers for the diagnosis of HFPEF.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Cell Biology

Functional delivery of lncRNA TUG1 by endothelial progenitor cells derived extracellular vesicles confers anti-inflammatory macrophage polarization in sepsis via impairing miR-9-5p-targeted SIRT1 inhibition

Wentao Ma et al.

Summary: This study reveals that EPCs derived EVs transmit TUG1 to alleviate sepsis by promoting macrophage M2 polarization. Additionally, TUG1 can competitively bind to miR-9-5p to upregulate SIRT1 expression, leading to the inhibition of miR-9-5p-mediated SIRT1 inhibition, which contributes to a more comprehensive understanding of the pathogenesis of sepsis.

CELL DEATH & DISEASE (2021)

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Article Medicine, Research & Experimental

miR-124 promotes apoptosis and inhibits the proliferation of vessel endothelial cells through P38/MAPK and PI3K/AKT pathways, making it a potential mechanism of vessel endothelial injury in acute myocardial infarction

Weimin Ma et al.

Summary: The study found that elevated levels of miR-124 in the peripheral blood of AMI patients and overexpression of miR-124 could promote apoptosis and inhibit proliferation of HUVECs. Overexpression of miR-124 also led to changes in the gene expression profile, mainly affecting the PI3K-AKT and metabolism-related signaling pathways.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Medicine, Research & Experimental

Differentially expressed TUG1 and miR-145-5p indicate different severity of chronic heart failure and predict 2-year survival prognosis

Qinwei Zhu et al.

Summary: In patients with chronic heart failure (CHF), upregulation of TUG1 and downregulation of miR-145-5p were observed, showing a negative correlation. Both TUG1 and miR-145-5p levels were associated with left ventricle ejection fraction and could indicate CHF severity. Serum levels of TUG1 and miR-145-5p had diagnostic value, especially when combined with BNP, and they were also independently associated with CHF prognosis. Additionally, TUG1 and miR-145-5p were linked to inflammation in CHF and may play a role in disease progression.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Cell Biology

Promoting roles of KLF5 in myocardial infarction in mice involving microRNA-27a suppression and the following GFPT2/TGF-β/Smad2/3 axis activation

Zhen Tian et al.

Summary: This study reveals that KLF5 may induce myocardial damage and fibrosis in MI by modulating the miR-27a and GFPT2/TGF-beta/Smad2/3 pathway. Inhibition of KLF5 with ML264 and intervention with miR-27a can help reduce cell and tissue damage in MI.

CELL CYCLE (2021)

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Article Cell Biology

LncRNA TUG1 acts as a competing endogenous RNA to mediate CTGF expression by sponging miR-133b in myocardial fibrosis after myocardial infarction

Songlin Zhang et al.

Summary: This study discovered that TUG1 mediates CTGF expression by sponging miR-133b in the activation of cardiac myofibroblasts, highlighting its significant role in myocardial fibrosis.

CELL BIOLOGY INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

TUG1 knockdown suppresses cardiac fibrosis after myocardial infarction

Qingsong Sun et al.

Summary: This study aims to investigate the impact of TUG1 on cardiac fibrosis following acute myocardial infarction (AMI) and elucidate the underlying molecular mechanism. The results demonstrate that knockdown of TUG1 improves cardiac function in AMI rats and suppresses the biological behavior of cardiac fibroblasts. Furthermore, TUG1 acts as a sponge for miR-590 and is involved in regulating the process of cardiac fibrosis.

MAMMALIAN GENOME (2021)

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Review Biochemistry & Molecular Biology

Role of long noncoding RNA taurine-upregulated gene 1 in cancers

Miao Da et al.

Summary: The abnormally expressed long non-coding RNA (lncRNA) TUG1 plays a critical role in regulating gene expression in malignant tumors, making it a potential clinical biomarker or therapeutic target for cancer. This review provides a basis for new research directions in cancer prevention, diagnosis, and treatment involving lncRNA TUG1.

MOLECULAR MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Circ_nuclear factor I X (circNfix) attenuates pressure overload-induced cardiac hypertrophy via regulating miR-145-5p/ATF3 axis

Jun Pan et al.

