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Advancements in the pathogenesis of hepatic osteodystrophy and the potential therapeutic of mesenchymal stromal cells

STEM CELL RESEARCH & THERAPY (2023)

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Article Gastroenterology & Hepatology

IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease

Jiwoon Park et al.

Summary: In this study, a human pluripotent stem cell-derived liver culture model was used to investigate the underlying mechanisms of the rs738409 C>G single nucleotide polymorphism (SNP) in susceptibility to non-alcoholic fatty liver disease (NAFLD). The study found that the I148M variant associated with rs738409 was involved in the development of NAFLD by enhancing IL-6/STAT3 activity. This study reveals a potential causal link between elevated IL-6/STAT3 activity and 148M-mediated susceptibility to NAFLD.

JOURNAL OF HEPATOLOGY (2023)

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Review Gastroenterology & Hepatology

Loss of liver function in chronic liver disease: An identity crisis

Carmen Berasain et al.

Summary: The identity of adult hepatocytes is established during embryonic development and regulated after birth. Transcription factors and pre-mRNA splicing regulators play a crucial role in defining the transcriptome, which determines the complex functions of the liver. Persistent downregulation of key identity genes is a major factor in chronic liver disease and organ dysfunction. Therefore, understanding the disruption of core transcription factors and splicing regulators in diseased hepatocytes is clinically important.

JOURNAL OF HEPATOLOGY (2023)

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Review Gastroenterology & Hepatology

Global epidemiology of cirrhosis - aetiology, trends and predictions

Daniel Q. Huang et al.

Summary: Cirrhosis is a major cause of morbidity and mortality in people with chronic liver disease globally. The epidemiology and burden of cirrhosis are changing due to factors such as obesity, alcohol consumption, and improved management of viral hepatitis. This review highlights global trends in cirrhosis epidemiology, the contributions of various liver diseases, and suggests ways to tackle the increasing burden of cirrhosis.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2023)

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Review Gastroenterology & Hepatology

Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis

Gabriel Mezzano et al.

Summary: The study revealed high global prevalence and mortality rates of ACLF, with regional variations possibly explained by triggers/aetiology of CLD or grade.

GUT (2022)

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Article Gastroenterology & Hepatology

Global burden of NAFLD and chronic liver disease among adolescents and young adults

James M. Paik et al.

Summary: The study found that the prevalence and mortality rates of chronic liver disease (CLD) have increased among adolescents and young adults aged 15-29, driven primarily by non-alcoholic fatty liver disease (NAFLD). Meanwhile, the proportion of hepatitis B virus (HBV) cases decreased across all age groups, highlighting a shift in the causes of CLD among the younger population.

HEPATOLOGY (2022)

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Article Biochemistry & Molecular Biology

PLGA-Based Composites for Various Biomedical Applications

Catia Vieira Rocha et al.

Summary: This review focuses on the combination of PLGA with different inorganic nanomaterials to overcome the limitations of the polymer and expand its applications in the field of nanomedicine. The physicochemical properties of these nanocomposites and various synthesis methods are discussed, along with recent progress in their design and biomedical applications, providing a framework for future research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Immunology

TNF in the liver: targeting a central player in inflammation

Gisa Tiegs et al.

Summary: Tumour necrosis factor-alpha (TNF) is a multifunctional cytokine that plays important roles in immunopathogenesis and liver functions. Targeting TNF signalling through anti-TNF therapies could be a potential treatment for TNF-related diseases.

SEMINARS IN IMMUNOPATHOLOGY (2022)

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Article Cell Biology

Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression

Ke Lu et al.

Summary: Hepatic osteodystrophy (HOD) is a metabolic bone disease associated with chronic liver disease. Upregulation of the phosphatase PP2Aca in the liver during HOD leads to downregulation of hepatokine lecithin-cholesterol acyltransferase (LCAT). Loss of LCAT function exacerbates bone loss in HOD mice. Cholesterol levels play a role in the regulation of osteoblast and osteoclast activities. LCAT improves liver function and reduces liver fibrosis in the HOD mouse model by promoting cholesterol transport from bone to liver.

CELL METABOLISM (2022)

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Editorial Material Cell Biology

Reverse cholesterol transport and hepatic osteodystrophy

Mone Zaidi et al.

