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DNA repair in tumor radioresistance: insights from fruit flies genetics

CELLULAR ONCOLOGY (2023)

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Article Multidisciplinary Sciences

PRKRA promotes pancreatic cancer progression by upregulating MMP1 transcription via the NF-& kappa;B pathway

Jiangdong Qiu et al.

Summary: This study found that PRKRA is overexpressed in pancreatic cancer tissues and is associated with poor prognosis. PRKRA promotes the proliferation, migration, and chemoresistance of pancreatic cancer cells by upregulating the transcription of MMP1 via the NF-κB pathway. The proliferation of pancreatic cancer organoids and sensitivity to chemotherapy are influenced by the expression of PRKRA and MMP1.

HELIYON (2023)

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Review Medicine, Research & Experimental

Molecular landscape of LncRNAs in bladder cancer: From drug resistance to novel LncRNA-based therapeutic strategies

Amirreza Mehmandar-Oskuie et al.

Summary: Bladder cancer is a prevalent and challenging malignancy worldwide. Long noncoding RNAs (lncRNAs) have been identified as playing significant roles in the development and progression of bladder cancer. Abnormal expression of lncRNAs impacts various functions related to bladder cancer, and they show potential as prognostic and diagnostic biomarkers. The use of genetic tools and anti-tumor agents has also been explored in preclinical cancer models.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Cell Biology

Co-amplification of CBX3 with EGFR or RAC1 in human cancers corroborated by a conserved genetic interaction among the genes

Giuseppe Bosso et al.

Summary: CBX3 overexpression is common in cancer and promotes cancer cell proliferation, serving as a poor prognosis marker in various types of human cancers. Co-amplification of CBX3 gene with either EGFR or RAC1 results in increased levels of CBX3, EGFR, and RAC1. Simultaneous overexpression of CBX3, RAC1, and EGFR is associated with worse prognosis compared to singular upregulation of these genes. Co-occurrence of low-grade and high-grade amplification between CBX3 and EGFR or RAC1 is linked to reduced patient lifespan. Genetic interactions between CBX3 and RAC1/EGFR are observed in Drosophila melanogaster, suggesting evolutionarily conserved functional relationships.

CELL DEATH DISCOVERY (2023)

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Review Immunology

The multifunctional protein HMGB1: 50 years of discovery

Daolin Tang et al.

Summary: Fifty years since the discovery of HMGB1 protein, its physiological and pathological roles have been extensively studied. This Review covers the structure, localization, and functions of HMGB1 in immune responses, including historical foundations and recent advances.

NATURE REVIEWS IMMUNOLOGY (2023)

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Article Biology

Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila

Julia Hofstetter et al.

Summary: The transcription factor SPT5 physically interacts with MYC oncoproteins and plays a crucial role in tumor development and survival. Knockdown of SPT5 enhances eye defects caused by Myc overexpression and inhibits the growth of experimentally induced neuroblast tumors, resulting in extended lifespan of tumor-bearing animals. These findings highlight SPT5 as a potential drug target in human oncology.

LIFE SCIENCE ALLIANCE (2023)

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Review Biochemistry & Molecular Biology

Recent advances of NEAT1-miRNA interactions in cancer

Hui Zhou et al.

Summary: With a high incidence rate, cancer is a leading cause of human mortality. Non-coding RNAs, specifically long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have emerged as important regulators in tumorigenesis. Among them, the lncRNA NEAT1 has attracted significant attention due to its dysregulation in various cancers, where it acts as either an oncogene or a tumor suppressor gene. Accumulating evidence suggests that NEAT1 plays a critical role in carcinogenesis, influencing processes such as proliferation, invasion, survival, drug resistance, and metastasis. NEAT1 is considered as a potential biomarker and therapeutic target for the diagnosis and prognosis of different cancer types. The mechanisms underlying the role of NEAT1 in cancer primarily involve interactions with miRNAs. NEAT1-miRNA regulatory networks have garnered considerable interest among researchers worldwide, as they play significant roles in tumorigenesis. This review summarizes the interaction between NEAT1 and miRNAs in the regulation of protein-coding genes in cancer, with the goal of advancing our understanding of NEAT1-miRNA interactions for the development of new diagnostic biomarkers and therapeutic approaches.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2022)

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Article Oncology

Glioblastoma recurrent cells switch between ATM and ATR pathway as an alternative strategy to survive radiation stress

Ekjot Kaur et al.