Summary: This study revealed the involvement of circNfix in regulating cardiac hypertrophy, acting through the miR-145-5p/ATF3 axis. Overexpression of circNfix could prevent the progression of cardiac hypertrophy, suggesting a potential role as a molecular target for cardiac hypertrophy treatment.

BIOENGINEERED (2021)

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Article Biology

Knockdown of TUG1 rescues cardiomyocyte hypertrophy through targeting the miR-497/MEF2C axis

Guorong Zhang et al.

Summary: The study revealed that TUG1 was upregulated and miR-497 was downregulated in models of cardiac hypertrophy. Knockdown of TUG1 or overexpression of miR-497 could alleviate hypertrophy induced by Ang II in cardiomyocytes. TUG1 acted as a sponge of miR-497 and mediated the protective effects against Ang II-induced cardiomyocyte hypertrophy.

OPEN LIFE SCIENCES (2021)

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Article Medicine, Research & Experimental

Urinary expression of long non-coding RNA TUG1 in non-diabetic patients with glomerulonephritides

Fernando Javier Salazar-Torres et al.

Summary: Metabolic alterations play a crucial role in the development of kidney disease. The lncRNA TUG1, known for regulating podocyte health and mitochondrial biogenesis, was found to have significantly lower expression in the urinary sediment of non-diabetic patients with glomerulonephritides, particularly those diagnosed with Focal Segmental Glomerulosclerosis (FSGS). Loss of TUG1 expression in urine was strongly associated with FSGS and could potentially serve as a non-invasive biomarker for assessing podocytopathy.

BIOMEDICAL REPORTS (2021)

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Article Biochemistry & Molecular Biology

LncRNA TUG1 competitively binds to miR-340 to accelerate myocardial ischemia-reperfusion injury

Xianqiu Wu et al.

Summary: The study revealed the significance of TUG1/miR-340/HDAC4/beta-catenin/GLUT1 axes in MIRI, promoting myocardial ischemia-reperfusion injury by affecting cell survival and apoptosis.

FASEB JOURNAL (2021)

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Article Genetics & Heredity

Increased expression of urinary exosomal LnCRNA TUG-1 in early bladder cancer

Mohammad Sarfi et al.

Summary: This study evaluated the expression levels of oncogenic lncRNAs MALAT-1 and TUG-1 in urinary exosomes of early stages of bladder cancer. Results showed significant upregulation of TUG-1 in early stages, suggesting it could be a potential non-invasive urinary exosome-based biomarker.

GENE REPORTS (2021)

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Article Cell Biology

MiR-590-3p regulates proliferation, migration and collagen synthesis of cardiac fibroblast by targeting ZEB1

Xiaolong Yuan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

LncRNA TUG1 mediates ischemic myocardial injury by targeting miR-132-3p/HDAC3 axis

Qiang Su et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Article Cell Biology

LncRNA TUG1 alleviates cardiac hypertrophy by targeting miR-34a/DKK1/Wnt-β-catenin signalling

Qingxia Fang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Medicine, Research & Experimental

LncRNA TUG1 regulates proliferation and apoptosis by regulating miR-148b/IGF2 axis in ox-LDL-stimulated VSMC and HUVEC

Xiaoguang Wu et al.

LIFE SCIENCES (2020)

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Article Chemistry, Medicinal

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

Ganhua You et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

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Review Pharmacology & Pharmacy

Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide

Hai-Jian Sun et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring

Olga Krzywinska et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Cell Biology

LncRNA TUG1 regulates ApoM to promote atherosclerosis progression through miR-92a/FXR1 axis

Liu Yang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Cell Biology

Recent advances on the roles of LncRNAs in cardiovascular disease

Yexian Fang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

Shintaro Maeda et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 Update From the GBD 2019 Study

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Oncology

Apolipoprotein M promotes the anti-inflammatory effect of high-density lipoprotein by binding to scavenger receptor BI

Shuang Yao et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

TheTug1lncRNA locus is essential for male fertility

Jordan P. Lewandowski et al.