Summary: In this study, Lu et al. reveal that chronic liver disease enhances the expression and activity of PP2Ac, leading to decreased excretion of LCAT. The reduced LCAT levels contribute to hepatic osteodystrophy (HOD) and worsen liver fibrosis. These findings suggest the potential use of recombinant LCAT as a treatment for HOD and liver fibrosis.

CELL METABOLISM (2022)

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Article Nutrition & Dietetics

Soy-whey dual-protein alleviates osteoporosis of ovariectomized rats via regulating bone fat metabolism through gut-liver-bone axis

Jingjie Zhang et al.

Summary: The study demonstrates that dual-protein (DP) intervention could significantly improve osteoporosis by regulating bone marrow adipose tissue content and mesenchymal stem cell lineage differentiation. DP supplementation led to improvements in bone mineral density, bone microstructure, and bone biomechanics in ovariectomized rats. The intervention also resulted in decreased levels of serum osteocalcin and parathyroid hormone, reduced bone marrow adipocytes, increased osteoblasts, and elevated expression of osteoprotegerin. The analysis of fecal metabolites and intestinal microbiota revealed significant changes, indicating the involvement of fat metabolism-related molecules and bacterial taxa. These findings suggest that the interaction between intestinal microbiota and metabolites may mediate the effect of DP intervention.

NUTRITION (2022)

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Review Cell & Tissue Engineering

The assessment of mesenchymal stem cells therapy in acute on chronic liver failure and chronic liver disease: a systematic review and meta-analysis of randomized controlled clinical trials

Yuwei Liu et al.

Summary: This systematic review and meta-analysis suggest that MSCs therapy has potential efficacy in improving liver function in patients with chronic liver disease. It was found to improve MELD scores, albumin levels, and coagulation function, but had no significant effects on survival rate and aminotransferase levels. MSCs therapy showed therapeutic effects in patients with both acute on chronic liver failure and cirrhosis, and had a similar efficacy between BM-MSCs and UC-MSCs treatment. The therapy was generally safe with only fever as a reported adverse event.

STEM CELL RESEARCH & THERAPY (2022)

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Article Engineering, Biomedical

Natural Plant Tissue with Bioinspired Nano Amyloid and Hydroxyapatite as Green Scaffolds for Bone Regeneration

Yuzhou Li et al.

Summary: Bone defects are a growing problem worldwide, and traditional bone substitutes have limitations due to their limited resources and biosafety concerns. Plant-based scaffolds are being studied as an environmentally friendly alternative, but their bioinertia to mammalian cells hampers bone regeneration. This study proposes a novel concept of a plant bone substitute that involves coating decellularized plants with nano amyloids and nano hydroxyapatites, facilitating the connection between plant scaffolds and animal tissue regeneration. The natural microporosity of plants guides the alignment of mammalian cells and the bioactive nano amyloids drastically improve cell adhesion, viability, and proliferation. Furthermore, nano-hydroxyapatite crystals deposited on the amyloid promote osteogenic differentiation. In vivo experiments demonstrate successful trabeculae regeneration in the scaffold. This hierarchical design harnesses the unique microstructure of natural plants and the high bioactivity of the nano amyloid/hydroxyapatite coatings, providing an abundant resource for bone substitutes. Additionally, plant materials functionalized with these coatings have potential applications in tissue engineering and biomedical fields beyond bone regeneration.

ADVANCED HEALTHCARE MATERIALS (2022)

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Review Cell & Tissue Engineering

Mesenchymal stromal cells: promising treatment for liver cirrhosis

Lichao Yao et al.

Summary: Liver fibrosis is a wound-healing process characterized by excessive buildup of scar tissue within the liver. It can be caused by various factors, including lipid deposition, drugs, viruses, and autoimmune reactions. Mesenchymal stromal cells (MSCs) have shown promise in repairing liver injury and promoting liver regeneration through cell migration, immune regulation, hepatogenic differentiation, and paracrine mechanisms.

STEM CELL RESEARCH & THERAPY (2022)

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Review Cell & Tissue Engineering

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Simona Bolamperti et al.

Summary: Bone remodeling is a continuous cellular process that replaces old and damaged bone with new bone on the same surface. Recent research has shown that all bone cells participate in bone remodeling by interacting with their progenitors, other cells, and bone matrix constituents at different differentiation stages.

BONE RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Boron-doped Biphasic Hydroxyapatite/β-Tricalcium Phosphate for Bone Tissue Engineering

Ahmet Engin Pazarceviren et al.

