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Article
Immunology
Jue Tao Lim et al.
Summary: This study investigated the postacute risk and burden of cardiovascular, cerebrovascular, and other thrombotic complications following SARS-CoV-2 infection in a highly vaccinated multiethnic Southeast Asian population. The results showed that individuals with COVID-19 had increased risk and burden of new-incident cardiovascular and cerebrovascular complications compared to the control group. However, these risks were attenuated in vaccinated and boosted individuals. Conversely, risks and burdens of subsequent complications were higher in hospitalized and severe COVID-19 cases compared to nonhospitalized cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Sophie Alice Müller et al.
Lancet Global Health
(2023)
Article
Biochemistry & Molecular Biology
Yapeng Su et al.
Summary: Post-acute sequelae of COVID-19 (PASC) is an emerging global crisis, and the quantifiable risk factors and biological associations are not well understood. In this study, a deep multi-omic investigation was conducted on 309 COVID-19 patients, and four PASC-anticipating risk factors were identified at the time of initial diagnosis. The study also observed changes in immune states during recovery from COVID-19.
Article
Biochemistry & Molecular Biology
Yan Xie et al.
Summary: Individuals with COVID-19, even those who were not hospitalized during the acute phase of the infection, are at an increased long-term risk of various cardiovascular disorders. A study using national healthcare databases found that beyond the first 30 days after infection, individuals with COVID-19 have an elevated risk of developing cerebrovascular disorders, heart diseases, and other cardiovascular complications. The risk increases depending on the care setting during the acute phase.
Article
Biochemistry & Molecular Biology
Tao Chen et al.
Summary: The iProX integrated proteome resource has been greatly improved with an up-to-date big data platform to support large-scale data storage, efficient querying, and reanalysis, meeting the demands of the rapidly growing field of proteomics.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ziyad Al-Aly et al.
Summary: This study analyzed the US Department of Veterans Affairs national healthcare databases to investigate the occurrence of Long COVID and death risk after breakthrough SARS-CoV-2 infection. The findings showed that vaccination significantly reduced the risk of death and post-acute sequelae but did not eliminate them completely. These results underscore the importance of further research on prevention and post-acute care for breakthrough infections.
Article
Biochemistry & Molecular Biology
Brad T. Sherman et al.
Summary: DAVID, a popular bioinformatics resource system, has undergone updates in 2021, including the rebuilding of the DAVID Gene system, increasing the number of gene-term records for annotation types, adding new annotations, assigning specific subgroups, and adding a species parameter for improved user experience.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Ling Leng et al.
Summary: This study used a quantitative spatial proteomics strategy to investigate the proteome of myocardia and microvessels in different regions of the heart in COVID-19 patients. The results showed molecular dysfunctions in different cardiac regions, with the myocardia and microvessels of the left atrial being the most susceptible to virus infection and inflammation.
Review
Cardiac & Cardiovascular Systems
Vincenzo Nuzzi et al.
Summary: This review summarizes the current knowledge on myocardial involvement in COVID-19, including the incidence, pathogenetic mechanisms, and clinical implications. It is important to systematically assess myocardial injury for prognostication and potential therapeutic implications in severe COVID-19 infection.
CURRENT CARDIOLOGY REPORTS
(2022)
Article
Medicine, General & Internal
Gabriella Captur et al.
Summary: This study reveals that SARS-CoV-2 infection affects the plasma proteome for at least 6 weeks, and the proteomic signature at the time of seroconversion can predict the likelihood of persistent symptoms related to the infection.
Review
Cardiac & Cardiovascular Systems
Leonardo Italia et al.
Summary: The relationship between heart failure (HF) and coronavirus disease 2019 (COVID-19) is complex, with COVID-19 pandemic causing a reduction in HF hospitalizations but increasing HF mortality. Pre-existing HF is a risk factor for a more severe clinical course of COVID-19, and myocardial injury is common in COVID-19 patients, potentially leading to HF. Further research is needed to fully understand the long-term consequences of cardiac involvement in COVID-19 patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xiu Nie et al.