Summary: The primary treatment modality for glioblastoma (GBM) after surgery is radiation therapy. However, due to the increased DNA damage repair capacity of resistant residual GBM cells, recurrence is inevitable and the recurrent tumors become resistant to conventional therapy. This study shows that recurrent GBM cells utilize an alternate DNA damage repair kinase to overcome radiation-induced DNA damage, indicating the underlying heterogeneity within and across GBM samples.

MEDICAL ONCOLOGY (2022)

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Article Cell Biology

Novel lncRNA AL033381.2 Promotes Hepatocellular Carcinoma Progression by Upregulating PRKRA Expression

Feiran Wang et al.

Summary: This study identified a novel lncRNA AL033381.2 that is upregulated in hepatocellular carcinoma (HCC) and plays a role in the growth and metastasis of HCC. It was found that AL033381.2 binds to PRKRA and may be involved in AL033381.2-mediated oncogenic functions in HCC cells. In addition, a nanoparticle-based siRNA delivery system showed therapeutic effects in reducing the growth rate of HCC tumors in vivo.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Immunology

Lighting up the tumor fire with low-dose irradiation

Fernanda G. Herrera et al.

Summary: Recent studies have shown that low-dose radiation therapy effectively activates the immune system and synergizes with immunotherapy, enhancing immune response. These findings help redefine the role of radiation therapy in cancer immunotherapy.

TRENDS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory

Antonella Porrazzo et al.

Summary: Evidence from studies conducted in deep underground laboratories suggests that environmental radiation may trigger biological mechanisms to cope with genotoxic stress. Our study found that Drosophila neuroblasts are more sensitive to radiation-induced DNA breaks in the reduced radiation background of the LNGS underground laboratory, but this sensitivity can be rescued by increasing the underground gamma dose rate.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biology

Factors and molecular mechanisms of radiation resistance in cancer cells

Juan C. Alamilla-Presuel et al.

Summary: Radiation resistance is a cause of treatment failure and tumor relapse. Understanding cancer stem cells and associated signaling pathways can lead to new strategies for radiation therapy. The mechanisms of radiation resistance in different tumors are not fully understood, and molecular markers can help classify and treat more aggressive tumors.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

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Review Cell Biology

DNA single-strand break repair and human genetic disease

Keith W. Caldecott

Summary: DNA single-strand breaks (SSBs) are common DNA lesions in cells and can arise from exposure to genotoxins or normal DNA metabolic processes. If left unrepaired, SSBs can have serious consequences, including neurodegenerative diseases. This review discusses the current understanding of SSB repair mechanisms and their impact on neurological diseases.

TRENDS IN CELL BIOLOGY (2022)

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Article Genetics & Heredity

Obstacles and opportunities for base excision repair in chromatin

Dana J. Biechele-Speziale et al.

Summary: This article summarizes recent findings on the regulation of base excision repair (BER) pathway by DNA packaging and chromatin structures. It also presents available data indicating the potential role of chromatin modifications and remodeling in enabling BER.

DNA REPAIR (2022)

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Review Biochemistry & Molecular Biology

Panoramic view of microRNAs in regulating cancer stem cells

Yongzhi Zhao et al.

Summary: This article reviews the roles of mature miRNAs, miRNA precursors, and miRNA-processing machinery in regulating CSC properties, with a focus on the related molecular mechanisms. Studies have shown that mature miRNAs can modulate CSC initiation and stemness features by regulating multiple pathways and targeting stemness-related factors. Moreover, both miRNA precursors and miRNA-processing machinery can also affect CSC properties. miRNAs have potential applications in cancer diagnosis, predicting prognosis, and clinical therapy.

ESSAYS IN BIOCHEMISTRY (2022)

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Review Health Care Sciences & Services

Radio-lncRNAs: Biological Function and Potential Use as Biomarkers for Personalized Oncology

Joanna Kozlowska-Maslon et al.