Summary: The study found that boron-doped hydroxyapatite/tricalcium phosphates (BHTs) demonstrated optimized structural and bioactive properties, making them suitable for composite bone tissue constructs.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Sex-specific effects of 17 beta-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ER alpha and ER beta and require palmitoylation to translocate the receptors to the plasma membrane

D. Joshua Cohen et al.

Summary: Rat costochondral cartilage growth plate chondrocytes exhibit cell sex-specific responses to 17 beta-estradiol (E-2), testosterone, and dihydrotestosterone (DHT). Mechanistically, E-2 and DHT stimulate proliferation and extracellular matrix synthesis through protein kinase C (PKC) and phospholipase C (PLC). The study found that E-2 and DHT promote chondrocyte differentiation via the ability of androgen receptors (ARs) and estrogen receptors (ERs) to form a complex.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

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Review Cell Biology

Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis

Yuhe Jiang et al.

Summary: Osteoporosis is a systemic metabolic bone disease characterized by bone loss and microstructural degeneration, leading to increasing personal and societal costs. MSC transplantation shows promising potential in treating osteoporosis, but issues such as safety, transplant efficiency, and standardization of the manufacturing process need to be addressed. Comprehensive evaluation of clinical trials is essential for clinical translation of MSC therapy for osteoporosis.

CELL PROLIFERATION (2021)

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Review Cell & Tissue Engineering

Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy

Mauro Krampera et al.

Summary: MSCs have shown exceptional safety in clinical trials, but reliable potency assays to predict their immunosuppressive efficacy are still lacking. They are approved for certain diseases in Japan and Europe, but not in the United States. Researchers discuss potential mechanisms of action, experimental models, and approaches for identifying MSC effects in vivo.

CELL STEM CELL (2021)

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Review Biochemistry & Molecular Biology

Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment

Xiao-Yu He et al.

Summary: Osteoporosis is a severe public health concern among the elderly and postmenopausal adults, with related fractures posing a major cause of morbidity and mortality. Emerging technologies for treating osteoporosis, such as mesenchymal stem cells, exosomes, and biomimetic materials, have received increasing research attention and shown significant progress in reconstruction and repair of bones affected by osteoporosis-related fractures.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2021)

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Review Endocrinology & Metabolism

Discovery of the RANKL/RANK/OPG system

Hisataka Yasuda

Summary: Discovery of RANKL has led to significant advancements in osteoimmunology, development of denosumab as a clinically available treatment for osteoporosis and cancer-induced bone diseases. The RANKL/RANK/OPG system plays a pivotal role in osteoclast differentiation and function, with potential applications in cancer treatment discussed.

JOURNAL OF BONE AND MINERAL METABOLISM (2021)

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Article Cell Biology

Cabbage-derived three-dimensional cellulose scaffold-induced osteogenic differentiation of stem cells

Ali Salehi et al.

Summary: The study investigated the characteristics of decellularized cabbage leaves and their potential for promoting bone differentiation, as demonstrated by enhanced osteogenic differentiation of BM-MSCs on the scaffold. These results suggest that decellularized cabbage leaves have great potential for tissue engineering applications in bone regeneration.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Review Physiology

BONEMETASTASIS: MECHANISMS, THERAPIES, AND BIOMARKERS

Philippe Clezardin et al.

Summary: Skeletal metastases are common complications of many cancers, significantly impacting patients' quality of life. The multistage process of bone metastasis involves various cellular and molecular mechanisms. While existing bone-targeted agents have made progress, further research and more effective treatment options are still needed.

PHYSIOLOGICAL REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Management of Osteoporosis in Men: A Narrative Review

Fabio Vescini et al.

Summary: Male osteoporosis is often underdiagnosed, leading to undertreatment and higher morbidity and mortality compared to female patients. Understanding the differences in bone health between genders is crucial for effective management and prevention of osteoporotic fractures in men.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Multidisciplinary

The role of natural polymers in bone tissue engineering

Linqi Guo et al.

Summary: Bone is a dynamic self-healing organ with continuous remodeling, but surgical interventions and bone substitutes are needed for repairing large traumatic injuries. Bone tissue engineering aims to repair and regenerate tissues, with natural polymers like collagen and chitosan widely used in the field.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Biomedical

Matrix stiffening by self-mineralizable guided bone regeneration

Jing Li et al.

