[Bmim]BF4 ionic liquid: An efficient reaction medium for the one-pot multi-component synthesis of 2-amino-4, 6-diphenylpyridine-3-carbonitrile derivatives

One-pot condensation from aromatic aldehyde, methyl ketone, malononitrile and ammonium acetate in the presence of the ionic liquid (IL), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]), affords the corresponding 2-amino-4,6-diphenylpyridine-3-carbonitrile derivatives. This method has the advantage of short routine, high yields and being environmentally-friendly. Here, the need for catalyst is avoided through the use of catalytically active ionic liquid as solvent. Furthermore, the possible mechanism is also proposed. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.