Summary: Long non-coding RNAs (lncRNAs) play crucial regulatory roles in both normal and cancer cells, and are associated with tumorigenesis, treatment response, and patient outcomes. This review examines the role of lncRNAs in radiotherapy and their impact on treatment efficacy.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article Biology

Low dose rate γ-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious

A. Porrazzo et al.

Summary: Chronic low-dose radiation exposure reduces chromosome breaks and telomere dysfunction caused by high-dose irradiation in Drosophila cells. This protective response is associated with the downregulation of the Loquacious D gene, which is involved in esiRNA biogenesis. Loss of Loquacious D mimics the protective effect of low-dose radiation, suggesting its importance in the cellular response to radiation.

COMMUNICATIONS BIOLOGY (2022)

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Review Oncology

Radiotherapy-induced metabolic hallmarks in the tumor microenvironment

Anjali Mittal et al.

Summary: Radiation therapy alters cancer cell metabolism to reduce cytotoxic effects and also affects the tumor microenvironment by metabolite exchange to support tumor growth. Combining metabolic targets in the tumor microenvironment with radiotherapy can improve treatment response.

TRENDS IN CANCER (2022)

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Article Oncology

Radiotherapy may augment response to immunotherapy in metastatic uveal melanoma patients

Shirly Grynberg et al.

Summary: The study suggests that the combination therapy of radiotherapy and immunotherapy may significantly improve overall response rate and survival time in patients with metastatic uveal melanoma. Further prospective studies with larger sample sizes are warranted.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2022)

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Article Cell Biology

LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma

Zhen Guo et al.

Summary: Our study found that linc00312 is significantly down-regulated in NPC tissues and higher expression of linc00312 is associated with longer overall survival and better short-term radiotherapy efficacy. Overexpression of linc00312 increases NPC cells' sensitivity to ionizing radiation by hindering the DNA repair and cell cycle control mechanisms. DNA-PKcs was identified as the binding protein of linc00312, revealing a novel mechanism in the DNA damage response.

CELL DEATH & DISEASE (2021)

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Article Biochemistry & Molecular Biology

MS-275 (Entinostat) Promotes Radio-Sensitivity in PAX3-FOXO1 Rhabdomyosarcoma Cells

Matteo Cassandri et al.

Summary: The study evaluated the effects of MS-275 in combination with radiation therapy on RMS cells, showing that MS-275 could enhance radio-sensitivity and affect cell growth and DNA repair mechanisms through multiple pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

HIF2alpha-Associated Pseudohypoxia Promotes Radioresistance in Pheochromocytoma: Insights from 3D Models

Verena Seifert et al.

Summary: Low oxygen levels and genetic defects activating hypoxia signaling pathways contribute to tumorigenesis and therapy resistance. Pseudohypoxia plays a role in tumor formation and metastasis in pheochromocytomas and paragangliomas. Pseudohypoxia may protect against radiation treatments in these tumors, highlighting potential targets for radiosensitizing therapies.

CANCERS (2021)

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Article Cell Biology

MiR-20b and miR-125a promote tumorigenesis in radioresistant esophageal carcinoma cells

Didi Chen et al.

Aging-US (2021)

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Article Biology

Romidepsin (FK228) fails in counteracting the transformed phenotype of rhabdomyosarcoma cells but efficiently radiosensitizes, in vitro and in vivo, the alveolar phenotype subtype

Alessandra Rossetti et al.

Summary: FK228, an inhibitor of class I HDACs, showed reversible downregulation of class I HDACs expression and activity, induction of oxidative stress, DNA damage, and growth arrest leading to non-apoptotic cell death in RMS cells. Compared to HMSC, RMS expressed low levels of class I HDACs. FK228 combined with radiation therapy significantly reduced tumor mass in fusion-positive RMS cells, suggesting a potential strategy for treating aggressive RMS.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

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Article Cell Biology

DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma

Simona Camero et al.

Summary: The overexpression of DNMT3A and DNMT3B may contribute to radiotherapy failure in RMS, and their inhibition could be a promising radiosensitizing strategy for the treatment of patients with metastatic or recurrent RMS tumors.

CELLS (2021)

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Article Cell Biology

LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer

You-hong Wang et al.

Summary: This study found that LINC-PINT is significantly downregulated in nasopharyngeal cancer tissues compared to rhinitis tissues, and low LINC-PINT expressions are associated with poorer prognosis in patients receiving radiotherapy. LINC-PINT plays a functional role in inhibiting malignant phenotypes and sensitizing cancer cells to irradiation in vitro and in vivo. Mechanistically, LINC-PINT inhibits DNA damage repair through the ATM/ATR-Chk1/Chk2 signaling pathways and increases radiosensitivity by interacting with DNA-PKcs.