Summary: This study developed a self-mineralization strategy by covalently conjugating polyacrylic acid on Bio-Gide? membranes, enhancing mineralization and promoting bone regeneration. Experimental results showed that HBG underwent progressive mineralization in vivo, increased stiffness, and stimulated osteogenic differentiation of MSCs to expedite in-situ bone regeneration.

ACTA BIOMATERIALIA (2021)

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Review Oncology

Challenges and advances in clinical applications of mesenchymal stromal cells

Tian Zhou et al.

Summary: MSC therapy for clinical applications faces challenges due to inconsistent criteria for MSCs identity and their inherited heterogeneity. Strategies have been developed to overcome these challenges with the emergence of advanced biological techniques and substantial improvements in bio-engineered materials.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Rheumatology

Characterization and Function of Tumor Necrosis Factor and Interleukin-6-Induced Osteoclasts in Rheumatoid Arthritis

Kazuhiro Yokota et al.

Summary: The study demonstrated that TNF and IL-6-induced osteoclasts have the ability to absorb bone matrix, potentially contributing to the pathology of inflammatory arthritis associated with joint destruction, such as RA. The expression levels of proinflammatory cytokines were significantly increased in TNF and IL-6-induced osteoclasts, but not in RANKL-induced osteoclasts. The number of TNF and IL-6-induced osteoclasts correlated positively with the mTSS in RA patients, while RANKL-induced osteoclast numbers correlated negatively with the whole-body BMD of the same patients.

ARTHRITIS & RHEUMATOLOGY (2021)

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Article Multidisciplinary Sciences

Mesenchymal stromal cell apoptosis is required for their therapeutic function

Swee Heng Milon Pang et al.

Summary: Multipotent mesenchymal stromal cells (MSCs) have therapeutic benefits in preclinical models, with their apoptosis and immunosuppressive effects playing a crucial role in reducing disease severity and highlighting implications for cell-based therapies.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

3D Cartilage Regeneration With Certain Shape and Mechanical Strength Based on Engineered Cartilage Gel and Decalcified Bone Matrix

Zheng Ci et al.

Summary: By combining cartilage sheets and decalcified bone matrix, viable 3D cartilage with controlled shape and mechanical strength was successfully regenerated, demonstrating good biocompatibility and mechanical properties.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Sustained release of epigallocatechin-3-gallate from chitosan-based scaffolds to promote osteogenesis of mesenchymal stem cell

Jin Wang et al.

Summary: In this study, EGCG-loaded chitosan nanoparticles (ECN) were entrapped into chitosan/alginate (CS/Alg) scaffolds to improve the bioavailability of EGCG. The CS/Alg-ECN scaffolds continuously released EGCG for up to 16 days and promoted osteoblast differentiation through activating the Wnt/beta-catenin signaling pathway. This strategy demonstrates promise in promoting osteogenesis of MSCs.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Engineering, Biomedical

Recent advances in PLGA-based biomaterials for bone tissue regeneration

Shue Jin et al.

Summary: Bone regeneration is a complex interdisciplinary field that involves materials science, biomechanics, immunology, and biology. PLGA, with its good biocompatibility and adjustable biodegradability, has been widely used in bone tissue engineering. This review systematically covers the past and recent advances in developing PLGA-based bone regeneration materials, focusing on different application forms, advantages, and disadvantages.

ACTA BIOMATERIALIA (2021)

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Review Immunology

Role of interleukin-6 in bone destruction and bone repair in rheumatoid arthritis

Tsutomu Takeuchi et al.

Summary: Rheumatoid arthritis is a common inflammatory form of arthritis closely associated with bone-related cells and inflammatory cytokines. Inhibition of disease progression and joint destruction has become an important clinical goal in the treatment of RA. Recent studies have shown that drug intervention targeting proinflammatory cytokines like IL-6 can not only suppress bone and joint destruction, but also promote bone repair.

AUTOIMMUNITY REVIEWS (2021)

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Article Engineering, Biomedical

In-vitro assessment of β-tricalcium phosphate/bredigite-ciprofloxacin (CPFX) scaffolds for bone treatment applications

Foroogh Mofid Nakhaee et al.

Summary: This study investigated the impact of bredigite content on the structure, mechanical properties, in vitro bioactivity, and cell viability of beta-tricalcium phosphate (beta-TCP) scaffolds. Results showed that scaffolds with 20% bredigite exhibited improved compressive strength and better bioactivity compared to scaffolds with 10% bredigite. Additionally, the release kinetics of ciprofloxacin (CPFX) loaded beta-TCP/bredigite composites and antibacterial properties were studied, indicating that scaffolds containing 1%-3% CPFX had higher cell viability and antibacterial activity, making them potential candidates for bone infection treatment.

