4.7 Article

Inhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, Research & Experimental

Advances in energy metabolism in renal fibrosis

Xuejiao Wei et al.

Summary: Renal fibrosis is a common precursor to chronic kidney disease, and metabolic reprogramming is closely related to renal fibrosis. Targeted therapies for specific metabolic pathways are expected to be the next generation of treatments for renal fibrosis.

LIFE SCIENCES (2023)

Article Cell Biology

Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-(3 signaling and fibrosis

Shu Yang et al.

Summary: This study identifies the role of KLF13 in regulating TGF-(3 signaling and fibrosis. KLF13 recruits a repressor complex to the target genes of TGF-(3, limiting its fibrotic effects. However, persistent activation of TGF-(3 signaling reduces KLF13 levels through degradation and transcriptional inhibition mechanisms, offsetting the anti-fibrotic effect of KLF13.

CELL REPORTS (2023)

Review Biochemistry & Molecular Biology

Kidney fibrosis: from mechanisms to therapeutic medicines

Rongshuang Huang et al.

Summary: Chronic kidney disease (CKD) affects 10-14% of the global population, and kidney fibrosis is a hallmark manifestation of progressive CKD. However, there are currently no antifibrotic therapies available for CKD. Understanding the complex interplay between injured parenchyma and non-parenchymal cell lineages in the fibrotic niche, as well as the role of genetics and epigenetics, has shed light on the mechanisms of kidney fibrosis. Recent advancements in single-cell technology have helped answer key questions about profibrotic renal tubules, myofibroblast origins, immune cell involvement, and cell communication. Additionally, the reversible nature of epigenetic changes offers potential therapeutic strategies to halt or reverse kidney fibrosis. Developing biomarkers and antifibrotic treatments for CKD are also important areas of research.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Review Biochemistry & Molecular Biology

Effects of Isorhamnetin on Diabetes and Its Associated Complications: A Review of In Vitro and In Vivo Studies and a Post Hoc Transcriptome Analysis of Involved Molecular Pathways

Feten Zar Kalai et al.

Summary: Diabetes mellitus, especially type 2 (T2DM), is a global public health problem. Isorhamnetin, a plant flavonoid, has been studied for its potential anti-diabetic effects. It has been shown to reduce glucose levels, improve oxidative status, alleviate inflammation, and modulate lipid metabolism and adipocyte differentiation by regulating signaling pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Urology & Nephrology

Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease

Judy Baek et al.

Summary: Dyslipidaemia is a hallmark of chronic kidney disease (CKD), with insights from lipidomics studies suggesting that alterations in free fatty acid partitioning may contribute to CKD progression.

NATURE REVIEWS NEPHROLOGY (2022)

Article Biotechnology & Applied Microbiology

Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis

Mengling Wang et al.

Summary: This study demonstrates that ceria nanoparticles (CeNP-PEG) can potentially be used as a therapeutic option for renal fibrosis by modulating metabolic status and protecting mitochondrial function.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Endocrinology & Metabolism

PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease

Zongwei Zhang et al.

Summary: Glycolysis dysfunction is an important mechanism of podocyte injury in diabetic kidney disease (DKD). Cytoskeletal remodeling is related to foot process fusion of podocytes, but its connection with alterations of glycolysis in DKD has not been clarified.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Urology & Nephrology

Protein phosphatase 2Aca modulates fatty acid oxidation and glycolysis to determine tubular cell fate and kidney injury

Mengru Gu et al.

Summary: This study reveals that PP2Ac alpha is upregulated in damaged tubular cells in acute or chronic kidney injury, leading to suppression of fatty acid oxidation and promotion of glycolysis, resulting in cell death and fibrosis. PP2Ac alpha may serve as a promising therapeutic target for kidney injury.

KIDNEY INTERNATIONAL (2022)

Review Urology & Nephrology

Immunometabolic rewiring of tubular epithelial cells in kidney disease

Sanne van der Rijt et al.

Summary: Kidney tubular epithelial cells play a crucial role in the response to kidney injury and repair, and their metabolic abnormalities may contribute to kidney disease. Receptors of the innate immune system regulate the metabolic processes of these cells, and the interplay between immunometabolism and kidney health should be taken into consideration.

NATURE REVIEWS NEPHROLOGY (2022)

Article Nutrition & Dietetics

The mitigative effect of isorhamnetin against type 2 diabetes via gut microbiota regulation in mice

Jinjun Li et al.

Summary: The study demonstrates that isorhamnetin improves the symptoms of type 2 diabetes mellitus in mice, possibly through the mediation of gut microbiota. The gut microbiota is found to be significantly correlated with inflammatory factors, blood lipids, and short chain fatty acids.

FRONTIERS IN NUTRITION (2022)

Article Medicine, Research & Experimental

Dietary Restriction and Medical Therapy Drives PPARα-Regulated Improvements in Early Diabetic Kidney Disease in Male Rats

William Patrick Martin et al.

CLINICAL SCIENCE (2022)

Article Nutrition & Dietetics

Dietary Isorhamnetin Intake Is Associated with Lower Blood Pressure in Coronary Artery Disease Patients

Joanna Popiolek-Kalisz et al.

Summary: This study revealed a correlation between long-term dietary isorhamnetin intake and SBP values in coronary artery disease patients, especially in male participants. Specific food intake analysis indicated that consumption of onions, tomatoes, and blueberries could impact blood pressure values.

NUTRIENTS (2022)

Review Pharmacology & Pharmacy

Metabolic reprogramming: A novel therapeutic target in diabetic kidney disease

Mengdi Wang et al.