GENOME BIOLOGY (2020)

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Article Cell Biology

Inhibition of miR-148b ameliorates myocardial ischemia/reperfusion injury via regulation of Wnt/β-catenin signaling pathway

Mei Yang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Medicine, Research & Experimental

miR-9 knockdown inhibits hypoxia-induced cardiomyocyte apoptosis by targeting Yap1

Jiayong Zheng et al.

LIFE SCIENCES (2019)

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Review Immunology

Role of autophagy in atherosclerosis: foe or friend?

Mehdi Hassanpour et al.

JOURNAL OF INFLAMMATION-LONDON (2019)

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Article Cardiac & Cardiovascular Systems

Inhibition of lncRNA TUG1 upregulates miR-142-3p to ameliorate myocardial injury during ischemia and reperfusion via targeting HMGB1-and Rac1-induced autophagy

Qiang Su et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

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Article Cell Biology

LncRNA TUG1 contributes to cardiac hypertrophy via regulating miR-29b-3p

Xue Zou et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2019)

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Article Biochemistry & Molecular Biology

microRNA-340-5p inhibits hypoxia/reoxygenation-induced apoptosis and oxidative stress in cardiomyocytes by regulating the Act1/NF-κB pathway

Dong Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

The Smad3-miR-29b/miR-29c axis mediates the protective effect of macrophage migration inhibitory factor against cardiac fibrosis

Jing-nan Liang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

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Review Cardiac & Cardiovascular Systems

Non-coding RNAs in cardiovascular cell biology and atherosclerosis

Francesca Fasolo et al.

CARDIOVASCULAR RESEARCH (2019)

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Article Hematology

Elevated serum lncRNA TUG1 levels are a potential diagnostic biomarker of multiple myeloma

Qingqing Yin et al.

EXPERIMENTAL HEMATOLOGY (2019)

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Article Cell Biology

The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5

Di Yang et al.

CELL DEATH & DISEASE (2019)

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Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Pharmacology & Pharmacy

WNT Signaling in Cardiac and Vascular Disease

Sebastien Foulquier et al.

PHARMACOLOGICAL REVIEWS (2018)

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Article Cell Biology

TGF-β1 Signaling and Tissue Fibrosis

Kevin K. Kim et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

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Article Medicine, Research & Experimental

被撤回的出版物: TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells (Retracted article. See vol. 150, 2022)

Nianxin Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Medicine, Research & Experimental

被撤回的出版物: Long non-coding RNA TUG1 protects renal tubular epithelial cells against injury induced by lipopolysaccharide via regulating microRNA-223 (Retracted article. See vol. 149, 2022)

Yan Xu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Cardiac & Cardiovascular Systems

TUG1 knockdown ameliorates atherosclerosis via up-regulating the expression of miR-133a target gene FGF1

Lei Zhang et al.

CARDIOVASCULAR PATHOLOGY (2018)

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Editorial Material Cardiac & Cardiovascular Systems

Left ventricular ejection fraction and heart failure: an indissoluble marriage?

Donato Mele et al.

EUROPEAN JOURNAL OF HEART FAILURE (2018)

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Article Cell Biology

Cell-free lncRNA expression signatures in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer

Lutao Du et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Cardiac & Cardiovascular Systems

CTGF/CCN2 is an autocrine regulator of cardiac fibrosis

Lisa E. Dorn et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injury

Ling Zhang et al.

MOLECULAR MEDICINE (2018)

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Article Biochemistry & Molecular Biology

miR-26a inhibits atherosclerosis progression by targeting TRPC3

Min Feng et al.

CELL AND BIOSCIENCE (2018)

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Review Cardiac & Cardiovascular Systems

Management of Measurable Variable Cardiovascular Disease' Risk Factors

Sonja Francula-Zaninovic et al.

CURRENT CARDIOLOGY REVIEWS (2018)

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Article Cell Biology

HMGB1 Inhibits Apoptosis Following MI and Induces Autophagy via mTORC1 Inhibition

Eleonora Foglio et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Induction of MiR133a expression by IL-19 targets LDLRAPI. and reduces oxLDL uptake in VSMC

Khatuna Gabunia et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2017)

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Review Cardiac & Cardiovascular Systems

The Aging Cardiovascular System Understanding It at the Cellular and Clinical Levels

Francesco Paneni et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Ischemia/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists

Margherita Neri et al.