BIOMEDICAL MATERIALS (2021)

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Article Cell Biology

Scara3 regulates bone marrow mesenchymal stem cell fate switch between osteoblasts and adipocytes by promoting Foxo1

Peng Chen et al.

Summary: The study found that Scara3 is positively correlated with osteogenic-related genes, with its expression gradually decreasing during adipogenesis and increasing during osteogenesis in BMSCs. Deletion of Scara3 favored adipogenesis over osteogenesis, while overexpression of Scara3 significantly enhanced osteogenesis at the expense of adipogenesis. Mechanistically, Scara3 controls cell fate by promoting Foxo1 expression and autophagy flux.

CELL PROLIFERATION (2021)

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Article Biochemistry & Molecular Biology

Piezoelectric Microvibration Mitigates Estrogen Loss-Induced Osteoporosis and Promotes Piezo1, MicroRNA-29a, and Wnt3a Signaling in Osteoblasts

Re-Wen Wu et al.

Summary: This study found that 120 Hz piezoelectric microvibration stimulation intervention improved bone health in ovariectomized mice, reducing conditions like bone mineral density loss and trabecular microstructure deterioration. PMVS intervention promoted Piezo1, miR-29a, and Wnt signaling to enhance osteogenic activity and delay loss in bone mass and microstructure caused by estrogen deficiency.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy

Yu Fu et al.

Summary: Research has shown that mesenchymal stem cell transplantation plays a critical role in therapy, with apoptotic extracellular vesicles being key for intercellular communication and therapeutic efficacy.

CELL DEATH & DISEASE (2021)

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Review Cell & Tissue Engineering

Systemic therapy of MSCs in bone regeneration: a systematic review and meta-analysis

Jingfei Fu et al.

Summary: This study systematically reviewed the systemic therapy of MSCs for bone regeneration in preclinical experiments and found that it significantly increased bone mineral density, bone volume to tissue volume ratio, and the percentage of new bone area. Systemic treatment showed better results in bone loss caused by systemic disease.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling

Yulin He et al.

Summary: The transplantation of hUC-MSCs can improve liver function, degree of fibrosis, and liver damage in rats with ACLI or ACLF, likely mediated by inhibiting Notch signaling and reversing the imbalance of the Stat1/Stat3 pathway.

STEM CELL RESEARCH & THERAPY (2021)

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Article Biochemistry & Molecular Biology

LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss

Fei Liu et al.

Summary: The knockdown of LRRc17 rejuvenated senescent BMSCs and enhanced their therapeutic efficacy in osteoporosis by activating autophagy.

REDOX BIOLOGY (2021)

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Article Medicine, Research & Experimental

IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis

Anais Levescot et al.

Summary: The study reveals that IL-1 beta contributes to autoimmune arthritis by inducing osteoclastogenic capacity in Tregs, leading to bone erosion.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Medicine, Research & Experimental

New Frontiers in Osteoporosis Therapy

Cheng Cheng et al.

ANNUAL REVIEW OF MEDICINE, VOL 71, 2020 (2020)

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Article Endocrinology & Metabolism

Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition

Robert B. Conley et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

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Review Gastroenterology & Hepatology

The gut-liver axis in liver disease: Pathophysiological basis for therapy

Agustin Albillos et al.

JOURNAL OF HEPATOLOGY (2020)

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Review Engineering, Biomedical

Four-dimensional bioprinting: Current developments and applications in bone tissue engineering

Zhuqing Wan et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

β-tricalcium phosphate and octacalcium phosphate composite bioceramic material for bone tissue engineering

Xinxin Ding et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2020)

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Review Materials Science, Biomaterials

Role of nanofibers on MSCs fate: Influence of fiber morphologies, compositions and external stimuli

Ragavi Rajasekaran et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Multidisciplinary Sciences

Seasonal changes of circulating 25-hydroxyvitamin D correlate with the lower gut microbiome composition in inflammatory bowel disease patients

Katarina Soltys et al.

SCIENTIFIC REPORTS (2020)

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Review Cell Biology

Crosstalk between the growth hormone/insulin-like growth factor-1 axis and the gut microbiome: A new frontier for microbial endocrinology

Elizabeth A. Jensen et al.