CELL DEATH & DISEASE (2021)

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Article Biology

Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance

Yong-Li Dong et al.

Summary: Oncogenic RAS mutations lead to tumor resistance to radiation therapy. Cell-cell interactions in the tumor microenvironment are crucial for therapy outcomes. Blocking cell-cell communication loops can resensitize Ras tumor cells to irradiation.

COMMUNICATIONS BIOLOGY (2021)

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Article Biology

Knockdown of circ_0008344 contributes to radiosensitization in glioma via miR-433-3p/RNF2 axis

Liang Di et al.

Summary: This study revealed that circ_0008344 played a crucial role in radioresistance of glioma, with its down-regulation enhancing glioma cell susceptibility to radiation. It was found to interact with miR-433-3p and regulate radiosensitivity of glioma cells by sponging miR-433-3p. Additionally, RNF2 was identified as a target of miR-433-3p and regulated by the circ_0008344/miR-433-3p axis, indicating circ_0008344 as a potential diagnostic biomarker and therapeutic target in glioma radiotherapy.

JOURNAL OF BIOSCIENCES (2021)

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Review Medicine, General & Internal

Contemporary radiotherapy: present and future

Ravi A. Chandra et al.

Summary: With the increasing multidisciplinary nature of oncology care, radiation therapy plays a key role in the treatment of almost every cancer, yet remains one of the least understood fields. This review aims to summarize recent developments in radiation oncology for non-specialists, highlighting advancements in treatment technologies and the emerging frontiers in the field.

LANCET (2021)

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Review Cell Biology

The Roles of the Let-7 Family of MicroRNAs in the Regulation of Cancer Stemness

Yuxi Ma et al.

Summary: Cancer stem-like cells play a critical role in tumorigenesis, cancer progression, treatment resistance, and metastatic relapse. The let-7 family of microRNAs is important in regulating cancer stemness through various RNA-binding proteins, long non-coding RNAs, and circular RNAs. Targeting let-7 for cancer therapeutics has the potential to improve treatment efficacy by specifically targeting CSCs and modulating metabolic pathways.

CELLS (2021)

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Review Oncology

Radiation Resistance: A Matter of Transcription Factors

Chiara Galeaz et al.

Summary: Radiation therapy is a standard treatment for cancer, but resistance mechanisms remain a significant challenge to overcome. Understanding transcription factors activated post-radiation can lead to the development of new treatment strategies for enhanced effectiveness. NF-kappa B, NRF2, and HIF-1 induce antioxidant enzymes to mitigate the damaging effects of radiation therapy, thereby reducing treatment efficacy.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell & Tissue Engineering

miRNA signaling networks in cancer stem cells

Kosuke Yoshida et al.

Summary: Cancer stem cells (CSCs) are a small subpopulation of cells in many cancer types involved in tumor progression, with distinct features such as self-renewal, multidifferentiation, and resistance to therapy. Micro-RNAs (miRNAs) play a crucial role in regulating CSC properties, and understanding miRNA-induced modulation of CSC gene expression could lead to the development of promising biomarkers and therapeutic targets.

REGENERATIVE THERAPY (2021)

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Article Biochemistry & Molecular Biology

The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1α

Ying Wang et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Biochemistry & Molecular Biology

Long noncoding RNA LINC00630 promotes radio-resistance by regulating BEX1 gene methylation in colorectal cancer cells

Feng Liu et al.

IUBMB LIFE (2020)

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A three-lncRNA signature predicts clinical outcomes in low-grade glioma patients after radiotherapy

Wanzun Lin et al.

AGING-US (2020)

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Review Oncology

DNA damage response and resistance of cancer stem cells

Etna Abad et al.

CANCER LETTERS (2020)

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Article Oncology

HOTAIR Competitively Binds MiRNA330 as a Molecular Sponge to Increase the Resistance of Gastric Cancer to Trastuzumab

Liangyu Bie et al.

CURRENT CANCER DRUG TARGETS (2020)

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Article Oncology

Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells

Asmita Sharda et al.

CLINICAL EPIGENETICS (2020)

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Article Oncology

Inhibition of SETMAR-H3K36me2-NHEJ repair axis in residual disease cells prevents glioblastoma recurrence

Ekjot Kaur et al.