Summary: Diabetic kidney disease (DKD) is a common complication of diabetes mellitus, but its pathogenesis is poorly understood. Metabolic reprogramming plays a critical role in the development of DKD, and understanding its role may lead to new therapeutic approaches.

FRONTIERS IN PHARMACOLOGY (2022)

Article Multidisciplinary Sciences

PKM2 promotes pulmonary fibrosis by stabilizing TGF-beta 1 receptor I and enhancing TGF-beta 1 signaling

Shaoyan Gao et al.

Summary: Our study demonstrates that PKM2 promotes fibrosis progression by interacting with Smad7 and enhancing TGF-beta 1 signaling. Increased expression of PKM2 in the lungs of mice with pulmonary fibrosis contributes to fibrosis development. The PKM2 tetramer enhances TGF-beta 1 signaling by directly binding with Smad7, making it a key factor in fibrosis progression.

SCIENCE ADVANCES (2022)

Article Chemistry, Medicinal

Agathis robusta Bark Extract Protects from Renal Ischemia-Reperfusion Injury: Phytochemical, In Silico and In Vivo Studies

Maged E. Mohamed et al.

Summary: In this study, the chemical composition of ARBE was identified and the interaction between the major components of ARBE and RIRI-related targets was investigated using network pharmacology. The experimental results demonstrated the nephroprotective effect of ARBE in a rat model of RIRI.

PHARMACEUTICALS (2022)

Article Endocrinology & Metabolism

The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation

Haijie Liu et al.

Summary: Activation of PKM2 can prevent kidney fibrosis by suppressing the EMT program and aberrant glycolysis, offering a potential target for mitigating fibrosis in diabetic kidneys.

JOURNAL OF DIABETES INVESTIGATION (2021)

Article Medicine, Research & Experimental

New insight into the role of isorhamnetin as a regulator of insulin signaling pathway in type 2 diabetes mellitus rat model: Molecular and computational approach

Marwa Matboli et al.

Summary: The study showed that isorhamnetin (IHN) can ameliorate insulin resistance in type 2 diabetes by reducing the expression of m-TOR, IGF1-R, and LncRNA-RP11773H22.4, while increasing the expression of AKT2 mRNA, miR-1, and miR-3163.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cell Biology

KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease

Yutaro Mori et al.

Summary: Tubulointerstitial abnormalities can predict the progression of diabetic kidney disease, with KIM-1 playing a crucial role in this process. Targeting KIM-1 could be a potential therapeutic approach to alleviate renal damage.

CELL METABOLISM (2021)

Article Cell Biology

Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway

Yuqin Wu et al.

Summary: This study found that isorhamnetin can alleviate diabetes-exacerbated ischemia/reperfusion-induced brain injury by modulating the Akt/SIRT1/Nrf2/HO-1 signaling pathway, inhibiting cell apoptosis, inflammatory response, and oxidative stress.

INFLAMMATION (2021)

Article Cell Biology

CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys

Yanjuan Hou et al.

Summary: In diabetic nephropathy, CD36 mediates ROS production that enhances NLRP3 inflammasome activation, leading to IL-1 beta secretion and cell apoptosis. Inhibition of CD36 protects mice from tubulointerstitial inflammation and tubular epithelial cell apoptosis.

CELL DEATH & DISEASE (2021)

Review Cell Biology

Signaling Pathways Involved in Diabetic Renal Fibrosis

Yuqing Zhang et al.

Summary: The review discusses the pathological mechanisms of diabetic renal fibrosis and related signaling pathways to provide novel therapeutic intervention insights for clinical research.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Isorhamnetin, the xanthine oxidase inhibitor from Sophora japonica, ameliorates uric acid levels and renal function in hyperuricemic mice

Fuqi Wang et al.

Summary: The study discovered that isorhamnetin (IRh) from Sophora japonica effectively reduces serum UA levels and alleviates renal injury by inhibiting XOD activity. IRh may function as a therapeutic drug and dietary supplement to treat hyperuricemia.

FOOD & FUNCTION (2021)

Article Clinical Neurology

Dietary flavonols and risk of Alzheimer dementia

Thomas M. Holland et al.

NEUROLOGY (2020)

Article Oncology

PFKP is highly expressed in lung cancer and regulates glucose metabolism

Jianfei Shen et al.

CELLULAR ONCOLOGY (2020)

Review Medicine, Research & Experimental

Isorhamnetin: A review of pharmacological effects

Gang Gong et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Biochemistry & Molecular Biology

Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis

Rongbin Zheng et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Pharmacology & Pharmacy

Targeting renal fibrosis: Mechanisms and drug delivery systems

Madalina V. Nastase et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Article Urology & Nephrology

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

Mardiana Lee et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Review Endocrinology & Metabolism

Tubulointerstitial Biomarkers for Diabetic Nephropathy

Bancha Satirapoj

JOURNAL OF DIABETES RESEARCH (2018)

Article Cell Biology

SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis

Swayam Prakash Srivastava et al.

CELL DEATH & DISEASE (2018)

Article Medicine, General & Internal

Chronic kidney disease

Paola Romagnani et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Urology & Nephrology

Diagnosis and Management of Type 2 Diabetic Kidney Disease

Simit M. Doshi et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Review Urology & Nephrology

TGF-β: the master regulator of fibrosis

Xiao-ming Meng et al.

NATURE REVIEWS NEPHROLOGY (2016)

Article Biochemistry & Molecular Biology

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

Carol Kilkenny et al.

PLOS BIOLOGY (2010)

Article Medicine, Research & Experimental

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

JC Leemans et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Review Biochemistry & Molecular Biology

Mechanisms of TGF-β signaling from cell membrane to the nucleus

YG Shi et al.