GROWTH HORMONE & IGF RESEARCH (2020)

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Review Endocrinology & Metabolism

Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

Babak Arjmand et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Article Engineering, Biomedical

A modular design strategy to integrate mechanotransduction concepts in scaffold-based bone tissue engineering

Ali Entezari et al.

ACTA BIOMATERIALIA (2020)

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Article Cell & Tissue Engineering

Stem cell homing: From physiology to therapeutics

Jane L. Liesveld et al.

STEM CELLS (2020)

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Review Cell & Tissue Engineering

Molecular mechanosensors in osteocytes

Lei Qin et al.

BONE RESEARCH (2020)

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Article Engineering, Biomedical

Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect

Yuxiao Lai et al.

BIOMATERIALS (2019)

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Article Endocrinology & Metabolism

Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation

Fan Wang et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2019)

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Review Medicine, General & Internal

Osteoporosis

Juliet E. Compston et al.

LANCET (2019)

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Review Biochemistry & Molecular Biology

Hepatic OsteodystrophyMolecular Mechanisms Proposed to Favor Its Development

Sabrina Ehnert et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Nanoscience & Nanotechnology

Porous Se@SiO2 nanocomposite promotes migration and osteogenic differentiation of rat bone marrow mesenchymal stem cell to accelerate bone fracture healing in a rat model

Chunlin Li et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Engineering, Biomedical

Characterizing the impact of 2D and 3D culture conditions on the therapeutic effects of human mesenchymal stem cell secretome on corneal wound healing in vitro and ex vivo

Kaylene Carter et al.

ACTA BIOMATERIALIA (2019)

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Article Biochemistry & Molecular Biology

Biosynthesis of Silver nanoparticles using Bauhinia acuminate flower extract and their effect to promote osteogenesis of MSCs and improve meniscus injury healing

Dan Hu et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2019)

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Review Immunology

Interleukin-1 Family Cytokines: Keystones in Liver Inflammatory Diseases

Louise Barbier et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cell Biology

Prospect of mesenchymal stem cells in therapy of osteoporosis: A review

Leili Aghebati-Maleki et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Gastroenterology & Hepatology

Age and liver transplantation

Francois Durand et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Materials Science, Biomaterials

Scaffold strategies for modulating immune microenvironment during bone regeneration

Jianhua He et al.

Materials Science & Engineering C-Materials for Biological Applications (2019)

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Article Engineering, Biomedical

Multiple integrin ligands provide a highly adhesive and osteoinductive surface that improves selective cell retention technology

Keyu Luo et al.

ACTA BIOMATERIALIA (2019)

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Article Dentistry, Oral Surgery & Medicine

The effect of mesenchymal stem cells on osteoclast precursor cell differentiation

Takaharu Abe et al.

JOURNAL OF ORAL SCIENCE (2019)

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Review Biochemistry & Molecular Biology

Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment

Lifang Hu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Insulin-Like Growth Factor (IGF) System in Liver Diseases

Agnieszka Adamek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Cell & Tissue Engineering

CXCR4 Has the Potential to Enhance Bone Formation in Osteopenic Rats

Anita Sanghani et al.

TISSUE ENGINEERING PART A (2018)

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Article Multidisciplinary Sciences

Adipose mesenchymal stem cells from osteoporotic donors preserve functionality and modulate systemic inflammatory microenvironment in osteoporotic cytotherapy

Chen-Xi Zheng et al.

SCIENTIFIC REPORTS (2018)

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Article Endocrinology & Metabolism

Regulation of bone growth via ligand-specific activation of estrogen receptor alpha

Maryam Iravani et al.

JOURNAL OF ENDOCRINOLOGY (2017)

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Article Biochemistry & Molecular Biology

Enhanced osteogenesis of β-tricalcium phosphate reinforced silk fibroin scaffold for bone tissue biofabrication

Dae Hoon Lee et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Review Physiology

ESTROGENS AND ANDROGENS IN SKELETAL PHYSIOLOGY AND PATHOPHYSIOLOGY

Maria Almeida et al.

PHYSIOLOGICAL REVIEWS (2017)

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Review Cell & Tissue Engineering

The Promotional Effect of Mesenchymal Stem Cell Homing on Bone Tissue Regeneration

Qi Zhou et al.

