Therapeutic effect of adipose-derived mesenchymal stem cells in a porcine model of abdominal sepsis

Article Cell & Tissue Engineering

Mesenchymal Stem Cells Attenuate Sepsis-associated Acute Kidney Injury by Changing the Balance of Th17 cells/Tregs via Gal-9/Tim-3

Congjuan Luo et al.

Summary: The study aimed to investigate the protective effect of MSCs on CLP-induced SA-AKI and determine the mechanisms. The results showed that MSCs relieved SA-AKI by inducing Tregs and inhibiting Th17 cells via the Gal-9/Tim-3 pathway.

CURRENT STEM CELL RESEARCH & THERAPY (2023)

添加到收藏夹

Review Oncology

Therapeutic potential of mesenchymal stromal/stem cells in critical-care patients with systemic inflammatory response syndrome

Gerardo-Javier Marti-Chillon et al.

Summary: Despite advancements in ICU patient care, the management of those with SIRS is still a medical challenge. The hyperinflammatory state caused by initial injury and uncontrolled response leads to systemic hypotension and organ failure. MSCs, with their immunomodulatory and regenerative properties, are being explored as a potential therapy for SIRS.

CLINICAL AND TRANSLATIONAL MEDICINE (2023)

添加到收藏夹

Article Medicine, General & Internal

A Porcine Sepsis Model With Numerical Scoring for Early Prediction of Severity

Attila Rutai et al.

Summary: The study aims to develop a standardized research protocol to reproducibly characterize the progression of sepsis-related events within clinically-relevant time frames.

FRONTIERS IN MEDICINE (2022)

添加到收藏夹

Review Immunology

Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome

Maria Eugenia Fernandez-Santos et al.

Summary: This article reviews the current applications of MSCs in cell-based therapies and analyzes the methods of manufacturing and handling these cells, including pre-conditioning, cell homing, immunomodulation, etc. It also provides guidelines for intermediate quality control according to European and US regulations.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Veterinary Sciences

Activated Mesenchymal Stromal Cell Therapy for Treatment of Multi-Drug Resistant Bacterial Infections in Dogs

Valerie Johnson et al.

Summary: The study demonstrated that activated canine MSC produce and secrete antimicrobial peptides which synergize with common antibiotics for rapid bactericidal activity. Activated canine MSC also showed enhanced migration to inflammatory stimuli and secretion of factors related to wound healing, fibroblast proliferation, and recruitment of activated neutrophils. Clinical studies in dogs with chronic multidrug-resistant infections treated by activated MSC showed significant clinical benefit in terms of infection clearance and tissue healing.

FRONTIERS IN VETERINARY SCIENCE (2022)

添加到收藏夹

Article Immunology

Sepsis causes neutrophil infiltration in muscle leading to muscle atrophy and weakness in mice

Nobuto Nakanishi et al.

Summary: Sepsis-induced muscle atrophy leads to long-term physical dysfunction, with muscle-localized neutrophils playing a critical role in this process. Depletion of neutrophils in muscle can reverse sepsis-induced muscle atrophy and weakness, suggesting a potential therapeutic target for sepsis-related muscle complications.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Cell & Tissue Engineering

Enforced mesenchymal stem cell tissue colonization counteracts immunopathology

David Garcia-Bernal et al.

Summary: Mesenchymal stem/stromal cells (MSCs) have immunoregulatory properties and can be used for the treatment of inflammatory conditions and immune diseases. Through a mouse model, it was found that adipose tissue-derived MSCs (HCELL+ MSCs) can effectively recruit to the affected tissue and exert protective effects on immunopathology, reducing leukocyte infiltration and inflammatory cytokine levels, and improving survival.

NPJ REGENERATIVE MEDICINE (2022)

添加到收藏夹

Article Immunology

Evaluating IL-6 and IL-10 as rapid diagnostic tools for Gram-negative bacteria and as disease severity predictors in pediatric sepsis patients in the intensive care unit

Yunyu Zhang et al.

Summary: The study aimed to explore the diagnostic performance of IL-6 and IL-10 in distinguishing Gram-positive and Gram-negative bacteria types and predicting disease severity in ICU hospitalized pediatric sepsis patients. The results showed that IL-6 and IL-10 levels were significantly elevated in Gram-negative sepsis and their combination indicators were effective in identifying Gram-negative sepsis. However, the differences in IL-6 and IL-10 levels between Gram-positive and Gram-negative sepsis were less significant in patients with progressively deteriorating organ function. IL-6 and IL-10 had a certain diagnostic efficacy in predicting Gram-negative sepsis and NPMODS.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Microbiology

Mechanism and Potential of Extracellular Vesicles Derived From Mesenchymal Stem Cells for the Treatment of Infectious Diseases

Jingyi You et al.

Summary: Extracellular vesicles (EVs) are nano-sized membrane vesicles secreted by cells, serving as a mediator for cell-to-cell communication. Mesenchymal stem cells-derived EVs (MSC-EVs) have shown therapeutic value in treating infectious diseases by eliminating pathogens, regulating immunity, and repairing tissue damage.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Emergency Medicine

Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis

Zhiwei Huang et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2020)

添加到收藏夹

Article Medicine, General & Internal

Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study

Kristina E. Rudd et al.

LANCET (2020)

添加到收藏夹

Article Immunology

Evaluation of Mesenchymal Stem Cell Therapy for Sepsis: A Randomized Controlled Porcine Study

Jan Horak et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Immunology

The IL-2-IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor

Jan Damoiseaux

CLINICAL IMMUNOLOGY (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Efficacy of mesenchymal stem cell therapy for sepsis: a meta-analysis of preclinical studies

Xue-Yi Sun et al.