NEURO-ONCOLOGY (2020)

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Article Oncology

Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21

Cheng Wu et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

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Review Oncology

Non-Coding RNAs in Cancer Radiosensitivity: MicroRNAs and lncRNAs as Regulators of Radiation-Induced Signaling Pathways

Marta Podralska et al.

CANCERS (2020)

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hTERT promoter methylation promotes small cell lung cancer progression and radiotherapy resistance (Publication with Expression of Concern. See vol. 62, pg. 556, 2021)

Guangsheng Zhai et al.

JOURNAL OF RADIATION RESEARCH (2020)

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Review Cell Biology

The molecular basis and disease relevance of non-homologous DNA end joining

Bailin Zhao et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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lncRNA HOTAIR Promotes DNA Repair and Radioresistance of Breast Cancer via EZH2

Liyu Qian et al.

DNA AND CELL BIOLOGY (2020)

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Article Oncology

IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer

Yulan Zeng et al.

CANCER LETTERS (2020)

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Article Oncology

An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer

Laura Bourillon et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Article Cell Biology

High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy

Hongbing Ma et al.

CELL DEATH & DISEASE (2019)

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Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation

Eun-Jin Yun et al.

CLINICAL CANCER RESEARCH (2019)

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Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair

Ryan Robb et al.

CLINICAL CANCER RESEARCH (2019)

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Shieldin - the protector of DNA ends

Dheva Setiaputra et al.

EMBO REPORTS (2019)

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Review Cell Biology

DNA double-strand break repair-pathway choice in somatic mammalian cells

Ralph Scully et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system

Claire Lhuillier et al.

GENOME MEDICINE (2019)

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Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

Alexander Schulz et al.

CANCERS (2019)

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RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer

Annapurna Pranatharthi et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

Sara Genovese et al.

ELIFE (2019)

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Article Oncology

Pro-differentiating and radiosensitizing effects of inhibiting HDACs by PXD-101 (Belinostat) in in vitro and in vivo models of human rhabdomyosarcoma cell lines

Francesco Mararnpon et al.

CANCER LETTERS (2019)

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Article Multidisciplinary Sciences

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Jacqueline H. L. Fok et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

PRKRA/PACT Expression Promotes Chemoresistance of Mucinous Ovarian Cancer

Takeshi Hisamatsu et al.

MOLECULAR CANCER THERAPEUTICS (2019)

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Review Oncology

Involvement of the long noncoding RNA NEAT1 in carcinogenesis

Christiane Klec et al.

MOLECULAR ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells

Jinfang Hu et al.

BMB REPORTS (2019)

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Article Cell Biology

Effects of reduced natural background radiation on Drosophila melanogaster growth and development as revealed by the FLYINGLOW program

Patrizia Morciano et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Article Oncology

Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Ross D. Carruthers et al.

CANCER RESEARCH (2018)

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Reduction-oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics

R. Yahyapour et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2018)

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Review Biochemistry & Molecular Biology

Homologous recombination and the repair of DNA double-strand breaks

William Douglass Wright et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Overview of Biological, Epidemiological, and Clinical Evidence of Radiation Hormesis

Yuta Shibamoto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Radiation, inflammation and the immune response in cancer

Kelly J. McKelvey et al.

MAMMALIAN GENOME (2018)

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Article Multidisciplinary Sciences

The shieldin complex mediates 53BP1-dependent DNA repair

Sylvie M. Noordermeer et al.

NATURE (2018)

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Article Multidisciplinary Sciences

The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells

Yanzhe Gao et al.

SCIENTIFIC REPORTS (2018)

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Cell motility in cancer invasion and metastasis: insights from simple model organisms

Christina H. Stuelten et al.

NATURE REVIEWS CANCER (2018)

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Article Genetics & Heredity

DNA Repair in Drosophila: Mutagens, Models, and Missing Genes

Jeff Sekelsky

GENETICS (2017)

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Combined Radiation Therapy and Immune Checkpoint Blockade Therapy for Breast Cancer

Zishuo I. Hu et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2017)

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Article Oncology

14-3-3s Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2

Yifan Chen et al.