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Article Cell Biology

MiR-145-5p regulates hypoxia-induced inflammatory response and apoptosis in cardiomyocytes by targeting CD40

Ming Yuan et al.

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Urinary podocyte and TGF-β1 mRNA as markers for disease activity and progression in anti-glomerularbasement membrane nephritis

Akihiro Fukuda et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2017)

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Review Biochemistry & Molecular Biology

Myocyte enhancer factor 2C and its directly-interacting proteins: A review

Chen Dong et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2017)

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Article Medicine, Research & Experimental

Role of angiopoietin-2 in the cardioprotective effect of fibroblast growth factor 21 on ischemia/reperfusion-induced injury in H9c2 cardiomyocytes

Shuoqiang Hu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

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Article Biology

Tanshinone IIA suppresses the progression of atherosclerosis by inhibiting the apoptosis of vascular smooth muscle cells and the proliferation and migration of macrophages induced by ox-LDL

Baocai Wang et al.

BIOLOGY OPEN (2017)

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Article Biochemistry & Molecular Biology

The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling

Arti V. Shinde et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

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Article Cardiac & Cardiovascular Systems

MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

Varun Nagpal et al.

CIRCULATION (2016)

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Review Chemistry, Multidisciplinary

The roles of macrophage autophagy in atherosclerosis

Bo-zong Shao et al.

ACTA PHARMACOLOGICA SINICA (2016)

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Article Biochemistry & Molecular Biology

miRNA-133a attenuates lipid accumulation via TR4-CD36 pathway in macrophages

Xiao-Ping Peng et al.

BIOCHIMIE (2016)

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Editorial Material Cardiac & Cardiovascular Systems

How does fibrosis promote atrial fibrillation persistence: in silico findings, clinical observations, and experimental data

Stanley Nattel

CARDIOVASCULAR RESEARCH (2016)

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Article Cardiac & Cardiovascular Systems

Vascular Smooth Muscle Cells in Atherosclerosis

Martin R. Bennett et al.

CIRCULATION RESEARCH (2016)

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Review Cardiac & Cardiovascular Systems

Cardiac Fibrosis The Fibroblast Awakens

Joshua G. Travers et al.

CIRCULATION RESEARCH (2016)

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Article Oncology

Aberrant Expression of Breast Development-Related MicroRNAs, miR-22, miR-132, and miR-212, in Breast Tumor Tissues

Zahra Damavandi et al.

JOURNAL OF BREAST CANCER (2016)

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Article Immunology

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

Hana M. Russo et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Oncology

Fibroblast growth factor-1 attenuates TGF-β1-induced lung fibrosis

Chiko Shimbori et al.

JOURNAL OF PATHOLOGY (2016)

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Article Medicine, Research & Experimental

The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition

Junfeng Sun et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

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Article Oncology

MicroRNA-29b inhibits TGF-β1-induced fibrosis via regulation of the TGF-β1/Smad pathway in primary human endometrial stromal cells

Jingxiong Li et al.

MOLECULAR MEDICINE REPORTS (2016)

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Article Oncology

Identification of a serum circulating IncRNA panel for the diagnosis and recurrence prediction of bladder cancer

Weili Duan et al.

ONCOTARGET (2016)

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Article Cardiac & Cardiovascular Systems

Association of Circulating MicroRNA-124-3p Levels With Outcomes After Out-of-Hospital Cardiac Arrest A Substudy of a Randomized Clinical Trial

Yvan Devaux et al.

JAMA CARDIOLOGY (2016)

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Article Multidisciplinary Sciences

MicroRNA-497 Inhibits Cardiac Hypertrophy by Targeting Sirt4

Yimin Xiao et al.

PLOS ONE (2016)

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Review Toxicology

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

Yow Keat Tham et al.

ARCHIVES OF TOXICOLOGY (2015)

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Review Cardiac & Cardiovascular Systems

Long Noncoding RNAs and MicroRNAs in Cardiovascular Pathophysiology

Thomas Thum et al.