STEM CELL RESEARCH & THERAPY (2020)

添加到收藏夹

Review Surgery

Intra-abdominal sepsis: new definitions and current clinical standards

A. Hecker et al.

LANGENBECKS ARCHIVES OF SURGERY (2019)

添加到收藏夹

Article Cell & Tissue Engineering

Bone marrow vs Wharton's jelly mesenchymal stem cells in experimental sepsis: a comparative study

Caroline Laroye et al.

STEM CELL RESEARCH & THERAPY (2019)

添加到收藏夹

Review Cell & Tissue Engineering

Concise Review: Mesenchymal Stromal Cells Anno 2019: Dawn of the Therapeutic Era?

Martin J. Hoogduijn et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

添加到收藏夹

Article Immunology

Dissecting Allo-Sensitization After Local Administration of Human Allogeneic Adipose Mesenchymal Stem Cells in Perianal Fistulas of Crohn's Disease Patients

Alvaro Avivar-Valderas et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs

Andreas Robert Rudolf Weiss et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Thawed Mesenchymal Stem Cell Product Shows Comparable Immunomodulatory Potency to Cultured Cells In Vitro and in Polymicrobial Septic Animals

Yuan Tan et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Cell & Tissue Engineering

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

Jacques Galipeau et al.

CELL STEM CELL (2018)

添加到收藏夹

Review Anatomy & Morphology

Elevated leukocyte count as a harbinger of systemic inflammation, disease progression, and poor prognosis: a review

P. P. Chmielewski et al.

FOLIA MORPHOLOGICA (2018)

添加到收藏夹

Article Surgery

The effect of mesenchymal stem cell use on intra-abdominal adhesions in a rat model

Gokhan Karaca et al.

ANNALS OF SURGICAL TREATMENT AND RESEARCH (2018)

添加到收藏夹

Article Critical Care Medicine

MINIMUM QUALITY THRESHOLD IN PRE-CLINICAL SEPSIS STUDIES (MQTiPSS): AN INTERNATIONAL EXPERT CONSENSUS INITIATIVE FOR IMPROVEMENT OF ANIMAL MODELING IN SEPSIS

Marcin F. Osuchowski et al.

SHOCK (2018)

添加到收藏夹

Article Critical Care Medicine

Diagnostic and Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Early and Late Phase of Sepsis

Rajnish Kaushik et al.

INDIAN JOURNAL OF CRITICAL CARE MEDICINE (2018)

添加到收藏夹

Article Surgery

Evaluation of the effects of adipose-derived mesenchymal stem cells on intraperitoneal adhesions

Erdal Uysal et al.

TURKISH JOURNAL OF SURGERY (2018)

添加到收藏夹

Review Critical Care Medicine

The Importance of Haemogram Parameters in the Diagnosis and Prognosis of Septic Patients

Alina Elena Orfanu et al.

JOURNAL OF CRITICAL CARE MEDICINE (2017)

添加到收藏夹

Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

T cell exhaustion and Interleukin 2 downregulation

Mumtaz Y. Balkhi et al.

CYTOKINE (2015)

添加到收藏夹

Article Emergency Medicine

Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study)

Massimo Sartelli et al.

WORLD JOURNAL OF EMERGENCY SURGERY (2015)

添加到收藏夹

Review Anesthesiology

Cell-based Therapy for Acute Organ Injury Preclinical Evidence and Ongoing Clinical Trials Using Mesenchymal Stem Cells

Antoine Monsel et al.

ANESTHESIOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Dietary modulation of the microbiome affects autoinflammatory disease

John R. Lukens et al.

NATURE (2014)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Role of Circulating Lymphocytes in Patients with Sepsis

Raul de Pablo et al.

BIOMED RESEARCH INTERNATIONAL (2014)

添加到收藏夹

Review Medical Laboratory Technology

Biomarkers of sepsis

James D. Faix

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2013)

添加到收藏夹

Article Physiology

Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes

Anna Krasnodembskaya et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Mesenchymal Stem Cells Attenuate Peritoneal Injury through Secretion of TSG-6

Nan Wang et al.

PLOS ONE (2012)

添加到收藏夹

Article Cell & Tissue Engineering

Novel mechanism for mesenchymal stem cells in attenuating peritoneal adhesion: accumulating in the lung and secreting tumor necrosis factor α-stimulating gene-6

Nan Wang et al.

STEM CELL RESEARCH & THERAPY (2012)

添加到收藏夹

Article Surgery

A Clinically Applicable Porcine Model of Septic and Ischemia/Reperfusion-Induced Shock and Multiple Organ Injury

Brian D. Kubiak et al.

JOURNAL OF SURGICAL RESEARCH (2011)

添加到收藏夹

Article Immunology

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

Soufiane Ghannam et al.

JOURNAL OF IMMUNOLOGY (2010)

添加到收藏夹

Article Medicine, General & Internal

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

Jean-Louis Vincent et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)

添加到收藏夹

Article Medicine, General & Internal

An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist

Ivona Aksentijevich et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

添加到收藏夹

Article Cell & Tissue Engineering

Biodistribution, Long-term Survival, and Safety of Human Adipose Tissue-derived Mesenchymal Stem Cells Transplanted in Nude Mice by High Sensitivity Non-invasive Bioluminescence Imaging

Marta Vilalta et al.

STEM CELLS AND DEVELOPMENT (2008)

添加到收藏夹

Article Cell & Tissue Engineering

The immunogenicity of human adipose-derived cells: Temporal changes in vitro

Kevin McIntosh et al.

STEM CELLS (2006)

添加到收藏夹

Review Cell Biology

Interferon-γ:: an overview of signals, mechanisms and functions

K Schroder et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2004)

添加到收藏夹

Therapeutic effect of adipose-derived mesenchymal stem cells in a porcine model of abdominal sepsis

相关参考文献

导出引文

分享论文