CURRENT STEM CELL RESEARCH & THERAPY (2017)

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Article Pharmacology & Pharmacy

Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis In Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro

Chuandong Wang et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Review Biochemistry & Molecular Biology

Cellular and molecular mechanisms of alcohol-induced osteopenia

Zhenhua Luo et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

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Article Medicine, General & Internal

Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update From the American College of Physicians

Amir Qaseem et al.

ANNALS OF INTERNAL MEDICINE (2017)

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Article Biophysics

Synergetic effect of topological cue and periodic mechanical tension-stress on osteogenic differentiation of rat bone mesenchymal stem cells

Yao Liu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Endocrinology & Metabolism

Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model

A. Aversa et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2016)

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Article Gastroenterology & Hepatology

Prospective study of profile of hepatic osteodystrophy in patients with non-choleastatic liver cirrhosis and impact of bisphosphonate supplementation

Rinkesh Kumar Bansal et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2016)

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Article Medicine, Research & Experimental

Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics

Jau-Yi Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Review Endocrinology & Metabolism

Osteoporosis across chronic liver disease

M. Guarino et al.

OSTEOPOROSIS INTERNATIONAL (2016)

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Article Multidisciplinary Sciences

Gut microbiota induce IGF-1 and promote bone formation and growth

Jing Yan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Cell & Tissue Engineering

Systemic Mesenchymal Stromal Cell Transplantation Prevents Functional Bone Loss in a Mouse Model of Age-Related Osteoporosis

Jeffrey Kiernan et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

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Article Cell & Tissue Engineering

Allogeneic Mesenchymal Stem Cell Therapy Promotes Osteoblastogenesis and Prevents Glucocorticoid-Induced Osteoporosis

Bingdong Sui et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

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Review Cell Biology

Mesenchymal stem cells (MSCs) as skeletal therapeutics-an update

Hamid Saeed et al.

JOURNAL OF BIOMEDICAL SCIENCE (2016)

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Article Endocrinology & Metabolism

A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats

Ming Pei et al.

BONE (2015)

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Review Biotechnology & Applied Microbiology

Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy

Tan Li et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

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Article Medicine, General & Internal

Primary biliary cirrhosis

Elizabeth J. Carey et al.

LANCET (2015)

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Article Engineering, Biomedical

Mesenchymal stem cell and gelatin microparticle encapsulation in thermally and chemically gelling injectable hydrogels for tissue engineering

Stephanie N. Tzouanas et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

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Article Cell & Tissue Engineering

Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells or Their Conditioned Medium Prevents Bone Loss in Ovariectomized Nude Mice

Jee Hyun An et al.

TISSUE ENGINEERING PART A (2013)

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Article Engineering, Biomedical

The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats

Lei Cao et al.

BIOMATERIALS (2012)

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Article Cell Biology

Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures

Hui-Ting Chen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)

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Article Endocrinology & Metabolism

Osteoporosis After Transplantation

Carolina A. Moreira Kulak et al.

CURRENT OSTEOPOROSIS REPORTS (2012)

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Article Gastroenterology & Hepatology

Hepatic Osteodystrophy Is Common in Patients with Noncholestatic Liver Disease

N. S. Choudhary et al.

DIGESTIVE DISEASES AND SCIENCES (2011)

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Article Substance Abuse

Bone Mineral Density, Bone Turnover Markers and Cytokines in Alcohol-Induced Cirrhosis

Antonio Diez-Ruiz et al.

ALCOHOL AND ALCOHOLISM (2010)

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Article Cell Biology

Intra-bone marrow injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats

Natalia de Melo Ocarino et al.

CONNECTIVE TISSUE RESEARCH (2010)

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Article Gastroenterology & Hepatology

Low Bone Mass and Severity of Cholestasis Affect Fracture Risk in Patients With Primary Biliary Cirrhosis

Nuria Guanabens et al.

GASTROENTEROLOGY (2010)

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Article Biochemistry & Molecular Biology

Estrogen prevents bone loss via estrogen receptor α and induction of Fas ligand in osteoclasts

Takashi Nakamura et al.

CELL (2007)

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Article Cell & Tissue Engineering

Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors

Marek Honczarenko et al.

STEM CELLS (2006)

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Review Immunology

Posttransplantation bone disease

J Cunningham

TRANSPLANTATION (2005)

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Review Immunology

Chemokines: multiple levels of leukocyte migration control

B Moser et al.

TRENDS IN IMMUNOLOGY (2004)

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Article Cell & Tissue Engineering

Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells

N Ichioka et al.

STEM CELLS (2002)

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