CIRCULATION RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2

Ming-De Huang et al.

MOLECULAR CANCER (2015)

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Review Oncology

Apolipoprotein M: Research progress, regulation and metabolic functions (Review)

Li-Zhu Huang et al.

MOLECULAR MEDICINE REPORTS (2015)

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Article Nursing

Heart Failure Pathophysiology, Diagnosis, Medical Treatment Guidelines, and Nursing Management

Chad Rogers et al.

NURSING CLINICS OF NORTH AMERICA (2015)

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Article Multidisciplinary Sciences

MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis

Yong Zhang et al.

SCIENTIFIC REPORTS (2015)

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Article Genetics & Heredity

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature

Leah Cushing et al.

PLOS GENETICS (2015)

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Editorial Material Cardiac & Cardiovascular Systems

MiR-92a At the Heart of Lipid-Driven Endothelial Dysfunction

Menno P. J. de Winther et al.

CIRCULATION RESEARCH (2014)

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Review Medical Laboratory Technology

The decalog of long non-coding RNA involvement in cancer diagnosis and monitoring

Tanja Kunej et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2014)

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Article Cardiac & Cardiovascular Systems

Role of miR-145 in cardiac myofibroblast differentiation

Yao-Sheng Wang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

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Article Biochemistry & Molecular Biology

A Novel Histone Deacetylase Complex in the Control of Transcription and Genome Stability

Nicola Zilio et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

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Article Multidisciplinary Sciences

Mass-spectrometry-based draft of the human proteome

Mathias Wilhelm et al.

NATURE (2014)

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Article Multidisciplinary Sciences

miR-34a Modulates Angiotensin II-Induced Myocardial Hypertrophy by Direct Inhibition of ATG9A Expression and Autophagic Activity

Jionghua Huang et al.

PLOS ONE (2014)

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Article Cell Biology

P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression

E-b Zhang et al.

CELL DEATH & DISEASE (2014)

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Review Genetics & Heredity

Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation

Reena V. Kartha et al.

FRONTIERS IN GENETICS (2014)

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Review Peripheral Vascular Disease

The Importance of Autophagy in Cardioprotection

Sebastiano Sciarretta et al.

HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION (2014)

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Article Cell Biology

Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

Yu-Miao Wei et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2013)

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Article Cardiac & Cardiovascular Systems

2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Clyde W. Yancy et al.

CIRCULATION (2013)

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Review Geriatrics & Gerontology

Insulin-Like Growth Factor 2 in Development and Disease: A Mini-Review

Daniel Bergman et al.

GERONTOLOGY (2013)

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Review Medicine, Research & Experimental

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Derek J. Hausenloy et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Physiology

Serum microRNA-21 and microRNA-221 as Potential Biomarkers for Cerebrovascular Disease

Pei-Chien Tsai et al.

JOURNAL OF VASCULAR RESEARCH (2013)

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Review Cardiac & Cardiovascular Systems

The pathophysiology of heart failure

Clinton D. Kemp et al.

CARDIOVASCULAR PATHOLOGY (2012)

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Review Cardiac & Cardiovascular Systems

Aging and Atherosclerosis Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular Senescence

Julie C. Wang et al.

CIRCULATION RESEARCH (2012)

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Article Cell Biology

miR-145 is differentially regulated by TGF-ß1 and ischaemia and targets Disabled-2 expression and wnt/ß-catenin activity

Maritza E. Mayorga et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)

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Article Multidisciplinary Sciences

MicroRNA-145 Protects Cardiomyocytes against Hydrogen Peroxide (H2O2)-Induced Apoptosis through Targeting the Mitochondria Apoptotic Pathway

Ruotian Li et al.

PLOS ONE (2012)

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Review Cell Biology

Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis

Yuan Yuan et al.

PROTEIN & CELL (2012)

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Review Anesthesiology

Myocardial Ischemia Reperfusion Injury: From Basic Science to Clinical Bedside

Anja FranK et al.