Summary: This study used proteomic analysis to reveal the molecular mechanisms of multi-organ injuries in COVID-19 patients. The data showed significant upregulation of cathepsin L1 in the lung, instead of ACE2. Systemic hyperinflammation, dysregulation of glucose and fatty acid metabolism were detected in multiple organs.
Letter
Medicine, General & Internal
John P. Donnelly et al.
Summary: The study provides an overview of readmission reasons, ICU interventions during readmission, and proportions of death after initial hospital discharge among COVID-19 patients from US Veterans Affairs hospitals between March and June 2020.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Damian Szklarczyk et al.
Summary: The STRING database integrates various associations between proteins, including physical interactions and functional associations, by collecting evidence from sources such as literature, databases, computational predictions, and systematic transfers. STRING aims for wide coverage and provides extensive user interface features and querying methods for experimental data.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell & Tissue Engineering
Silvia Marchiano et al.
Summary: Research shows that SARS-CoV-2 selectively infects human pluripotent stem cell-derived cardiomyocytes, leading to a shift in host gene expression and impairment of cellular functions. This suggests that COVID-19-related cardiac symptoms may be a result of the direct cardiotoxic effect of the virus.
Article
Multidisciplinary Sciences
Toni M. Delorey et al.
Summary: This study using single-cell and spatial atlases revealed the impact of COVID-19 infection on lung, kidney, liver, and heart tissues, showing structural remodeling and viral RNA enrichment. Differences in lung inflammatory responses and transcriptional alterations in heart tissue of COVID-19 patients were also identified, along with cell types and genes associated with disease severity.
Article
Multidisciplinary Sciences
Alexey Stukalov et al.
Summary: The study reports a concurrent multi-omics analysis of SARS-CoV-2 and SARS-CoV, revealing both distinct and common molecular mechanisms between these closely related coronaviruses, as well as their impact on the host cell proteome. The results of this study may provide insights into the design of virus- and host-directed therapies for these coronaviruses.
Article
Cell Biology
Juan A. Perez-Bermejo et al.
Summary: This study found that heart cells of COVID-19 patients exposed to SARS-CoV-2 may suffer significant damage such as myofibrillar fragmentation and nuclear disruption, providing insights for potential therapeutic discovery.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Pediatrics
Ermias D. Belay et al.
Summary: This study conducted a cross-sectional analysis of a large cohort of patients with MIS-C in the United States, identifying 2 peaks that followed COVID-19 peaks by 2 to 5 weeks. The geographic and temporal association of MIS-C with the COVID-19 pandemic suggested that MIS-C resulted from delayed immunologic responses to SARS-CoV-2 infection. Clinical manifestations varied by age and presence or absence of preceding COVID-19.
Article
Cardiac & Cardiovascular Systems
Matteo Dal Ferro et al.
Summary: Myocarditis is rarely found in autopsy cohorts of COVID-19 patients and is not associated with the presence of SARS-CoV-2 in cardiomyocytes. Chronic and acute myocardial damage is consistently present and correlates with the severity of the COVID-19 disease and pre-existing comorbidities.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Critical Care Medicine
Davies Adeloye et al.
Summary: An international consensus exercise was conducted to identify research priorities for understanding the long-term effects of acute COVID-19, focusing on individuals with pre-existing airways disease. High priority was given to investigations on prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge, as well as comparisons of prevalence and severity of post-COVID-19 symptoms between patients with and without pre-existing airways disease.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Peng Zhou et al.
Article
Biochemistry & Molecular Biology
Ren-Di Jiang et al.
Article
Multidisciplinary Sciences
David E. Gordon et al.
Article
Cardiac & Cardiovascular Systems
Anuradha Lala et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Multidisciplinary Sciences
David E. Gordon et al.
Article
Cardiac & Cardiovascular Systems
Carlo Mario Lombardi et al.
Article
Biochemistry & Molecular Biology
Jie Ma et al.
NUCLEIC ACIDS RESEARCH
(2019)
Article
Biochemical Research Methods
Zuguang Gu et al.
Article
Biotechnology & Applied Microbiology
Juergen Cox et al.
NATURE BIOTECHNOLOGY
(2008)
Article
Biochemistry & Molecular Biology
P Shannon et al.