MOLECULAR CANCER RESEARCH (2017)

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Review Biochemistry & Molecular Biology

DNA Damage in Stem CellsDNA Damage in Stem Cells

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MOLECULAR CELL (2017)

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Non-homologous DNA end joining and alternative pathways to double-strand break repair

Howard H. Y. Chang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

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Article Oncology

Chromatin remodeling modulates radiosensitivity of the daughter cells derived from cell population exposed to low- and high-LET irradiation

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ONCOTARGET (2017)

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DNA Repair in Drosophila: Mutagens, Models, and Missing Genes

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GENETICS (2017)

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HDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cells

Francesco Marampon et al.

CANCER LETTERS (2017)

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Editorial Material Biochemistry & Molecular Biology

Transcript RNA supports precise repair of its own DNA gene

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RNA BIOLOGY (2016)

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JOURNAL OF PHYSICAL CHEMISTRY B (2016)

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Long noncoding RNAs: new insights into non-small cell lung cancer biology, diagnosis and therapy

Biagio Ricciuti et al.

MEDICAL ONCOLOGY (2016)

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Unraveling the mechanisms of extreme radioresistance in prokaryotes: Lessons from nature

Athanasia Pavlopoulou et al.

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A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

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Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila

Karine Narbonne-Reveau et al.

ELIFE (2016)

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Article Oncology

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

Sophia X. Pfister et al.

CANCER CELL (2015)

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Article Cell & Tissue Engineering

Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

Katarzyna Siudeja et al.

CELL STEM CELL (2015)

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A Drosophila model to investigate the neurotoxic side effects of radiation exposure

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LANCET (2015)

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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

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Opportunities and challenges of radiotherapy for treating cancer

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NATURE REVIEWS CLINICAL ONCOLOGY (2015)

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In vivo radioadaptive response: A review of studies relevant to radiation-induced cancer risk

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HUMAN & EXPERIMENTAL TOXICOLOGY (2015)

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Downregulation of high mobility group box 1 modulates telomere homeostasis and increases the radiosensitivity of human breast cancer cells

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INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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The network of epithelial-mesenchymal transition: potential new targets for tumor resistance

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Epigenetic DNA Methylation in Radiation Biology: On the Field or on the Sidelines?

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The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence

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Drosophila neuroblasts as a new model for the study of stem cell self-renewal and tumour formation

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Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination

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Involvement of microRNA-24 and DNA Methylation in Resistance of Nasopharyngeal Carcinoma to Ionizing Radiation

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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CH K1

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Genome-Wide Association Analysis of Radiation Resistance in Drosophila melanogaster

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CD133+cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells

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RADIOTHERAPY AND ONCOLOGY (2014)

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Epigenetics in radiotherapy: Where are we heading?

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RADIOTHERAPY AND ONCOLOGY (2014)

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RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

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MOLECULAR CELL (2013)

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A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

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MOLECULAR CELL (2013)

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Tumour heterogeneity in the clinic

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Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up

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53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

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Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors

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FRONTIERS IN PHARMACOLOGY (2013)

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The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man

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BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

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A small RNA response at DNA ends in Drosophila

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Nucleotide excision repair: new tricks with old bricks

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Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer

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Double-Strand Break End Resection and Repair Pathway Choice

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L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1

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EMBO JOURNAL (2011)

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Extremophiles: radiation resistance microbial reserves and therapeutic implications

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Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila

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Downregulation of Human DAB2IP Gene Expression in Prostate Cancer Cells Results in Resistance to Ionizing Radiation

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

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Asymmetric cell division: recent developments and their implications for tumour biology

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

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Global analysis of CpG methylation reveals epigenetic control of the radiosensitivity in lung cancer cell lines

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

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Regulatory roles of natural antisense transcripts

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The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells

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CURRENT BIOLOGY (2007)

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Radioadaptive response revisited

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The response of CD24-/low/CD44+ breast cancer-initiating cells to radiation

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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

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Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi

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CURRENT BIOLOGY (2006)

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Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster

E Caussinus et al.

NATURE GENETICS (2005)

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Normal microRNA maturation and germ-line stem cell maintenance requires loquacious, a double-stranded RNA-binding domain protein

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PLOS BIOLOGY (2005)

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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CANCER RESEARCH (2004)

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Review Biochemistry & Molecular Biology

Rad51 recombinase and recombination mediators

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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Hyper-resistance of meiotic cells to radiation due to a strong expression of a single recA-like gene in Caenorhabditis elegans

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NUCLEIC ACIDS RESEARCH (2000)

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