SEMINARS IN CARDIOTHORACIC AND VASCULAR ANESTHESIA (2012)

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Article Cardiac & Cardiovascular Systems

Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion

Hiromitsu Kanamori et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

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Review Cardiac & Cardiovascular Systems

Oxidative stress and heart failure

Hiroyuki Tsutsui et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

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Article Hematology

MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities

Mian Wang et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

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Article Pharmacology & Pharmacy

Tanshinone IIA attenuates atherosclerosis in ApoE-/- mice through down-regulation of scavenger receptor expression

Fu-Tian Tang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

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Article Biochemistry & Molecular Biology

Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response

Eric Frisdal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Article Cardiac & Cardiovascular Systems

Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling

Joo-ri Kim-Kaneyama et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)

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Article Biochemistry & Molecular Biology

MicroRNAs 1, 133, and 206: Critical factors of skeletal and cardiac muscle development, function, and disease

W. H. Davin Townley-Tilson et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

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Article Cardiac & Cardiovascular Systems

Inflammatory Markers and Incident Heart Failure Risk in Older Adults The Health ABC (Health, Aging, and Body Composition) Study

Andreas Kalogeropoulos et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

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Review Biochemistry & Molecular Biology

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

Eric Verdin et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

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Article Hematology

Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis

Thor Ueland et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

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Article Cardiac & Cardiovascular Systems

Heat-shock protein 90: A novel autoantigen in human carotid atherosclerosis

Rita Businaro et al.

ATHEROSCLEROSIS (2009)

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Article Cardiac & Cardiovascular Systems

MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4

Yunhui Cheng et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

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Article Multidisciplinary Sciences

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

Ahmad M. Khalil et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Cardiac & Cardiovascular Systems

Diagnostic and Prognostic Significance of Plasma N-Terminal-Pro-Brain Natriuretic Peptide in Decompensated Heart Failure with Preserved Ejection Fraction

Biju Paul et al.

HEART LUNG AND CIRCULATION (2008)

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Article Multidisciplinary Sciences

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

Eva van Rooij et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Review Oncology

PTEN, more than the AKT pathway

Carmen Blanco-Aparicio et al.

CARCINOGENESIS (2007)

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Article Medicine, General & Internal

Trends in prevalence and outcome of heart failure with preserved ejection fraction

Theophilus E. Owan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

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Article Cardiac & Cardiovascular Systems

Pathogenesis of atherosclerosis

E Falk

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)

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Review Oncology

Multiple roles of α-smooth muscle actin in mechanotransiduction

JX Wang et al.

EXPERIMENTAL CELL RESEARCH (2006)

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Review Cardiac & Cardiovascular Systems

The role of natriuretic peptides in cardioprotection

T Nishikimi et al.

CARDIOVASCULAR RESEARCH (2006)

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Article Pathology

Immunohistochemical expression of activated caspase-3 in human myocardial infarction

N Zidar et al.

VIRCHOWS ARCHIV (2006)

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Article Cardiac & Cardiovascular Systems

Myocardial ischemia and reperfusion injury

LM Buja

CARDIOVASCULAR PATHOLOGY (2005)

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Review Pharmacology & Pharmacy

Oxidative stress-elicited myocardial apoptosis during reperfusion

ZQ Zhao

CURRENT OPINION IN PHARMACOLOGY (2004)

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Review Biochemistry & Molecular Biology

Role of reactive oxygen species in ischemic preconditioning of subcellular organelles in the heart

HK Saini et al.

ANTIOXIDANTS & REDOX SIGNALING (2004)

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Article Cardiac & Cardiovascular Systems

Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction - The Framingham Heart Study

RS Vasan et al.

CIRCULATION (2003)

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Review Physiology

Cardiac hypertrophy: The good, the bad and the ugly

N Frey et al.

ANNUAL REVIEW OF PHYSIOLOGY (2003)

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Article Cardiac & Cardiovascular Systems

Fundamentals of reperfusion injury for the clinical cardiologist

S Verma et al.

CIRCULATION (2002)

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Review Multidisciplinary Sciences

New ideas about atrial fibrillation 50 years on

S Nattel

NATURE (2002)

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Article Multidisciplinary Sciences

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

RK Bruick

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Article Cell & Tissue Engineering

The role of MCP-1 in atherosclerosis

JR Harrington

STEM CELLS (2000)

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